Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR8B12 Gene

Aliases for OR8B12 Gene

  • Olfactory Receptor Family 8 Subfamily B Member 12 2 3 5
  • Olfactory Receptor OR11-317 3 4
  • Olfactory Receptor 8B12 3 4
  • Olfactory Receptor, Family 8, Subfamily B, Member 12 2
  • OR11-317 3
  • OR8B12 5

External Ids for OR8B12 Gene

Previous GeneCards Identifiers for OR8B12 Gene

  • GC11U990407
  • GC11M123951
  • GC11M123917
  • GC11M124412
  • GC11M124542
  • GC11M124543

Summaries for OR8B12 Gene

Entrez Gene Summary for OR8B12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8B12 Gene

OR8B12 (Olfactory Receptor Family 8 Subfamily B Member 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8B8.

UniProtKB/Swiss-Prot Summary for OR8B12 Gene

Gene Wiki entry for OR8B12 Gene

Additional gene information for OR8B12 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR8B12 Gene

Genomics for OR8B12 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR8B12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124070 Enhancer 1 FANTOM5 ENCODE 3 +474.2 474164 0.9 SP1 CTCF BACH1 JUND FOXA1 STAT3 RELA REST RAD21 IKZF2 piR-46501-021 VWA5A OR8B12 OR8G2P LOC107984403 OR10G7
GH11J124275 Enhancer 1.3 FANTOM5 Ensembl ENCODE 1.6 +268.3 268332 2.8 CTCF LEF1 JUND PKNOX1 MTA1 DPF2 HDAC1 ETV6 SOX6 GATAD2B VWA5A OR8G5 OR8D1 CCDC15 OR8G2P TBRG1 OR8B12 SLC5A4P1 lnc-OR8G5-5 piR-51137-027
GH11J124078 Enhancer 1.2 FANTOM5 ENCODE 1.5 +465.3 465283 3.3 LEF1 IKZF1 JUND FOXA1 DDX20 MTA2 PKNOX1 MTA1 ZNF24 DPF2 lnc-VWA5A-2 VWA5A ZNF202 SPA17 OR8G2P OR8B12 OR8D1 OR8A1 lnc-VWA5A-1 OR10G7
GH11J124642 Enhancer 1.1 FANTOM5 ENCODE 1.3 -98.7 -98672 2.4 CTCF TEAD4 LEF1 IKZF1 JUND FOXA1 ZNF143 ZIC2 PKNOX1 ZNF24 ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
GH11J124588 Enhancer 0.2 FANTOM5 6.8 -43.7 -43733 0.4 OR8A1 OR8G1 OR8D1 OR8D2 OR8G2P OR8B12 OR8B8 SPA17 lnc-OR8A1-1-001 OR8Q1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR8B12 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR8B12

Top Transcription factor binding sites by QIAGEN in the OR8B12 gene promoter:
  • CUTL1
  • Gfi-1
  • HOXA9
  • HOXA9B
  • LCR-F1
  • Meis-1
  • Meis-1a
  • RREB-1

Genomic Locations for OR8B12 Gene

Genomic Locations for OR8B12 Gene
chr11:124,539,635-124,545,333
(GRCh38/hg38)
Size:
5,699 bases
Orientation:
Minus strand
chr11:124,412,578-124,413,575
(GRCh37/hg19)
Size:
998 bases
Orientation:
Minus strand

Genomic View for OR8B12 Gene

Genes around OR8B12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8B12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8B12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8B12 Gene

Proteins for OR8B12 Gene

  • Protein details for OR8B12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGG6-OR8BC_HUMAN
    Recommended name:
    Olfactory receptor 8B12
    Protein Accession:
    Q8NGG6
    Secondary Accessions:
    • B2RNF6
    • Q6IEW8
    • Q96RC7

    Protein attributes for OR8B12 Gene

    Size:
    310 amino acids
    Molecular mass:
    34372 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B12 Gene

Post-translational modifications for OR8B12 Gene

  • Glycosylation at Asn5, Asn164, and Asn189
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8B12 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B12 Gene

Domains & Families for OR8B12 Gene

Gene Families for OR8B12 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8B12 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR8B12 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-317 (OR8BC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGG6

UniProtKB/Swiss-Prot:

OR8BC_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B12: view

Function for OR8B12 Gene

Molecular function for OR8B12 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8B12: view
genes like me logo Genes that share phenotypes with OR8B12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8B12

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8B12 Gene

Localization for OR8B12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B12 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8B12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8B12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8B12 Gene

Pathways & Interactions for OR8B12 Gene

genes like me logo Genes that share pathways with OR8B12: view

Pathways by source for OR8B12 Gene

Interacting Proteins for OR8B12 Gene

Gene Ontology (GO) - Biological Process for OR8B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B12: view

No data available for SIGNOR curated interactions for OR8B12 Gene

Drugs & Compounds for OR8B12 Gene

No Compound Related Data Available

Transcripts for OR8B12 Gene

mRNA/cDNA for OR8B12 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR8B12

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B12 Gene

No ASD Table

Relevant External Links for OR8B12 Gene

GeneLoc Exon Structure for
OR8B12

Expression for OR8B12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8B12 Gene

mRNA differential expression in normal tissues according to GTEx for OR8B12 Gene

This gene is overexpressed in Testis (x47.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR8B12

SOURCE GeneReport for Unigene cluster for OR8B12 Gene:

Hs.553634
genes like me logo Genes that share expression patterns with OR8B12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8B12 Gene

Orthologs for OR8B12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B12 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia LOC513334 30
  • 85.08 (n)
-- 31
  • 82 (a)
OneToMany
-- 31
  • 79 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or8b12b 46 Olfr875 31
  • 84 (a)
OneToMany
Or8b12c 46 Olfr876 31
  • 83 (a)
OneToMany
Or8b12 46 Olfr874 30 17 31
  • 82.15 (n)
OneToMany
Or12k8 46 Olfr361
  • chr2:37,084,781-37,085,746
Dog
(Canis familiaris)
Mammalia OR8B12 31
  • 84 (a)
OneToOne
LOC489314 30
  • 83.6 (n)
Rat
(Rattus norvegicus)
Mammalia Olr1196 30
  • 82.9 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 72 (a)
ManyToMany
-- 31
  • 72 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
Species where no ortholog for OR8B12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR8B12 Gene

ENSEMBL:
Gene Tree for OR8B12 (if available)
TreeFam:
Gene Tree for OR8B12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR8B12: view image

Paralogs for OR8B12 Gene

(449) SIMAP similar genes for OR8B12 Gene using alignment to 1 proteins:

  • OR8BC_HUMAN

Pseudogenes.org Pseudogenes for OR8B12 Gene

genes like me logo Genes that share paralogs with OR8B12: view

Variants for OR8B12 Gene

Additional dbSNP identifiers (rs#s) for OR8B12 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR8B12 Gene

Variant ID Type Subtype PubMed ID
nsv518199 CNV gain 19592680

Variation tolerance for OR8B12 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8B12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8B12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR8B12 Gene

Disorders for OR8B12 Gene

No disorders were found for OR8B12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8B12 Gene

Publications for OR8B12 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR8B12 Gene

Sources for OR8B12 Gene