Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR7D2 Gene

Aliases for OR7D2 Gene

  • Olfactory Receptor Family 7 Subfamily D Member 2 2 3 5
  • HTPCRH03 2 3 4
  • OR19-4 2 3 4
  • Olfactory Receptor OR19-10 3 4
  • Olfactory Receptor 19-4 3 4
  • Olfactory Receptor 7D2 3 4
  • Olfactory Receptor, Family 7, Subfamily D, Member 2 2
  • FLJ38149 2
  • OR19-10 3
  • OR7D2 5

External Ids for OR7D2 Gene

Previous GeneCards Identifiers for OR7D2 Gene

  • GC19U990187
  • GC19P009157
  • GC19P009298

Summaries for OR7D2 Gene

Entrez Gene Summary for OR7D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7D2 Gene

OR7D2 (Olfactory Receptor Family 7 Subfamily D Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7D4.

UniProtKB/Swiss-Prot Summary for OR7D2 Gene

Gene Wiki entry for OR7D2 Gene

Additional gene information for OR7D2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR7D2 Gene

Genomics for OR7D2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR7D2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7D2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR7D2

Top Transcription factor binding sites by QIAGEN in the OR7D2 gene promoter:
  • AREB6
  • FOXI1
  • GR
  • GR-beta
  • HFH-3
  • Ik-2
  • ITF-2
  • Tal-1beta
  • TBP
  • TFIID

Genomic Locations for OR7D2 Gene

Genomic Locations for OR7D2 Gene
chr19:9,178,979-9,188,818
(GRCh38/hg38)
Size:
9,840 bases
Orientation:
Plus strand
chr19:9,296,270-9,299,493
(GRCh37/hg19)
Size:
3,224 bases
Orientation:
Plus strand

Genomic View for OR7D2 Gene

Genes around OR7D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7D2 Gene

Proteins for OR7D2 Gene

  • Protein details for OR7D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RA2-OR7D2_HUMAN
    Recommended name:
    Olfactory receptor 7D2
    Protein Accession:
    Q96RA2
    Secondary Accessions:
    • Q6IFJ7
    • Q8N133

    Protein attributes for OR7D2 Gene

    Size:
    312 amino acids
    Molecular mass:
    34747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7D2 Gene

Post-translational modifications for OR7D2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR7D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7D2 Gene

Domains & Families for OR7D2 Gene

Gene Families for OR7D2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7D2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR7D2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-10 (OR7D2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96RA2

UniProtKB/Swiss-Prot:

OR7D2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7D2: view

Function for OR7D2 Gene

Molecular function for OR7D2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily D,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR7D2 Gene

Gene Ontology (GO) - Molecular Function for OR7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR7D2: view

Animal Model Products

CRISPR Products

miRNA for OR7D2 Gene

miRTarBase miRNAs that target OR7D2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7D2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR7D2 Gene

Localization for OR7D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7D2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7D2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7D2 Gene

Pathways & Interactions for OR7D2 Gene

genes like me logo Genes that share pathways with OR7D2: view

Pathways by source for OR7D2 Gene

Interacting Proteins for OR7D2 Gene

Gene Ontology (GO) - Biological Process for OR7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 12175488
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR7D2: view

No data available for SIGNOR curated interactions for OR7D2 Gene

Drugs & Compounds for OR7D2 Gene

No Compound Related Data Available

Transcripts for OR7D2 Gene

mRNA/cDNA for OR7D2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7D2

Alternative Splicing Database (ASD) splice patterns (SP) for OR7D2 Gene

No ASD Table

Relevant External Links for OR7D2 Gene

GeneLoc Exon Structure for
OR7D2

Expression for OR7D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR7D2 Gene

mRNA differential expression in normal tissues according to GTEx for OR7D2 Gene

This gene is overexpressed in Testis (x7.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR7D2

SOURCE GeneReport for Unigene cluster for OR7D2 Gene:

Hs.531755
genes like me logo Genes that share expression patterns with OR7D2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7D2 Gene

Orthologs for OR7D2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7D2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC468710 30
  • 99.04 (n)
OR7D2 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR7D2 30 31
  • 87.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC611376 30
  • 87.29 (n)
-- 31
  • 63 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Olr1193 30
  • 68.42 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 64 (a)
ManyToMany
OPOR17 31
  • 64 (a)
ManyToMany
-- 31
  • 64 (a)
ManyToMany
-- 31
  • 64 (a)
ManyToMany
OPOR9 31
  • 63 (a)
ManyToMany
OPOR20 31
  • 63 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
OPOR24 31
  • 61 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
OPOR21 31
  • 61 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
-- 31
  • 60 (a)
ManyToMany
OPOR142 31
  • 60 (a)
ManyToMany
OPOR13 31
  • 59 (a)
ManyToMany
-- 31
  • 58 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr871 31
  • 62 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 58 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
Species where no ortholog for OR7D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR7D2 Gene

ENSEMBL:
Gene Tree for OR7D2 (if available)
TreeFam:
Gene Tree for OR7D2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7D2: view image

Paralogs for OR7D2 Gene

(456) SIMAP similar genes for OR7D2 Gene using alignment to 1 proteins:

  • OR7D2_HUMAN

Pseudogenes.org Pseudogenes for OR7D2 Gene

genes like me logo Genes that share paralogs with OR7D2: view

Variants for OR7D2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR7D2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs13345452 - p.Thr197Met

Additional dbSNP identifiers (rs#s) for OR7D2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR7D2 Gene

Variant ID Type Subtype PubMed ID
esv2762024 CNV gain 21179565
nsv2411 CNV deletion 18451855
nsv509720 CNV insertion 20534489
nsv516657 CNV gain 19592680
nsv523472 CNV loss 19592680

Variation tolerance for OR7D2 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7D2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7D2 Gene

Disorders for OR7D2 Gene

No disorders were found for OR7D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7D2 Gene

Publications for OR7D2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR7D2 Gene

Sources for OR7D2 Gene