Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8G5 Gene

Aliases for OR8G5 Gene

  • Olfactory Receptor Family 8 Subfamily G Member 5 2 3 5
  • Olfactory Receptor OR11-298 3 4
  • Olfactory Receptor 8G5 3 4
  • Olfactory Receptor 8G6 3 4
  • OR8G5P 3 4
  • OR8G6 3 4
  • Olfactory Receptor, Family 8, Subfamily G, Member 5 Pseudogene 3
  • Olfactory Receptor, Family 8, Subfamily G, Member 6 3
  • Olfactory Receptor, Family 8, Subfamily G, Member 5 2
  • OR11-298 3

External Ids for OR8G5 Gene

Previous HGNC Symbols for OR8G5 Gene

  • OR8G5P
  • OR8G6

Previous GeneCards Identifiers for OR8G5 Gene

  • GC11P123673
  • GC11P123640
  • GC11P124120
  • GC11P124134
  • GC11P124264

Summaries for OR8G5 Gene

Entrez Gene Summary for OR8G5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8G5 Gene

OR8G5 (Olfactory Receptor Family 8 Subfamily G Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8G1.

UniProtKB/Swiss-Prot Summary for OR8G5 Gene

Gene Wiki entry for OR8G5 Gene

Additional gene information for OR8G5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8G5 Gene

Genomics for OR8G5 Gene

GeneHancer (GH) Regulatory Elements for OR8G5 Gene

Promoters and enhancers for OR8G5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124241 Enhancer 0.3 FANTOM5 500.7 +0.1 81 0.1 NFE2 OR8G1 OR8G5 lnc-OR8G5-6 TMEM225 SPA17 VWA5A
GH11J124275 Enhancer 1.3 FANTOM5 Ensembl ENCODE 9.1 +35.8 35843 2.8 GTF2E2 HES1 RUNX1 CTBP1 HDAC3 NCOR1 MBD2 NEUROD1 ZNF282 NFIC VWA5A OR8G5 OR8D1 CCDC15 OR8G2P TBRG1 OR8B12 SLC5A4P1 lnc-OR8G5-5 piR-51137-027
GH11J124330 Enhancer 0.8 Ensembl ENCODE 5.8 +88.3 88343 3.4 EP300 REST CTCF NFIC SMC3 TRIM28 SPI1 IKZF1 RAD21 HLTF VWA5A OR8D1 OR8G5 CCDC15 OR8B7P lnc-OR8D2-1
GH11J124285 Enhancer 0.7 Ensembl ENCODE 5.1 +44.9 44861 1.8 CREB1 CEBPB FOSL1 EZH2 TCF7L2 TAF1 GATA2 FOS POLR2A FOXA1 VWA5A OR8D1 OR8G5 CCDC15 SLC5A4P1 lnc-OR8G5-5 piR-51137-027 lnc-OR8G5-6
GH11J124294 Enhancer 0.4 Ensembl 5.9 +53.7 53743 0.2 PBX2 SPI1 MEIS2 piR-51137-027 OR8D1 OR8G5 lnc-OR8G5-5 SLC5A4P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8G5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8G5

Top Transcription factor binding sites by QIAGEN in the OR8G5 gene promoter:
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • E47
  • Meis-1
  • Meis-1a
  • POU2F1
  • POU2F1a
  • S8
  • Tal-1

Genomic Locations for OR8G5 Gene

Genomic Locations for OR8G5 Gene
chr11:124,241,158-124,323,224
(GRCh38/hg38)
Size:
82,067 bases
Orientation:
Plus strand
chr11:124,134,723-124,135,763
(GRCh37/hg19)
Size:
1,041 bases
Orientation:
Plus strand

Genomic View for OR8G5 Gene

Genes around OR8G5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8G5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8G5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8G5 Gene

Proteins for OR8G5 Gene

  • Protein details for OR8G5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG78-OR8G5_HUMAN
    Recommended name:
    Olfactory receptor 8G5
    Protein Accession:
    Q8NG78
    Secondary Accessions:
    • B2RND3
    • Q6IEU6

    Protein attributes for OR8G5 Gene

    Size:
    346 amino acids
    Molecular mass:
    38798 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06171.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for OR8G5 Gene

Post-translational modifications for OR8G5 Gene

  • Glycosylation at Asn16 and Asn40
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8G5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8G5 Gene

Domains & Families for OR8G5 Gene

Gene Families for OR8G5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8G5 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR8G5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 8, subfamily G, member 5 (B2RND3_HUMAN)
  • Olfactory receptor, family 8, subfamily G, member 5 (B2RND4_HUMAN)
  • Olfactory receptor OR11-298 (OR8G5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NG78

UniProtKB/Swiss-Prot:

OR8G5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8G5: view

Function for OR8G5 Gene

Molecular function for OR8G5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8G5: view
genes like me logo Genes that share phenotypes with OR8G5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8G5 Gene

Localization for OR8G5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8G5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8G5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8G5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8G5 Gene

Pathways & Interactions for OR8G5 Gene

genes like me logo Genes that share pathways with OR8G5: view

Pathways by source for OR8G5 Gene

Interacting Proteins for OR8G5 Gene

;

Gene Ontology (GO) - Biological Process for OR8G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8G5: view

No data available for SIGNOR curated interactions for OR8G5 Gene

Drugs & Compounds for OR8G5 Gene

No Compound Related Data Available

Transcripts for OR8G5 Gene

mRNA/cDNA for OR8G5 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8G5 Gene

No ASD Table

Relevant External Links for OR8G5 Gene

GeneLoc Exon Structure for
OR8G5

Expression for OR8G5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8G5

SOURCE GeneReport for Unigene cluster for OR8G5 Gene:

Hs.722725
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8G5 Gene

Orthologs for OR8G5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR8G5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466826 30
  • 98.55 (n)
OR8G5 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 80 (a)
ManyToMany
-- 31
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TPCR79 31
  • 80 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or8g21 47 Olfr935 17 31 30
  • 79.65 (n)
Olfr936 31
  • 76 (a)
ManyToMany
Olfr44 31
  • 76 (a)
ManyToMany
Olfr937 31
  • 76 (a)
ManyToMany
Or8g17 47 Olfr146 31
  • 74 (a)
ManyToMany
Olfr943 31
  • 69 (a)
ManyToMany
Or8g32 47 Olfr951 31
  • 69 (a)
ManyToMany
Or8g34 47 Olfr954 31
  • 69 (a)
ManyToMany
Olfr27 31
  • 68 (a)
ManyToMany
Olfr1537 31
  • 68 (a)
ManyToMany
Olfr945 31
  • 68 (a)
ManyToMany
Olfr944 31
  • 65 (a)
ManyToMany
Olfr948 31
  • 65 (a)
ManyToMany
Or8g22-ps 47 Olfr936-ps1
  • chr9:39,046,620-39,047,540
Or8g25-ps 47 Olfr941-ps1
  • chr9:39,104,052-39,104,992
Or8g31-ps 47 Olfr949-ps1
  • chr9:39,364,552-39,365,506
rat
(Rattus norvegicus)
Mammalia LOC100910051 30
  • 77.74 (n)
oppossum
(Monodelphis domestica)
Mammalia OPOR89 31 31
  • 72 (a)
ManyToMany
-- 31
  • 72 (a)
ManyToMany
-- 31
  • 72 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
OPOR128 31
  • 70 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
OPOR88 31
  • 69 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii or115-7 30
  • 48.23 (n)
Species where no ortholog for OR8G5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR8G5 Gene

ENSEMBL:
Gene Tree for OR8G5 (if available)
TreeFam:
Gene Tree for OR8G5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8G5: view image

Paralogs for OR8G5 Gene

(454) SIMAP similar genes for OR8G5 Gene using alignment to 3 proteins:

  • OR8G5_HUMAN
  • B2RND3_HUMAN
  • B2RND4_HUMAN

Pseudogenes.org Pseudogenes for OR8G5 Gene

genes like me logo Genes that share paralogs with OR8G5: view

Variants for OR8G5 Gene

Additional dbSNP identifiers (rs#s) for OR8G5 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR8G5 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680
esv2745180 CNV deletion 23290073
esv2745184 CNV deletion 23290073
nsv975993 CNV duplication 23825009

Variation tolerance for OR8G5 Gene

Gene Damage Index Score: 19.09; 98.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8G5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8G5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8G5 Gene

Disorders for OR8G5 Gene

Additional Disease Information for OR8G5

No disorders were found for OR8G5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8G5 Gene

Publications for OR8G5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  2. Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein. (PMID: 22199357) Meng X … Leslie KK (The Journal of biological chemistry 2012) 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for OR8G5 Gene

Sources for OR8G5 Gene