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Aliases for OR6Y1 Gene

Aliases for OR6Y1 Gene

  • Olfactory Receptor Family 6 Subfamily Y Member 1 2 3 5
  • Olfactory Receptor OR1-11 3 4
  • Olfactory Receptor 6Y2 3 4
  • OR6Y2 3 4
  • Olfactory Receptor, Family 6, Subfamily Y, Member 1 2
  • Olfactory Receptor 6Y1 3
  • OR1-11 3

External Ids for OR6Y1 Gene

Previous HGNC Symbols for OR6Y1 Gene

  • OR6Y2

Previous GeneCards Identifiers for OR6Y1 Gene

  • GC01U990366
  • GC01M155734
  • GC01M155329
  • GC01M156783

Summaries for OR6Y1 Gene

Entrez Gene Summary for OR6Y1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6Y1 Gene

OR6Y1 (Olfactory Receptor Family 6 Subfamily Y Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6P1.

UniProtKB/Swiss-Prot for OR6Y1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6Y1 Gene

Additional gene information for OR6Y1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6Y1 Gene

Genomics for OR6Y1 Gene

GeneHancer (GH) Regulatory Elements for OR6Y1 Gene

Promoters and enhancers for OR6Y1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J158333 Enhancer 0.5 FANTOM5 dbSUPER 3.6 +220.4 220425 0.2 CD1E CD1B OR6Y1 OR10K2 OR6K6 OR10T2 CD1C
GH01J158564 Enhancer 0.2 Ensembl 0.4 -10.4 -10396 0.4 OR6P1 OR6Y1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6Y1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6Y1 gene promoter:
  • FOXL1
  • FOXC1
  • E47
  • GATA-1
  • LCR-F1
  • AML1a
  • NRSF form 2
  • NRSF form 1
  • c-Myb
  • Lmo2

Genomic Locations for OR6Y1 Gene

Genomic Locations for OR6Y1 Gene
9,856 bases
Minus strand
978 bases
Minus strand

Genomic View for OR6Y1 Gene

Genes around OR6Y1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6Y1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6Y1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6Y1 Gene

Proteins for OR6Y1 Gene

  • Protein details for OR6Y1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6Y1
    Protein Accession:
    Secondary Accessions:
    • Q6IFS0

    Protein attributes for OR6Y1 Gene

    325 amino acids
    Molecular mass:
    36636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6Y1 Gene

Post-translational modifications for OR6Y1 Gene

  • Glycosylation at isoforms=191 and isoforms=10
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6Y1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6Y1 Gene

Domains & Families for OR6Y1 Gene

Gene Families for OR6Y1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6Y1 Gene

Suggested Antigen Peptide Sequences for OR6Y1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6Y1: view

Function for OR6Y1 Gene

Molecular function for OR6Y1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR6Y1: view
genes like me logo Genes that share phenotypes with OR6Y1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6Y1 Gene

Localization for OR6Y1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6Y1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6Y1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6Y1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6Y1 Gene

Pathways & Interactions for OR6Y1 Gene

genes like me logo Genes that share pathways with OR6Y1: view

Pathways by source for OR6Y1 Gene

Interacting Proteins for OR6Y1 Gene

Gene Ontology (GO) - Biological Process for OR6Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6Y1: view

No data available for SIGNOR curated interactions for OR6Y1 Gene

Drugs & Compounds for OR6Y1 Gene

No Compound Related Data Available

Transcripts for OR6Y1 Gene

mRNA/cDNA for OR6Y1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR6Y1 Gene

Olfactory receptor, family 6, subfamily Y, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6Y1 Gene

No ASD Table

Relevant External Links for OR6Y1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6Y1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6Y1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6Y1 Gene:


SOURCE GeneReport for Unigene cluster for OR6Y1 Gene:

genes like me logo Genes that share expression patterns with OR6Y1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6Y1 Gene

Orthologs for OR6Y1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6Y1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC469529 33
  • 98.67 (n)
OR6Y1 34
  • 97 (a)
(Canis familiaris)
Mammalia OR6Y1 34 33
  • 85.86 (n)
(Bos Taurus)
Mammalia OR6Y1 34 33
  • 85.61 (n)
(Mus musculus)
Mammalia Or6y1 51 Olfr220 16 34 33
  • 84.37 (n)
(Rattus norvegicus)
Mammalia Olr1602 33
  • 84.21 (n)
(Monodelphis domestica)
Mammalia OR6Y1 34
  • 83 (a)
(Anolis carolinensis)
Reptilia OR6Y1 34
  • 65 (a)
Species where no ortholog for OR6Y1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6Y1 Gene

Gene Tree for OR6Y1 (if available)
Gene Tree for OR6Y1 (if available)
Evolutionary constrained regions (ECRs) for OR6Y1: view image

Paralogs for OR6Y1 Gene

Paralogs for OR6Y1 Gene

(453) SIMAP similar genes for OR6Y1 Gene using alignment to 1 proteins:

  • OR6Y1_HUMAN Pseudogenes for OR6Y1 Gene

genes like me logo Genes that share paralogs with OR6Y1: view

Variants for OR6Y1 Gene

Sequence variations from dbSNP and Humsavar for OR6Y1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000140900 -- 158,546,811(-) G/A downstream_transcript_variant
rs1002260911 -- 158,548,930(-) A/G upstream_transcript_variant
rs1002694914 -- 158,546,888(-) A/C downstream_transcript_variant
rs1003355955 -- 158,550,064(-) C/T upstream_transcript_variant
rs1004646831 -- 158,548,968(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR6Y1 Gene

Variant ID Type Subtype PubMed ID
dgv15n17 CNV loss 16327808
dgv40n27 CNV loss 19166990
dgv443n100 CNV loss 25217958
dgv444n100 CNV gain 25217958
esv2422163 CNV deletion 20811451
esv2667471 CNV deletion 23128226
esv2764188 CNV loss 21179565
esv3578210 CNV loss 25503493
esv3587675 CNV loss 21293372
esv3587676 CNV gain 21293372
nsv442095 CNV loss 18776908
nsv470743 CNV loss 18288195
nsv515774 CNV loss 19592680
nsv547983 CNV loss 21841781
nsv547984 CNV loss 21841781

Variation tolerance for OR6Y1 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6Y1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6Y1 Gene

Disorders for OR6Y1 Gene

Additional Disease Information for OR6Y1

No disorders were found for OR6Y1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6Y1 Gene

Publications for OR6Y1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Seventy-five genetic loci influencing the human red blood cell. (PMID: 23222517) van der Harst P … Chambers JC (Nature 2012) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR6Y1 Gene

Sources for OR6Y1 Gene

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