Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR7G2 Gene

Aliases for OR7G2 Gene

  • Olfactory Receptor Family 7 Subfamily G Member 2 2 3 5
  • OST260 2 3 4
  • Olfactory Receptor OR19-6 3 4
  • Olfactory Receptor 19-13 3 4
  • Olfactory Receptor 7G2 3 4
  • OR19-13 3 4
  • Olfactory Receptor, Family 7, Subfamily G, Member 2 2
  • OR19-6 3
  • OR7G2 5

External Ids for OR7G2 Gene

Previous GeneCards Identifiers for OR7G2 Gene

  • GC19U990181
  • GC19M009074
  • GC19M009075
  • GC19M009212

Summaries for OR7G2 Gene

Entrez Gene Summary for OR7G2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7G2 Gene

OR7G2 (Olfactory Receptor Family 7 Subfamily G Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7G1.

UniProtKB/Swiss-Prot Summary for OR7G2 Gene

Gene Wiki entry for OR7G2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR7G2 Gene

Genomics for OR7G2 Gene

GeneHancer (GH) Regulatory Elements Pubs


Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR7G2

Top Transcription factor binding sites by QIAGEN in the OR7G2 gene promoter:
  • CREB
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for OR7G2 Gene

Latest Assembly
chr19:9,100,407-9,107,475
(GRCh38/hg38)
Size:
7,069 bases
Orientation:
Minus strand

Previous Assembly
chr19:9,212,945-9,213,982
(GRCh37/hg19 by Entrez Gene)
Size:
1,038 bases
Orientation:
Minus strand

chr19:9,212,945-9,213,982
(GRCh37/hg19 by Ensembl)
Size:
1,038 bases
Orientation:
Minus strand

Genomic View for OR7G2 Gene

Genes around OR7G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7G2 Gene

Proteins for OR7G2 Gene

  • Protein details for OR7G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG99-OR7G2_HUMAN
    Recommended name:
    Olfactory receptor 7G2
    Protein Accession:
    Q8NG99
    Secondary Accessions:
    • Q6IFJ4
    • Q96RA0

    Protein attributes for OR7G2 Gene

    Size:
    324 amino acids
    Molecular mass:
    35931 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04666.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR7G2 Gene

Post-translational modifications for OR7G2 Gene

  • Glycosylation at Asn5 and Asn89

Other Protein References for OR7G2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7G2 Gene

Domains & Families for OR7G2 Gene

Gene Families for OR7G2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7G2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR7G2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-6 (OR7G2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NG99

UniProtKB/Swiss-Prot:

OR7G2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7G2: view

Function for OR7G2 Gene

Molecular function for OR7G2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR7G2 Gene

Gene Ontology (GO) - Molecular Function for OR7G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with OR7G2: view
genes like me logo Genes that share phenotypes with OR7G2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7G2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7G2 Gene

Localization for OR7G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7G2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7G2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7G2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7G2 Gene

Pathways & Interactions for OR7G2 Gene

genes like me logo Genes that share pathways with OR7G2: view

Pathways by source for OR7G2 Gene

Interacting Proteins for OR7G2 Gene

Gene Ontology (GO) - Biological Process for OR7G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR7G2: view

No data available for SIGNOR curated interactions for OR7G2 Gene

Drugs & Compounds for OR7G2 Gene

No Compound Related Data Available

Transcripts for OR7G2 Gene

mRNA/cDNA for OR7G2 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7G2

Alternative Splicing Database (ASD) splice patterns (SP) for OR7G2 Gene

No ASD Table

Relevant External Links for OR7G2 Gene

GeneLoc Exon Structure for
OR7G2

Expression for OR7G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR7G2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR7G2

SOURCE GeneReport for Unigene cluster for OR7G2 Gene:

Hs.553774
genes like me logo Genes that share expression patterns with OR7G2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7G2 Gene

Orthologs for OR7G2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7G2 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia OR7G1 29
  • 82.25 (n)
OR7G2 30
  • 74 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR7G2 29
  • 81.16 (n)
OR28G07 30
  • 76 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or7g33 45 Olfr853 29 16
  • 72.35 (n)
Or7g34 45 Olfr854 30
  • 72 (a)
OneToMany
Or7g27 45 Olfr845 30
  • 72 (a)
OneToMany
Or7g31 45 Olfr850 30
  • 70 (a)
OneToMany
Or7g16 45 Olfr828 30
  • 70 (a)
OneToMany
Or7g20 45 Olfr835 30
  • 68 (a)
OneToMany
Or7g17 45 Olfr829 30
  • 68 (a)
OneToMany
Olfr844 30
  • 68 (a)
OneToMany
Or7g28 45 Olfr846 30
  • 67 (a)
OneToMany
Or7g30 45 Olfr849 30
  • 66 (a)
OneToMany
Or7g35 45 Olfr855 30
  • 66 (a)
OneToMany
Or7g29 45 Olfr847 30
  • 65 (a)
OneToMany
Or7g32 45 Olfr851 30
  • 64 (a)
OneToMany
Or7g18 45 Olfr830 30
  • 62 (a)
OneToMany
Olfr843 30
  • 62 (a)
OneToMany
Or7g21 45 Olfr836 30
  • 62 (a)
OneToMany
Or7g22 45 Olfr837
  • chr9:19,136,995-19,137,930
Or7g23 45 Olfr839
  • chr9:19,174,739-19,175,674
Or7g24-ps 45 Olfr840-ps1
  • chr9:19,204,868-19,205,669
Or7g26-ps 45 Olfr844-ps1
  • chr9:19,318,530-19,319,462
Or7n1-ps 45 Olfr848-ps1
  • chr9:19,403,642-19,404,529
Or7s1-ps 45 Olfr831-ps1
  • chr9:18,931,931-18,932,951
Or7s1-ps 45 Olfr833-ps1
  • chr9:18,970,010-18,970,873
Rat
(Rattus norvegicus)
Mammalia Olr1145 29
  • 72.02 (n)
Species where no ortholog for OR7G2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR7G2 Gene

ENSEMBL:
Gene Tree for OR7G2 (if available)
TreeFam:
Gene Tree for OR7G2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7G2: view image
Alliance of Genome Resources:
Additional Orthologs for OR7G2

Paralogs for OR7G2 Gene

(455) SIMAP similar genes for OR7G2 Gene using alignment to 1 proteins:

  • OR7G2_HUMAN
genes like me logo Genes that share paralogs with OR7G2: view

Variants for OR7G2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR7G2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs4804401 -- p.Phe281Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR7G2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR7G2 Gene

Variant ID Type Subtype PubMed ID
esv2762024 CNV gain 21179565
nsv1056401 CNV gain 25217958
nsv509720 CNV insertion 20534489
nsv961171 CNV duplication 23825009

Variation tolerance for OR7G2 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7G2
Leiden Open Variation Database (LOVD)
OR7G2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7G2 Gene

Disorders for OR7G2 Gene

Additional Disease Information for OR7G2

No disorders were found for OR7G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7G2 Gene

Publications for OR7G2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for OR7G2 Gene

Sources for OR7G2 Gene