OR8B8 Gene (Protein Coding)

Olfactory Receptor Family 8 Subfamily B Member 8

GC11M124440
GIFtS:
30
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8B8 Gene

Aliases for OR8B8 Gene

  • Olfactory Receptor Family 8 Subfamily B Member 8 2 3 5
  • Olfactory-Like Receptor JCG8 3 4
  • Olfactory Receptor TPCR85 3 4
  • Olfactory Receptor 8B8 3 4
  • TPCR85 2 3
  • Olfactory Receptor, Family 8, Subfamily B, Member 8 2
  • Olfactory Receptor OR11-316 3
  • OR8B8 5

External Ids for OR8B8 Gene

Previous GeneCards Identifiers for OR8B8 Gene

  • GC11M126311
  • GC11M125823
  • GC11M124343
  • GC11M123848
  • GC11M123163
  • GC11M123815

Summaries for OR8B8 Gene

Entrez Gene Summary for OR8B8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8B8 Gene

OR8B8 (Olfactory Receptor Family 8 Subfamily B Member 8) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8B12.

UniProtKB/Swiss-Prot Summary for OR8B8 Gene

Gene Wiki entry for OR8B8 Gene

Additional gene information for OR8B8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8B8 Gene

Genomics for OR8B8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR8B8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J124481 Promoter/Enhancer 1.1 Ensembl ENCODE 10.5 -36.1 -36105 1.2 NCOR1 IKZF1 TAF9B MAFF ELF1 ZNF316 NFE2 MAFK ZNF205 SUPT5H HSALNG0087886 OR8B9P OR8B8 OR8B10P HSALNG0087888 OR8B12
GH11J124607 Enhancer 0.7 Ensembl 9.3 -162.4 -162405 0.6 TAF9B MAFF ZNF316 NFE2 MAFK ATF1 ZNF318 ZNF384 MAFG TCF12 HSALNG0087889 OR8B8 ROBO3 PANX3 OR8Q1P OR8A1
GH11J124482 Enhancer 0.5 ENCODE 10.5 -36.9 -36948 0.1 ZNF316 NFE2 MAFG ATF3 FOS MAFK PKNOX1 CBFA2T3 OR8B9P OR8B8 HSALNG0087886 HSALNG0087888 OR8B12
GH11J124511 Enhancer 0.5 Ensembl 10.4 -66.3 -66305 0.4 ZNF316 MAFG MAFK MAFF EMSY OR8B4 OR8B8 piR-32097 OR8B9P OR8B12 HSALNG0087889
GH11J124518 Enhancer 0.5 Ensembl 9.7 -73.5 -73504 0.8 SPI1 BATF BMI1 RFX1 JUNB OR8B10P OR8A1 OR8B8 OR8A3P OR8B12 HSALNG0087889
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8B8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8B8

Top Transcription factor binding sites by QIAGEN in the OR8B8 gene promoter:
  • AML1a
  • AREB6
  • ATF6
  • C/EBPalpha
  • COMP1
  • GATA-1
  • GATA-2
  • GATA-3
  • Zic1
  • ZID

Genomic Locations for OR8B8 Gene

Latest Assembly
chr11:124,437,445-124,445,696
(GRCh38/hg38)
Size:
8,252 bases
Orientation:
Minus strand

Previous Assembly
chr11:124,307,341-124,315,592
(GRCh37/hg19 by Entrez Gene)
Size:
8,252 bases
Orientation:
Minus strand

chr11:124,310,022-124,311,054
(GRCh37/hg19 by Ensembl)
Size:
1,033 bases
Orientation:
Minus strand

Genomic View for OR8B8 Gene

Genes around OR8B8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8B8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8B8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR8B8 Gene

Proteins for OR8B8 Gene

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  • Protein details for OR8B8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15620-OR8B8_HUMAN
    Recommended name:
    Olfactory receptor 8B8
    Protein Accession:
    Q15620
    Secondary Accessions:
    • A1L446
    • Q96RC8

    Protein attributes for OR8B8 Gene

    Size:
    311 amino acids
    Molecular mass:
    34482 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B8 Gene

Post-translational modifications for OR8B8 Gene

  • Glycosylation at Asn5

Other Protein References for OR8B8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B8 Gene

Domains & Families for OR8B8 Gene

Gene Families for OR8B8 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8B8 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8B8 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory-like receptor JCG8 (OR8B8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15620

UniProtKB/Swiss-Prot:

OR8B8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B8: view

Function for OR8B8 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for OR8B8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.

Phenotypes From GWAS Catalog for OR8B8 Gene

Gene Ontology (GO) - Molecular Function for OR8B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8B8: view
genes like me logo Genes that share phenotypes with OR8B8: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8B8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8B8 Gene

Localization for OR8B8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B8 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8B8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR8B8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8B8 Gene

Pathways & Interactions for OR8B8 Gene

genes like me logo Genes that share pathways with OR8B8: view

Pathways by source for OR8B8 Gene

1 BioSystems pathway for OR8B8 Gene
1 KEGG pathway for OR8B8 Gene

Interacting Proteins for OR8B8 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000330280 Q15620-OR8B8_HUMAN for OR8B8 Gene via STRING IID

GPS-Prot Interaction Network for OR8B8

Gene Ontology (GO) - Biological Process for OR8B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA,NAS 9119360
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B8: view

No data available for SIGNOR curated interactions for OR8B8 Gene

Drugs & Compounds for OR8B8 Gene

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No Compound Related Data Available

Transcripts for OR8B8 Gene

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mRNA/cDNA for OR8B8 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8B8

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B8 Gene

No ASD Table

Relevant External Links for OR8B8 Gene

GeneLoc Exon Structure for
OR8B8

Expression for OR8B8 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8B8 Gene

mRNA expression in normal human tissues for OR8B8 Gene
mRNA expression by GTEx for OR8B8 GenemRNA expression by BioGPS for OR8B8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8B8

SOURCE GeneReport for Unigene cluster for OR8B8 Gene:

Hs.351822

mRNA Expression by UniProt/SwissProt for OR8B8 Gene:

Q15620-OR8B8_HUMAN
Tissue specificity: Expressed in the tongue and testis.

Evidence on tissue expression from TISSUES for OR8B8 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with OR8B8: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8B8 Gene

Orthologs for OR8B8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC100615359 29
  • 98.8 (n)
Cow
(Bos Taurus)
 Mammalia OR8B8 29 30
  • 88.17 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LOC489317 29
  • 87.53 (n)
OR8B8 30
  • 87 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Olr1201 29
  • 85.59 (n)
Mouse
(Mus musculus)
 Mammalia Or8b8 45 Olfr145 29 16 30
  • 85.05 (n)
 OneToOne
Or8c12-ps 45 Olfr879-ps1
  • chr9:37,941,457-37,942,093
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 77 (a)
 ManyToMany
-- 30
  • 75 (a)
 ManyToMany
-- 30
  • 73 (a)
 ManyToMany
Species where no ortholog for OR8B8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8B8 Gene

ENSEMBL:
Gene Tree for OR8B8 (if available)
TreeFam:
Gene Tree for OR8B8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8B8: view image
Alliance of Genome Resources:
Additional Orthologs for OR8B8

Paralogs for OR8B8 Gene

Paralogs for OR8B8 Gene

(448) SIMAP similar genes for OR8B8 Gene using alignment to 1 proteins:

  • OR8B8_HUMAN

Pseudogenes.org Pseudogenes for OR8B8 Gene

genes like me logo Genes that share paralogs with OR8B8: view

Variants for OR8B8 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8B8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8B8 Gene

Variant ID Type Subtype PubMed ID
esv3892105 CNV gain 25118596

Variation tolerance for OR8B8 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8B8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8B8
Leiden Open Variation Database (LOVD)
OR8B8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8B8 Gene

Disorders for OR8B8 Gene

Additional Disease Information for OR8B8

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR8B8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8B8 Gene

Publications for OR8B8 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin JC … Haertlé T (Chemical senses 2001) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Olfactory-like receptor cDNAs are present in human lingual cDNA libraries. (PMID: 15950192) Durzyński L … Haertlé T (Biochemical and biophysical research communications 2005) 22

ExternalLinks

View latest publications for OR8B8 gene in Mastermind

Products for OR8B8 Gene

Sources for OR8B8 Gene