Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR8B8 Gene

Aliases for OR8B8 Gene

  • Olfactory Receptor Family 8 Subfamily B Member 8 2 3 5
  • Olfactory-Like Receptor JCG8 3 4
  • Olfactory Receptor TPCR85 3 4
  • Olfactory Receptor, Family 8, Subfamily B, Member 8 2
  • Olfactory Receptor OR11-316 3
  • Olfactory Receptor 8B8 3
  • TPCR85 3

External Ids for OR8B8 Gene

Previous GeneCards Identifiers for OR8B8 Gene

  • GC11M126311
  • GC11M125823
  • GC11M124343
  • GC11M123848
  • GC11M123163
  • GC11M123815

Summaries for OR8B8 Gene

Entrez Gene Summary for OR8B8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8B8 Gene

OR8B8 (Olfactory Receptor Family 8 Subfamily B Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8B12.

UniProtKB/Swiss-Prot for OR8B8 Gene

  • Odorant receptor (Potential). May be involved in taste perception.

Gene Wiki entry for OR8B8 Gene

Additional gene information for OR8B8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8B8 Gene

Genomics for OR8B8 Gene

GeneHancer (GH) Regulatory Elements for OR8B8 Gene

Promoters and enhancers for OR8B8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124481 Promoter/Enhancer 1.3 Ensembl ENCODE 10.4 -36.1 -36064 0.9 PKNOX1 ATF1 TAF9B ARNT NFRKB ZBTB40 ZNF766 ZBTB2 ELF1 GMEB1 OR8B9P OR8B8 OR8B10P GC11M124467
GH11J124482 Enhancer 0.6 ENCODE 10.4 -36.9 -36948 0.1 PKNOX1 ZNF740 MAFG CBFA2T3 ZNF316 NFE2 FOS MAFK OR8B9P OR8B8 GC11M124467
GH11J124521 Enhancer 0.2 FANTOM5 20.1 -75.8 -75800 0.3 OR8A1 OR8B8 OR10G7 OR8G2P OR8G1 OR8B12 OR8D1 OR8D2 OR8B10P OR8A3P
GH11J124642 Enhancer 1.3 FANTOM5 Ensembl ENCODE 1.2 -198.4 -198359 2.5 ATF1 PKNOX1 ARNT YY1 TCF12 POLR2B ZNF766 E2F8 ZNF143 FOS ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
GH11J124588 Enhancer 0.2 FANTOM5 6.3 -143.4 -143370 0.4 OR8A1 OR8G1 OR8D1 OR8D2 OR8G2P OR8B12 OR8B8 SPA17 OR8Q1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8B8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR8B8 gene promoter:
  • AREB6
  • ATF6
  • C/EBPalpha
  • COMP1
  • GATA-1
  • GATA-2
  • GATA-3
  • Zic1
  • AML1a
  • ZID

Genomic Locations for OR8B8 Gene

Genomic Locations for OR8B8 Gene
8,252 bases
Minus strand
1,033 bases
Minus strand

Genomic View for OR8B8 Gene

Genes around OR8B8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8B8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8B8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8B8 Gene

Proteins for OR8B8 Gene

  • Protein details for OR8B8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8B8
    Protein Accession:
    Secondary Accessions:
    • A1L446
    • Q96RC8

    Protein attributes for OR8B8 Gene

    311 amino acids
    Molecular mass:
    34482 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B8 Gene

Post-translational modifications for OR8B8 Gene

Other Protein References for OR8B8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B8 Gene

Domains & Families for OR8B8 Gene

Gene Families for OR8B8 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8B8 Gene

Suggested Antigen Peptide Sequences for OR8B8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B8: view

Function for OR8B8 Gene

Molecular function for OR8B8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.

Gene Ontology (GO) - Molecular Function for OR8B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8B8: view
genes like me logo Genes that share phenotypes with OR8B8: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8B8 Gene

Localization for OR8B8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8B8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR8B8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8B8 Gene

Pathways & Interactions for OR8B8 Gene

genes like me logo Genes that share pathways with OR8B8: view

Pathways by source for OR8B8 Gene

1 KEGG pathway for OR8B8 Gene

Interacting Proteins for OR8B8 Gene

Gene Ontology (GO) - Biological Process for OR8B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B8: view

No data available for SIGNOR curated interactions for OR8B8 Gene

Drugs & Compounds for OR8B8 Gene

No Compound Related Data Available

Transcripts for OR8B8 Gene

mRNA/cDNA for OR8B8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8B8 Gene

Olfactory receptor, family 8, subfamily B, member 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B8 Gene

No ASD Table

Relevant External Links for OR8B8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8B8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR8B8 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8B8 Gene:


SOURCE GeneReport for Unigene cluster for OR8B8 Gene:


mRNA Expression by UniProt/SwissProt for OR8B8 Gene:

Tissue specificity: Expressed in the tongue and testis.

Evidence on tissue expression from TISSUES for OR8B8 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with OR8B8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8B8 Gene

Orthologs for OR8B8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100615359 33
  • 98.8 (n)
(Bos Taurus)
Mammalia OR8B8 34 33
  • 88.17 (n)
(Canis familiaris)
Mammalia LOC489317 33
  • 87.53 (n)
OR8B8 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Olr1201 33
  • 85.59 (n)
(Mus musculus)
Mammalia Or8b8 51 Olfr145 16 34 33
  • 85.05 (n)
Or8c12-ps 51 Olfr879-ps1
  • chr9:37,941,457-37,942,093
(Monodelphis domestica)
Mammalia -- 34
  • 77 (a)
-- 34
  • 75 (a)
-- 34
  • 73 (a)
Species where no ortholog for OR8B8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8B8 Gene

Gene Tree for OR8B8 (if available)
Gene Tree for OR8B8 (if available)
Evolutionary constrained regions (ECRs) for OR8B8: view image

Paralogs for OR8B8 Gene

Paralogs for OR8B8 Gene

(448) SIMAP similar genes for OR8B8 Gene using alignment to 1 proteins:

  • OR8B8_HUMAN Pseudogenes for OR8B8 Gene

genes like me logo Genes that share paralogs with OR8B8: view

Variants for OR8B8 Gene

Sequence variations from dbSNP and Humsavar for OR8B8 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000497890 -- 124,439,943(-) C/T downstream_transcript_variant
rs1000810891 -- 124,439,880(-) C/T downstream_transcript_variant
rs1000946071 -- 124,440,154(-) G/A/T coding_sequence_variant, missense_variant
rs1003707278 -- 124,441,620(-) G/A upstream_transcript_variant
rs1003759564 -- 124,441,791(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR8B8 Gene

Variant ID Type Subtype PubMed ID
esv3892105 CNV gain 25118596

Variation tolerance for OR8B8 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8B8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8B8 Gene

Disorders for OR8B8 Gene

Additional Disease Information for OR8B8

No disorders were found for OR8B8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8B8 Gene

Publications for OR8B8 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 2 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin JC … Haertlé T (Chemical senses 2001) 3 4 58
  4. Olfactory-like receptor cDNAs are present in human lingual cDNA libraries. (PMID: 15950192) Durzyński L … Haertlé T (Biochemical and biophysical research communications 2005) 22 58
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 58

Products for OR8B8 Gene

Sources for OR8B8 Gene

Loading form....