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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR8B8 (Olfactory Receptor Family 8 Subfamily B Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8B12.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J124481 | Promoter/Enhancer | 1.1 | Ensembl ENCODE | 10.5 | -36.1 | -36105 | 1.2 | IKZF1 PKNOX1 ZNF740 DPF2 SOX6 UBTF ZNF184 ZNF766 HMBOX1 POLR2A | OR8B9P OR8B8 OR8B10P HSALNG0087888 OR8B12 | |
GH11J124607 | Enhancer | 0.8 | Ensembl | 9.3 | -162.4 | -162405 | 0.6 | JUND PKNOX1 HDAC1 SOX6 FOXJ2 EP300 ZNF766 TAF9B NFE2 ZNF316 | OR8B8 ROBO3 PANX3 OR8Q1P lnc-OR8A1-1-002 OR8A1 | |
GH11J124482 | Enhancer | 0.5 | ENCODE | 10.5 | -36.9 | -36948 | 0.1 | PKNOX1 ZNF740 NFE2 ZNF316 MAFG ATF3 FOS CBFA2T3 MAFK | OR8B9P OR8B8 HSALNG0087888 OR8B12 | |
GH11J124511 | Enhancer | 0.5 | Ensembl | 10.4 | -66.3 | -66305 | 0.4 | ZNF316 MAFG MAFK MAFF EMSY | OR8B8 OR8B4 piR-32097 OR8B9P OR8B12 | |
GH11J124518 | Enhancer | 0.5 | Ensembl | 9.7 | -73.5 | -73504 | 0.8 | RFX1 BMI1 JUNB SPI1 BATF | OR8B10P OR8A1 OR8B8 OR8A3P OR8B12 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | NAS | 9119360 |
GO:0005549 | odorant binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | NAS | 9119360 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IBA,NAS | 9119360 |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC100615359 30 |
|
||
Cow (Bos Taurus) |
Mammalia | OR8B8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC489317 30 |
|
||
OR8B8 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Olr1201 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or8b8 46 Olfr145 30 17 31 |
|
OneToOne |
|
Or8c12-ps 46 Olfr879-ps1 |
|
|
|||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3892105 | CNV | gain | 25118596 |
No disorders were found for OR8B8 Gene.