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Aliases for OR8D2 Gene

Aliases for OR8D2 Gene

  • Olfactory Receptor Family 8 Subfamily D Member 2 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor-Like Protein JCG2 3 4
  • Olfactory Receptor OR11-303 3 4
  • Olfactory Receptor, Family 8, Subfamily D, Member 2 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 8, Subfamily D, Member 2 3
  • Olfactory Receptor 8D2 3
  • JCG2 3

External Ids for OR8D2 Gene

Previous GeneCards Identifiers for OR8D2 Gene

  • GC11U990223
  • GC11M123727
  • GC11M123694
  • GC11M124189

Summaries for OR8D2 Gene

Entrez Gene Summary for OR8D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR8D2 Gene

OR8D2 (Olfactory Receptor Family 8 Subfamily D Member 2 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8D1.

UniProtKB/Swiss-Prot for OR8D2 Gene

  • Odorant receptor (Potential). May be involved in taste perception.

Gene Wiki entry for OR8D2 Gene

Additional gene information for OR8D2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8D2 Gene

Genomics for OR8D2 Gene

GeneHancer (GH) Regulatory Elements for OR8D2 Gene

Promoters and enhancers for OR8D2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124008 Enhancer 0.2 FANTOM5 9.1 +311.6 311614 0.4 OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR10G4 OR6M1 OR8G1 OR10S1 OR8D2
GH11J124642 Enhancer 1.3 FANTOM5 Ensembl ENCODE 1.3 -323.8 -323767 2.5 ATF1 PKNOX1 ARNT YY1 TCF12 POLR2B ZNF766 E2F8 ZNF143 FOS ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
GH11J124588 Enhancer 0.2 FANTOM5 8.1 -268.8 -268778 0.4 OR8A1 OR8G1 OR8D1 OR8D2 OR8G2P OR8B12 OR8B8 SPA17 OR8Q1P
GH11J124521 Enhancer 0.2 FANTOM5 4.9 -201.2 -201208 0.3 OR8A1 OR8B8 OR10G7 OR8G2P OR8G1 OR8B12 OR8D1 OR8D2 OR8B10P OR8A3P
GH11J124191 Enhancer 0.4 FANTOM5 1.3 +128.2 128199 0.3 FOSL1 MAFG VWA5A OR8A1 OR6X1 OR10G7 OR8G2P OR8B12 OR4D5 OR10G4 OR8G1 OR6M1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8D2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR8D2 gene promoter:
  • AREB6
  • Meis-1b
  • Meis-1a
  • Meis-1
  • FOXL1
  • C/EBPalpha

Genomic Locations for OR8D2 Gene

Genomic Locations for OR8D2 Gene
1,051 bases
Minus strand
1,051 bases
Minus strand

Genomic View for OR8D2 Gene

Genes around OR8D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8D2 Gene

Proteins for OR8D2 Gene

  • Protein details for OR8D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8D2
    Protein Accession:
    Secondary Accessions:
    • B9EH49
    • Q6IFR0

    Protein attributes for OR8D2 Gene

    311 amino acids
    Molecular mass:
    34857 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8D2 Gene

Post-translational modifications for OR8D2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8D2 Gene

Domains & Families for OR8D2 Gene

Gene Families for OR8D2 Gene

Protein Domains for OR8D2 Gene

Suggested Antigen Peptide Sequences for OR8D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8D2: view

Function for OR8D2 Gene

Molecular function for OR8D2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.
GENATLAS Biochemistry:
olfactory receptor,family 8,subfamily D,member 2,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8D2: view
genes like me logo Genes that share phenotypes with OR8D2: view

Animal Model Products

CRISPR Products

miRNA for OR8D2 Gene

miRTarBase miRNAs that target OR8D2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8D2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR8D2 Gene

Localization for OR8D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8D2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8D2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8D2 Gene

Pathways & Interactions for OR8D2 Gene

genes like me logo Genes that share pathways with OR8D2: view

Pathways by source for OR8D2 Gene

1 KEGG pathway for OR8D2 Gene

Interacting Proteins for OR8D2 Gene

Gene Ontology (GO) - Biological Process for OR8D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8D2: view

No data available for SIGNOR curated interactions for OR8D2 Gene

Drugs & Compounds for OR8D2 Gene

No Compound Related Data Available

Transcripts for OR8D2 Gene

mRNA/cDNA for OR8D2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8D2 Gene

Olfactory receptor, family 8, subfamily D, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8D2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8D2 Gene

No ASD Table

Relevant External Links for OR8D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR8D2 Gene

Protein differential expression in normal tissues from HIPED for OR8D2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR8D2 Gene

Protein tissue co-expression partners for OR8D2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8D2 Gene:


SOURCE GeneReport for Unigene cluster for OR8D2 Gene:


mRNA Expression by UniProt/SwissProt for OR8D2 Gene:

Tissue specificity: Expressed in the tongue.
genes like me logo Genes that share expression patterns with OR8D2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8D2 Gene

Orthologs for OR8D2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466829 33
  • 98.29 (n)
(Bos Taurus)
Mammalia LOC100301297 33
  • 85.93 (n)
(Mus musculus)
Mammalia Or8d2 51 Olfr924 33
  • 83.82 (n)
Or8d2b 51 Olfr926 16
Species where no ortholog for OR8D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8D2 Gene

Gene Tree for OR8D2 (if available)
Gene Tree for OR8D2 (if available)

Paralogs for OR8D2 Gene

Paralogs for OR8D2 Gene

(450) SIMAP similar genes for OR8D2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR8D2: view

Variants for OR8D2 Gene

Sequence variations from dbSNP and Humsavar for OR8D2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000282321 -- 124,321,919(-) G/T upstream_transcript_variant
rs1000649796 -- 124,320,072(-) G/T coding_sequence_variant, missense_variant
rs1001193652 -- 124,321,780(-) G/T upstream_transcript_variant
rs1001646218 -- 124,322,172(-) T/C upstream_transcript_variant
rs1002293292 -- 124,318,795(-) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR8D2 Gene

Variant ID Type Subtype PubMed ID
esv2761718 CNV loss 21179565
esv3579937 CNV loss 25503493
esv3627975 CNV loss 21293372
esv3892105 CNV gain 25118596
nsv826113 CNV loss 20364138
nsv826115 CNV loss 20364138

Variation tolerance for OR8D2 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.55; 96.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8D2 Gene

Disorders for OR8D2 Gene

Additional Disease Information for OR8D2

No disorders were found for OR8D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8D2 Gene

Publications for OR8D2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin JC … Haertlé T (Chemical senses 2001) 3 4 58
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 58
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58
  5. An investigation into the human serum "interactome". (PMID: 15174051) Zhou M … Conrads TP (Electrophoresis 2004) 3 58

Products for OR8D2 Gene

Sources for OR8D2 Gene

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