Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6X1 Gene

Aliases for OR6X1 Gene

  • Olfactory Receptor Family 6 Subfamily X Member 1 2 3 5
  • Olfactory Receptor OR11-270 3 4
  • Olfactory Receptor 6X1 3 4
  • Olfactory Receptor, Family 6, Subfamily X, Member 1 2
  • OR11-270 3
  • OR6X1 5

External Ids for OR6X1 Gene

Previous GeneCards Identifiers for OR6X1 Gene

  • GC11U990322
  • GC11M123162
  • GC11M123129
  • GC11M123624

Summaries for OR6X1 Gene

Entrez Gene Summary for OR6X1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6X1 Gene

OR6X1 (Olfactory Receptor Family 6 Subfamily X Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6F1.

UniProtKB/Swiss-Prot Summary for OR6X1 Gene

Gene Wiki entry for OR6X1 Gene

Additional gene information for OR6X1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6X1 Gene

Genomics for OR6X1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6X1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123740 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.4 +12.7 12749 4.4 PRDM10 TFE3 ZNF512 LEF1 POLR2A ZNF7 BACH1 JUND GABPA MTA2 ZNF202 lnc-GRAMD1B-6 lnc-ZNF202-1 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P
GH11J123774 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.1 -21.3 -21306 5.3 ZNF316 MAFF USF1 MAFK ETS1 JUN PRDM10 ZNF143 ZNF558 TAF1 ZNF202 OR6X1 OR6M1 TMEM225 OR8D4 RNU1-21P RF00003-018 HSALNG0087854
GH11J123796 Enhancer 0.4 Ensembl ENCODE 10.6 -42.8 -42807 1.3 MEIS2 HSALNG0087854 LOC105369544 OR6X1 OR6M1
GH11J123695 Enhancer 0.2 FANTOM5 15.7 +59.2 59211 0.4 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1 OR10G9
GH11J123786 Enhancer 0.3 dbSUPER 10.9 -32.2 -32201 1 ATF4 OR6X1 OR8D4 ZNF202 HSALNG0087854 OR6M1 RF00003-018 RNU1-21P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6X1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6X1

Top Transcription factor binding sites by QIAGEN in the OR6X1 gene promoter:
  • aMEF-2
  • FAC1
  • FOXD1
  • LCR-F1
  • Lmo2
  • MEF-2
  • MEF-2A
  • Pbx1a
  • TBP
  • YY1

Genomic Locations for OR6X1 Gene

Genomic Locations for OR6X1 Gene
chr11:123,753,488-123,754,545
(GRCh38/hg38)
Size:
1,058 bases
Orientation:
Minus strand
chr11:123,624,196-123,625,253
(GRCh37/hg19)
Size:
1,058 bases
Orientation:
Minus strand

Genomic View for OR6X1 Gene

Genes around OR6X1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6X1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6X1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6X1 Gene

Proteins for OR6X1 Gene

  • Protein details for OR6X1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH79-OR6X1_HUMAN
    Recommended name:
    Olfactory receptor 6X1
    Protein Accession:
    Q8NH79
    Secondary Accessions:
    • B9EGW9
    • Q6IFA0

    Protein attributes for OR6X1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34727 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6X1 Gene

Post-translational modifications for OR6X1 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6X1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6X1 Gene

Domains & Families for OR6X1 Gene

Gene Families for OR6X1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6X1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR6X1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-270 (OR6X1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH79

UniProtKB/Swiss-Prot:

OR6X1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6X1: view

Function for OR6X1 Gene

Molecular function for OR6X1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6X1 Gene

Gene Ontology (GO) - Molecular Function for OR6X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR6X1: view
genes like me logo Genes that share phenotypes with OR6X1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6X1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6X1 Gene

Localization for OR6X1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6X1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6X1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6X1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6X1 Gene

Pathways & Interactions for OR6X1 Gene

genes like me logo Genes that share pathways with OR6X1: view

Pathways by source for OR6X1 Gene

Interacting Proteins for OR6X1 Gene

Gene Ontology (GO) - Biological Process for OR6X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6X1: view

No data available for SIGNOR curated interactions for OR6X1 Gene

Drugs & Compounds for OR6X1 Gene

No Compound Related Data Available

Transcripts for OR6X1 Gene

mRNA/cDNA for OR6X1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6X1

Alternative Splicing Database (ASD) splice patterns (SP) for OR6X1 Gene

No ASD Table

Relevant External Links for OR6X1 Gene

GeneLoc Exon Structure for
OR6X1

Expression for OR6X1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6X1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6X1

SOURCE GeneReport for Unigene cluster for OR6X1 Gene:

Hs.553759
genes like me logo Genes that share expression patterns with OR6X1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6X1 Gene

Orthologs for OR6X1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6X1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466811 30
  • 98.5 (n)
OR6X1 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR6X1 31
  • 86 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or6x1 46 Olfr986 30 17 31
  • 84.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1341 30
  • 83.01 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR6X1 31
  • 76 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 48 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 40 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia OR6X1 31
  • 46 (a)
OneToOne
Species where no ortholog for OR6X1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6X1 Gene

ENSEMBL:
Gene Tree for OR6X1 (if available)
TreeFam:
Gene Tree for OR6X1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6X1: view image

Paralogs for OR6X1 Gene

(450) SIMAP similar genes for OR6X1 Gene using alignment to 1 proteins:

  • OR6X1_HUMAN
genes like me logo Genes that share paralogs with OR6X1: view

Variants for OR6X1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6X1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs12364099 - p.Thr190Asn

Additional dbSNP identifiers (rs#s) for OR6X1 Gene

Variation tolerance for OR6X1 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6X1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6X1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR6X1 Gene

Disorders for OR6X1 Gene

Additional Disease Information for OR6X1

No disorders were found for OR6X1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6X1 Gene

Publications for OR6X1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. A genome-wide association study of total serum and mite-specific IgEs in asthma patients. (PMID: 23967269) Kim JH … Shin HD (PloS one 2013) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S … Wolf PA (BMC medical genetics 2007) 41
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR6X1 Gene

Sources for OR6X1 Gene