Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8G1 Gene

Aliases for OR8G1 Gene

  • Olfactory Receptor Family 8 Subfamily G Member 1 2 3 5
  • Olfactory Receptor, Family 8, Subfamily G, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR11-281 3 4
  • Olfactory Receptor TPCR25 3 4
  • Olfactory Receptor 8G1 3 4
  • HSTPCR25 2 3
  • OR8G1P 3 4
  • TPCR25 2 3
  • Olfactory Receptor, Family 8, Subfamily G, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 8 Subfamily G Member 1 (Gene/Pseudogene) 2
  • OR8G1 5

External Ids for OR8G1 Gene

Previous HGNC Symbols for OR8G1 Gene

  • OR8G1P

Previous GeneCards Identifiers for OR8G1 Gene

  • GC11P126121
  • GC11P125634
  • GC11P124154
  • GC11P123672
  • GC11P123627
  • GC11P124121
  • GC11P124122
  • GC11P124249
  • GC11P124243
  • GC11P124245

Summaries for OR8G1 Gene

Entrez Gene Summary for OR8G1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This family member represents a polymorphic pseudogene, whereby some individuals have a functional allele that encodes a full-length protein, while others have a non-functional allele due to the presence of an early stop codon and a 3' end deletion. [provided by RefSeq, Feb 2014]

GeneCards Summary for OR8G1 Gene

OR8G1 (Olfactory Receptor Family 8 Subfamily G Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8G5.

UniProtKB/Swiss-Prot Summary for OR8G1 Gene

Gene Wiki entry for OR8G1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8G1 Gene

Genomics for OR8G1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8G1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124241 Enhancer 0.3 FANTOM5 250.7 +0.1 144 0.1 NFE2 OR8G1 TMEM225 SPA17 VWA5A NONHSAG009926.2 OR8G5 HSALNG0087874 lnc-OR8G5-6
GH11J124206 Enhancer 1.1 Ensembl ENCODE 13.9 -33.5 -33518 1.2 MYC NCOR1 IKZF1 ZNF592 NFIC NONO REST HES1 MBD2 MNT OR8F1P lnc-OR10D3-1 VWA5A OR8G1 lnc-OR8D1-1 OR10D3 lnc-OR8G5-6
GH11J124249 Enhancer 0.7 Ensembl 18.6 +8.7 8705 1.6 ZNF592 MNT ELF1 ZNF316 NFE2 IRF9 EHMT2 FOXM1 RAD51 EP400 NONHSAG009926.2 OR8G1 VWA5A OR8G5 HSALNG0087874 lnc-OR8G5-6
GH11J124264 Enhancer 0.6 Ensembl 18.9 +23.9 23905 2 ZNF592 ZNF316 NFE2 MAFG L3MBTL2 NR2C1 ATF3 CTBP1 MGA EMSY VWA5A OR8G1 lnc-OR8G5-4 OR8G5 HSALNG0087874 OR8D1 lnc-OR8G5-6
GH11J124271 Enhancer 0.4 Ensembl 18.5 +30.1 30105 0.4 ZNF316 NFE2 MAFG EMSY lnc-OR8G5-4 OR8G1 lnc-OR8G5-5 OR8G5 HSALNG0087874 OR8D1 lnc-OR8G5-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8G1 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the OR8G1 gene promoter:
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • E47
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • S8
  • Tal-1

Genomic Locations for OR8G1 Gene

Latest Assembly
chr11:124,241,095-124,254,364
(GRCh38/hg38)
Size:
13,270 bases
Orientation:
Plus strand

Previous Assembly
chr11:124,120,423-124,121,287
(GRCh37/hg19 by Entrez Gene)
Size:
865 bases
Orientation:
Plus strand

chr11:124,120,423-124,135,763
(GRCh37/hg19 by Ensembl)
Size:
15,341 bases
Orientation:
Plus strand

Genomic View for OR8G1 Gene

Genes around OR8G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8G1 Gene

Proteins for OR8G1 Gene

  • Protein details for OR8G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15617-OR8G1_HUMAN
    Recommended name:
    Olfactory receptor 8G1
    Protein Accession:
    Q15617
    Secondary Accessions:
    • Q8NG88

    Protein attributes for OR8G1 Gene

    Size:
    311 amino acids
    Molecular mass:
    34904 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8G1 Gene

Post-translational modifications for OR8G1 Gene

  • Glycosylation at Asn5 and Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8G1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8G1 Gene

Domains & Families for OR8G1 Gene

Gene Families for OR8G1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8G1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8G1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor TPCR25 (OR8G1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15617

UniProtKB/Swiss-Prot:

OR8G1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8G1: view

Function for OR8G1 Gene

Molecular function for OR8G1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR8G1 Gene

Gene Ontology (GO) - Molecular Function for OR8G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8G1: view
genes like me logo Genes that share phenotypes with OR8G1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8G1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8G1 Gene

Localization for OR8G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8G1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8G1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR8G1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8G1 Gene

Pathways & Interactions for OR8G1 Gene

genes like me logo Genes that share pathways with OR8G1: view

Pathways by source for OR8G1 Gene

1 BioSystems pathway for OR8G1 Gene
1 KEGG pathway for OR8G1 Gene

Interacting Proteins for OR8G1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000476313 Q15617-OR8G1_HUMAN for OR8G1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR8G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA,NAS 9119360
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8G1: view

No data available for SIGNOR curated interactions for OR8G1 Gene

Drugs & Compounds for OR8G1 Gene

No Compound Related Data Available

Transcripts for OR8G1 Gene

mRNA/cDNA for OR8G1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8G1

Alternative Splicing Database (ASD) splice patterns (SP) for OR8G1 Gene

No ASD Table

Relevant External Links for OR8G1 Gene

GeneLoc Exon Structure for
OR8G1

Expression for OR8G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8G1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8G1 Gene

This gene is overexpressed in Testis (x53.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8G1

SOURCE GeneReport for Unigene cluster for OR8G1 Gene:

Hs.448172
genes like me logo Genes that share expression patterns with OR8G1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8G1 Gene

Orthologs for OR8G1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8G1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia LOC526276 29
  • 84.78 (n)
-- 30
  • 75 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia LOC102151657 29
  • 79.65 (n)
TPCR79 30
  • 79 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Olfr967 29 16
  • 77.63 (n)
Olfr935 30
  • 74 (a)
ManyToMany
Olfr936 30
  • 72 (a)
ManyToMany
Olfr146 30
  • 72 (a)
ManyToMany
Or8ab1-ps 45 Olfr940-ps1
  • chr9:39,092,688-39,093,169
Or8ab1-ps 45 Olfr950-ps1
  • chr9:39,383,330-39,384,276
Or8ab2-ps 45 Olfr953-ps1
  • chr9:39,452,325-39,453,313
Or8ac1-ps 45 Olfr942-ps1
  • chr9:39,158,924-39,159,919
Or8g26 45 Olfr943
  • chr9:39,184,042-39,185,121
Or8g28 45 Olfr945
  • chr9:39,257,723-39,258,679
Or8o1-ps 45 Olfr1556-ps1
  • chr10:106,502,737-106,503,295
Rat
(Rattus norvegicus)
Mammalia Olr1321 29
  • 76.98 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 74 (a)
ManyToMany
OPOR89 30 30
  • 74 (a)
ManyToMany
-- 30
  • 74 (a)
ManyToMany
OPOR128 30
  • 72 (a)
ManyToMany
-- 30
  • 72 (a)
ManyToMany
-- 30
  • 72 (a)
ManyToMany
-- 30
  • 71 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
OPOR88 30
  • 70 (a)
ManyToMany
-- 30
  • 69 (a)
ManyToMany
-- 30
  • 69 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
Species where no ortholog for OR8G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8G1 Gene

ENSEMBL:
Gene Tree for OR8G1 (if available)
TreeFam:
Gene Tree for OR8G1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8G1: view image
Alliance of Genome Resources:
Additional Orthologs for OR8G1

Paralogs for OR8G1 Gene

(456) SIMAP similar genes for OR8G1 Gene using alignment to 2 proteins:

  • OR8G1_HUMAN
  • V9GY26_HUMAN
genes like me logo Genes that share paralogs with OR8G1: view

Variants for OR8G1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR8G1 Gene

OR8G1_HUMAN-Q15617
A stop codon in the gene coding for this protein at position Tyr-259 is responsible for functional diversity thus producing thus a pseudogene.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8G1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs4482039 -- p.Ala247Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8G1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8G1 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680
esv24586 CNV gain 19812545
esv2745180 CNV deletion 23290073
esv2745184 CNV deletion 23290073
nsv975992 CNV duplication 23825009

Additional Variant Information for OR8G1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8G1
Leiden Open Variation Database (LOVD)
OR8G1

SNP Genotyping and Copy Number Assays for research

No data available for Variation tolerance for OR8G1 Gene

Disorders for OR8G1 Gene

Additional Disease Information for OR8G1

No disorders were found for OR8G1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8G1 Gene

Publications for OR8G1 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 2 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Extensive copy-number variation of the human olfactory receptor gene family. (PMID: 18674749) Young JM … Trask BJ (American journal of human genetics 2008) 3

Products for OR8G1 Gene

Sources for OR8G1 Gene