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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR7C1 (Olfactory Receptor Family 7 Subfamily C Member 1) is a Protein Coding gene. Diseases associated with OR7C1 include Periosteal Osteogenic Sarcoma and Hypertrophy Of Breast. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7C2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | TAS,IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007283 | spermatogenesis | TAS | 9268701 |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC748178 30 |
|
||
OR7C1 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
OR10D01 31 |
|
OneToMany | |||
LOC102151861 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | OR7A10 30 |
|
||
-- 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Olr1077 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or7c19 46 Olfr371 31 |
|
ManyToMany |
|
Olfr1352 30 17 |
|
||||
Or7b1-ps 46 Olfr1327-ps1 |
|
|
|||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
OPOR20 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
OPOR9 31 |
|
ManyToMany | |||
OPOR17 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
OPOR24 31 |
|
ManyToMany | |||
OPOR142 31 |
|
ManyToMany | |||
OPOR21 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
OPOR13 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10415312 | - | p.Glu171Lys | |||
rs10415562 | - | p.Val126Ile | |||
rs16979912 | - | p.Ser210Pro | |||
rs17230134 | - | p.Ser99Gly |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3643751 | CNV | loss | 21293372 |
esv3893167 | CNV | gain | 25118596 |
nsv509722 | CNV | insertion | 20534489 |
nsv963011 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
periosteal osteogenic sarcoma |
|
|
hypertrophy of breast |
|
|