Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR7C2 Gene

Aliases for OR7C2 Gene

  • Olfactory Receptor Family 7 Subfamily C Member 2 2 3 5
  • OR19-18 2 3 4
  • Olfactory Receptor OR19-22 3 4
  • Olfactory Receptor 19-18 3 4
  • Olfactory Receptor 7C2 3 4
  • Olfactory Receptor 7C3 3 4
  • OR7C3 3 4
  • Olfactory Receptor Family 7 Subfamily C Member 2 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 7, Subfamily C, Member 2 2
  • Olfactory Receptor, Family 7, Subfamily C, Member 3 3
  • CIT-HSP-87M17 3
  • OR7C2 5

External Ids for OR7C2 Gene

Previous HGNC Symbols for OR7C2 Gene

  • OR7C3

Previous GeneCards Identifiers for OR7C2 Gene

  • GC19P015431
  • GC19P014853
  • GC19P014913
  • GC19P014869
  • GC19P015052

Summaries for OR7C2 Gene

Entrez Gene Summary for OR7C2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7C2 Gene

OR7C2 (Olfactory Receptor Family 7 Subfamily C Member 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7C1.

UniProtKB/Swiss-Prot Summary for OR7C2 Gene

Gene Wiki entry for OR7C2 Gene

Additional gene information for OR7C2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR7C2 Gene

Genomics for OR7C2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR7C2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014525 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 -413.3 -413298 5.9 BCLAF1 SP1 ZNF207 NCOR1 MYC ZNF600 IKZF1 KLF9 POLR2A CEBPA TECR MIR639 lnc-GIPC1-1 piR-33843 YJU2B AKAP8 MRI1 BRD4 ZNF333 DNAJB1
GH19J015091 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.3 +150.7 150712 0.8 ZNF654 ZIC2 CTCF RAD21 RFX5 SMC3 ZNF384 ZNF362 ZNF143 SCRT2 OR7C2 SYDE1 lnc-ILVBL-1 OR1I1 lnc-OR7C2-1
GH19J014550 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.5 -388.9 -388889 5.2 MYC NCOR1 ZNF600 IKZF1 ZNF592 CEBPA NFIC ZIC2 YY1 MXD4 MIR23AHG YJU2B RFX1 AKAP8L MRI1 AKAP8 SLC1A6 OR7C2 LOC112268253 DNAJB1
GH19J014459 Enhancer 0.5 FANTOM5 Ensembl ENCODE 4.9 -481.8 -481788 1.4 ENSG00000267474 OR7C2 DDX39A IL27RA PKN1 ZNF333 HSALNG0124309 PTGER1 L13715-003
GH19J014979 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 0.3 +38.3 38306 1.6 ZBTB48 ZNF768 ZNF398 ZSCAN4 EGR2 ZNF143 POLR2A ZFHX2 KDM1A ZNF335 SLC1A6 lnc-OR7A17-2 GIPC1 piR-33103-010 CCDC105 OR7C2 lnc-OR7C2-1 RF00017-2575
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7C2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR7C2

Top Transcription factor binding sites by QIAGEN in the OR7C2 gene promoter:
  • AML1a
  • CUTL1
  • E47
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • NF-kappaB
  • NF-kappaB1
  • RelA

Genomic Locations for OR7C2 Gene

Latest Assembly
chr19:14,941,489-14,942,448
(GRCh38/hg38)
Size:
960 bases
Orientation:
Plus strand

Previous Assembly
chr19:15,052,301-15,053,260
(GRCh37/hg19 by Entrez Gene)
Size:
960 bases
Orientation:
Plus strand

chr19:15,052,301-15,053,260
(GRCh37/hg19 by Ensembl)
Size:
960 bases
Orientation:
Plus strand

Genomic View for OR7C2 Gene

Genes around OR7C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7C2 Gene

Proteins for OR7C2 Gene

  • Protein details for OR7C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60412-OR7C2_HUMAN
    Recommended name:
    Olfactory receptor 7C2
    Protein Accession:
    O60412
    Secondary Accessions:
    • O43881
    • Q6IFP9

    Protein attributes for OR7C2 Gene

    Size:
    319 amino acids
    Molecular mass:
    35323 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04611.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR7C2 Gene

Post-translational modifications for OR7C2 Gene

  • Glycosylation at Asn5

Other Protein References for OR7C2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7C2 Gene

Domains & Families for OR7C2 Gene

Gene Families for OR7C2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7C2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR7C2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-22 (OR7C2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60412

UniProtKB/Swiss-Prot:

OR7C2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7C2: view

Function for OR7C2 Gene

Molecular function for OR7C2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily C,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR7C2 Gene

Gene Ontology (GO) - Molecular Function for OR7C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with OR7C2: view
genes like me logo Genes that share phenotypes with OR7C2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7C2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7C2 Gene

Localization for OR7C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7C2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7C2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7C2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7C2 Gene

Pathways & Interactions for OR7C2 Gene

genes like me logo Genes that share pathways with OR7C2: view

Pathways by source for OR7C2 Gene

1 KEGG pathway for OR7C2 Gene

Interacting Proteins for OR7C2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: O60412-OR7C2_HUMAN ENSP00000248072 for OR7C2 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for OR7C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR7C2: view

No data available for SIGNOR curated interactions for OR7C2 Gene

Drugs & Compounds for OR7C2 Gene

No Compound Related Data Available

Transcripts for OR7C2 Gene

mRNA/cDNA for OR7C2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7C2

Alternative Splicing Database (ASD) splice patterns (SP) for OR7C2 Gene

No ASD Table

Relevant External Links for OR7C2 Gene

GeneLoc Exon Structure for
OR7C2

Expression for OR7C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR7C2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR7C2

SOURCE GeneReport for Unigene cluster for OR7C2 Gene:

Hs.589620
genes like me logo Genes that share expression patterns with OR7C2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7C2 Gene

Orthologs for OR7C2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7C2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC468751 29
  • 99.16 (n)
OR7C2 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR7C2 29 30
  • 82.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OR08B08 30
  • 80 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or7c70 45 Olfr1356 29 16 30
  • 78.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1086 29
  • 78.27 (n)
Oppossum
(Monodelphis domestica)
Mammalia OPOR20 30
  • 66 (a)
ManyToMany
OPOR17 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
OPOR24 30
  • 63 (a)
ManyToMany
OPOR9 30
  • 63 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
OPOR21 30
  • 61 (a)
ManyToMany
-- 30
  • 61 (a)
ManyToMany
-- 30
  • 61 (a)
ManyToMany
OPOR13 30
  • 60 (a)
ManyToMany
OPOR142 30
  • 59 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 61 (a)
ManyToMany
-- 30
  • 59 (a)
ManyToMany
-- 30
  • 58 (a)
ManyToMany
-- 30
  • 56 (a)
ManyToMany
Species where no ortholog for OR7C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR7C2 Gene

ENSEMBL:
Gene Tree for OR7C2 (if available)
TreeFam:
Gene Tree for OR7C2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7C2: view image
Alliance of Genome Resources:
Additional Orthologs for OR7C2

Paralogs for OR7C2 Gene

(452) SIMAP similar genes for OR7C2 Gene using alignment to 1 proteins:

  • OR7C2_HUMAN
genes like me logo Genes that share paralogs with OR7C2: view

Variants for OR7C2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR7C2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11883178 -- p.Arg122His
rs8113325 -- p.Thr118Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR7C2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR7C2 Gene

Variant ID Type Subtype PubMed ID
esv3893167 CNV gain 25118596
nsv1063744 CNV gain 25217958
nsv2424 CNV deletion 18451855
nsv510756 CNV deletion 20534489
nsv961190 CNV duplication 23825009

Variation tolerance for OR7C2 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7C2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7C2
Leiden Open Variation Database (LOVD)
OR7C2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7C2 Gene

Disorders for OR7C2 Gene

Additional Disease Information for OR7C2

No disorders were found for OR7C2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7C2 Gene

Publications for OR7C2 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for OR7C2 Gene

Sources for OR7C2 Gene