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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR7E24 (Olfactory Receptor Family 7 Subfamily E Member 24) is a Protein Coding gene. Diseases associated with OR7E24 include Peroxisome Biogenesis Disorder 2A. Among its related pathways are Signaling by GPCR and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7D4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19J009638 | Enhancer | 0.2 | FANTOM5 | 4.5 | +391.0 | 391007 | 0.3 | piR-59475 ZNF561 OR7D4 ZNF846 ZNF177 OR7E24 OLFM2 ZNF559 ZNF562 ZNF426 | ||
GH19J009305 | Promoter/Enhancer | 1.6 | Ensembl ENCODE CraniofacialAtlas | 0.2 | +60.7 | 60666 | 5.6 | TEAD4 PRDM10 IKZF1 KDM1A POLR2A JUND PRDM1 PHF21A RBFOX2 PKNOX1 | ZNF699 hsa-miR-5095-262 lnc-ZNF699-1 ZNF266 ZNF426 ZNF561 ENSG00000267510 OR7E24 | |
GH19J009270 | Enhancer | 0.2 | FANTOM5 | 0.4 | +23.1 | 23090 | 0.2 | OR7E19P ZNF699 OR7D1P ZNF846 ZNF177 OR7H1P OR7E24 | ||
GH19J009296 | Enhancer | 0.2 | ENCODE | 0.3 | +49.3 | 49256 | 0.2 | ENSG00000267510 ZNF699 hsa-miR-5095-262 OR7E24 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | GPCRs, Other |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | LOC516475 30 |
|
||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | OR16A11 31 |
|
OneToOne | |
LOC610532 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Or7e177 46 Olfr873 30 17 31 |
|
OneToMany |
|
Or7e174 46 Olfr868 31 |
|
OneToMany |
|
||
Or7e173 46 Olfr866 31 |
|
OneToMany |
|
||
Or7e176 46 Olfr872 31 |
|
OneToMany |
|
||
Or7e175 46 Olfr869 31 |
|
OneToMany |
|
||
Or7e178 46 Olfr18 |
|
|
|||
Rat (Rattus norvegicus) |
Mammalia | Olfr873 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs374077378 | Not Provided: CIC-DUX Sarcoma | 9,251,064(+) | C/CT | FRAMESHIFT_VARIANT | |
rs12980833 | - | p.Ser193Phe | |||
rs2240928 | - | p.Pro242Ser |
Disorder | Aliases | PubMed IDs |
---|---|---|
peroxisome biogenesis disorder 2a |
|
|