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OR7E24 Gene(Protein Coding)

Olfactory Receptor Family 7 Subfamily E Member 24

GCID:
GC19P009250
GIFtS:
39
Genes Participants
UDN Logo

Aliases for OR7E24 Gene

Aliases for OR7E24 Gene

  • Olfactory Receptor Family 7 Subfamily E Member 24 2 3 5
  • Olfactory Receptor OR19-14 3 4
  • OR7E24P 3 4
  • Olfactory Receptor, Family 7, Subfamily E, Member 24 Pseudogene 2
  • Olfactory Receptor, Family 7, Subfamily E, Member 24 2
  • Olfactory Receptor 7E24 3
  • OR7E24Q 3
  • OR19-8 3
  • HSHT2 3

External Ids for OR7E24 Gene

Previous HGNC Symbols for OR7E24 Gene

  • OR7E24P

Previous GeneCards Identifiers for OR7E24 Gene

  • GC19P009221
  • GC19P009210
  • GC19P009213
  • GC19P009223
  • GC19P009361

Summaries for OR7E24 Gene

Entrez Gene Summary for OR7E24 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7E24 Gene

OR7E24 (Olfactory Receptor Family 7 Subfamily E Member 24) is a Protein Coding gene. Among its related pathways are GPCRs, Other and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR7E24 Gene

  • Odorant receptor.

Additional gene information for OR7E24 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7E24 Gene

Genomics for OR7E24 Gene

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  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for OR7E24 Gene

Promoters and enhancers for OR7E24 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J008388 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 14.6 -854.5 -854500 10.3 MLX IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC GLIS1 RAB11B HNRNPM ELAVL1 ZNF699 ZNF558 XAB2 ZNF317 MAP2K7 ZNF559 ENSG00000269300
GH19J008444 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 14.6 -801.2 -801174 3.9 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 HNRNPM ENSG00000279827 MARCH2 LINC01862 ENSG00000261866 OR7G3 LYPLA2P2 ELOCP29 OR7E25P OR7H1P
GH19J008306 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.6 -939.5 -939541 3.3 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CD320 RPS28 ELAVL1 HNRNPM XAB2 ZNF558 LINC01862 ENSG00000261866 LYPLA2P2 RPL21P129
GH19J010005 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 14.6 +761.0 760969 4.8 HDGF PKNOX1 SIN3A FEZF1 GLI4 GLIS2 FOS SP3 MIER2 TSHZ1 COL5A3 LOC100419831 ZNF559 ZNF177 KRI1 ZNF121 ZNF846 LOC100418883 OR7D1P OR7E19P
GH19J009935 Enhancer 0.7 ENCODE 14.6 +688.5 688538 0.1 PKNOX1 MXI1 KLF1 ZSCAN18 ZSCAN4 KLF17 SIN3A ZNF2 HIC1 ZNF335 OLFM2 LOC100418883 OR7H1P OR7E19P OR7E24 OR7E25P OR7E18P ELOCP29 OR7G3 OR7E16P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7E24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR7E24 gene promoter:
  • LHX3b
  • Lhx3a
  • POU6F1 (c2)
  • TFIID
  • TBP
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • AML1a

Genomic Locations for OR7E24 Gene

Genomic Locations for OR7E24 Gene
chr19:9,247,344-9,252,625
(GRCh38/hg38)
Size:
5,282 bases
Orientation:
Plus strand
chr19:9,361,606-9,362,820
(GRCh37/hg19)
Size:
1,215 bases
Orientation:
Plus strand

Genomic View for OR7E24 Gene

Genes around OR7E24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7E24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7E24 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR7E24 Gene

Proteins for OR7E24 Gene

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  • Protein details for OR7E24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IFN5-O7E24_HUMAN
    Recommended name:
    Olfactory receptor 7E24
    Protein Accession:
    Q6IFN5
    Secondary Accessions:
    • B9EJD9
    • Q9UPJ1

    Protein attributes for OR7E24 Gene

    Size:
    339 amino acids
    Molecular mass:
    38279 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD03353.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OR7E24 Gene

Protein Expression for OR7E24 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OR7E24 Gene

  • Glycosylation at Asn23
  • Modification sites at PhosphoSitePlus

Other Protein References for OR7E24 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7E24 Gene

Domains & Families for OR7E24 Gene

Gene Families for OR7E24 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7E24 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OR7E24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IFN5

UniProtKB/Swiss-Prot:

O7E24_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7E24: view

Function for OR7E24 Gene

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  2. CRISPR
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Molecular function for OR7E24 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily E,member 24,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR7E24 Gene

Gene Ontology (GO) - Molecular Function for OR7E24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR7E24: view
genes like me logo Genes that share phenotypes with OR7E24: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7E24 Gene

Localization for OR7E24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7E24 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7E24 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7E24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR7E24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7E24 Gene

Pathways & Interactions for OR7E24 Gene

genes like me logo Genes that share pathways with OR7E24: view

Pathways by source for OR7E24 Gene

1 BioSystems pathway for OR7E24 Gene
1 KEGG pathway for OR7E24 Gene

Interacting Proteins for OR7E24 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000387523%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000366488%0d%0a9606.ENSP00000248150%0d%0a
Selected Interacting proteins: ENSP00000387523 Q6IFN5-O7E24_HUMAN for OR7E24 Gene via STRING IID

GPS-Prot Interaction Network for OR7E24

Gene Ontology (GO) - Biological Process for OR7E24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR7E24: view

No data available for SIGNOR curated interactions for OR7E24 Gene

Drugs & Compounds for OR7E24 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for OR7E24 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OR7E24 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR7E24 Gene

Olfactory receptor, family 7, subfamily E, member 24:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR7E24 Gene

No ASD Table

Relevant External Links for OR7E24 Gene

GeneLoc Exon Structure for
OR7E24
ECgene alternative splicing isoforms for
OR7E24

Expression for OR7E24 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR7E24 Gene

mRNA expression in normal human tissues for OR7E24 Gene
mRNA expression by BioGPS for OR7E24 GenemRNA expression by GTEx for OR7E24 Gene

mRNA differential expression in normal tissues according to GTEx for OR7E24 Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for OR7E24 Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR7E24 Gene



Protein tissue co-expression partners for OR7E24 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR7E24 Gene:

OR7E24

SOURCE GeneReport for Unigene cluster for OR7E24 Gene:

Hs.129832
genes like me logo Genes that share expression patterns with OR7E24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7E24 Gene

Orthologs for OR7E24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7E24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia LOC516475 33
  • 82.85 (n)
-- 34
  • 75 (a)
 OneToMany
-- 34
  • 74 (a)
 OneToMany
-- 34
  • 74 (a)
 OneToMany
-- 34
  • 73 (a)
 OneToMany
-- 34
  • 72 (a)
 OneToMany
-- 34
  • 71 (a)
 OneToMany
-- 34
  • 70 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia OR16A11 34
  • 79 (a)
 OneToOne
LOC610532 33
  • 72.41 (n)
mouse
(Mus musculus)
 Mammalia Or7e177 51 Olfr873 16 34 33
  • 78.09 (n)
Or7e174 51 Olfr868 34
  • 68 (a)
 OneToMany
Or7e173 51 Olfr866 34
  • 67 (a)
 OneToMany
Or7e176 51 Olfr872 34
  • 65 (a)
 OneToMany
Or7e175 51 Olfr869 34
  • 65 (a)
 OneToMany
Or7e178 51 Olfr18
  • chr9:20,313,926-20,314,810
rat
(Rattus norvegicus)
 Mammalia Olfr873 33
  • 77.36 (n)
Species where no ortholog for OR7E24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7E24 Gene

ENSEMBL:
Gene Tree for OR7E24 (if available)
TreeFam:
Gene Tree for OR7E24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7E24: view image

Paralogs for OR7E24 Gene

(455) SIMAP similar genes for OR7E24 Gene using alignment to 1 proteins:

  • O7E24_HUMAN

Pseudogenes.org Pseudogenes for OR7E24 Gene

genes like me logo Genes that share paralogs with OR7E24: view

No data available for Paralogs for OR7E24 Gene

Variants for OR7E24 Gene

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Sequence variations from dbSNP and Humsavar for OR7E24 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000343010 -- 9,249,200(+) A/G upstream_transcript_variant
rs1000848589 -- 9,249,623(+) G/T upstream_transcript_variant
rs1001184879 -- 9,250,921(+) T/C upstream_transcript_variant
rs1001235787 -- 9,250,706(+) T/C upstream_transcript_variant
rs1002860120 -- 9,252,487(+) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR7E24 Gene

Variant ID Type Subtype PubMed ID
nsv523472 CNV loss 19592680
nsv962983 CNV duplication 23825009

Variation tolerance for OR7E24 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7E24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7E24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7E24 Gene

Disorders for OR7E24 Gene

Additional Disease Information for OR7E24

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR7E24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7E24 Gene

Publications for OR7E24 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. (PMID: 9268701) Vanderhaeghen P … Parmentier M (Biochemical and biophysical research communications 1997) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 58

Products for OR7E24 Gene

Sources for OR7E24 Gene

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