Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8D1 Gene

Aliases for OR8D1 Gene

  • Olfactory Receptor Family 8 Subfamily D Member 1 2 3 5
  • OST004 2 3 4
  • Olfactory Receptor-Like Protein JCG9 3 4
  • Olfactory Receptor OR11-301 3 4
  • Olfactory Receptor 8D1 3 4
  • Olfactory Receptor 8D3 3 4
  • OR8D3 3 4
  • Olfactory Receptor, Family 8, Subfamily D, Member 1 2
  • Olfactory Receptor, Family 8, Subfamily D, Member 3 3
  • Olfactory-Like Receptor JCG9 3
  • PDJ9J14 3
  • OR8D1 5
  • JCG9 3

External Ids for OR8D1 Gene

Previous HGNC Symbols for OR8D1 Gene

  • OR8D3

Previous GeneCards Identifiers for OR8D1 Gene

  • GC11U990224
  • GC11M123718
  • GC11M123684
  • GC11M124179

Summaries for OR8D1 Gene

Entrez Gene Summary for OR8D1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8D1 Gene

OR8D1 (Olfactory Receptor Family 8 Subfamily D Member 1) is a Protein Coding gene. Diseases associated with OR8D1 include Wilson-Turner X-Linked Mental Retardation Syndrome. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8D2.

UniProtKB/Swiss-Prot Summary for OR8D1 Gene

Gene Wiki entry for OR8D1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8D1 Gene

Genomics for OR8D1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8D1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124275 Enhancer 1.2 FANTOM5 Ensembl ENCODE 7.9 +38.1 38098 2.8 NCOR1 ZNF592 NFIC HES1 BHLHE40 MBD2 ARNT RAD21 TAL1 RUNX1 VWA5A OR8G5 OR8D1 CCDC15 OR8G2P TBRG1 OR8B12 SLC5A4P1 HSALNG0087874 lnc-OR8G5-6
GH11J124330 Enhancer 0.8 Ensembl ENCODE 10.3 -14.4 -14402 3.4 NFIC REST RAD21 SMC3 HLTF CTCF SPI1 IKZF1 PKNOX1 IKZF2 VWA5A OR8D1 OR8G5 CCDC15 OR8B7P OR8D2 lnc-OR8D2-1 HSALNG0087881 OR8B2
GH11J124193 Enhancer 0.9 Ensembl ENCODE 8 +120.8 120844 2.9 ZNF654 ZNF592 NFIC REST CTCF MAX RAD21 SMC3 STAT3 TBP VWA5A OR8D1 SPA17 HSALNG0087872 lnc-OR10D3-1 OR10D3 lnc-OR8G5-6 OR8G1
GH11J124173 Enhancer 0.8 Ensembl ENCODE 9.4 +140.8 140792 1.4 ZNF316 NFE2 MAFG MAFK RFX1 MAFF CSDE1 NFE2L2 RAD21 POLR2A VWA5A OR8D1 lnc-OR8G5-6 OR10D3
GH11J124301 Enhancer 0.5 Ensembl 9 +12.7 12699 2 CEBPB EP300 NFE2 JUND MAFG ATF3 FOS EGR1 NONHSAG009928.2 VWA5A OR8D1 piR-51137-027 OR8G5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8D1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8D1

Top Transcription factor binding sites by QIAGEN in the OR8D1 gene promoter:
  • AREB6
  • Meis-1
  • Meis-1a
  • Meis-1b
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for OR8D1 Gene

Latest Assembly
chr11:124,302,831-124,315,099
(GRCh38/hg38)
Size:
12,269 bases
Orientation:
Minus strand

Previous Assembly
chr11:124,172,727-124,183,845
(GRCh37/hg19 by Entrez Gene)
Size:
11,119 bases
Orientation:
Minus strand

chr11:124,179,708-124,180,733
(GRCh37/hg19 by Ensembl)
Size:
1,026 bases
Orientation:
Minus strand

Genomic View for OR8D1 Gene

Genes around OR8D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8D1 Gene

Proteins for OR8D1 Gene

  • Protein details for OR8D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ84-OR8D1_HUMAN
    Recommended name:
    Olfactory receptor 8D1
    Protein Accession:
    Q8WZ84
    Secondary Accessions:
    • B2RNL4
    • Q6IEW1
    • Q8NGH0

    Protein attributes for OR8D1 Gene

    Size:
    308 amino acids
    Molecular mass:
    34445 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8D1 Gene

Post-translational modifications for OR8D1 Gene

  • Glycosylation at Asn5 and Asn186
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8D1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8D1 Gene

Domains & Families for OR8D1 Gene

Gene Families for OR8D1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8D1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8D1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor-like protein JCG9 (OR8D1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WZ84

UniProtKB/Swiss-Prot:

OR8D1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8D1: view

Function for OR8D1 Gene

Molecular function for OR8D1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.

Gene Ontology (GO) - Molecular Function for OR8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8D1: view
genes like me logo Genes that share phenotypes with OR8D1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8D1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8D1 Gene

Localization for OR8D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8D1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8D1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8D1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8D1 Gene

Pathways & Interactions for OR8D1 Gene

genes like me logo Genes that share pathways with OR8D1: view

Pathways by source for OR8D1 Gene

Interacting Proteins for OR8D1 Gene

Gene Ontology (GO) - Biological Process for OR8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8D1: view

No data available for SIGNOR curated interactions for OR8D1 Gene

Drugs & Compounds for OR8D1 Gene

No Compound Related Data Available

Transcripts for OR8D1 Gene

mRNA/cDNA for OR8D1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8D1

Alternative Splicing Database (ASD) splice patterns (SP) for OR8D1 Gene

No ASD Table

Relevant External Links for OR8D1 Gene

GeneLoc Exon Structure for
OR8D1

Expression for OR8D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8D1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8D1 Gene

This gene is overexpressed in Testis (x42.5) and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for OR8D1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR8D1 Gene



Protein tissue co-expression partners for OR8D1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8D1

SOURCE GeneReport for Unigene cluster for OR8D1 Gene:

Hs.504211

mRNA Expression by UniProt/SwissProt for OR8D1 Gene:

Q8WZ84-OR8D1_HUMAN
Tissue specificity: Expressed in the tongue.
genes like me logo Genes that share expression patterns with OR8D1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8D1 Gene

Orthologs for OR8D1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8D1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466828 29
  • 99.24 (n)
Mouse
(Mus musculus)
Mammalia Or8d1b 45 Olfr933 16 30
  • 85 (a)
OneToMany
Or8d1 45 Olfr26 29 16 30
  • 84.2 (n)
OneToMany
Or8d23 45 Olfr930 30
  • 79 (a)
OneToMany
Or8d22-ps 45 Olfr925-ps1
  • chr9:38,868,866-38,869,662
Dog
(Canis familiaris)
Mammalia OR8D1 30
  • 80 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR8D1 30
  • 79 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 59 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 57 (a)
OneToMany
Species where no ortholog for OR8D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8D1 Gene

ENSEMBL:
Gene Tree for OR8D1 (if available)
TreeFam:
Gene Tree for OR8D1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8D1: view image
Alliance of Genome Resources:
Additional Orthologs for OR8D1

Paralogs for OR8D1 Gene

(453) SIMAP similar genes for OR8D1 Gene using alignment to 1 proteins:

  • OR8D1_HUMAN
genes like me logo Genes that share paralogs with OR8D1: view

Variants for OR8D1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8D1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2510433 -- p.Phe102Val
rs4936919 -- p.Leu194Pro
rs7107539 -- p.Cys127Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8D1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8D1 Gene

Variant ID Type Subtype PubMed ID
esv3892105 CNV gain 25118596
nsv826113 CNV loss 20364138

Variation tolerance for OR8D1 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.33; 97.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8D1
Leiden Open Variation Database (LOVD)
OR8D1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8D1 Gene

Disorders for OR8D1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR8D1 Gene - From: COP

Disorder Aliases PubMed IDs
wilson-turner x-linked mental retardation syndrome
  • wts
- elite association - COSMIC cancer census association via MalaCards
Search OR8D1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR8D1

genes like me logo Genes that share disorders with OR8D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR8D1 Gene

Publications for OR8D1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin JC … Haertlé T (Chemical senses 2001) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Olfactory-like receptor cDNAs are present in human lingual cDNA libraries. (PMID: 15950192) Durzyński L … Haertlé T (Biochemical and biophysical research communications 2005) 22
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR8D1 Gene

Sources for OR8D1 Gene