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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR7D4 (Olfactory Receptor Family 7 Subfamily D Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7D2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19J009638 | Enhancer | 0.2 | FANTOM5 | 14.8 | -418.8 | -418762 | 0.3 | piR-59475 ZNF561 OR7D4 ZNF846 ZNF177 OR7E24 OLFM2 ZNF559 ZNF562 ZNF426 | ||
GH19J009666 | Enhancer | 0.5 | FANTOM5 Ensembl | 1.5 | -446.9 | -446914 | 1 | PHB2 | piR-52078 ZNF846 ZNF559 ZNF559-ZNF177 OR7D4 ZNF121 ZNF177 ZNF426 OLFM2 ZNF562 | |
GH19J009205 | Enhancer | 0.6 | ENCODE | 0.4 | +13.9 | 13909 | 0.2 | CTCF REST RAD21 TRIM22 SMC3 ZNF654 ZNF18 ARID4B RB1 ARID2 | piR-53177-025 OR7E25P OR7D11P OR7D4 OR7D2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OR7D4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC484973 30 |
|
||
-- 31 |
|
OneToMany | |||
OR10A07 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Or7d41 46 Olfr39 30 17 31 |
|
OneToMany |
|
Or7d42 46 Olfr77 31 |
|
OneToMany |
|
||
Or7d43 46 Olfr867 31 |
|
OneToMany |
|
||
Or7d45-ps 46 Olfr861-ps1 |
|
|
|||
Rat (Rattus norvegicus) |
Mammalia | Olr1186 30 |
|
||
Cow (Bos Taurus) |
Mammalia | LOC785624 30 |
|
||
-- 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
OPOR17 31 |
|
ManyToMany | |||
OPOR20 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
OPOR9 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
OPOR21 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
OPOR24 31 |
|
ManyToMany | |||
OPOR142 31 |
|
ManyToMany | |||
OPOR13 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
777412 | Benign: not provided | 9,213,914(-) | G/A | SYNONYMOUS_VARIANT | |
777413 | Likely Benign: not provided | 9,214,342(-) | A/G | SYNONYMOUS_VARIANT | |
rs1205320769 | - | p.Cys139Tyr | |||
rs1310684516 | - | p.Cys139Arg | |||
rs1321662937 | - | p.Leu162Pro |
No disorders were found for OR7D4 Gene.