Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR7E24 Gene

Aliases for OR7E24 Gene

  • Olfactory Receptor Family 7 Subfamily E Member 24 2 3 5
  • Olfactory Receptor OR19-14 3 4
  • Olfactory Receptor 7E24 3 4
  • OR7E24P 3 4
  • OR7E24Q 2 3
  • OR19-8 2 3
  • HSHT2 2 3
  • Olfactory Receptor, Family 7, Subfamily E, Member 24 Pseudogene 2
  • Olfactory Receptor, Family 7, Subfamily E, Member 24 2
  • OR7E24 5

External Ids for OR7E24 Gene

Previous HGNC Symbols for OR7E24 Gene

  • OR7E24P

Previous GeneCards Identifiers for OR7E24 Gene

  • GC19P009221
  • GC19P009210
  • GC19P009213
  • GC19P009223
  • GC19P009361

Summaries for OR7E24 Gene

Entrez Gene Summary for OR7E24 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7E24 Gene

OR7E24 (Olfactory Receptor Family 7 Subfamily E Member 24) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7D4.

UniProtKB/Swiss-Prot Summary for OR7E24 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR7E24 Gene

Genomics for OR7E24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR7E24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009638 Enhancer 0.2 FANTOM5 4.5 +391.0 391007 0.3 piR-59475 ZNF561 OR7D4 ZNF846 ZNF177 OR7E24 OLFM2 ZNF559 ZNF562 ZNF426
GH19J009305 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 0.2 +60.7 60666 5.6 IKZF1 POLR2A YY1 REST SMAD5 MBD2 TBP ZEB1 THAP11 ELF1 hsa-miR-5095-262 ZNF699 lnc-ZNF699-1 ZNF266 ZNF426 ZNF561 HSALNG0123810 OR7E24
GH19J009270 Enhancer 0.2 FANTOM5 0.4 +23.1 23090 0.2 OR7E19P ZNF699 OR7D1P ZNF846 ZNF177 OR7H1P OR7E24
GH19J009296 Enhancer 0.2 ENCODE 0.3 +49.3 49256 0.2 HSALNG0123810 ZNF699 hsa-miR-5095-262 OR7E24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7E24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR7E24

Top Transcription factor binding sites by QIAGEN in the OR7E24 gene promoter:
  • AML1a
  • Lhx3a
  • LHX3b
  • POU6F1 (c2)
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • TBP
  • TFIID

Genomic Locations for OR7E24 Gene

Latest Assembly
chr19:9,247,344-9,252,625
(GRCh38/hg38)
Size:
5,282 bases
Orientation:
Plus strand

Previous Assembly
chr19:9,358,020-9,363,301
(GRCh37/hg19 by Entrez Gene)
Size:
5,282 bases
Orientation:
Plus strand

chr19:9,361,606-9,362,820
(GRCh37/hg19 by Ensembl)
Size:
1,215 bases
Orientation:
Plus strand

Genomic View for OR7E24 Gene

Genes around OR7E24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7E24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7E24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7E24 Gene

Proteins for OR7E24 Gene

  • Protein details for OR7E24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IFN5-O7E24_HUMAN
    Recommended name:
    Olfactory receptor 7E24
    Protein Accession:
    Q6IFN5
    Secondary Accessions:
    • B9EJD9
    • Q9UPJ1

    Protein attributes for OR7E24 Gene

    Size:
    339 amino acids
    Molecular mass:
    38279 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD03353.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OR7E24 Gene

Post-translational modifications for OR7E24 Gene

  • Glycosylation at Asn23
  • Modification sites at PhosphoSitePlus

Other Protein References for OR7E24 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7E24 Gene

Domains & Families for OR7E24 Gene

Gene Families for OR7E24 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7E24 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR7E24 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-14 (O7E24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IFN5

UniProtKB/Swiss-Prot:

O7E24_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7E24: view

Function for OR7E24 Gene

Molecular function for OR7E24 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily E,member 24,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR7E24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR7E24: view
genes like me logo Genes that share phenotypes with OR7E24: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7E24

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7E24 Gene

Localization for OR7E24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7E24 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7E24 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7E24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7E24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7E24 Gene

Pathways & Interactions for OR7E24 Gene

genes like me logo Genes that share pathways with OR7E24: view

Pathways by source for OR7E24 Gene

1 BioSystems pathway for OR7E24 Gene
1 KEGG pathway for OR7E24 Gene

Interacting Proteins for OR7E24 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000387523 Q6IFN5-O7E24_HUMAN for OR7E24 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR7E24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR7E24: view

No data available for SIGNOR curated interactions for OR7E24 Gene

Drugs & Compounds for OR7E24 Gene

No Compound Related Data Available

Transcripts for OR7E24 Gene

mRNA/cDNA for OR7E24 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7E24

Alternative Splicing Database (ASD) splice patterns (SP) for OR7E24 Gene

No ASD Table

Relevant External Links for OR7E24 Gene

GeneLoc Exon Structure for
OR7E24

Expression for OR7E24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR7E24 Gene

mRNA differential expression in normal tissues according to GTEx for OR7E24 Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for OR7E24 Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR7E24 Gene



Protein tissue co-expression partners for OR7E24 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR7E24

SOURCE GeneReport for Unigene cluster for OR7E24 Gene:

Hs.129832
genes like me logo Genes that share expression patterns with OR7E24: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7E24 Gene

Orthologs for OR7E24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7E24 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia LOC516475 29
  • 82.85 (n)
-- 30
  • 75 (a)
OneToMany
-- 30
  • 74 (a)
OneToMany
-- 30
  • 74 (a)
OneToMany
-- 30
  • 73 (a)
OneToMany
-- 30
  • 72 (a)
OneToMany
-- 30
  • 71 (a)
OneToMany
-- 30
  • 70 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia OR16A11 30
  • 79 (a)
OneToOne
LOC610532 29
  • 72.41 (n)
Mouse
(Mus musculus)
Mammalia Or7e177 45 Olfr873 29 16 30
  • 78.09 (n)
OneToMany
Or7e174 45 Olfr868 30
  • 68 (a)
OneToMany
Or7e173 45 Olfr866 30
  • 67 (a)
OneToMany
Or7e176 45 Olfr872 30
  • 65 (a)
OneToMany
Or7e175 45 Olfr869 30
  • 65 (a)
OneToMany
Or7e178 45 Olfr18
  • chr9:20,313,926-20,314,810
Rat
(Rattus norvegicus)
Mammalia Olfr873 29
  • 77.36 (n)
Species where no ortholog for OR7E24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR7E24 Gene

ENSEMBL:
Gene Tree for OR7E24 (if available)
TreeFam:
Gene Tree for OR7E24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7E24: view image
Alliance of Genome Resources:
Additional Orthologs for OR7E24

Paralogs for OR7E24 Gene

(455) SIMAP similar genes for OR7E24 Gene using alignment to 1 proteins:

  • O7E24_HUMAN
genes like me logo Genes that share paralogs with OR7E24: view

Variants for OR7E24 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR7E24 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs201985790 Not Provided: CIC-DUX Sarcoma 9,251,064(+) C/CT
NM_001079935.1(OR7E24):c.32dup (p.Leu12fs)
FRAMESHIFT
rs12980833 -- p.Ser193Phe
rs2240928 -- p.Pro242Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR7E24 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR7E24 Gene

Variant ID Type Subtype PubMed ID
nsv523472 CNV loss 19592680
nsv962983 CNV duplication 23825009

Variation tolerance for OR7E24 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7E24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7E24
Leiden Open Variation Database (LOVD)
OR7E24

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7E24 Gene

Disorders for OR7E24 Gene

Additional Disease Information for OR7E24

No disorders were found for OR7E24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7E24 Gene

Publications for OR7E24 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  3. Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. (PMID: 9268701) Vanderhaeghen P … Parmentier M (Biochemical and biophysical research communications 1997) 2 3
  4. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. (PMID: 32126975) Barnes IHA … Frankish A (BMC genomics 2020) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR7E24 Gene

Sources for OR7E24 Gene