Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8D4 Gene

Aliases for OR8D4 Gene

  • Olfactory Receptor Family 8 Subfamily D Member 4 2 3 5
  • Olfactory Receptor OR11-275 3 4
  • Olfactory Receptor 8D4 3 4
  • Olfactory Receptor, Family 8, Subfamily D, Member 4 2
  • OR11-275 3
  • OR8D4 5

External Ids for OR8D4 Gene

Previous GeneCards Identifiers for OR8D4 Gene

  • GC11U990345
  • GC11P123315
  • GC11P123282
  • GC11P123777

Summaries for OR8D4 Gene

Entrez Gene Summary for OR8D4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8D4 Gene

OR8D4 (Olfactory Receptor Family 8 Subfamily D Member 4) is a Protein Coding gene. Diseases associated with OR8D4 include Retinitis Pigmentosa 3. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8A1.

UniProtKB/Swiss-Prot Summary for OR8D4 Gene

Gene Wiki entry for OR8D4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8D4 Gene

Genomics for OR8D4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8D4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123903 Enhancer 0.5 Ensembl 250.7 +1.8 1834 0.4 BATF ATF2 JUNB ZBED1 EED RUNX3 ETV6 OR8D4 OR4D5
GH11J123477 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 7.5 -422.2 -422194 4 BCLAF1 ZNF654 BCL11A CTCF REST TRIM22 ELF1 RAD21 IRF4 SMC3 CLMP GRAMD1B ENSG00000254710 OR8D4 OR6M1 HSALNG0087835 HSALNG0087834 HSALNG0087833 MN309418 SCN3B
GH11J123774 Enhancer 0.9 Ensembl ENCODE dbSUPER 9.7 -126.3 -126316 5.3 ETS1 MAFF ZNF316 MAFK PRDM10 TAF1 SP1 POU5F1 NANOG ZNF143 ZNF202 OR6X1 OR6M1 TMEM225 OR8D4 HSALNG0087853 HSALNG0087854
GH11J123740 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 3 -160.4 -160371 4.4 BCLAF1 ZNF207 ZNF600 MYC NCOR1 POLR2A NFIC YY1 MXD4 REST ZNF202 lnc-ZNF202-1 lnc-GRAMD1B-6 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P
GH11J123861 Enhancer 0.3 Ensembl 10.5 -40.4 -40366 0.4 POLR2A OR6M3P lnc-TMEM225-1 TMEM225 OR8D4 OR6M1 OR6T1 OR6M2P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8D4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8D4

Top Transcription factor binding sites by QIAGEN in the OR8D4 gene promoter:
  • GATA-2
  • ITF-2
  • LCR-F1
  • NF-E2
  • NF-E2 p45
  • Pax-2
  • Pax-2a
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1beta

Genomic Locations for OR8D4 Gene

Latest Assembly
chr11:123,902,167-123,909,229
(GRCh38/hg38)
Size:
7,063 bases
Orientation:
Plus strand

Previous Assembly
chr11:123,772,874-123,779,936
(GRCh37/hg19 by Entrez Gene)
Size:
7,063 bases
Orientation:
Plus strand

chr11:123,777,109-123,778,183
(GRCh37/hg19 by Ensembl)
Size:
1,075 bases
Orientation:
Plus strand

Genomic View for OR8D4 Gene

Genes around OR8D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8D4 Gene

Proteins for OR8D4 Gene

  • Protein details for OR8D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGM9-OR8D4_HUMAN
    Recommended name:
    Olfactory receptor 8D4
    Protein Accession:
    Q8NGM9
    Secondary Accessions:
    • Q6IFE9

    Protein attributes for OR8D4 Gene

    Size:
    314 amino acids
    Molecular mass:
    35019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8D4 Gene

Post-translational modifications for OR8D4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8D4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8D4 Gene

Domains & Families for OR8D4 Gene

Gene Families for OR8D4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8D4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8D4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-275 (OR8D4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGM9

UniProtKB/Swiss-Prot:

OR8D4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8D4: view

Function for OR8D4 Gene

Molecular function for OR8D4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR8D4 Gene

Gene Ontology (GO) - Molecular Function for OR8D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8D4: view
genes like me logo Genes that share phenotypes with OR8D4: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8D4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8D4 Gene

Localization for OR8D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8D4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8D4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8D4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8D4 Gene

Pathways & Interactions for OR8D4 Gene

genes like me logo Genes that share pathways with OR8D4: view

Pathways by source for OR8D4 Gene

Interacting Proteins for OR8D4 Gene

Gene Ontology (GO) - Biological Process for OR8D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8D4: view

No data available for SIGNOR curated interactions for OR8D4 Gene

Drugs & Compounds for OR8D4 Gene

No Compound Related Data Available

Transcripts for OR8D4 Gene

mRNA/cDNA for OR8D4 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8D4

Alternative Splicing Database (ASD) splice patterns (SP) for OR8D4 Gene

No ASD Table

Relevant External Links for OR8D4 Gene

GeneLoc Exon Structure for
OR8D4

Expression for OR8D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8D4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8D4

SOURCE GeneReport for Unigene cluster for OR8D4 Gene:

Hs.449688
genes like me logo Genes that share expression patterns with OR8D4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8D4 Gene

Orthologs for OR8D4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR8D4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466815 29
  • 98.62 (n)
OR8D4 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR8D4 29 30
  • 87.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100688741 29
  • 85.74 (n)
OR8D4 30
  • 83 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or8d4 45 Olfr985 29 16 30
  • 83.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1340 29
  • 83.44 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR8D4 30
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 59 (a)
OneToMany
Chicken
(Gallus gallus)
Aves OR8D4 29
  • 59.74 (n)
Species where no ortholog for OR8D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8D4 Gene

ENSEMBL:
Gene Tree for OR8D4 (if available)
TreeFam:
Gene Tree for OR8D4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8D4: view image
Alliance of Genome Resources:
Additional Orthologs for OR8D4

Paralogs for OR8D4 Gene

(453) SIMAP similar genes for OR8D4 Gene using alignment to 1 proteins:

  • OR8D4_HUMAN

Pseudogenes.org Pseudogenes for OR8D4 Gene

genes like me logo Genes that share paralogs with OR8D4: view

Variants for OR8D4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8D4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10750250 -- p.Cys120Tyr
rs10790610 -- p.Phe200Leu
rs12270203 -- p.Phe205Ser
rs17127947 -- p.Leu55Arg
rs17127950 -- p.Ile92Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8D4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8D4 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680

Variation tolerance for OR8D4 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.73; 98.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8D4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8D4
Leiden Open Variation Database (LOVD)
OR8D4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8D4 Gene

Disorders for OR8D4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR8D4 Gene - From: COP

Disorder Aliases PubMed IDs
retinitis pigmentosa 3
  • rp3
- elite association - COSMIC cancer census association via MalaCards
Search OR8D4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR8D4

genes like me logo Genes that share disorders with OR8D4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR8D4 Gene

Publications for OR8D4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR8D4 Gene

Sources for OR8D4 Gene