Free for academic non-profit institutions. Other users need a Commercial license
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This family member represents a polymorphic pseudogene, whereby some individuals have a functional allele that encodes a full-length protein, while others have a non-functional allele due to the presence of an early stop codon and a 3' end deletion. [provided by RefSeq, Feb 2014]
OR8G1 (Olfactory Receptor Family 8 Subfamily G Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8G5.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J124241 | Enhancer | 0.3 | FANTOM5 | 600.7 | +0.1 | 144 | 0.1 | NFE2 | LOC112267863 OR8G1 lnc-OR8G5-6 TMEM225 SPA17 VWA5A OR8G5 | |
GH11J124206 | Enhancer | 1.1 | Ensembl ENCODE | 13.9 | -33.5 | -33518 | 1.2 | LEF1 IKZF1 JUND DDX20 MTA2 PKNOX1 ZNF24 MTA1 REST NR2C1 | OR8F1P lnc-OR10D3-1 VWA5A OR8G1 lnc-OR8D1-1 OR8G2P OR10D3 | |
GH11J124249 | Enhancer | 0.8 | Ensembl | 18.6 | +8.7 | 8705 | 1.6 | ZNF24 ZNF740 HDAC1 MGA ZNF766 CTBP1 NFE2 E2F5 ZNF316 NR2C2 | NONHSAG009926.2 OR8G1 VWA5A LOC112267863 OR8G5 lnc-OR8G5-6 | |
GH11J124264 | Enhancer | 0.6 | Ensembl | 18.9 | +23.9 | 23905 | 2 | MGA CTBP1 NFE2 ZNF316 NR2C2 FOSL1 MAFG ZNF644 ZNF592 ATF3 | VWA5A OR8G1 lnc-OR8G5-4 OR8G5 LOC112267863 lnc-OR8G5-6 OR8D1 | |
GH11J124271 | Enhancer | 0.4 | Ensembl | 18.5 | +30.0 | 30005 | 0.6 | NFE2 ZNF316 MAFG EMSY | lnc-OR8G5-4 OR8G1 OR8D1 SLC5A4P1 lnc-OR8G5-5 OR8G5 LOC112267863 lnc-OR8G5-6 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | NAS | 9119360 |
GO:0005549 | odorant binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | NAS | 9119360 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | GPCRs, Other |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IBA,NAS | 9119360 |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | LOC526276 30 |
|
||
-- 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | LOC102151657 30 |
|
||
TPCR79 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Olfr967 30 17 |
|
||
Olfr935 31 |
|
ManyToMany | |||
Olfr936 31 |
|
ManyToMany | |||
Olfr146 31 |
|
ManyToMany | |||
Or8ab1-ps 46 Olfr940-ps1 |
|
|
|||
Or8ab1-ps 46 Olfr950-ps1 |
|
|
|||
Or8ab2-ps 46 Olfr953-ps1 |
|
|
|||
Or8ac1-ps 46 Olfr942-ps1 |
|
|
|||
Or8g26 46 Olfr943 |
|
|
|||
Or8g28 46 Olfr945 |
|
|
|||
Or8o1-ps 46 Olfr1556-ps1 |
|
|
|||
Rat (Rattus norvegicus) |
Mammalia | Olr1321 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
OPOR89 31 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
OPOR128 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
OPOR88 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs4482039 | - | p.Ala247Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv82n21 | CNV | gain | 19592680 |
esv24586 | CNV | gain | 19812545 |
esv2745180 | CNV | deletion | 23290073 |
esv2745184 | CNV | deletion | 23290073 |
nsv975992 | CNV | duplication | 23825009 |
No disorders were found for OR8G1 Gene.