OR7C1 Gene (Protein Coding)

Olfactory Receptor Family 7 Subfamily C Member 1

GC19M014789
GIFtS:
36
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR7C1 Gene

Aliases for OR7C1 Gene

  • Olfactory Receptor Family 7 Subfamily C Member 1 2 3 5
  • Olfactory Receptor OR19-16 3 4
  • Olfactory Receptor TPCR86 3 4
  • Olfactory Receptor 7C1 3 4
  • Olfactory Receptor 7C4 3 4
  • OR19-5 2 3
  • OR7C4 3 4
  • Olfactory Receptor, Family 7, Subfamily C, Member 1 2
  • Olfactory Receptor, Family 7, Subfamily C, Member 4 3
  • CIT-HSP-146E8 3
  • HSTPCR86P 3
  • TPCR86 3
  • OR7C1 5

External Ids for OR7C1 Gene

Previous HGNC Symbols for OR7C1 Gene

  • OR7C4

Previous GeneCards Identifiers for OR7C1 Gene

  • GC19M015278
  • GC19M015330
  • GC19M014782
  • GC19M014770
  • GC19M014909
  • GC19M014801
  • GC19M014797

Summaries for OR7C1 Gene

Entrez Gene Summary for OR7C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7C1 Gene

OR7C1 (Olfactory Receptor Family 7 Subfamily C Member 1) is a Protein Coding gene. Diseases associated with OR7C1 include Periosteal Osteogenic Sarcoma and Hypertrophy Of Breast. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7C2.

UniProtKB/Swiss-Prot Summary for OR7C1 Gene

Gene Wiki entry for OR7C1 Gene

Additional gene information for OR7C1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR7C1 Gene

Genomics for OR7C1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR7C1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J014834 Enhancer 0.3 Ensembl ENCODE 250.7 +0.3 262 1 OR7A5 OR7C1 lnc-OR7C1-1 lnc-OR7A10-1 ADGRE2
GH19J015123 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 -289.9 -289876 3.7 SP1 ZNF207 MYC ZNF600 ZNF580 ATF2 POLR2A CEBPA ZNF10 ZIC2 ILVBL ENSG00000268564 lnc-NOTCH3-1 AKAP8 BRD4 ZNF333 TPM4 AKAP8L DDX39A OR1I1
GH19J015194 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10 -362.7 -362725 7 ZNF600 JUND CHD4 ZBTB10 ZNF341 ZEB1 KLF7 MAX ZBTB7B SIN3A NOTCH3 EPHX3 RNU6-782P AKAP8 OR7C1 RF00017-2580 ILVBL lnc-OR7C2-1
GH19J014782 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 12.2 +50.4 50446 4.1 ZNF654 MYC IKZF1 NCOR1 NFIC REST CTCF CEBPB BHLHE40 ZBTB7B piR-43105-328 DCAF15 DDX39A RFX1 ADGRE2 AKAP8 BRD4 OR7C1 ZNF333 ADGRE3
GH19J014775 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 11.7 +59.1 59138 2.5 NCOR1 MYC IKZF1 ZIC2 NONO CTCF SMAD5 TBP ZNF341 MNT ADGRE2 lnc-OR7C1-2 OR7C1 ZNF333 HSALNG0124338 ADGRE3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7C1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR7C1

Top Transcription factor binding sites by QIAGEN in the OR7C1 gene promoter:
  • E47
  • FOXO1
  • FOXO1a
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • POU3F1
  • PPAR-alpha
  • Tal-1

Genomic Locations for OR7C1 Gene

Latest Assembly
chr19:14,789,260-14,835,376
(GRCh38/hg38)
Size:
46,117 bases
Orientation:
Minus strand

Previous Assembly
chr19:14,909,327-14,945,997
(GRCh37/hg19 by Entrez Gene)
Size:
36,671 bases
Orientation:
Minus strand

chr19:14,909,958-14,911,023
(GRCh37/hg19 by Ensembl)
Size:
1,066 bases
Orientation:
Minus strand

Genomic View for OR7C1 Gene

Genes around OR7C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7C1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR7C1 Gene

Proteins for OR7C1 Gene

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  3. Assay products for research

  • Protein details for OR7C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76099-OR7C1_HUMAN
    Recommended name:
    Olfactory receptor 7C1
    Protein Accession:
    O76099
    Secondary Accessions:
    • Q15621
    • Q6IFP2
    • Q96R94

    Protein attributes for OR7C1 Gene

    Size:
    320 amino acids
    Molecular mass:
    35519 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7C1 Gene

Protein Expression for OR7C1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OR7C1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR7C1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7C1 Gene

Domains & Families for OR7C1 Gene

Gene Families for OR7C1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7C1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR7C1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor TPCR86 (OR7C1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O76099

UniProtKB/Swiss-Prot:

OR7C1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7C1: view

Function for OR7C1 Gene

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  6. Cell Lines for research

Molecular function for OR7C1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily C,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR7C1 Gene

Gene Ontology (GO) - Molecular Function for OR7C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS,IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR7C1: view
genes like me logo Genes that share phenotypes with OR7C1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7C1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7C1 Gene

Localization for OR7C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7C1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7C1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7C1 Gene

Pathways & Interactions for OR7C1 Gene

genes like me logo Genes that share pathways with OR7C1: view

Pathways by source for OR7C1 Gene

1 BioSystems pathway for OR7C1 Gene
1 KEGG pathway for OR7C1 Gene

Interacting Proteins for OR7C1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 24)
STRING Interaction Network
Selected Interacting proteins: ENSP00000248073 O76099-OR7C1_HUMAN for OR7C1 Gene via STRING IID

GPS-Prot Interaction Network for OR7C1

Gene Ontology (GO) - Biological Process for OR7C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007283 spermatogenesis TAS 9268701
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR7C1: view

No data available for SIGNOR curated interactions for OR7C1 Gene

Drugs & Compounds for OR7C1 Gene

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No Compound Related Data Available

Transcripts for OR7C1 Gene

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mRNA/cDNA for OR7C1 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7C1

Alternative Splicing Database (ASD) splice patterns (SP) for OR7C1 Gene

No ASD Table

Relevant External Links for OR7C1 Gene

GeneLoc Exon Structure for
OR7C1

Expression for OR7C1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR7C1 Gene

mRNA expression in normal human tissues for OR7C1 Gene
mRNA expression by BioGPS for OR7C1 GenemRNA expression by GTEx for OR7C1 Gene

mRNA differential expression in normal tissues according to GTEx for OR7C1 Gene

This gene is overexpressed in Pituitary (x9.3), Testis (x9.2), Skin - Sun Exposed (Lower leg) (x4.4), and Adrenal Gland (x4.1).

Protein differential expression in normal tissues from HIPED for OR7C1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR7C1 Gene



Protein tissue co-expression partners for OR7C1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR7C1

SOURCE GeneReport for Unigene cluster for OR7C1 Gene:

Hs.466053
genes like me logo Genes that share expression patterns with OR7C1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7C1 Gene

Orthologs for OR7C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7C1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC748178 29
  • 98.12 (n)
OR7C1 30
  • 97 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia -- 30
  • 79 (a)
 OneToMany
OR10D01 30
  • 78 (a)
 OneToMany
LOC102151861 29
  • 74.63 (n)
Cow
(Bos Taurus)
 Mammalia OR7A10 29
  • 74.11 (n)
-- 30
  • 68 (a)
 ManyToMany
Rat
(Rattus norvegicus)
 Mammalia Olr1077 29
  • 69.18 (n)
Mouse
(Mus musculus)
 Mammalia Or7c19 45 Olfr371 30
  • 69 (a)
 ManyToMany
Olfr1352 29 16
  • 67.98 (n)
Or7b1-ps 45 Olfr1327-ps1
  • chrX:74,762,037-74,762,879
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 67 (a)
 ManyToMany
OPOR20 30
  • 67 (a)
 ManyToMany
-- 30
  • 67 (a)
 ManyToMany
-- 30
  • 67 (a)
 ManyToMany
-- 30
  • 66 (a)
 ManyToMany
OPOR9 30
  • 65 (a)
 ManyToMany
OPOR17 30
  • 65 (a)
 ManyToMany
-- 30
  • 65 (a)
 ManyToMany
OPOR24 30
  • 64 (a)
 ManyToMany
OPOR142 30
  • 63 (a)
 ManyToMany
OPOR21 30
  • 63 (a)
 ManyToMany
-- 30
  • 63 (a)
 ManyToMany
-- 30
  • 63 (a)
 ManyToMany
-- 30
  • 62 (a)
 ManyToMany
-- 30
  • 62 (a)
 ManyToMany
OPOR13 30
  • 61 (a)
 ManyToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 61 (a)
 ManyToMany
-- 30
  • 60 (a)
 ManyToMany
-- 30
  • 59 (a)
 ManyToMany
-- 30
  • 55 (a)
 ManyToMany
Species where no ortholog for OR7C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR7C1 Gene

ENSEMBL:
Gene Tree for OR7C1 (if available)
TreeFam:
Gene Tree for OR7C1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7C1: view image
Alliance of Genome Resources:
Additional Orthologs for OR7C1

Paralogs for OR7C1 Gene

Paralogs for OR7C1 Gene

(455) SIMAP similar genes for OR7C1 Gene using alignment to 1 proteins:

  • OR7C1_HUMAN

Pseudogenes.org Pseudogenes for OR7C1 Gene

genes like me logo Genes that share paralogs with OR7C1: view

Variants for OR7C1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR7C1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10415312 -- p.Glu171Lys
rs10415562 -- p.Val126Ile
rs16979912 -- p.Ser210Pro
rs17230134 -- p.Ser99Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR7C1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR7C1 Gene

Variant ID Type Subtype PubMed ID
esv3643751 CNV loss 21293372
esv3893167 CNV gain 25118596
nsv509722 CNV insertion 20534489
nsv963011 CNV duplication 23825009

Variation tolerance for OR7C1 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.68; 78.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7C1 Gene

Human Gene Mutation Database (HGMD)
OR7C1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7C1
Leiden Open Variation Database (LOVD)
OR7C1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7C1 Gene

Disorders for OR7C1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR7C1 Gene - From: COP

Disorder Aliases PubMed IDs
periosteal osteogenic sarcoma
  • periosteal osteosarcoma
hypertrophy of breast
  • breasts enlarged
- elite association - COSMIC cancer census association via MalaCards
Search OR7C1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR7C1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OR7C1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR7C1 Gene

Publications for OR7C1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 3 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

ExternalLinks

View latest publications for OR7C1 gene in Mastermind

Products for OR7C1 Gene

Sources for OR7C1 Gene