Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8D2 Gene

Aliases for OR8D2 Gene

  • Olfactory Receptor Family 8 Subfamily D Member 2 2 3 5
  • Olfactory Receptor-Like Protein JCG2 3 4
  • Olfactory Receptor OR11-303 3 4
  • Olfactory Receptor 8D2 3 4
  • Olfactory Receptor, Family 8, Subfamily D, Member 2 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 8 Subfamily D Member 2 (Gene/Pseudogene) 2
  • OR8D2 5
  • JCG2 3

External Ids for OR8D2 Gene

Previous GeneCards Identifiers for OR8D2 Gene

  • GC11U990223
  • GC11M123727
  • GC11M123694
  • GC11M124189

Summaries for OR8D2 Gene

Entrez Gene Summary for OR8D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR8D2 Gene

OR8D2 (Olfactory Receptor Family 8 Subfamily D Member 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8D1.

UniProtKB/Swiss-Prot Summary for OR8D2 Gene

Gene Wiki entry for OR8D2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8D2 Gene

Genomics for OR8D2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8D2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124588 Enhancer 0.2 FANTOM5 8.1 -268.8 -268778 0.4 OR8A1 OR8G1 OR8D1 OR8D2 OR8G2P OR8B12 OR8B8 SPA17 lnc-OR8A1-1-001 lnc-OR8A1-1-002
GH11J124008 Enhancer 0.2 FANTOM5 9.1 +311.6 311614 0.4 OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR6T1 OR10G4 OR6M1 OR8G1 OR10S1
GH11J124642 Enhancer 1.1 FANTOM5 ENCODE 1.3 -323.7 -323717 2.4 ZNF654 NCOR1 MYC IKZF1 ZNF10 ZIC2 ZBTB10 YY1 CTCF CEBPB ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
GH11J124521 Enhancer 0.2 FANTOM5 4.9 -201.2 -201208 0.3 OR8A1 OR8B8 OR10G7 OR8G2P OR8G1 OR8B12 OR8D1 OR8D2 OR8B10P OR8A3P
GH11J124191 Enhancer 0.3 FANTOM5 1.3 +128.2 128199 0.3 MAFG VWA5A OR8A1 OR6X1 OR10G7 OR8G2P OR8B12 OR4D5 OR10G4 OR8G1 OR6M1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8D2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8D2

Top Transcription factor binding sites by QIAGEN in the OR8D2 gene promoter:
  • AREB6
  • C/EBPalpha
  • FOXL1
  • Meis-1
  • Meis-1a
  • Meis-1b

Genomic Locations for OR8D2 Gene

Latest Assembly
chr11:124,319,238-124,320,288
(GRCh38/hg38)
Size:
1,051 bases
Orientation:
Minus strand

Previous Assembly
chr11:124,189,158-124,190,093
(GRCh37/hg19 by Entrez Gene)
Size:
936 bases
Orientation:
Minus strand

Genomic View for OR8D2 Gene

Genes around OR8D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8D2 Gene

Proteins for OR8D2 Gene

  • Protein details for OR8D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZM6-OR8D2_HUMAN
    Recommended name:
    Olfactory receptor 8D2
    Protein Accession:
    Q9GZM6
    Secondary Accessions:
    • B9EH49
    • Q6IFR0

    Protein attributes for OR8D2 Gene

    Size:
    311 amino acids
    Molecular mass:
    34857 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8D2 Gene

Post-translational modifications for OR8D2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8D2 Gene

Domains & Families for OR8D2 Gene

Gene Families for OR8D2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8D2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8D2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor-like protein JCG2 (OR8D2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZM6

UniProtKB/Swiss-Prot:

OR8D2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8D2: view

Function for OR8D2 Gene

Molecular function for OR8D2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.
GENATLAS Biochemistry:
olfactory receptor,family 8,subfamily D,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR8D2 Gene

Gene Ontology (GO) - Molecular Function for OR8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8D2: view
genes like me logo Genes that share phenotypes with OR8D2: view

Animal Models for research

miRNA for OR8D2 Gene

miRTarBase miRNAs that target OR8D2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8D2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR8D2 Gene

Localization for OR8D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8D2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8D2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8D2 Gene

Pathways & Interactions for OR8D2 Gene

genes like me logo Genes that share pathways with OR8D2: view

Pathways by source for OR8D2 Gene

1 KEGG pathway for OR8D2 Gene

Interacting Proteins for OR8D2 Gene

Gene Ontology (GO) - Biological Process for OR8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8D2: view

No data available for SIGNOR curated interactions for OR8D2 Gene

Drugs & Compounds for OR8D2 Gene

No Compound Related Data Available

Transcripts for OR8D2 Gene

mRNA/cDNA for OR8D2 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8D2

Alternative Splicing Database (ASD) splice patterns (SP) for OR8D2 Gene

No ASD Table

Relevant External Links for OR8D2 Gene

GeneLoc Exon Structure for
OR8D2

Expression for OR8D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8D2 Gene

Protein differential expression in normal tissues from HIPED for OR8D2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR8D2 Gene



Protein tissue co-expression partners for OR8D2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8D2

SOURCE GeneReport for Unigene cluster for OR8D2 Gene:

Hs.504212

mRNA Expression by UniProt/SwissProt for OR8D2 Gene:

Q9GZM6-OR8D2_HUMAN
Tissue specificity: Expressed in the tongue.
genes like me logo Genes that share expression patterns with OR8D2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8D2 Gene

Orthologs for OR8D2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8D2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466829 29
  • 98.29 (n)
Cow
(Bos Taurus)
Mammalia LOC100301297 29
  • 85.93 (n)
Mouse
(Mus musculus)
Mammalia Or8d2 45 Olfr924 29 16
  • 83.82 (n)
Or8d2b 45 Olfr926 16
Species where no ortholog for OR8D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8D2 Gene

ENSEMBL:
Gene Tree for OR8D2 (if available)
TreeFam:
Gene Tree for OR8D2 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR8D2

Paralogs for OR8D2 Gene

(450) SIMAP similar genes for OR8D2 Gene using alignment to 1 proteins:

  • OR8D2_HUMAN
genes like me logo Genes that share paralogs with OR8D2: view

Variants for OR8D2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8D2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2466620 -- p.Pro263Leu
rs2512219 -- p.Arg122His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8D2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8D2 Gene

Variant ID Type Subtype PubMed ID
esv2761718 CNV loss 21179565
esv3579937 CNV loss 25503493
esv3627975 CNV loss 21293372
esv3892105 CNV gain 25118596
nsv826113 CNV loss 20364138
nsv826115 CNV loss 20364138

Variation tolerance for OR8D2 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.55; 96.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8D2
Leiden Open Variation Database (LOVD)
OR8D2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8D2 Gene

Disorders for OR8D2 Gene

Additional Disease Information for OR8D2

No disorders were found for OR8D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8D2 Gene

Publications for OR8D2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin JC … Haertlé T (Chemical senses 2001) 3 4
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3

Products for OR8D2 Gene

Sources for OR8D2 Gene