Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR7A5 Gene

Aliases for OR7A5 Gene

  • Olfactory Receptor Family 7 Subfamily A Member 5 2 3 5
  • Olfactory Receptor, Family 7, Subfamily A, Member 5 Pseudogene 2 3
  • Olfactory Receptor OR19-17 3 4
  • Olfactory Receptor TPCR92 3 4
  • Olfactory Receptor 7A5 3 4
  • HTPCR2 2 3
  • Olfactory Receptor, Family 7, Subfamily A, Member 5 2
  • OR7A5 5

External Ids for OR7A5 Gene

Previous GeneCards Identifiers for OR7A5 Gene

  • GC19U990190
  • GC19M014798
  • GC19M014937
  • GC19M014903
  • GC19M014792

Summaries for OR7A5 Gene

Entrez Gene Summary for OR7A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7A5 Gene

OR7A5 (Olfactory Receptor Family 7 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with OR7A5 include Retinal Arteries, Tortuosity Of. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7A10.

UniProtKB/Swiss-Prot Summary for OR7A5 Gene

Gene Wiki entry for OR7A5 Gene

Additional gene information for OR7A5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR7A5 Gene

Genomics for OR7A5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR7A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014834 Promoter 0.3 Ensembl 600.7 +0.4 384 0.2 OR7A5 OR7C1 lnc-OR7C1-1 lnc-OR7A10-1 ADGRE2
GH19J014835 Enhancer 0.2 ENCODE 630.4 +0.1 61 0.2 OR7A5 OR7C1 lnc-OR7C1-1 lnc-OR7A10-1 ADGRE2
GH19J014782 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 5.8 +50.4 50425 4 CTCF PRDM10 ZNF512 LEF1 IKZF1 JUND ETV6 MTA2 PKNOX1 MTA1 piR-43105-328 DCAF15 DDX39A RFX1 ADGRE2 AKAP8 BRD4 OR7C1 ZNF333 ADGRE3
GH19J014794 Enhancer 0.8 Ensembl 12 +39.6 39584 1.8 JUND PKNOX1 REST ZNF740 DPF2 HDAC1 SOX6 EP300 NFE2 HDAC2 ADGRE2 OR7A5 TECR ENSG00000256210 lnc-ADGRE2-1 lnc-OR7C1-1 OR7C1
GH19J014821 Enhancer 0.4 Ensembl 16.4 +13.1 13084 1.2 MEF2D SPI1 ELF1 CEBPB OR7A5 OR7A10 ADGRE2 piR-31292-081 lnc-OR7A10-1 OR7C1 lnc-OR7C1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7A5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR7A5

Top Transcription factor binding sites by QIAGEN in the OR7A5 gene promoter:
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • POU3F1
  • PPAR-gamma1
  • PPAR-gamma2
  • Sox5

Genomic Locations for OR7A5 Gene

Genomic Locations for OR7A5 Gene
chr19:14,824,251-14,835,285
(GRCh38/hg38)
Size:
11,035 bases
Orientation:
Minus strand
chr19:14,903,302-14,946,188
(GRCh37/hg19)
Size:
42,887 bases
Orientation:
Minus strand

Genomic View for OR7A5 Gene

Genes around OR7A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7A5 Gene

Proteins for OR7A5 Gene

  • Protein details for OR7A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15622-OR7A5_HUMAN
    Recommended name:
    Olfactory receptor 7A5
    Protein Accession:
    Q15622
    Secondary Accessions:
    • B2R682
    • Q6IFP1
    • Q96R96

    Protein attributes for OR7A5 Gene

    Size:
    319 amino acids
    Molecular mass:
    35579 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7A5 Gene

Post-translational modifications for OR7A5 Gene

  • Glycosylation at Asn5

Other Protein References for OR7A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7A5 Gene

Domains & Families for OR7A5 Gene

Gene Families for OR7A5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7A5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR7A5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor TPCR92 (OR7A5_HUMAN)
  • OR7A5 protein (Q17RS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15622

UniProtKB/Swiss-Prot:

OR7A5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7A5: view

Function for OR7A5 Gene

Molecular function for OR7A5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily A,member 5,pseudogene,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR7A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
genes like me logo Genes that share ontologies with OR7A5: view
genes like me logo Genes that share phenotypes with OR7A5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7A5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7A5 Gene

Localization for OR7A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7A5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR7A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7A5 Gene

Pathways & Interactions for OR7A5 Gene

genes like me logo Genes that share pathways with OR7A5: view

Pathways by source for OR7A5 Gene

1 KEGG pathway for OR7A5 Gene

Interacting Proteins for OR7A5 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000316955 Q15622-OR7A5_HUMAN for OR7A5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR7A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR7A5: view

No data available for SIGNOR curated interactions for OR7A5 Gene

Drugs & Compounds for OR7A5 Gene

No Compound Related Data Available

Transcripts for OR7A5 Gene

mRNA/cDNA for OR7A5 Gene

5 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7A5

Alternative Splicing Database (ASD) splice patterns (SP) for OR7A5 Gene

No ASD Table

Relevant External Links for OR7A5 Gene

GeneLoc Exon Structure for
OR7A5

Expression for OR7A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR7A5 Gene

mRNA differential expression in normal tissues according to GTEx for OR7A5 Gene

This gene is overexpressed in Brain - Substantia nigra (x9.6), Brain - Spinal cord (cervical c-1) (x6.4), and Pituitary (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR7A5

SOURCE GeneReport for Unigene cluster for OR7A5 Gene:

Hs.137573

Evidence on tissue expression from TISSUES for OR7A5 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with OR7A5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7A5 Gene

Orthologs for OR7A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7A5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC747786 30
  • 99.27 (n)
OR7A5 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC610545 30
  • 81.96 (n)
Cow
(Bos Taurus)
Mammalia LOC783313 30
  • 80.13 (n)
Mouse
(Mus musculus)
Mammalia Olfr57 30 17
  • 78.99 (n)
Olfr1355 31
  • 65 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Olr1075 30
  • 78.23 (n)
Species where no ortholog for OR7A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR7A5 Gene

ENSEMBL:
Gene Tree for OR7A5 (if available)
TreeFam:
Gene Tree for OR7A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7A5: view image

Paralogs for OR7A5 Gene

(459) SIMAP similar genes for OR7A5 Gene using alignment to 2 proteins:

  • OR7A5_HUMAN
  • Q17RS1_HUMAN

Pseudogenes.org Pseudogenes for OR7A5 Gene

genes like me logo Genes that share paralogs with OR7A5: view

Variants for OR7A5 Gene

Additional dbSNP identifiers (rs#s) for OR7A5 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR7A5 Gene

Variant ID Type Subtype PubMed ID
esv3893167 CNV gain 25118596
nsv978777 CNV duplication 23825009

Variation tolerance for OR7A5 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.10; 61.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7A5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR7A5 Gene

Disorders for OR7A5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR7A5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinal arteries, tortuosity of
  • rator
- elite association - COSMIC cancer census association via MalaCards
Search OR7A5 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with OR7A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR7A5 Gene

Publications for OR7A5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  5. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 3 4

Products for OR7A5 Gene

Sources for OR7A5 Gene