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Aliases for OR8D4 Gene

Aliases for OR8D4 Gene

  • Olfactory Receptor Family 8 Subfamily D Member 4 2 3 5
  • Olfactory Receptor OR11-275 3 4
  • Olfactory Receptor, Family 8, Subfamily D, Member 4 2
  • Olfactory Receptor 8D4 3
  • OR11-275 3

External Ids for OR8D4 Gene

Previous GeneCards Identifiers for OR8D4 Gene

  • GC11U990345
  • GC11P123315
  • GC11P123282
  • GC11P123777

Summaries for OR8D4 Gene

Entrez Gene Summary for OR8D4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8D4 Gene

OR8D4 (Olfactory Receptor Family 8 Subfamily D Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8A1.

UniProtKB/Swiss-Prot for OR8D4 Gene

  • Odorant receptor.

Gene Wiki entry for OR8D4 Gene

Additional gene information for OR8D4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8D4 Gene

Genomics for OR8D4 Gene

GeneHancer (GH) Regulatory Elements for OR8D4 Gene

Promoters and enhancers for OR8D4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123477 Enhancer 1.2 FANTOM5 Ensembl ENCODE 7.5 -422.2 -422194 4 HDGF PKNOX1 FOXA2 BATF IRF4 RAD21 ZNF143 ATF7 ETV6 BCLAF1 GRAMD1B ENSG00000254710 CLMP OR8D4 OR6M1 GC11M123460 GC11P123564
GH11J123773 Enhancer 0.8 ENCODE dbSUPER 9.7 -125.9 -125948 4.6 USF1 NANOG ETS1 SP1 ZNF316 POU5F1 ZNF143 PRDM10 MAFK EMSY ZNF202 OR6X1 OR6M1 TMEM225 OR8D4 RNU1-21P LOC105369544
GH11J123740 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 3 -160.1 -160094 3.8 HNRNPUL1 PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF202 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P OR4D5 TMEM225
GH11J123695 Enhancer 0.2 FANTOM5 15.1 -206.8 -206833 0.4 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1 OR10G9
GH11J124008 Enhancer 0.2 FANTOM5 15 +106.5 106507 0.4 OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR10G4 OR6M1 OR8G1 OR10S1 OR8D2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8D4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR8D4 gene promoter:
  • GATA-2
  • Tal-1beta
  • ITF-2
  • Pax-2
  • Pax-2a
  • LCR-F1
  • PPAR-gamma1
  • PPAR-gamma2
  • NF-E2 p45
  • NF-E2

Genomic Locations for OR8D4 Gene

Genomic Locations for OR8D4 Gene
7,063 bases
Plus strand
1,075 bases
Plus strand

Genomic View for OR8D4 Gene

Genes around OR8D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8D4 Gene

Proteins for OR8D4 Gene

  • Protein details for OR8D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8D4
    Protein Accession:
    Secondary Accessions:
    • Q6IFE9

    Protein attributes for OR8D4 Gene

    314 amino acids
    Molecular mass:
    35019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8D4 Gene

Post-translational modifications for OR8D4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8D4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8D4 Gene

Domains & Families for OR8D4 Gene

Gene Families for OR8D4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8D4 Gene

Suggested Antigen Peptide Sequences for OR8D4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8D4: view

Function for OR8D4 Gene

Molecular function for OR8D4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR8D4 Gene

Gene Ontology (GO) - Molecular Function for OR8D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8D4: view

Phenotypes for OR8D4 Gene

genes like me logo Genes that share phenotypes with OR8D4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8D4 Gene

Localization for OR8D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8D4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8D4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8D4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8D4 Gene

Pathways & Interactions for OR8D4 Gene

genes like me logo Genes that share pathways with OR8D4: view

Pathways by source for OR8D4 Gene

Interacting Proteins for OR8D4 Gene

Gene Ontology (GO) - Biological Process for OR8D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8D4: view

No data available for SIGNOR curated interactions for OR8D4 Gene

Drugs & Compounds for OR8D4 Gene

No Compound Related Data Available

Transcripts for OR8D4 Gene

mRNA/cDNA for OR8D4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8D4 Gene

Olfactory receptor, family 8, subfamily D, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8D4 Gene

No ASD Table

Relevant External Links for OR8D4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR8D4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8D4 Gene:


SOURCE GeneReport for Unigene cluster for OR8D4 Gene:

genes like me logo Genes that share expression patterns with OR8D4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8D4 Gene

Orthologs for OR8D4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR8D4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466815 33
  • 98.62 (n)
OR8D4 34
  • 97 (a)
(Bos Taurus)
Mammalia OR8D4 34 33
  • 87.74 (n)
(Canis familiaris)
Mammalia LOC100688741 33
  • 85.74 (n)
OR8D4 34
  • 83 (a)
(Mus musculus)
Mammalia Or8d4 51 Olfr985 16 34 33
  • 83.87 (n)
(Rattus norvegicus)
Mammalia Olr1340 33
  • 83.44 (n)
(Monodelphis domestica)
Mammalia OR8D4 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
(Gallus gallus)
Aves OR8D4 33
  • 59.74 (n)
Species where no ortholog for OR8D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8D4 Gene

Gene Tree for OR8D4 (if available)
Gene Tree for OR8D4 (if available)
Evolutionary constrained regions (ECRs) for OR8D4: view image

Paralogs for OR8D4 Gene

Paralogs for OR8D4 Gene

(453) SIMAP similar genes for OR8D4 Gene using alignment to 1 proteins:

  • OR8D4_HUMAN Pseudogenes for OR8D4 Gene

genes like me logo Genes that share paralogs with OR8D4: view

Variants for OR8D4 Gene

Sequence variations from dbSNP and Humsavar for OR8D4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001105458 -- 123,906,244(+) G/A/T upstream_transcript_variant
rs1001415968 -- 123,904,903(+) C/T upstream_transcript_variant
rs1005631909 -- 123,905,229(+) G/A upstream_transcript_variant
rs1007298845 -- 123,905,850(+) A/G/T upstream_transcript_variant
rs1009652095 -- 123,906,198(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR8D4 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680

Variation tolerance for OR8D4 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.73; 98.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8D4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8D4 Gene

Disorders for OR8D4 Gene

Additional Disease Information for OR8D4

No disorders were found for OR8D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8D4 Gene

Publications for OR8D4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR8D4 Gene

Sources for OR8D4 Gene

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