Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR7A17 Gene

Aliases for OR7A17 Gene

  • Olfactory Receptor Family 7 Subfamily A Member 17 2 3 5
  • Olfactory Receptor 7A17 3 4
  • HTPCRX19 2 3
  • Olfactory Receptor, Family 7, Subfamily A, Member 17 2
  • Olfactory Receptor OR19-20 3
  • BC85395_4 3
  • OR7A17 5

External Ids for OR7A17 Gene

Previous GeneCards Identifiers for OR7A17 Gene

  • GC19M015360
  • GC19M015384
  • GC19M014836
  • GC19M014852
  • GC19M014991

Summaries for OR7A17 Gene

Entrez Gene Summary for OR7A17 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7A17 Gene

OR7A17 (Olfactory Receptor Family 7 Subfamily A Member 17) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7A10.

UniProtKB/Swiss-Prot Summary for OR7A17 Gene

Gene Wiki entry for OR7A17 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR7A17 Gene

Genomics for OR7A17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR7A17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014678 Enhancer 0.4 FANTOM5 Ensembl 21.4 +207.1 207132 0.4 OR7A17 OR1I1 SLC1A6 HSALNG0124328-001 HSALNG0124328-002 LOC107985308 ZNF333 ADGRE3 CLEC17A
GH19J014389 Enhancer 0.4 FANTOM5 dbSUPER 4.5 +496.9 496853 0.2 FJ601684-219 HSALNG0124300 lnc-DDX39A-1 DDX39A OR7A17 PKN1 RFX1 ZNF333 IL27RA DCAF15
GH19J014597 Enhancer 0.4 FANTOM5 dbSUPER 3.8 +288.3 288333 0.3 ADGRE3 NOTCH3 OR7A17 OR1I1 PRKACA PKN1 ZNF333 HSALNG0124318 RF00017-2572 CLEC17A
GH19J014888 Enhancer 0.7 ENCODE 0.7 -2.7 -2738 1.3 ZNF654 CTCF REST TRIM22 BHLHE40 MNT MAX RAD21 SMC3 EBF1 OR7A18P lnc-OR7A17-1 piR-38051-142 OR7C1 RNU6-782P OR7A5 OR7A17 RF00017-2574 OR7C2
GH19J014890 Enhancer 1 Ensembl ENCODE 0.4 -5.2 -5169 1.4 IKZF1 NCOR1 NFIC HES1 BHLHE40 MAFF NBN TAL1 ZNF316 NFE2 RF00017-2574 OR7A10 OR7C1 RNU6-782P SYDE1 OR7A5 piR-38051-142 OR7A17 OR7A1P OR7C2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7A17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR7A17

Top Transcription factor binding sites by QIAGEN in the OR7A17 gene promoter:
  • NF-AT4
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • RP58

Genomic Locations for OR7A17 Gene

Latest Assembly
chr19:14,878,203-14,886,132
(GRCh38/hg38)
Size:
7,930 bases
Orientation:
Minus strand

Previous Assembly
chr19:14,989,015-14,996,944
(GRCh37/hg19 by Entrez Gene)
Size:
7,930 bases
Orientation:
Minus strand

chr19:14,991,138-14,992,264
(GRCh37/hg19 by Ensembl)
Size:
1,127 bases
Orientation:
Minus strand

Genomic View for OR7A17 Gene

Genes around OR7A17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7A17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7A17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7A17 Gene

Proteins for OR7A17 Gene

  • Protein details for OR7A17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14581-OR7AH_HUMAN
    Recommended name:
    Olfactory receptor 7A17
    Protein Accession:
    O14581
    Secondary Accessions:
    • Q6IFQ6
    • Q96R98

    Protein attributes for OR7A17 Gene

    Size:
    309 amino acids
    Molecular mass:
    34013 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7A17 Gene

Post-translational modifications for OR7A17 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR7A17 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7A17 Gene

Domains & Families for OR7A17 Gene

Gene Families for OR7A17 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7A17 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR7A17 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 7A17 (OR7AH_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14581

UniProtKB/Swiss-Prot:

OR7AH_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7A17: view

Function for OR7A17 Gene

Molecular function for OR7A17 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR7A17 Gene

Gene Ontology (GO) - Molecular Function for OR7A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with OR7A17: view
genes like me logo Genes that share phenotypes with OR7A17: view

Animal Models for research

miRNA for OR7A17 Gene

miRTarBase miRNAs that target OR7A17

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7A17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR7A17 Gene

Localization for OR7A17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7A17 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7A17 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7A17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7A17 Gene

Pathways & Interactions for OR7A17 Gene

genes like me logo Genes that share pathways with OR7A17: view

Pathways by source for OR7A17 Gene

1 KEGG pathway for OR7A17 Gene

Interacting Proteins for OR7A17 Gene

Gene Ontology (GO) - Biological Process for OR7A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR7A17: view

No data available for SIGNOR curated interactions for OR7A17 Gene

Drugs & Compounds for OR7A17 Gene

No Compound Related Data Available

Transcripts for OR7A17 Gene

mRNA/cDNA for OR7A17 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7A17

Alternative Splicing Database (ASD) splice patterns (SP) for OR7A17 Gene

No ASD Table

Relevant External Links for OR7A17 Gene

GeneLoc Exon Structure for
OR7A17

Expression for OR7A17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR7A17 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR7A17

SOURCE GeneReport for Unigene cluster for OR7A17 Gene:

Hs.247717
genes like me logo Genes that share expression patterns with OR7A17: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7A17 Gene

Orthologs for OR7A17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7A17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC747830 29
  • 86.99 (n)
-- 30
  • 81 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia LOC782513 29
  • 81.79 (n)
Mouse
(Mus musculus)
Mammalia Or7a40 45 Olfr19 29 16 30
  • 78.68 (n)
ManyToMany
Olfr1352 30
  • 74 (a)
ManyToMany
Olfr1353 30
  • 71 (a)
ManyToMany
Or7a35 45 Olfr1351 30
  • 68 (a)
ManyToMany
Olfr1354 30
  • 65 (a)
ManyToMany
Olfr8 30
  • 63 (a)
ManyToMany
Or7a41 45 Olfr57
  • chr10:79,034,798-79,035,754
Species where no ortholog for OR7A17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR7A17 Gene

ENSEMBL:
Gene Tree for OR7A17 (if available)
TreeFam:
Gene Tree for OR7A17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7A17: view image
Alliance of Genome Resources:
Additional Orthologs for OR7A17

Paralogs for OR7A17 Gene

(453) SIMAP similar genes for OR7A17 Gene using alignment to 1 proteins:

  • OR7AH_HUMAN

Pseudogenes.org Pseudogenes for OR7A17 Gene

genes like me logo Genes that share paralogs with OR7A17: view

Variants for OR7A17 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR7A17 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10404119 -- p.Ala69Ser
rs10405129 -- p.Ile46Thr
rs10405148 -- p.Val37Ala
rs13345394 -- p.Ala237Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR7A17 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR7A17 Gene

Variant ID Type Subtype PubMed ID
dgv1719n106 CNV deletion 24896259
esv2669817 CNV deletion 23128226
esv2718221 CNV deletion 23290073
esv2718222 CNV deletion 23290073
esv3583259 CNV loss 25503493
esv3583261 CNV loss 25503493
esv3643754 CNV loss 21293372
esv3893167 CNV gain 25118596
nsv1123224 CNV deletion 24896259
nsv1148645 CNV deletion 26484159
nsv961188 CNV duplication 23825009

Variation tolerance for OR7A17 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.79; 96.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7A17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7A17
Leiden Open Variation Database (LOVD)
OR7A17

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7A17 Gene

Disorders for OR7A17 Gene

Additional Disease Information for OR7A17

No disorders were found for OR7A17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7A17 Gene

Publications for OR7A17 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  5. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3

Products for OR7A17 Gene

Sources for OR7A17 Gene