Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR7D4 Gene

Aliases for OR7D4 Gene

  • Olfactory Receptor Family 7 Subfamily D Member 4 2 3 5
  • OR19-B 2 3 4
  • Olfactory Receptor OR19-7 3 4
  • Olfactory Receptor 7D4 3 4
  • OR7D4P 3 4
  • Hg105 2 3
  • Olfactory Receptor, Family 7, Subfamily D, Member 4 Pseudogene 3
  • Olfactory Receptor, Family 7, Subfamily D, Member 4 2
  • Odorant Receptor Family 7 Subfamily D Member 4 RT 3
  • Odorant Receptor Family Subfamily D Member 4RT 4
  • OR19-7 3
  • OR19B 3
  • OR7D4 5

External Ids for OR7D4 Gene

Previous HGNC Symbols for OR7D4 Gene

  • OR7D4P

Previous GeneCards Identifiers for OR7D4 Gene

  • GC19M009186
  • GC19M009187
  • GC19M009324

Summaries for OR7D4 Gene

Entrez Gene Summary for OR7D4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7D4 Gene

OR7D4 (Olfactory Receptor Family 7 Subfamily D Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7D2.

UniProtKB/Swiss-Prot Summary for OR7D4 Gene

  • Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

Gene Wiki entry for OR7D4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR7D4 Gene

Genomics for OR7D4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR7D4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009638 Enhancer 0.2 FANTOM5 14.8 -418.8 -418762 0.3 piR-59475 ZNF561 OR7D4 ZNF846 ZNF177 OR7E24 OLFM2 ZNF559 ZNF562 ZNF426
GH19J009666 Enhancer 0.3 FANTOM5 1.5 -446.6 -446625 0.4 HSALNG0123845 piR-52078 ZNF846 ZNF559 ZNF559-ZNF177 OR7D4 ZNF121 ZNF426 OLFM2 ZNF177
GH19J009205 Enhancer 0.6 ENCODE 0.4 +13.9 13909 0.2 ZNF654 CTCF REST TRIM22 RAD21 SMC3 ZNF18 ARID4B ARID2 RB1 piR-53177-025 OR7E25P OR7D11P OR7D4 OR7D2
GH19J009190 Enhancer 0.4 Ensembl 0.3 +29.7 29688 0.2 TCF12 CBFA2T2 CBFA2T3 OR7E16P lnc-OR7D4-1 OR7D2 OR7D4
GH19J009189 Enhancer 0.2 Ensembl 0.3 +30.1 30088 0.2 OR7E16P OR7D2 lnc-OR7D4-1 OR7D4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7D4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR7D4

Top Transcription factor binding sites by QIAGEN in the OR7D4 gene promoter:
  • Lhx3a
  • LHX3b
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU6F1 (c2)
  • SREBP-1a
  • SREBP-1b

Genomic Locations for OR7D4 Gene

Latest Assembly
chr19:9,210,276-9,219,589
(GRCh38/hg38)
Size:
9,314 bases
Orientation:
Minus strand

Previous Assembly
chr19:9,320,952-9,330,265
(GRCh37/hg19 by Entrez Gene)
Size:
9,314 bases
Orientation:
Minus strand

chr19:9,324,526-9,325,542
(GRCh37/hg19 by Ensembl)
Size:
1,017 bases
Orientation:
Minus strand

Genomic View for OR7D4 Gene

Genes around OR7D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7D4 Gene

Proteins for OR7D4 Gene

  • Protein details for OR7D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG98-OR7D4_HUMAN
    Recommended name:
    Olfactory receptor 7D4
    Protein Accession:
    Q8NG98
    Secondary Accessions:
    • A8CAH8
    • A8CAH9
    • A8CAI0
    • A8CAI1
    • B9EH79

    Protein attributes for OR7D4 Gene

    Size:
    312 amino acids
    Molecular mass:
    34448 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7D4 Gene

Post-translational modifications for OR7D4 Gene

  • Glycosylation at Asn5

Other Protein References for OR7D4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7D4 Gene

Domains & Families for OR7D4 Gene

Gene Families for OR7D4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7D4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR7D4 Gene

GenScript: Design optimal peptide antigens:
  • Odorant receptor family 7 subfamily D member 4 WM variant (A8CAH9_HUMAN)
  • Odorant receptor family 7 subfamily D member 4 S84N variant (A8CAI0_HUMAN)
  • Odorant receptor family 7 subfamily D member 4 P79L variant (A8CAI1_HUMAN)
  • Olfactory receptor OR19-7 (OR7D4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NG98

UniProtKB/Swiss-Prot:

OR7D4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7D4: view

Function for OR7D4 Gene

Molecular function for OR7D4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

Gene Ontology (GO) - Molecular Function for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with OR7D4: view
genes like me logo Genes that share phenotypes with OR7D4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7D4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7D4 Gene

Localization for OR7D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7D4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7D4 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7D4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7D4 Gene

Pathways & Interactions for OR7D4 Gene

genes like me logo Genes that share pathways with OR7D4: view

Pathways by source for OR7D4 Gene

Interacting Proteins for OR7D4 Gene

Gene Ontology (GO) - Biological Process for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR7D4: view

No data available for SIGNOR curated interactions for OR7D4 Gene

Drugs & Compounds for OR7D4 Gene

No Compound Related Data Available

Transcripts for OR7D4 Gene

mRNA/cDNA for OR7D4 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7D4

Alternative Splicing Database (ASD) splice patterns (SP) for OR7D4 Gene

No ASD Table

Relevant External Links for OR7D4 Gene

GeneLoc Exon Structure for
OR7D4

Expression for OR7D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR7D4 Gene

mRNA differential expression in normal tissues according to GTEx for OR7D4 Gene

This gene is overexpressed in Testis (x33.4), Brain - Hypothalamus (x5.2), Brain - Cortex (x4.9), Cervix - Ectocervix (x4.8), and Cervix - Endocervix (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR7D4

SOURCE GeneReport for Unigene cluster for OR7D4 Gene:

Hs.446910

mRNA Expression by UniProt/SwissProt for OR7D4 Gene:

Q8NG98-OR7D4_HUMAN
Tissue specificity: Nasal olfactory epithelium.
genes like me logo Genes that share expression patterns with OR7D4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7D4 Gene

Orthologs for OR7D4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7D4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR7D4 29 30
  • 98.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC484973 29
  • 85.04 (n)
-- 30
  • 82 (a)
OneToMany
OR10A07 30
  • 78 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or7d41 45 Olfr39 29 16 30
  • 78.46 (n)
OneToMany
Or7d42 45 Olfr77 30
  • 70 (a)
OneToMany
Or7d43 45 Olfr867 30
  • 68 (a)
OneToMany
Or7d45-ps 45 Olfr861-ps1
  • chr9:19,875,907-19,876,577
Rat
(Rattus norvegicus)
Mammalia Olr1186 29
  • 77.81 (n)
Cow
(Bos Taurus)
Mammalia LOC785624 29
  • 71.1 (n)
-- 30
  • 70 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 66 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
OPOR17 30
  • 65 (a)
ManyToMany
OPOR20 30
  • 64 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
OPOR9 30
  • 64 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
OPOR21 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
OPOR24 30
  • 61 (a)
ManyToMany
OPOR142 30
  • 61 (a)
ManyToMany
OPOR13 30
  • 60 (a)
ManyToMany
-- 30
  • 60 (a)
ManyToMany
-- 30
  • 59 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 59 (a)
ManyToMany
-- 30
  • 58 (a)
ManyToMany
-- 30
  • 55 (a)
ManyToMany
-- 30
  • 55 (a)
ManyToMany
Species where no ortholog for OR7D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR7D4 Gene

ENSEMBL:
Gene Tree for OR7D4 (if available)
TreeFam:
Gene Tree for OR7D4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7D4: view image
Alliance of Genome Resources:
Additional Orthologs for OR7D4

Paralogs for OR7D4 Gene

(459) SIMAP similar genes for OR7D4 Gene using alignment to 3 proteins:

  • OR7D4_HUMAN
  • A8CAH9_HUMAN
  • A8CAI1_HUMAN

Pseudogenes.org Pseudogenes for OR7D4 Gene

genes like me logo Genes that share paralogs with OR7D4: view

Variants for OR7D4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR7D4 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10419202 Benign: not provided 9,213,914(-) G/A
NM_001005191.2(OR7D4):c.924C>T (p.Ala308=)
SYNONYMOUS
rs116460228 Likely Benign: not provided 9,214,342(-) A/G
NM_001005191.2(OR7D4):c.496T>C (p.Leu166=)
SYNONYMOUS
rs120532076 -- p.Cys139Tyr
rs131068451 -- p.Cys139Arg
rs132166293 -- p.Leu162Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR7D4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR7D4 Gene

Variant ID Type Subtype PubMed ID
nsv523472 CNV loss 19592680
nsv963001 CNV duplication 23825009

Variation tolerance for OR7D4 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.58; 82.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7D4 Gene

Human Gene Mutation Database (HGMD)
OR7D4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7D4
Leiden Open Variation Database (LOVD)
OR7D4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7D4 Gene

Disorders for OR7D4 Gene

Additional Disease Information for OR7D4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR7D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7D4 Gene

Publications for OR7D4 Gene

  1. Genetic variation in a human odorant receptor alters odour perception. (PMID: 17873857) Keller A … Matsunami H (Nature 2007) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction. (PMID: 29246659) Hornung J … Derntl B (Hormones and behavior 2018) 3
  5. Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution. (PMID: 26072518) Hoover KC … Matsunami H (Chemical senses 2015) 3

Products for OR7D4 Gene

Sources for OR7D4 Gene