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Aliases for OR7C1 Gene

Aliases for OR7C1 Gene

  • Olfactory Receptor Family 7 Subfamily C Member 1 2 3 5
  • Olfactory Receptor OR19-16 3 4
  • Olfactory Receptor TPCR86 3 4
  • Olfactory Receptor 7C4 3 4
  • OR7C4 3 4
  • Olfactory Receptor, Family 7, Subfamily C, Member 4 3
  • Olfactory Receptor, Family 7, Subfamily C, Member 1 2
  • Olfactory Receptor 7C1 3
  • CIT-HSP-146E8 3
  • HSTPCR86P 3
  • OR19-5 3
  • TPCR86 3

External Ids for OR7C1 Gene

Previous HGNC Symbols for OR7C1 Gene

  • OR7C4

Previous GeneCards Identifiers for OR7C1 Gene

  • GC19M015278
  • GC19M015330
  • GC19M014782
  • GC19M014770
  • GC19M014909
  • GC19M014801
  • GC19M014797

Summaries for OR7C1 Gene

Entrez Gene Summary for OR7C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7C1 Gene

OR7C1 (Olfactory Receptor Family 7 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7C2.

UniProtKB/Swiss-Prot for OR7C1 Gene

  • Odorant receptor.

Gene Wiki entry for OR7C1 Gene

Additional gene information for OR7C1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7C1 Gene

Genomics for OR7C1 Gene

GeneHancer (GH) Regulatory Elements for OR7C1 Gene

Promoters and enhancers for OR7C1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014835 Enhancer 0.2 ENCODE 650.7 +0.2 152 0.2 OR7A5 OR7C1 GC19M014827
GH19J015194 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -362.8 -362763 6.5 HDGF PKNOX1 ZNF133 NEUROD1 SIN3A ZNF2 ZBTB7B GLIS2 KLF7 FOS NOTCH3 AKAP8 BRD4 EPHX3 RNU6-782P ZNF333 TPM4 OR7C1 MIR6795 GC19M015202
GH19J015123 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.8 -289.9 -289876 3.7 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ILVBL ENSG00000268564 AKAP8 BRD4 ZNF333 TPM4 AKAP8L OR10H2 OR1AB1P LINC01855
GH19J014775 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.6 +59.0 58968 2.1 CLOCK ATF1 SIN3A POLR2B ZNF766 GLIS2 ATF7 RUNX3 SP3 NCOA1 ADGRE2 OR7C1 ZNF333 GC19M014744
GH19J014782 Enhancer 1.5 FANTOM5 Ensembl ENCODE 12.2 +50.5 50516 4 HDGF PKNOX1 ARNT ZNF2 ZBTB7B ZNF766 CBX5 ZNF143 FOS JUNB DCAF15 DDX39A AKAP8 RFX1 ADGRE2 BRD4 OR7C1 ADGRE5 ZNF333 ADGRE3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR7C1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR7C1 gene promoter:

Genomic Locations for OR7C1 Gene

Genomic Locations for OR7C1 Gene
46,117 bases
Minus strand

Genomic View for OR7C1 Gene

Genes around OR7C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7C1 Gene

Proteins for OR7C1 Gene

  • Protein details for OR7C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 7C1
    Protein Accession:
    Secondary Accessions:
    • Q15621
    • Q6IFP2
    • Q96R94

    Protein attributes for OR7C1 Gene

    320 amino acids
    Molecular mass:
    35519 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7C1 Gene

Post-translational modifications for OR7C1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR7C1 Gene

No data available for DME Specific Peptides for OR7C1 Gene

Domains & Families for OR7C1 Gene

Gene Families for OR7C1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7C1 Gene

Suggested Antigen Peptide Sequences for OR7C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7C1: view

Function for OR7C1 Gene

Molecular function for OR7C1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily C,member 1,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR7C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA,TAS --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR7C1: view
genes like me logo Genes that share phenotypes with OR7C1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7C1 Gene

Localization for OR7C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7C1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR7C1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7C1 Gene

Pathways & Interactions for OR7C1 Gene

genes like me logo Genes that share pathways with OR7C1: view

Pathways by source for OR7C1 Gene

1 KEGG pathway for OR7C1 Gene

Interacting Proteins for OR7C1 Gene

Gene Ontology (GO) - Biological Process for OR7C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007283 spermatogenesis TAS 9268701
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR7C1: view

No data available for SIGNOR curated interactions for OR7C1 Gene

Drugs & Compounds for OR7C1 Gene

No Compound Related Data Available

Transcripts for OR7C1 Gene

mRNA/cDNA for OR7C1 Gene

(2) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR7C1 Gene

Olfactory receptor, family 7, subfamily C, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR7C1 Gene

No ASD Table

Relevant External Links for OR7C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR7C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR7C1 Gene

mRNA differential expression in normal tissues according to GTEx for OR7C1 Gene

This gene is overexpressed in Pituitary (x9.3), Testis (x9.2), Skin - Sun Exposed (Lower leg) (x4.4), and Adrenal Gland (x4.1).

Protein differential expression in normal tissues from HIPED for OR7C1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR7C1 Gene

Protein tissue co-expression partners for OR7C1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR7C1 Gene:


SOURCE GeneReport for Unigene cluster for OR7C1 Gene:

genes like me logo Genes that share expression patterns with OR7C1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7C1 Gene

Orthologs for OR7C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC748178 33
  • 98.12 (n)
OR7C1 34
  • 97 (a)
(Canis familiaris)
Mammalia -- 34
  • 79 (a)
OR10D01 34
  • 78 (a)
LOC102151861 33
  • 74.63 (n)
(Bos Taurus)
Mammalia OR7A10 33
  • 74.11 (n)
-- 34
  • 68 (a)
(Rattus norvegicus)
Mammalia Olr1077 33
  • 69.18 (n)
(Mus musculus)
Mammalia Or7c19 51 Olfr371 34
  • 69 (a)
Olfr1352 16 33
  • 67.98 (n)
Or7b1-ps 51 Olfr1327-ps1
  • chrX:74,762,037-74,762,879
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OPOR20 34
  • 67 (a)
-- 34
  • 67 (a)
-- 34
  • 67 (a)
-- 34
  • 66 (a)
OPOR9 34
  • 65 (a)
OPOR17 34
  • 65 (a)
-- 34
  • 65 (a)
OPOR24 34
  • 64 (a)
OPOR142 34
  • 63 (a)
OPOR21 34
  • 63 (a)
-- 34
  • 63 (a)
-- 34
  • 63 (a)
-- 34
  • 62 (a)
-- 34
  • 62 (a)
OPOR13 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
-- 34
  • 60 (a)
-- 34
  • 59 (a)
-- 34
  • 55 (a)
Species where no ortholog for OR7C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7C1 Gene

Gene Tree for OR7C1 (if available)
Gene Tree for OR7C1 (if available)
Evolutionary constrained regions (ECRs) for OR7C1: view image

Paralogs for OR7C1 Gene

Paralogs for OR7C1 Gene

(455) SIMAP similar genes for OR7C1 Gene using alignment to 1 proteins:

  • OR7C1_HUMAN Pseudogenes for OR7C1 Gene

genes like me logo Genes that share paralogs with OR7C1: view

Variants for OR7C1 Gene

Sequence variations from dbSNP and Humsavar for OR7C1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000049959 -- 14,820,201(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000090018 -- 14,817,790(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000244047 -- 14,835,080(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000455400 -- 14,797,725(-) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000554452 -- 14,825,888(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OR7C1 Gene

Variant ID Type Subtype PubMed ID
esv3643751 CNV loss 21293372
esv3893167 CNV gain 25118596
nsv509722 CNV insertion 20534489
nsv963011 CNV duplication 23825009

Variation tolerance for OR7C1 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.68; 78.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7C1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7C1 Gene

Disorders for OR7C1 Gene

Additional Disease Information for OR7C1

No disorders were found for OR7C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7C1 Gene

Publications for OR7C1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  4. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for OR7C1 Gene

Sources for OR7C1 Gene

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