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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR8B3 (Olfactory Receptor Family 8 Subfamily B Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8B2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J124406 | Enhancer | 0.3 | Ensembl | 0.7 | +4.3 | 4266 | 0.5 | HLF | LOC107984404 OR8X1P lnc-OR8B3-1 OR8B3 OR8B2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | -- |
GO:0005549 | odorant binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IBA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
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Chimpanzee (Pan troglodytes) |
Mammalia | LOC466832 30 |
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Dog (Canis familiaris) |
Mammalia | LOC100687027 30 |
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Cow (Bos Taurus) |
Mammalia | LOC511657 30 |
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Rat (Rattus norvegicus) |
Mammalia | Olr1235 30 |
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Mouse (Mus musculus) |
Mammalia | Or8b3 46 Olfr147 30 17 |
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Or8b36 46 Olfr883 |
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Or8b3b 46 Olfr918 |
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Or8b42 46 Olfr901 |
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Or8b57 46 Olfr983 |
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Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2424130 | CNV | deletion | 19546169 |
esv2658517 | CNV | deletion | 23128226 |
esv2745185 | CNV | deletion | 23290073 |
esv2760171 | CNV | loss | 21179565 |
esv3627976 | CNV | loss | 21293372 |
esv3627979 | CNV | loss | 21293372 |
esv3892105 | CNV | gain | 25118596 |
nsv436130 | CNV | deletion | 17901297 |
nsv983072 | CNV | duplication | 23825009 |
No disorders were found for OR8B3 Gene.