Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6V1 Gene

Aliases for OR6V1 Gene

  • Olfactory Receptor Family 6 Subfamily V Member 1 2 3 5
  • Olfactory Receptor OR7-3 3 4
  • Olfactory Receptor 6V1 3 4
  • GPR138 2 3
  • Olfactory Receptor, Family 6, Subfamily V, Member 1 2
  • OR6V1 5

External Ids for OR6V1 Gene

Previous GeneCards Identifiers for OR6V1 Gene

  • GC07U990314
  • GC07P142222
  • GC07P142266
  • GC07P142459
  • GC07P142749
  • GC07P143053
  • GC07P144235
  • GC07P144370
  • GC07P144498
  • GC07P144740
  • GC07P143113
  • GC07P143204
  • GC07P143398
  • GC07P143545
  • GC07P143679
  • GC07P143818
  • GC07P143958
  • GC07P144091
  • GC07P144969
  • GC07P145228

Summaries for OR6V1 Gene

Entrez Gene Summary for OR6V1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6V1 Gene

OR6V1 (Olfactory Receptor Family 6 Subfamily V Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6S1.

UniProtKB/Swiss-Prot Summary for OR6V1 Gene

Gene Wiki entry for OR6V1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6V1 Gene

Genomics for OR6V1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6V1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J143215 Enhancer 1 Ensembl ENCODE 10 +164.2 164181 3.4 BCLAF1 ZNF207 ZNF654 ZNF592 YY1 CTCF REST DEK TRIM22 ARNT GSTK1 TAS2R39 KEL LLCFC1 TRPV5 TCAF2 LOC154761 OR9P1P OR6V1 TAS2R40
GH07J143008 Enhancer 0.9 Ensembl ENCODE 10.2 -44.1 -44133 0.8 ZNF654 MYC CTCF REST ZNF592 TRIM22 BHLHE40 SIN3A IRF2 RAD21 HSALNG0061937 TAS2R40 EPHB6 OR9P1P OR6V1 TCAF1 OR9A2 KEL
GH07J143012 Enhancer 0.8 Ensembl ENCODE 11.2 -36.6 -36619 8.6 JUND ZNF316 NFE2 ZFP91 MAFK SRF MAFG MAFF POLR2A NFE2L2 ZYX OR9P1P OR6V1 TAS2R39 KEL LLCFC1 TRPV5 TRBV11-2 HSALNG0061937 OR9A2
GH07J142908 Enhancer 0.8 Ensembl ENCODE 9.9 -142.2 -142246 3.1 IKZF1 CTCF ELF1 ZNF316 YY1 MCM5 RAD21 ZNF143 MAFF MAFK CASP2 KEL TRPV5 LLCFC1 LOC154761 EPHB6 TCAF2 RN7SL535P OR9P1P OR6V1
GH07J143003 Enhancer 0.7 ENCODE 10.2 -48.7 -48711 0.2 ZNF654 YY1 CTCF REST TRIM22 ARNT RAD21 SMC3 SKIL EHMT2 TAS2R40 OR9A2 OR9P1P OR6V1 HSALNG0061937 KEL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6V1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6V1

Top Transcription factor binding sites by QIAGEN in the OR6V1 gene promoter:
  • Brachyury
  • GATA-2
  • HNF-4alpha1
  • HOXA9
  • HOXA9B
  • Meis-1
  • POU2F1
  • POU2F1a
  • S8
  • Sox5

Genomic Locations for OR6V1 Gene

Latest Assembly
chr7:143,052,320-143,053,347
(GRCh38/hg38)
Size:
1,028 bases
Orientation:
Plus strand

Previous Assembly
chr7:142,749,438-142,750,379
(GRCh37/hg19 by Entrez Gene)
Size:
942 bases
Orientation:
Plus strand

chr7:142,749,417-142,750,444
(GRCh37/hg19 by Ensembl)
Size:
1,028 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr7(ALT_REF_LOCI_1):1,075,408-1,076,349 (+)

Genomic View for OR6V1 Gene

Genes around OR6V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6V1 Gene

Proteins for OR6V1 Gene

  • Protein details for OR6V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N148-OR6V1_HUMAN
    Recommended name:
    Olfactory receptor 6V1
    Protein Accession:
    Q8N148
    Secondary Accessions:
    • A4D2I0
    • B9EH48
    • Q6IF70

    Protein attributes for OR6V1 Gene

    Size:
    313 amino acids
    Molecular mass:
    34902 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04790.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR6V1 Gene

Post-translational modifications for OR6V1 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6V1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6V1 Gene

Domains & Families for OR6V1 Gene

Gene Families for OR6V1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6V1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6V1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR7-3 (OR6V1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N148

UniProtKB/Swiss-Prot:

OR6V1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6V1: view

Function for OR6V1 Gene

Molecular function for OR6V1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6V1 Gene

Gene Ontology (GO) - Molecular Function for OR6V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR6V1: view
genes like me logo Genes that share phenotypes with OR6V1: view

Animal Models for research

miRNA for OR6V1 Gene

miRTarBase miRNAs that target OR6V1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6V1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR6V1 Gene

Localization for OR6V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6V1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6V1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6V1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6V1 Gene

Pathways & Interactions for OR6V1 Gene

genes like me logo Genes that share pathways with OR6V1: view

Pathways by source for OR6V1 Gene

Interacting Proteins for OR6V1 Gene

Gene Ontology (GO) - Biological Process for OR6V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6V1: view

No data available for SIGNOR curated interactions for OR6V1 Gene

Drugs & Compounds for OR6V1 Gene

No Compound Related Data Available

Transcripts for OR6V1 Gene

mRNA/cDNA for OR6V1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6V1

Alternative Splicing Database (ASD) splice patterns (SP) for OR6V1 Gene

No ASD Table

Relevant External Links for OR6V1 Gene

GeneLoc Exon Structure for
OR6V1

Expression for OR6V1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6V1 Gene

Protein differential expression in normal tissues from HIPED for OR6V1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR6V1 Gene



Protein tissue co-expression partners for OR6V1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6V1

SOURCE GeneReport for Unigene cluster for OR6V1 Gene:

Hs.554721
genes like me logo Genes that share expression patterns with OR6V1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6V1 Gene

Orthologs for OR6V1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6V1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC472558 29
  • 98.94 (n)
OR6V1 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR6V1 29 30
  • 87.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OR6V1 29
  • 85.9 (n)
-- 30
  • 42 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia OR6V1 30
  • 70 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Olfr461 30
  • 43 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii or101-1 30
  • 38 (a)
OneToMany
Species where no ortholog for OR6V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OR6V1 Gene

ENSEMBL:
Gene Tree for OR6V1 (if available)
TreeFam:
Gene Tree for OR6V1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6V1: view image
Alliance of Genome Resources:
Additional Orthologs for OR6V1

Paralogs for OR6V1 Gene

(447) SIMAP similar genes for OR6V1 Gene using alignment to 1 proteins:

  • OR6V1_HUMAN

Pseudogenes.org Pseudogenes for OR6V1 Gene

genes like me logo Genes that share paralogs with OR6V1: view

Variants for OR6V1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6V1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs10245778 -- p.Ser237Phe
rs7779316 -- p.Val295Ala
rs7791886 -- p.Arg269Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6V1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR6V1 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.32; 85.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6V1
Leiden Open Variation Database (LOVD)
OR6V1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR6V1 Gene

Disorders for OR6V1 Gene

Additional Disease Information for OR6V1

No disorders were found for OR6V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6V1 Gene

Publications for OR6V1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4
  3. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti WB … O'Dowd BF (Biochemical and biophysical research communications 2003) 2 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR6V1 Gene

Sources for OR6V1 Gene