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Aliases for OR7G3 Gene

Aliases for OR7G3 Gene

  • Olfactory Receptor Family 7 Subfamily G Member 3 2 3 5
  • Olfactory Receptor OR19-9 3 4
  • Olfactory Receptor 7G3 3 4
  • OST085 3 4
  • Olfactory Receptor, Family 7, Subfamily G, Member 3 2

External Ids for OR7G3 Gene

Previous GeneCards Identifiers for OR7G3 Gene

  • GC19U990180
  • GC19M009241

Summaries for OR7G3 Gene

Entrez Gene Summary for OR7G3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7G3 Gene

OR7G3 (Olfactory Receptor Family 7 Subfamily G Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7G2.

UniProtKB/Swiss-Prot for OR7G3 Gene

Gene Wiki entry for OR7G3 Gene

Additional gene information for OR7G3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7G3 Gene

Genomics for OR7G3 Gene

GeneHancer (GH) Regulatory Elements for OR7G3 Gene

Promoters and enhancers for OR7G3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009073 Enhancer 1.2 Ensembl ENCODE 11.2 +52.0 51952 2.8 ZFX CBFA2T2 ZNF148 TRIM24 SP7 ZNF639 EGR1 SMARCA4 FOSL2 CAVIN1 MUC16 ZNF414 LOC100419831 ZNF559 ZNF558 HNRNPM ZNF266 OR7G1 ZNF699 ZNF121
GH19J009069 Enhancer 0.7 Ensembl ENCODE 11.2 +56.8 56847 1.1 SP1 ZNF341 EZH2 BACH1 MUC16 OR7G1 OR7G3 GC19P009058 OR1M4P
GH19J009128 Enhancer 0.8 Ensembl ENCODE 0.7 -3.3 -3251 4.8 IKZF1 IKZF2 EED RUNX3 NR2F1 IRF2 EBF1 JUN JUND GC19P009131 MUC16 OR7G3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7G3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR7G3 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • CREB
  • FosB
  • Fra-1
  • JunB
  • JunD
  • LUN-1
  • PPAR-gamma2

Genomic Locations for OR7G3 Gene

Genomic Locations for OR7G3 Gene
939 bases
Minus strand
939 bases
Minus strand

Genomic View for OR7G3 Gene

Genes around OR7G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7G3 Gene

Proteins for OR7G3 Gene

  • Protein details for OR7G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 7G3
    Protein Accession:
    Secondary Accessions:
    • Q6IFJ6
    • Q96R99

    Protein attributes for OR7G3 Gene

    312 amino acids
    Molecular mass:
    34439 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7G3 Gene

Post-translational modifications for OR7G3 Gene

  • Glycosylation at posLast=9393 and isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR7G3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7G3 Gene

Domains & Families for OR7G3 Gene

Gene Families for OR7G3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7G3 Gene

Suggested Antigen Peptide Sequences for OR7G3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-9 (OR7G3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7G3: view

Function for OR7G3 Gene

Molecular function for OR7G3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR7G3 Gene

Gene Ontology (GO) - Molecular Function for OR7G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR7G3: view
genes like me logo Genes that share phenotypes with OR7G3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7G3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7G3 Gene

Localization for OR7G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7G3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7G3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7G3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7G3 Gene

Pathways & Interactions for OR7G3 Gene

genes like me logo Genes that share pathways with OR7G3: view

Pathways by source for OR7G3 Gene

Interacting Proteins for OR7G3 Gene

Gene Ontology (GO) - Biological Process for OR7G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR7G3: view

No data available for SIGNOR curated interactions for OR7G3 Gene

Drugs & Compounds for OR7G3 Gene

No Compound Related Data Available

Transcripts for OR7G3 Gene

mRNA/cDNA for OR7G3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OR7G3 Gene

Olfactory receptor, family 7, subfamily G, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7G3

Alternative Splicing Database (ASD) splice patterns (SP) for OR7G3 Gene

No ASD Table

Relevant External Links for OR7G3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR7G3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR7G3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR7G3 Gene:


SOURCE GeneReport for Unigene cluster for OR7G3 Gene:

genes like me logo Genes that share expression patterns with OR7G3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7G3 Gene

Orthologs for OR7G3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7G3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC468708 34
  • 98.08 (n)
(Canis familiaris)
Mammalia LOC100685759 34
  • 85.15 (n)
(Mus musculus)
Mammalia Or7g12 51 Olfr834 17 34
  • 77.53 (n)
Or7g19 51 Olfr832 35
  • 75 (a)
(Rattus norvegicus)
Mammalia Olr1125 34
  • 76.24 (n)
(Bos Taurus)
Mammalia OR7G3 34
  • 76.17 (n)
-- 35
  • 72 (a)
Species where no ortholog for OR7G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7G3 Gene

Gene Tree for OR7G3 (if available)
Gene Tree for OR7G3 (if available)
Evolutionary constrained regions (ECRs) for OR7G3: view image

Paralogs for OR7G3 Gene

(458) SIMAP similar genes for OR7G3 Gene using alignment to 1 proteins:

  • OR7G3_HUMAN Pseudogenes for OR7G3 Gene

genes like me logo Genes that share paralogs with OR7G3: view

Variants for OR7G3 Gene

Sequence variations from dbSNP and Humsavar for OR7G3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000194749 -- 9,128,089(-) G/A upstream_transcript_variant
rs1000369813 -- 9,126,050(-) A/G coding_sequence_variant, synonymous_variant
rs1000808380 -- 9,127,882(-) C/T upstream_transcript_variant
rs1001241043 -- 9,128,879(-) C/A upstream_transcript_variant
rs1003317177 -- 9,125,865(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR7G3 Gene

Variant ID Type Subtype PubMed ID
esv2762024 CNV gain 21179565
esv3643627 CNV gain 21293372
nsv1056401 CNV gain 25217958
nsv509720 CNV insertion 20534489
nsv961172 CNV duplication 23825009

Variation tolerance for OR7G3 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.44; 96.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7G3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7G3 Gene

Disorders for OR7G3 Gene

Additional Disease Information for OR7G3

No disorders were found for OR7G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7G3 Gene

Publications for OR7G3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan JA … Goldberg AL (The EMBO journal 2013) 3 58
  4. Association between olfactory receptor genes, eating behavior traits and adiposity: results from the Quebec Family Study. (PMID: 22044667) Choquette AC … Pérusse L (Physiology & behavior 2012) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for OR7G3 Gene

Sources for OR7G3 Gene

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