OR8B3 Gene (Protein Coding)

Olfactory Receptor Family 8 Subfamily B Member 3

GC11M124396
GIFtS:
26
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8B3 Gene

Aliases for OR8B3 Gene

  • Olfactory Receptor Family 8 Subfamily B Member 3 2 3 5
  • Olfactory Receptor OR11-311 3 4
  • Olfactory Receptor 8B3 3 4
  • Olfactory Receptor, Family 8, Subfamily B, Member 3 2
  • OR11-311 3
  • OR8B3 5

External Ids for OR8B3 Gene

Previous GeneCards Identifiers for OR8B3 Gene

  • GC11U990229
  • GC11M123771
  • GC11M124266

Summaries for OR8B3 Gene

Entrez Gene Summary for OR8B3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8B3 Gene

OR8B3 (Olfactory Receptor Family 8 Subfamily B Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8B2.

UniProtKB/Swiss-Prot Summary for OR8B3 Gene

Additional gene information for OR8B3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8B3 Gene

Genomics for OR8B3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR8B3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J124406 Enhancer 0.3 Ensembl 0.7 +4.3 4266 0.5 HLF HSALNG0087883 LOC107984404 OR8X1P lnc-OR8B3-1 OR8B3 OR8B2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8B3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8B3

Top Transcription factor binding sites by QIAGEN in the OR8B3 gene promoter:
  • AP-1
  • AREB6
  • c-Fos
  • c-Jun
  • Cdc5
  • GR
  • GR-alpha
  • HNF-3beta
  • Pbx1a

Genomic Locations for OR8B3 Gene

Latest Assembly
chr11:124,395,534-124,410,495
(GRCh38/hg38)
Size:
14,962 bases
Orientation:
Minus strand

Previous Assembly
chr11:124,265,430-124,268,920
(GRCh37/hg19 by Entrez Gene)
Size:
3,491 bases
Orientation:
Minus strand

Genomic View for OR8B3 Gene

Genes around OR8B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8B3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR8B3 Gene

Proteins for OR8B3 Gene

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  • Protein details for OR8B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGG8-OR8B3_HUMAN
    Recommended name:
    Olfactory receptor 8B3
    Protein Accession:
    Q8NGG8
    Secondary Accessions:
    • Q6IFQ8
    • Q8NGH1

    Protein attributes for OR8B3 Gene

    Size:
    313 amino acids
    Molecular mass:
    35305 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B3 Gene

Post-translational modifications for OR8B3 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8B3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B3 Gene

Domains & Families for OR8B3 Gene

Gene Families for OR8B3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8B3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8B3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-311 (OR8B3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGG8

UniProtKB/Swiss-Prot:

OR8B3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B3: view

Function for OR8B3 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for OR8B3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 8,subfamily B,member 3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR8B3 Gene

Gene Ontology (GO) - Molecular Function for OR8B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8B3: view
genes like me logo Genes that share phenotypes with OR8B3: view

Animal Models for research

miRNA for OR8B3 Gene

miRTarBase miRNAs that target OR8B3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8B3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR8B3 Gene

Localization for OR8B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8B3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8B3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8B3 Gene

Pathways & Interactions for OR8B3 Gene

genes like me logo Genes that share pathways with OR8B3: view

Pathways by source for OR8B3 Gene

1 KEGG pathway for OR8B3 Gene

Interacting Proteins for OR8B3 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000346611 Q8NGG8-OR8B3_HUMAN for OR8B3 Gene via STRING IID

GPS-Prot Interaction Network for OR8B3

Gene Ontology (GO) - Biological Process for OR8B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B3: view

No data available for SIGNOR curated interactions for OR8B3 Gene

Drugs & Compounds for OR8B3 Gene

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No Compound Related Data Available

Transcripts for OR8B3 Gene

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mRNA/cDNA for OR8B3 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8B3

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B3 Gene

No ASD Table

Relevant External Links for OR8B3 Gene

GeneLoc Exon Structure for
OR8B3

Expression for OR8B3 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8B3 Gene

mRNA expression in normal human tissues for OR8B3 Gene
mRNA expression by GTEx for OR8B3 Gene

mRNA differential expression in normal tissues according to GTEx for OR8B3 Gene

This gene is overexpressed in Testis (x44.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8B3

SOURCE GeneReport for Unigene cluster for OR8B3 Gene:

Hs.690456
genes like me logo Genes that share expression patterns with OR8B3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8B3 Gene

Orthologs for OR8B3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC466832 29
  • 97.98 (n)
Dog
(Canis familiaris)
 Mammalia LOC100687027 29
  • 88.35 (n)
Cow
(Bos Taurus)
 Mammalia LOC511657 29
  • 87.33 (n)
Rat
(Rattus norvegicus)
 Mammalia Olr1235 29
  • 84.09 (n)
Mouse
(Mus musculus)
 Mammalia Or8b3 45 Olfr147 29 16
  • 82.22 (n)
Or8b36 45 Olfr883
  • chr9:38,025,808-38,026,734
Or8b3b 45 Olfr918
  • chr9:38,672,507-38,673,481
Or8b42 45 Olfr901
  • chr9:38,430,284-38,431,216
Or8b57 45 Olfr983
  • chr9:40,092,020-40,092,964
Species where no ortholog for OR8B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8B3 Gene

ENSEMBL:
Gene Tree for OR8B3 (if available)
TreeFam:
Gene Tree for OR8B3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8B3: view image
Alliance of Genome Resources:
Additional Orthologs for OR8B3

Paralogs for OR8B3 Gene

Paralogs for OR8B3 Gene

(438) SIMAP similar genes for OR8B3 Gene using alignment to 1 proteins:

  • OR8B3_HUMAN
genes like me logo Genes that share paralogs with OR8B3: view

Variants for OR8B3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8B3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs507335 -- p.His20Arg
rs530992 -- p.Met114Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8B3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8B3 Gene

Variant ID Type Subtype PubMed ID
esv2424130 CNV deletion 19546169
esv2658517 CNV deletion 23128226
esv2745185 CNV deletion 23290073
esv2760171 CNV loss 21179565
esv3627976 CNV loss 21293372
esv3627979 CNV loss 21293372
esv3892105 CNV gain 25118596
nsv436130 CNV deletion 17901297
nsv983072 CNV duplication 23825009

Variation tolerance for OR8B3 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8B3
Leiden Open Variation Database (LOVD)
OR8B3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8B3 Gene

Disorders for OR8B3 Gene

Additional Disease Information for OR8B3

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR8B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8B3 Gene

Publications for OR8B3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

ExternalLinks

View latest publications for OR8B3 gene in Mastermind

Products for OR8B3 Gene

Sources for OR8B3 Gene