OR8B4 Gene (Protein Coding)

Olfactory Receptor Family 8 Subfamily B Member 4

GC11M124423
GIFtS:
29
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8B4 Gene

Aliases for OR8B4 Gene

  • Olfactory Receptor Family 8 Subfamily B Member 4 2 3
  • Olfactory Receptor Family 8 Subfamily B Member 4 (Gene/Pseudogene) 2 5
  • Olfactory Receptor OR11-315 3 4
  • Olfactory Receptor 8B4 3 4
  • OR8B4P 3 4
  • Olfactory Receptor, Family 8, Subfamily B, Member 4 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 8, Subfamily B, Member 4 Pseudogene 3
  • OR11-315 3
  • OR8B4 5

External Ids for OR8B4 Gene

Previous HGNC Symbols for OR8B4 Gene

  • OR8B4P

Previous GeneCards Identifiers for OR8B4 Gene

  • GC11U990228
  • GC11M123832
  • GC11M123799
  • GC11M124293

Summaries for OR8B4 Gene

Entrez Gene Summary for OR8B4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR8B4 Gene

OR8B4 (Olfactory Receptor Family 8 Subfamily B Member 4) is a Protein Coding gene. Diseases associated with OR8B4 include Miles-Carpenter Syndrome. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8B3.

UniProtKB/Swiss-Prot Summary for OR8B4 Gene

Gene Wiki entry for OR8B4 Gene

Additional gene information for OR8B4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8B4 Gene

Genomics for OR8B4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR8B4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J124511 Enhancer 0.5 Ensembl 10.4 -87.1 -87108 0.4 ZNF316 MAFG MAFK MAFF EMSY OR8B8 OR8B4 piR-32097 OR8B9P OR8B12
GH11J124595 Enhancer 0.4 Ensembl 10.2 -175.8 -175807 1.8 POLR2A HMBOX1 NR2F6 ATF2 OR8Q1P lnc-OR8A1-1-002 OR8B4 OR8B8 ROBO3 PANX3 lnc-OR8A1-1-001 OR8A1
GH11J124642 Enhancer 1.1 FANTOM5 ENCODE 2.9 -219.1 -219112 2.4 CTCF TEAD4 LEF1 IKZF1 JUND FOXA1 ZNF143 ZIC2 PKNOX1 ZNF24 ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
GH11J124454 Enhancer 0.2 Ensembl 10.5 -29.8 -29808 0.6 OR8B10P OR8B4 OR8A2P OR8B8 OR8B12
GH11J124008 Enhancer 0.2 FANTOM5 4 +416.2 416219 0.4 OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR6T1 OR10G4 OR6M1 OR8G1 OR10S1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8B4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8B4

Top Transcription factor binding sites by QIAGEN in the OR8B4 gene promoter:
  • AREB6
  • ATF6
  • C/EBPalpha
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pbx1a

Genomic Locations for OR8B4 Gene

Genomic Locations for OR8B4 Gene
chr11:124,423,904-124,424,893
(GRCh38/hg38)
Size:
990 bases
Orientation:
Minus strand
chr11:124,293,807-124,294,789
(GRCh37/hg19)
Size:
983 bases
Orientation:
Minus strand

Genomic View for OR8B4 Gene

Genes around OR8B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8B4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR8B4 Gene

Proteins for OR8B4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OR8B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RC9-OR8B4_HUMAN
    Recommended name:
    Olfactory receptor 8B4
    Protein Accession:
    Q96RC9
    Secondary Accessions:
    • B2RNF8
    • Q6IFQ7

    Protein attributes for OR8B4 Gene

    Size:
    309 amino acids
    Molecular mass:
    34404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B4 Gene

Post-translational modifications for OR8B4 Gene

  • Glycosylation at Asn5

Other Protein References for OR8B4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B4 Gene

Domains & Families for OR8B4 Gene

Gene Families for OR8B4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8B4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR8B4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-315 (OR8B4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96RC9

UniProtKB/Swiss-Prot:

OR8B4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B4: view

Function for OR8B4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for OR8B4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR8B4 Gene

Gene Ontology (GO) - Molecular Function for OR8B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8B4: view
genes like me logo Genes that share phenotypes with OR8B4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8B4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8B4 Gene

Localization for OR8B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8B4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8B4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8B4 Gene

Pathways & Interactions for OR8B4 Gene

genes like me logo Genes that share pathways with OR8B4: view

Pathways by source for OR8B4 Gene

1 KEGG pathway for OR8B4 Gene

Interacting Proteins for OR8B4 Gene

Selected Interacting proteins: Q96RC9-OR8B4_HUMAN for OR8B4 Gene via IID

GPS-Prot Interaction Network for OR8B4

Gene Ontology (GO) - Biological Process for OR8B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B4: view

No data available for SIGNOR curated interactions for OR8B4 Gene

Drugs & Compounds for OR8B4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for OR8B4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OR8B4 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8B4

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B4 Gene

No ASD Table

Relevant External Links for OR8B4 Gene

GeneLoc Exon Structure for
OR8B4

Expression for OR8B4 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8B4 Gene

mRNA expression in normal human tissues for OR8B4 Gene
mRNA expression by GTEx for OR8B4 GenemRNA expression by BioGPS for OR8B4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8B4

SOURCE GeneReport for Unigene cluster for OR8B4 Gene:

Hs.553671
genes like me logo Genes that share expression patterns with OR8B4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8B4 Gene

Orthologs for OR8B4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B4 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
 Mammalia OR8B4 30
  • 89.18 (n)
Cow
(Bos Taurus)
 Mammalia OR8B4 30
  • 86.52 (n)
Rat
(Rattus norvegicus)
 Mammalia Olr1202 30
  • 84.36 (n)
Mouse
(Mus musculus)
 Mammalia Or8b4 46 Olfr878 30 17
  • 83.93 (n)
Species where no ortholog for OR8B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8B4 Gene

ENSEMBL:
Gene Tree for OR8B4 (if available)
TreeFam:
Gene Tree for OR8B4 (if available)

Paralogs for OR8B4 Gene

Paralogs for OR8B4 Gene

(436) SIMAP similar genes for OR8B4 Gene using alignment to 1 proteins:

  • OR8B4_HUMAN

Pseudogenes.org Pseudogenes for OR8B4 Gene

genes like me logo Genes that share paralogs with OR8B4: view

Variants for OR8B4 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8B4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10750270 - p.Glu22Gly
rs4057749 - p.Cys178Arg
rs4057750 - p.Tyr131His
rs7116575 - p.Cys140Phe

Additional dbSNP identifiers (rs#s) for OR8B4 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR8B4 Gene

Variant ID Type Subtype PubMed ID
esv3892105 CNV gain 25118596

Variation tolerance for OR8B4 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.69; 99.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8B4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8B4 Gene

Disorders for OR8B4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR8B4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
miles-carpenter syndrome
  • miles-carpenter x-linked mental retardation syndrome
- elite association - COSMIC cancer census association via MalaCards
Search OR8B4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR8B4

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with OR8B4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR8B4 Gene

Publications for OR8B4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3

ExternalLinks

View latest publications for OR8B4 gene in Mastermind

Products for OR8B4 Gene

Sources for OR8B4 Gene