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Aliases for OR7C2 Gene

Aliases for OR7C2 Gene

  • Olfactory Receptor Family 7 Subfamily C Member 2 2 3 5
  • Olfactory Receptor OR19-22 3 4
  • Olfactory Receptor 19-18 3 4
  • Olfactory Receptor 7C2 3 4
  • Olfactory Receptor 7C3 3 4
  • OR19-18 3 4
  • OR7C3 3 4
  • Olfactory Receptor, Family 7, Subfamily C, Member 3 3
  • Olfactory Receptor, Family 7, Subfamily C, Member 2 2
  • CIT-HSP-87M17 3

External Ids for OR7C2 Gene

Previous HGNC Symbols for OR7C2 Gene

  • OR7C3

Previous GeneCards Identifiers for OR7C2 Gene

  • GC19P015431
  • GC19P014853
  • GC19P014913
  • GC19P014869
  • GC19P015052

Summaries for OR7C2 Gene

Entrez Gene Summary for OR7C2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7C2 Gene

OR7C2 (Olfactory Receptor Family 7 Subfamily C Member 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7C1.

UniProtKB/Swiss-Prot for OR7C2 Gene

Gene Wiki entry for OR7C2 Gene

Additional gene information for OR7C2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7C2 Gene

Genomics for OR7C2 Gene

GeneHancer (GH) Regulatory Elements for OR7C2 Gene

Promoters and enhancers for OR7C2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014525 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 -413.3 -413264 6 HDGF CC2D1A ZNF652 SP1 ELF3 CBFA2T2 NKRF POLR2A MLLT1 CEBPG DNAJB1 TECR MIR639 PIR54842 GC19P014531 GC19P014530 CCDC130 AKAP8 MRI1 BRD4
GH19J015091 Enhancer 1 FANTOM5 Ensembl ENCODE 11.3 +150.8 150812 1 CTCF ZNF384 RAD21 ZIC2 SCRT2 RFX5 SMC3 ZNF654 ZNF362 RNU6-782P OR7C2 SYDE1 GC19P015087 OR1I1
GH19J014550 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 3.5 -388.9 -388889 5.2 CC2D1A ELF3 MNT MLLT1 ZNF121 SP1 PPARG ZNF644 EGR1 KAT8 ENSG00000267519 CCDC130 RFX1 AKAP8L MRI1 AKAP8 SLC1A6 OR7C2 NDUFB7 DNAJB1
GH19J014459 Enhancer 0.6 FANTOM5 Ensembl ENCODE 4.9 -481.9 -481864 1.2 ENSG00000267474 OR7C2 DDX39A IL27RA PKN1 ZNF333 PTGER1
GH19J014979 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 0.3 +38.3 38312 1.6 ZSCAN4 POLR2A ZBTB26 ZBTB48 ZFHX2 ZNF768 ZNF335 ZNF143 ZNF398 EGR2 SLC1A6 GIPC1 CCDC105 OR7C2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7C2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR7C2 gene promoter:
  • AML1a
  • CUTL1
  • E47
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • NF-kappaB
  • NF-kappaB1
  • RelA

Genomic Locations for OR7C2 Gene

Genomic Locations for OR7C2 Gene
chr19:14,941,489-14,942,448
(GRCh38/hg38)
Size:
960 bases
Orientation:
Plus strand
chr19:15,052,301-15,053,260
(GRCh37/hg19)
Size:
960 bases
Orientation:
Plus strand

Genomic View for OR7C2 Gene

Genes around OR7C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7C2 Gene

Proteins for OR7C2 Gene

  • Protein details for OR7C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60412-OR7C2_HUMAN
    Recommended name:
    Olfactory receptor 7C2
    Protein Accession:
    O60412
    Secondary Accessions:
    • O43881
    • Q6IFP9

    Protein attributes for OR7C2 Gene

    Size:
    319 amino acids
    Molecular mass:
    35323 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04611.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR7C2 Gene

Post-translational modifications for OR7C2 Gene

Other Protein References for OR7C2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7C2 Gene

Domains & Families for OR7C2 Gene

Gene Families for OR7C2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7C2 Gene

Suggested Antigen Peptide Sequences for OR7C2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-22 (OR7C2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60412

UniProtKB/Swiss-Prot:

OR7C2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7C2: view

Function for OR7C2 Gene

Molecular function for OR7C2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily C,member 2,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR7C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR7C2: view
genes like me logo Genes that share phenotypes with OR7C2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7C2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7C2 Gene

Localization for OR7C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7C2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7C2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7C2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7C2 Gene

Pathways & Interactions for OR7C2 Gene

genes like me logo Genes that share pathways with OR7C2: view

Pathways by source for OR7C2 Gene

1 KEGG pathway for OR7C2 Gene

Interacting Proteins for OR7C2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000248072%0d9606.ENSP00000233596%0d9606.ENSP00000248572%0d9606.ENSP00000259030%0d9606.ENSP00000296142%0d9606.ENSP00000303482%0d
Selected Interacting proteins: ENSP00000248072 O60412-OR7C2_HUMAN for OR7C2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR7C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR7C2: view

No data available for SIGNOR curated interactions for OR7C2 Gene

Drugs & Compounds for OR7C2 Gene

No Compound Related Data Available

Transcripts for OR7C2 Gene

mRNA/cDNA for OR7C2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OR7C2 Gene

Olfactory receptor, family 7, subfamily C, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7C2

Alternative Splicing Database (ASD) splice patterns (SP) for OR7C2 Gene

No ASD Table

Relevant External Links for OR7C2 Gene

GeneLoc Exon Structure for
OR7C2
ECgene alternative splicing isoforms for
OR7C2

Expression for OR7C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR7C2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR7C2 Gene:

OR7C2

SOURCE GeneReport for Unigene cluster for OR7C2 Gene:

Hs.589620
genes like me logo Genes that share expression patterns with OR7C2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7C2 Gene

Orthologs for OR7C2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468751 34
  • 99.16 (n)
OR7C2 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR7C2 35 34
  • 82.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OR08B08 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or7c70 51 Olfr1356 17 35 34
  • 78.62 (n)
rat
(Rattus norvegicus)
Mammalia Olr1086 34
  • 78.27 (n)
oppossum
(Monodelphis domestica)
Mammalia OPOR20 35
  • 66 (a)
ManyToMany
OPOR17 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
OPOR24 35
  • 63 (a)
ManyToMany
OPOR9 35
  • 63 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
OPOR21 35
  • 61 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
OPOR13 35
  • 60 (a)
ManyToMany
OPOR142 35
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
Species where no ortholog for OR7C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7C2 Gene

ENSEMBL:
Gene Tree for OR7C2 (if available)
TreeFam:
Gene Tree for OR7C2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7C2: view image

Paralogs for OR7C2 Gene

(452) SIMAP similar genes for OR7C2 Gene using alignment to 1 proteins:

  • OR7C2_HUMAN
genes like me logo Genes that share paralogs with OR7C2: view

Variants for OR7C2 Gene

Sequence variations from dbSNP and Humsavar for OR7C2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001173907 -- 14,940,076(+) TTTTTT/TTTTTTT upstream_transcript_variant
rs1001646186 -- 14,940,367(+) T/C upstream_transcript_variant
rs1002580331 -- 14,941,249(+) C/T upstream_transcript_variant
rs1003173197 -- 14,942,611(+) C/A/T downstream_transcript_variant
rs1003646990 -- 14,940,410(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR7C2 Gene

Variant ID Type Subtype PubMed ID
esv3893167 CNV gain 25118596
nsv1063744 CNV gain 25217958
nsv2424 CNV deletion 18451855
nsv510756 CNV deletion 20534489
nsv961190 CNV duplication 23825009

Variation tolerance for OR7C2 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7C2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7C2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7C2 Gene

Disorders for OR7C2 Gene

Additional Disease Information for OR7C2

No disorders were found for OR7C2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7C2 Gene

Publications for OR7C2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  4. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 3 4 58
  5. Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. (PMID: 22552337) Kim RN … Park HS (Journal of genetics 2012) 3 58

Products for OR7C2 Gene

Sources for OR7C2 Gene

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