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Aliases for OR8B4 Gene

Aliases for OR8B4 Gene

  • Olfactory Receptor Family 8 Subfamily B Member 4 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-315 3 4
  • OR8B4P 3 4
  • Olfactory Receptor, Family 8, Subfamily B, Member 4 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 8, Subfamily B, Member 4 Pseudogene 3
  • Olfactory Receptor 8B4 3
  • OR11-315 3

External Ids for OR8B4 Gene

Previous HGNC Symbols for OR8B4 Gene

  • OR8B4P

Previous GeneCards Identifiers for OR8B4 Gene

  • GC11U990228
  • GC11M123832
  • GC11M123799
  • GC11M124293

Summaries for OR8B4 Gene

Entrez Gene Summary for OR8B4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR8B4 Gene

OR8B4 (Olfactory Receptor Family 8 Subfamily B Member 4 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding.

UniProtKB/Swiss-Prot for OR8B4 Gene

  • Odorant receptor.

Gene Wiki entry for OR8B4 Gene

Additional gene information for OR8B4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8B4 Gene

Genomics for OR8B4 Gene

GeneHancer (GH) Regulatory Elements for OR8B4 Gene

Promoters and enhancers for OR8B4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124642 Enhancer 1.3 FANTOM5 Ensembl ENCODE 2.9 -219.2 -219162 2.5 ATF1 PKNOX1 ARNT YY1 TCF12 POLR2B ZNF766 E2F8 ZNF143 FOS ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
GH11J124008 Enhancer 0.2 FANTOM5 4 +416.2 416219 0.4 OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR10G4 OR6M1 OR8G1 OR10S1 OR8D2
GH11J124682 Enhancer 0.4 FANTOM5 1.8 -258.2 -258153 0.3 ZNF507 SETDB1 OR8B4 MSANTD2 SPA17 SIAE
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8B4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR8B4 gene promoter:
  • AREB6
  • NF-AT
  • Pbx1a
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • ATF6
  • C/EBPalpha

Genomic Locations for OR8B4 Gene

Genomic Locations for OR8B4 Gene
990 bases
Minus strand
983 bases
Minus strand

Genomic View for OR8B4 Gene

Genes around OR8B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8B4 Gene

Proteins for OR8B4 Gene

  • Protein details for OR8B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8B4
    Protein Accession:
    Secondary Accessions:
    • B2RNF8
    • Q6IFQ7

    Protein attributes for OR8B4 Gene

    309 amino acids
    Molecular mass:
    34404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B4 Gene

Post-translational modifications for OR8B4 Gene

Other Protein References for OR8B4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B4 Gene

Domains & Families for OR8B4 Gene

Gene Families for OR8B4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8B4 Gene

Suggested Antigen Peptide Sequences for OR8B4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B4: view

Function for OR8B4 Gene

Molecular function for OR8B4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8B4: view
genes like me logo Genes that share phenotypes with OR8B4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8B4 Gene

Localization for OR8B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8B4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8B4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8B4 Gene

Pathways & Interactions for OR8B4 Gene

genes like me logo Genes that share pathways with OR8B4: view

Pathways by source for OR8B4 Gene

Gene Ontology (GO) - Biological Process for OR8B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B4: view

No data available for SIGNOR curated interactions for OR8B4 Gene

Drugs & Compounds for OR8B4 Gene

No Compound Related Data Available

Transcripts for OR8B4 Gene

mRNA/cDNA for OR8B4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8B4 Gene

Olfactory receptor, family 8, subfamily B, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B4 Gene

No ASD Table

Relevant External Links for OR8B4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8B4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR8B4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8B4 Gene:


SOURCE GeneReport for Unigene cluster for OR8B4 Gene:

genes like me logo Genes that share expression patterns with OR8B4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8B4 Gene

Orthologs for OR8B4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia OR8B4 33
  • 89.18 (n)
(Bos Taurus)
Mammalia OR8B4 33
  • 86.52 (n)
(Rattus norvegicus)
Mammalia Olr1202 33
  • 84.36 (n)
(Mus musculus)
Mammalia Or8b4 51 Olfr878 16 33
  • 83.93 (n)
Species where no ortholog for OR8B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8B4 Gene

Gene Tree for OR8B4 (if available)
Gene Tree for OR8B4 (if available)

Paralogs for OR8B4 Gene

(436) SIMAP similar genes for OR8B4 Gene using alignment to 1 proteins:

  • OR8B4_HUMAN Pseudogenes for OR8B4 Gene

genes like me logo Genes that share paralogs with OR8B4: view

No data available for Paralogs for OR8B4 Gene

Variants for OR8B4 Gene

Sequence variations from dbSNP and Humsavar for OR8B4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001108940 -- 124,426,802(-) C/A upstream_transcript_variant
rs1001874749 -- 124,425,576(-) G/A upstream_transcript_variant
rs1002163803 -- 124,425,815(-) A/G upstream_transcript_variant
rs1002441185 -- 124,425,197(-) A/G upstream_transcript_variant
rs1002814022 -- 124,423,875(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR8B4 Gene

Variant ID Type Subtype PubMed ID
esv3892105 CNV gain 25118596

Variation tolerance for OR8B4 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.69; 99.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8B4 Gene

Disorders for OR8B4 Gene

Additional Disease Information for OR8B4

No disorders were found for OR8B4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8B4 Gene

Publications for OR8B4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 58
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for OR8B4 Gene

Sources for OR8B4 Gene

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