Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8B2 Gene

Aliases for OR8B2 Gene

  • Olfactory Receptor Family 8 Subfamily B Member 2 2 3 5
  • Olfactory Receptor OR11-309 3 4
  • Olfactory Receptor 8B2 3 4
  • Olfactory Receptor, Family 8, Subfamily B, Member 2 2
  • Olfactory Receptor OR11-310 3
  • OR11-309 3
  • OR11-310 3
  • OR8B2 5

External Ids for OR8B2 Gene

Previous GeneCards Identifiers for OR8B2 Gene

  • GC11U990230
  • GC11M123757
  • GC11M124252

Summaries for OR8B2 Gene

Entrez Gene Summary for OR8B2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8B2 Gene

OR8B2 (Olfactory Receptor Family 8 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8B3.

UniProtKB/Swiss-Prot Summary for OR8B2 Gene

Gene Wiki entry for OR8B2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8B2 Gene

Genomics for OR8B2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124330 Enhancer 0.8 Ensembl ENCODE 0.2 +67.8 67819 3.4 NFIC REST RAD21 SMC3 HLTF CTCF SPI1 IKZF1 PKNOX1 IKZF2 VWA5A OR8D1 OR8G5 CCDC15 OR8B7P OR8D2 lnc-OR8D2-1 HSALNG0087881 OR8B2
GH11J124406 Enhancer 0.3 Ensembl 0.4 -8.9 -8909 0.5 HLF HSALNG0087883 LOC107984404 OR8X1P lnc-OR8B3-1 OR8B3 OR8B2
GH11J124339 Enhancer 0.4 Ensembl 0.2 +57.7 57719 1.2 SOX5 SPI1 SOX13 PKNOX1 OR8B6P lnc-OR8D2-1 VWA5A OR8B8 OR8D1 OR8B7P OR8D2 OR8B2
GH11J124345 Enhancer 0.4 Ensembl 0.2 +50.9 50851 1.5 CEBPB TCF7L2 ATF4 VWA5A OR8G5 OR8D1 OR8B6P OR8B5P OR8D2 OR8B2
GH11J124325 Enhancer 0.2 Ensembl 0.2 +71.6 71619 0.2 OR8B7P VWA5A HSALNG0087881 OR8D2 OR8B2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8B2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8B2

Top Transcription factor binding sites by QIAGEN in the OR8B2 gene promoter:
  • AREB6
  • Bach1
  • Cdc5
  • GR
  • GR-alpha
  • HNF-3beta
  • NF-E2
  • NF-E2 p45
  • Sox9

Genomic Locations for OR8B2 Gene

Latest Assembly
chr11:124,382,394-124,397,320
(GRCh38/hg38)
Size:
14,927 bases
Orientation:
Minus strand

Previous Assembly
chr11:124,252,290-124,254,395
(GRCh37/hg19 by Entrez Gene)
Size:
2,106 bases
Orientation:
Minus strand

Genomic View for OR8B2 Gene

Genes around OR8B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8B2 Gene

Proteins for OR8B2 Gene

  • Protein details for OR8B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD0-OR8B2_HUMAN
    Recommended name:
    Olfactory receptor 8B2
    Protein Accession:
    Q96RD0
    Secondary Accessions:
    • Q8NGH2

    Protein attributes for OR8B2 Gene

    Size:
    313 amino acids
    Molecular mass:
    35272 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B2 Gene

Post-translational modifications for OR8B2 Gene

  • Glycosylation at Asn5

Other Protein References for OR8B2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B2 Gene

Domains & Families for OR8B2 Gene

Gene Families for OR8B2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8B2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR8B2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-309 (OR8B2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96RD0

UniProtKB/Swiss-Prot:

OR8B2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B2: view

Function for OR8B2 Gene

Molecular function for OR8B2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 8,subfamily B,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR8B2 Gene

Gene Ontology (GO) - Molecular Function for OR8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR8B2: view
genes like me logo Genes that share phenotypes with OR8B2: view

Animal Models for research

miRNA for OR8B2 Gene

miRTarBase miRNAs that target OR8B2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8B2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR8B2 Gene

Localization for OR8B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8B2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8B2 Gene

Pathways & Interactions for OR8B2 Gene

genes like me logo Genes that share pathways with OR8B2: view

Pathways by source for OR8B2 Gene

Interacting Proteins for OR8B2 Gene

Gene Ontology (GO) - Biological Process for OR8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B2: view

No data available for SIGNOR curated interactions for OR8B2 Gene

Drugs & Compounds for OR8B2 Gene

No Compound Related Data Available

Transcripts for OR8B2 Gene

mRNA/cDNA for OR8B2 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8B2

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B2 Gene

No ASD Table

Relevant External Links for OR8B2 Gene

GeneLoc Exon Structure for
OR8B2

Expression for OR8B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8B2 Gene

mRNA differential expression in normal tissues according to GTEx for OR8B2 Gene

This gene is overexpressed in Testis (x45.7).

Protein differential expression in normal tissues from HIPED for OR8B2 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR8B2 Gene



Protein tissue co-expression partners for OR8B2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8B2

SOURCE GeneReport for Unigene cluster for OR8B2 Gene:

Hs.576944
genes like me logo Genes that share expression patterns with OR8B2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8B2 Gene

Orthologs for OR8B2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466832 29
  • 98.4 (n)
Dog
(Canis familiaris)
Mammalia LOC100687027 29
  • 87.93 (n)
Cow
(Bos Taurus)
Mammalia LOC511657 29
  • 86.9 (n)
Rat
(Rattus norvegicus)
Mammalia Olr1235 29
  • 83.33 (n)
Mouse
(Mus musculus)
Mammalia Olfr147 29
  • 81.47 (n)
Or8b38 45 Olfr885
  • chr9:38,061,322-38,062,248
Species where no ortholog for OR8B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8B2 Gene

ENSEMBL:
Gene Tree for OR8B2 (if available)
TreeFam:
Gene Tree for OR8B2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8B2: view image
Alliance of Genome Resources:
Additional Orthologs for OR8B2

Paralogs for OR8B2 Gene

(442) SIMAP similar genes for OR8B2 Gene using alignment to 1 proteins:

  • OR8B2_HUMAN
genes like me logo Genes that share paralogs with OR8B2: view

Variants for OR8B2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8B2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs28373946 -- p.His20Arg
rs503220 -- p.Ser273Phe
rs530740 -- p.Leu27Phe
rs886202 -- p.Leu164Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR8B2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR8B2 Gene

Variant ID Type Subtype PubMed ID
esv2658517 CNV deletion 23128226
esv2745185 CNV deletion 23290073
esv3627976 CNV loss 21293372
esv3627979 CNV loss 21293372
esv3892105 CNV gain 25118596
nsv975238 CNV duplication 23825009

Variation tolerance for OR8B2 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.00; 89.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8B2
Leiden Open Variation Database (LOVD)
OR8B2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8B2 Gene

Disorders for OR8B2 Gene

Additional Disease Information for OR8B2

No disorders were found for OR8B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8B2 Gene

Publications for OR8B2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR8B2 Gene

Sources for OR8B2 Gene