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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
OR8D2 (Olfactory Receptor Family 8 Subfamily D Member 2) is a Protein Coding gene. Diseases associated with OR8D2 include Tylosis With Esophageal Cancer. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8D1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J124588 | Enhancer | 0.2 | FANTOM5 | 8.1 | -268.8 | -268778 | 0.4 | OR8A1 OR8G1 OR8D1 OR8D2 OR8G2P OR8B12 OR8B8 SPA17 lnc-OR8A1-1-001 OR8Q1P | ||
GH11J124008 | Enhancer | 0.2 | FANTOM5 | 9.1 | +311.6 | 311614 | 0.4 | OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR6T1 OR10G4 OR6M1 OR8G1 OR10S1 | ||
GH11J124642 | Enhancer | 1.1 | FANTOM5 ENCODE | 1.3 | -323.7 | -323717 | 2.4 | CTCF TEAD4 LEF1 IKZF1 JUND FOXA1 ZNF143 ZIC2 PKNOX1 ZNF24 | ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1 | |
GH11J124521 | Enhancer | 0.2 | FANTOM5 | 4.9 | -201.2 | -201208 | 0.3 | OR8A1 OR8B8 OR10G7 OR8G2P OR8G1 OR8B12 OR8D1 OR8D2 OR8B10P OR8A3P | ||
GH11J124191 | Enhancer | 0.4 | FANTOM5 | 1.3 | +128.2 | 128199 | 0.3 | FOSL1 MAFG | VWA5A OR8A1 OR6X1 OR10G7 OR8G2P OR8B12 OR4D5 OR10G4 OR8G1 OR6M1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | -- |
GO:0005549 | odorant binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IBA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC466829 30 |
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Cow (Bos Taurus) |
Mammalia | LOC100301297 30 |
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Mouse (Mus musculus) |
Mammalia | Or8d2 46 Olfr924 30 17 |
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Or8d2b 46 Olfr926 17 |
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Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2761718 | CNV | loss | 21179565 |
esv3579937 | CNV | loss | 25503493 |
esv3627975 | CNV | loss | 21293372 |
esv3892105 | CNV | gain | 25118596 |
nsv826113 | CNV | loss | 20364138 |
nsv826115 | CNV | loss | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
tylosis with esophageal cancer |
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