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OR8A1 Gene(Protein Coding)

Olfactory Receptor Family 8 Subfamily A Member 1

GCID:
GC11P124569
GIFtS:
40
Genes Participants
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Aliases for OR8A1 Gene

Aliases for OR8A1 Gene

  • Olfactory Receptor Family 8 Subfamily A Member 1 2 3 5
  • Olfactory Receptor OR11-318 3 4
  • OST025 3 4
  • Olfactory Receptor, Family 8, Subfamily A, Member 1 2
  • Olfactory Receptor 8A1 3
  • OR11-318 3

External Ids for OR8A1 Gene

Previous GeneCards Identifiers for OR8A1 Gene

  • GC00U990586
  • GC11P123978
  • GC11P123945
  • GC11P124439

Summaries for OR8A1 Gene

Entrez Gene Summary for OR8A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8A1 Gene

OR8A1 (Olfactory Receptor Family 8 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8D4.

UniProtKB/Swiss-Prot for OR8A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR8A1 Gene

Additional gene information for OR8A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8A1 Gene

Genomics for OR8A1 Gene

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  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for OR8A1 Gene

Promoters and enhancers for OR8A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11I124521 Enhancer 0.2 FANTOM5 43.8 -45.2 -45164 0.3 OR8A1 OR8B8 OR10G7 OR8G2P OR8G1 OR8B12 OR8D1 OR8D2 OR8B10P OR8A3P
GH11I124642 Enhancer 1.4 FANTOM5 Ensembl ENCODE 3.1 +77.4 77395 2.5 ATF1 PKNOX1 ARNT YY1 TCF12 POLR2B ZNF766 E2F8 ZNF143 FOS ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
GH11I124588 Enhancer 0.2 FANTOM5 16.7 +22.4 22406 0.4 OR8A1 OR8G1 OR8D1 OR8D2 OR8G2P OR8B12 OR8B8 SPA17 OR8Q1P
GH11I124191 Enhancer 0.4 FANTOM5 4.3 -374.6 -374571 0.3 FOSL1 MAFG VWA5A OR8A1 OR6X1 OR10G7 OR8G2P OR8B12 OR4D5 OR10G4 OR8G1 OR6M1
GH11I124078 Enhancer 1.2 FANTOM5 ENCODE 1.2 -486.6 -486610 3.3 HDGF PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 ATF7 CAVIN1 VWA5A ZNF202 SPA17 OR8G2P OR8B12 OR8D1 OR8A1 LOC105369545 GC11M124060
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR8A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR8A1 gene promoter:

Genomic Locations for OR8A1 Gene

Genomic Locations for OR8A1 Gene
chr11:124,566,660-124,602,563
(GRCh38/hg38)
Size:
35,904 bases
Orientation:
Plus strand
chr11:124,439,893-124,441,037
(GRCh37/hg19)

Genomic View for OR8A1 Gene

Genes around OR8A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8A1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR8A1 Gene

Proteins for OR8A1 Gene

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  • Protein details for OR8A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGG7-OR8A1_HUMAN
    Recommended name:
    Olfactory receptor 8A1
    Protein Accession:
    Q8NGG7
    Secondary Accessions:
    • Q6IEW7
    • Q96RC6

    Protein attributes for OR8A1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06052.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR8A1 Gene

Protein Expression for OR8A1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OR8A1 Gene

  • Glycosylation at isoforms=22
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8A1 Gene

Domains & Families for OR8A1 Gene

Gene Families for OR8A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OR8A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGG7

UniProtKB/Swiss-Prot:

OR8A1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8A1: view

Function for OR8A1 Gene

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Molecular function for OR8A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR8A1 Gene

Gene Ontology (GO) - Molecular Function for OR8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8A1: view
genes like me logo Genes that share phenotypes with OR8A1: view

Animal Models for OR8A1 Gene

MGI Knock Outs for OR8A1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OR8A1 Gene

Localization for OR8A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR8A1 Gene

Pathways & Interactions for OR8A1 Gene

genes like me logo Genes that share pathways with OR8A1: view

Pathways by source for OR8A1 Gene

1 KEGG pathway for OR8A1 Gene

Interacting Proteins for OR8A1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000284287%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000409581%0d%0a9606.ENSP00000371594%0d%0a
Selected Interacting proteins: ENSP00000284287 for OR8A1 Gene via STRING

Gene Ontology (GO) - Biological Process for OR8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8A1: view

No data available for SIGNOR curated interactions for OR8A1 Gene

Drugs & Compounds for OR8A1 Gene

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No Compound Related Data Available

Transcripts for OR8A1 Gene

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  4. Clone

mRNA/cDNA for OR8A1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8A1 Gene

Olfactory receptor, family 8, subfamily A, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8A1 Gene

No ASD Table

Relevant External Links for OR8A1 Gene

GeneLoc Exon Structure for
OR8A1
ECgene alternative splicing isoforms for
OR8A1

Expression for OR8A1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR8A1 Gene

mRNA expression in normal human tissues for OR8A1 Gene
mRNA expression by GTEx for OR8A1 GenemRNA expression by BioGPS for OR8A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8A1 Gene

This gene is overexpressed in Testis (x37.8) and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for OR8A1 Gene

This gene is overexpressed in Saliva (51.6) and Islet of Langerhans (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR8A1 Gene



Protein tissue co-expression partners for OR8A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8A1 Gene:

OR8A1

SOURCE GeneReport for Unigene cluster for OR8A1 Gene:

Hs.632104
genes like me logo Genes that share expression patterns with OR8A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8A1 Gene

Orthologs for OR8A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC451635 33
  • 99.18 (n)
OR8A1 34
  • 99 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia -- 34
  • 88 (a)
 OneToMany
LOC783205 33
  • 87.59 (n)
-- 34
  • 85 (a)
 OneToMany
-- 34
  • 84 (a)
 OneToMany
-- 34
  • 83 (a)
 OneToMany
-- 34
  • 82 (a)
 OneToMany
-- 34
  • 82 (a)
 OneToMany
-- 34
  • 80 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia OR8A1 33 34
  • 87.27 (n)
mouse
(Mus musculus)
 Mammalia Or8a1b 51 Olfr160 16 34
  • 85 (a)
Olfr151 33
  • 83.06 (n)
Or8a1-ps 51 Olfr151-ps1
  • chr9:37,730,056-37,730,981
Or8d6 51 Olfr974
  • chr9:39,942,262-39,943,191
rat
(Rattus norvegicus)
 Mammalia Olr1194 33
  • 84.47 (n)
oppossum
(Monodelphis domestica)
 Mammalia OR8A1 34
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 59 (a)
 OneToMany
Species where no ortholog for OR8A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8A1 Gene

ENSEMBL:
Gene Tree for OR8A1 (if available)
TreeFam:
Gene Tree for OR8A1 (if available)

Paralogs for OR8A1 Gene

Paralogs for OR8A1 Gene

(454) SIMAP similar genes for OR8A1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR8A1 Gene

genes like me logo Genes that share paralogs with OR8A1: view

Variants for OR8A1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for OR8A1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000009950 -- 124,571,362(+) A/C/G downstream_transcript_variant
rs1000967324 -- 124,570,083(+) TCCCATGCATCCC/TCCC coding_sequence_variant, inframe_deletion
rs1001108690 -- 124,569,868(+) T/C upstream_transcript_variant
rs1003000164 -- 124,571,416(+) C/T downstream_transcript_variant
rs1004883182 -- 124,571,171(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR8A1 Gene

Variant ID Type Subtype PubMed ID
nsv1045156 CNV loss 25217958
nsv518199 CNV gain 19592680

Variation tolerance for OR8A1 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.97; 92.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR8A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8A1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8A1 Gene

Disorders for OR8A1 Gene

Additional Disease Information for OR8A1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR8A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8A1 Gene

Publications for OR8A1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. (PMID: 25390645) Otowa T … Hettema JM (PloS one 2014) 3 58
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

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Sources for OR8A1 Gene

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