OR7D4 Gene (Protein Coding)

Olfactory Receptor Family 7 Subfamily D Member 4

GC19M009213
GIFtS:
33
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR7D4 Gene

Aliases for OR7D4 Gene

  • Olfactory Receptor Family 7 Subfamily D Member 4 2 3 5
  • Olfactory Receptor OR19-7 3 4
  • Olfactory Receptor 7D4 3 4
  • OR7D4P 3 4
  • OR19-B 3 4
  • Olfactory Receptor, Family 7, Subfamily D, Member 4 Pseudogene 3
  • Olfactory Receptor, Family 7, Subfamily D, Member 4 2
  • Odorant Receptor Family 7 Subfamily D Member 4 RT 3
  • Odorant Receptor Family Subfamily D Member 4RT 4
  • OR19-7 3
  • OR19B 3
  • Hg105 3

External Ids for OR7D4 Gene

Previous HGNC Symbols for OR7D4 Gene

  • OR7D4P

Previous GeneCards Identifiers for OR7D4 Gene

  • GC19M009186
  • GC19M009187
  • GC19M009324

Summaries for OR7D4 Gene

Entrez Gene Summary for OR7D4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7D4 Gene

OR7D4 (Olfactory Receptor Family 7 Subfamily D Member 4) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7D2.

UniProtKB/Swiss-Prot Summary for OR7D4 Gene

  • Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

Gene Wiki entry for OR7D4 Gene

Additional gene information for OR7D4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR7D4 Gene

Genomics for OR7D4 Gene

GeneHancer (GH) Regulatory Elements for OR7D4 Gene

Promoters and enhancers for OR7D4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J009638 Enhancer 0.2 FANTOM5 14.8 -418.8 -418762 0.3 piR-59475 ZNF561 OR7D4 ZNF846 ZNF177 OR7E24 OLFM2 ZNF559 ZNF562 ZNF426
GH19J009666 Enhancer 0.5 FANTOM5 Ensembl 1.5 -446.9 -446914 1 PHB2 piR-52078 ZNF846 ZNF559 ZNF559-ZNF177 OR7D4 ZNF121 ZNF177 ZNF426 OLFM2 ZNF562
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7D4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR7D4 gene promoter:
  • Lhx3a
  • LHX3b
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU6F1 (c2)
  • SREBP-1a
  • SREBP-1b

Genomic Locations for OR7D4 Gene

Genomic Locations for OR7D4 Gene
chr19:9,210,276-9,219,589
(GRCh38/hg38)
Size:
9,314 bases
Orientation:
Minus strand
chr19:9,324,526-9,325,547
(GRCh37/hg19)
Size:
1,022 bases
Orientation:
Minus strand

Genomic View for OR7D4 Gene

Genes around OR7D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7D4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR7D4 Gene

Proteins for OR7D4 Gene

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  • Protein details for OR7D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG98-OR7D4_HUMAN
    Recommended name:
    Olfactory receptor 7D4
    Protein Accession:
    Q8NG98
    Secondary Accessions:
    • A8CAH8
    • A8CAH9
    • A8CAI0
    • A8CAI1
    • B9EH79

    Protein attributes for OR7D4 Gene

    Size:
    312 amino acids
    Molecular mass:
    34448 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7D4 Gene

Post-translational modifications for OR7D4 Gene

  • Glycosylation at Asn5

Other Protein References for OR7D4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7D4 Gene

Domains & Families for OR7D4 Gene

Gene Families for OR7D4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7D4 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR7D4 Gene

GenScript: Design optimal peptide antigens:
  • Odorant receptor family 7 subfamily D member 4 WM variant (A8CAH9_HUMAN)
  • Odorant receptor family 7 subfamily D member 4 S84N variant (A8CAI0_HUMAN)
  • Odorant receptor family 7 subfamily D member 4 P79L variant (A8CAI1_HUMAN)
  • Olfactory receptor OR19-7 (OR7D4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NG98

UniProtKB/Swiss-Prot:

OR7D4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7D4: view

Function for OR7D4 Gene

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Molecular function for OR7D4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

Gene Ontology (GO) - Molecular Function for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR7D4: view
genes like me logo Genes that share phenotypes with OR7D4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7D4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7D4 Gene

Localization for OR7D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7D4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7D4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7D4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7D4 Gene

Pathways & Interactions for OR7D4 Gene

genes like me logo Genes that share pathways with OR7D4: view

Pathways by source for OR7D4 Gene

1 KEGG pathway for OR7D4 Gene

Interacting Proteins for OR7D4 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000310488 Q8NG98-OR7D4_HUMAN for OR7D4 Gene via STRING IID

GPS-Prot Interaction Network for OR7D4

Gene Ontology (GO) - Biological Process for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR7D4: view

No data available for SIGNOR curated interactions for OR7D4 Gene

Drugs & Compounds for OR7D4 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for OR7D4 Gene

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mRNA/cDNA for OR7D4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7D4

Alternative Splicing Database (ASD) splice patterns (SP) for OR7D4 Gene

No ASD Table

Relevant External Links for OR7D4 Gene

GeneLoc Exon Structure for
OR7D4
ECgene alternative splicing isoforms for
OR7D4

Expression for OR7D4 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR7D4 Gene

mRNA expression in normal human tissues for OR7D4 Gene
mRNA expression by GTEx for OR7D4 GenemRNA expression by BioGPS for OR7D4 Gene

mRNA differential expression in normal tissues according to GTEx for OR7D4 Gene

This gene is overexpressed in Testis (x33.4), Brain - Hypothalamus (x5.2), Brain - Cortex (x4.9), Cervix - Ectocervix (x4.8), and Cervix - Endocervix (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of OR7D4 Gene:

OR7D4

SOURCE GeneReport for Unigene cluster for OR7D4 Gene:

Hs.446910

mRNA Expression by UniProt/SwissProt for OR7D4 Gene:

Q8NG98-OR7D4_HUMAN
Tissue specificity: Nasal olfactory epithelium.
genes like me logo Genes that share expression patterns with OR7D4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7D4 Gene

Orthologs for OR7D4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7D4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia OR7D4 33 32
  • 98.93 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia LOC484973 32
  • 85.04 (n)
-- 33
  • 82 (a)
 OneToMany
OR10A07 33
  • 78 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Or7d41 49 Olfr39 17 33 32
  • 78.46 (n)
Or7d42 49 Olfr77 33
  • 70 (a)
 OneToMany
Or7d43 49 Olfr867 33
  • 68 (a)
 OneToMany
Or7d45-ps 49 Olfr861-ps1
  • chr9:19,875,907-19,876,577
rat
(Rattus norvegicus)
 Mammalia Olr1186 32
  • 77.81 (n)
cow
(Bos Taurus)
 Mammalia LOC785624 32
  • 71.1 (n)
-- 33
  • 70 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 33
  • 66 (a)
 ManyToMany
-- 33
  • 65 (a)
 ManyToMany
-- 33
  • 65 (a)
 ManyToMany
OPOR17 33
  • 65 (a)
 ManyToMany
OPOR20 33
  • 64 (a)
 ManyToMany
-- 33
  • 64 (a)
 ManyToMany
OPOR9 33
  • 64 (a)
 ManyToMany
-- 33
  • 62 (a)
 ManyToMany
OPOR21 33
  • 62 (a)
 ManyToMany
-- 33
  • 62 (a)
 ManyToMany
-- 33
  • 62 (a)
 ManyToMany
OPOR24 33
  • 61 (a)
 ManyToMany
OPOR142 33
  • 61 (a)
 ManyToMany
OPOR13 33
  • 60 (a)
 ManyToMany
-- 33
  • 60 (a)
 ManyToMany
-- 33
  • 59 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 59 (a)
 ManyToMany
-- 33
  • 58 (a)
 ManyToMany
-- 33
  • 55 (a)
 ManyToMany
-- 33
  • 55 (a)
 ManyToMany
Species where no ortholog for OR7D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7D4 Gene

ENSEMBL:
Gene Tree for OR7D4 (if available)
TreeFam:
Gene Tree for OR7D4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7D4: view image

Paralogs for OR7D4 Gene

Paralogs for OR7D4 Gene

(459) SIMAP similar genes for OR7D4 Gene using alignment to 3 proteins:

  • OR7D4_HUMAN
  • A8CAH9_HUMAN
  • A8CAI1_HUMAN

Pseudogenes.org Pseudogenes for OR7D4 Gene

genes like me logo Genes that share paralogs with OR7D4: view

Variants for OR7D4 Gene

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Sequence variations from dbSNP and Humsavar for OR7D4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000162779 -- 9,215,690(-) T/C upstream_transcript_variant
rs1001047207 -- 9,215,164(-) G/A/T upstream_transcript_variant
rs1001076415 -- 9,215,012(-) T/C upstream_transcript_variant
rs1001388855 -- 9,216,418(-) A/T upstream_transcript_variant
rs1001568538 -- 9,215,029(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR7D4 Gene

Variant ID Type Subtype PubMed ID
nsv523472 CNV loss 19592680
nsv963001 CNV duplication 23825009

Variation tolerance for OR7D4 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.58; 82.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7D4 Gene

Human Gene Mutation Database (HGMD)
OR7D4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7D4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7D4 Gene

Disorders for OR7D4 Gene

Additional Disease Information for OR7D4

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR7D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7D4 Gene

Publications for OR7D4 Gene

  1. Genetic variation in a human odorant receptor alters odour perception. (PMID: 17873857) Keller A … Matsunami H (Nature 2007) 3 4 56
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56
  3. Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction. (PMID: 29246659) Hornung J … Derntl B (Hormones and behavior 2018) 3 56
  4. Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution. (PMID: 26072518) Hoover KC … Matsunami H (Chemical senses 2015) 3 56
  5. Association between olfactory receptor genes, eating behavior traits and adiposity: results from the Quebec Family Study. (PMID: 22044667) Choquette AC … Pérusse L (Physiology & behavior 2012) 3 56

ExternalLinks

View latest publications for OR7D4 gene in Mastermind

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