Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR7A10 Gene

Aliases for OR7A10 Gene

  • Olfactory Receptor Family 7 Subfamily A Member 10 2 3 5
  • Olfactory Receptor OR19-18 3 4
  • Olfactory Receptor 7A10 3 4
  • OST027 3 4
  • Olfactory Receptor, Family 7, Subfamily A, Member 10 2
  • BC85395_3 3
  • OR19-18 3
  • OR7A10 5

External Ids for OR7A10 Gene

Previous GeneCards Identifiers for OR7A10 Gene

  • GC19U990195
  • GC19M014813
  • GC19M014814
  • GC19M014951

Summaries for OR7A10 Gene

Entrez Gene Summary for OR7A10 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7A10 Gene

OR7A10 (Olfactory Receptor Family 7 Subfamily A Member 10) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7A17.

UniProtKB/Swiss-Prot Summary for OR7A10 Gene

Gene Wiki entry for OR7A10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR7A10 Gene

Genomics for OR7A10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR7A10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014890 Enhancer 1 Ensembl ENCODE 11.4 -42.4 -42379 1.4 IKZF1 NCOR1 NFIC HES1 BHLHE40 MAFF NBN TAL1 ZNF316 NFE2 RF00017-2574 OR7A10 OR7C1 RNU6-782P SYDE1 OR7A5 piR-38051-142 OR7A17 OR7A1P OR7C2
GH19J015135 Enhancer 0.9 Ensembl ENCODE 10.2 -287.2 -287172 1.9 ZNF217 MBD2 CTBP1 SMARCE1 FOXA1 DPF2 RFX1 TOE1 NFIB NCOA3 SYDE1 EPHX3 SLC1A6 CCDC105 OR7A10 OR7C1 ILVBL HSALNG0124357 NOTCH3 lnc-OR7C2-1
GH19J014632 Enhancer 0.8 Ensembl ENCODE 10.1 +216.4 216421 0.6 MYC SIX5 ETS1 MNT ZNF217 THAP11 HCFC1 USF2 SUZ12 ZNF143 ZNF333 OR7A10 ENSG00000275432 HSALNG0124326 RF00017-2573 CLEC17A ADGRE3
GH19J015097 Enhancer 0.7 ENCODE 10 -250.1 -250131 2.6 CEBPA CEBPB THAP11 FOXA2 SAP130 TEAD3 FOXP1 MBD1 TBP KDM1A lnc-ILVBL-1 RNU6-782P AKAP8L OR7C1 OR7A10 SYDE1 MG828564 OR1I1 lnc-OR7C2-1
GH19J014821 Enhancer 0.4 Ensembl 12 +26.7 26721 1.2 ELF1 SPI1 CEBPB MEF2D OR7A5 OR7A10 ADGRE2 piR-31292-081 lnc-OR7A10-1 lnc-OR7C1-1 OR7C1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR7A10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR7A10

Top Transcription factor binding sites by QIAGEN in the OR7A10 gene promoter:
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • E47
  • HNF-4alpha1
  • PPAR-gamma1
  • PPAR-gamma2
  • Sox5
  • Tal-1

Genomic Locations for OR7A10 Gene

Latest Assembly
chr19:14,840,466-14,848,922
(GRCh38/hg38)
Size:
8,457 bases
Orientation:
Minus strand

Previous Assembly
chr19:14,951,278-14,959,734
(GRCh37/hg19 by Entrez Gene)
Size:
8,457 bases
Orientation:
Minus strand

chr19:14,951,760-14,952,689
(GRCh37/hg19 by Ensembl)
Size:
930 bases
Orientation:
Minus strand

Genomic View for OR7A10 Gene

Genes around OR7A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7A10 Gene

Proteins for OR7A10 Gene

  • Protein details for OR7A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76100-OR7AA_HUMAN
    Recommended name:
    Olfactory receptor 7A10
    Protein Accession:
    O76100
    Secondary Accessions:
    • Q6IFP0
    • Q96R97

    Protein attributes for OR7A10 Gene

    Size:
    309 amino acids
    Molecular mass:
    34406 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7A10 Gene

Post-translational modifications for OR7A10 Gene

  • Glycosylation at Asn5

Other Protein References for OR7A10 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7A10 Gene

Domains & Families for OR7A10 Gene

Gene Families for OR7A10 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7A10 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR7A10 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-18 (OR7AA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O76100

UniProtKB/Swiss-Prot:

OR7AA_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7A10: view

Function for OR7A10 Gene

Molecular function for OR7A10 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily A,member 10,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR7A10 Gene

Gene Ontology (GO) - Molecular Function for OR7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR7A10: view
genes like me logo Genes that share phenotypes with OR7A10: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7A10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7A10 Gene

Localization for OR7A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7A10 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7A10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR7A10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7A10 Gene

Pathways & Interactions for OR7A10 Gene

genes like me logo Genes that share pathways with OR7A10: view

Pathways by source for OR7A10 Gene

1 BioSystems pathway for OR7A10 Gene
1 KEGG pathway for OR7A10 Gene

Interacting Proteins for OR7A10 Gene

Gene Ontology (GO) - Biological Process for OR7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR7A10: view

No data available for SIGNOR curated interactions for OR7A10 Gene

Drugs & Compounds for OR7A10 Gene

No Compound Related Data Available

Transcripts for OR7A10 Gene

mRNA/cDNA for OR7A10 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR7A10

Alternative Splicing Database (ASD) splice patterns (SP) for OR7A10 Gene

No ASD Table

Relevant External Links for OR7A10 Gene

GeneLoc Exon Structure for
OR7A10

Expression for OR7A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR7A10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR7A10

SOURCE GeneReport for Unigene cluster for OR7A10 Gene:

Hs.553776
genes like me logo Genes that share expression patterns with OR7A10: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7A10 Gene

Orthologs for OR7A10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7A10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC747795 29
  • 98.27 (n)
OR7A10 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC100299465 29
  • 82.3 (n)
Dog
(Canis familiaris)
Mammalia OR10G12 29
  • 81.06 (n)
Rat
(Rattus norvegicus)
Mammalia Olr1073 29
  • 75.11 (n)
Mouse
(Mus musculus)
Mammalia Olfr57 30
  • 69 (a)
ManyToMany
Or7a36 45 Olfr1352
  • chr10:78,983,792-78,984,718
Or7a37 45 Olfr1353
  • chr10:78,969,651-78,970,577
Or7a38 45 Olfr1354
  • chr10:78,916,842-78,917,771
Or7a39 45 Olfr1355
  • chr10:78,879,174-78,880,103
Species where no ortholog for OR7A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR7A10 Gene

ENSEMBL:
Gene Tree for OR7A10 (if available)
TreeFam:
Gene Tree for OR7A10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR7A10: view image
Alliance of Genome Resources:
Additional Orthologs for OR7A10

Paralogs for OR7A10 Gene

(453) SIMAP similar genes for OR7A10 Gene using alignment to 1 proteins:

  • OR7AA_HUMAN
genes like me logo Genes that share paralogs with OR7A10: view

Variants for OR7A10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR7A10 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10221530 -- p.Ala273Thr
rs11880955 -- p.Ile225Leu
rs12972670 -- p.Met151Thr
rs9305052 -- p.Gln183Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR7A10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR7A10 Gene

Variant ID Type Subtype PubMed ID
esv2718220 CNV deletion 23290073
esv3893167 CNV gain 25118596
nsv1061249 CNV loss 25217958
nsv978778 CNV duplication 23825009

Variation tolerance for OR7A10 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.56; 88.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7A10
Leiden Open Variation Database (LOVD)
OR7A10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7A10 Gene

Disorders for OR7A10 Gene

Additional Disease Information for OR7A10

No disorders were found for OR7A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7A10 Gene

Publications for OR7A10 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. (PMID: 32126975) Barnes IHA … Frankish A (BMC genomics 2020) 3
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3

Products for OR7A10 Gene

Sources for OR7A10 Gene