Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6P1 Gene

Aliases for OR6P1 Gene

  • Olfactory Receptor Family 6 Subfamily P Member 1 2 3 5
  • Olfactory Receptor OR1-12 3 4
  • Olfactory Receptor 6P1 3 4
  • Olfactory Receptor, Family 6, Subfamily P, Member 1 2
  • Seven Transmembrane Helix Receptor 3
  • OR6P1 5

External Ids for OR6P1 Gene

Previous GeneCards Identifiers for OR6P1 Gene

  • GC01U990384
  • GC01M155750
  • GC01M155345
  • GC01M156799

Summaries for OR6P1 Gene

Entrez Gene Summary for OR6P1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6P1 Gene

OR6P1 (Olfactory Receptor Family 6 Subfamily P Member 1) is a Protein Coding gene. Diseases associated with OR6P1 include Benign Epilepsy With Centrotemporal Spikes. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR6B3.

UniProtKB/Swiss-Prot Summary for OR6P1 Gene

Gene Wiki entry for OR6P1 Gene

Additional gene information for OR6P1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6P1 Gene

Genomics for OR6P1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6P1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J158527 Enhancer 0.4 Ensembl 10.5 +42.9 42879 0.2 ZNF512 CTCF TCF7L2 OR6N1 OR6P1 OR10X1 ENSG00000231434 OR6Y1 OR10R2
GH01J158648 Enhancer 0.3 Ensembl 9.8 -78.5 -78521 0.6 CTCF CEBPB SPTA1 OR6K2 OR6N1 OR6P1 OR6K6 MN308821 MN308820 OR10Z1
GH01J158654 Enhancer 0.3 ENCODE 9.8 -84.4 -84359 0.8 REST SPI1 SPTA1 OR6K2 OR6N1 OR6P1 OR6K6 MN308821 MN308822 OR10Z1
GH01J158607 Enhancer 0.2 Ensembl 10.6 -36.7 -36721 0.2 OR10X1 OR6P1 OR6K2 OR6N2 OR6N1 OR10Z1 lnc-OR10X1-4 SPTA1
GH01J158634 Enhancer 0.2 Ensembl 10 -64.6 -64621 1.2 MN308819 OR10X1 OR6K2 OR6N1 OR6P1 OR10R2 lnc-OR10X1-4 OR10Z1 SPTA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6P1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6P1

Genomic Locations for OR6P1 Gene

Genomic Locations for OR6P1 Gene
chr1:158,560,606-158,570,580
(GRCh38/hg38)
Size:
9,975 bases
Orientation:
Minus strand
chr1:158,532,441-158,533,394
(GRCh37/hg19)
Size:
954 bases
Orientation:
Minus strand

Genomic View for OR6P1 Gene

Genes around OR6P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6P1 Gene

Proteins for OR6P1 Gene

  • Protein details for OR6P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGX9-OR6P1_HUMAN
    Recommended name:
    Olfactory receptor 6P1
    Protein Accession:
    Q8NGX9
    Secondary Accessions:
    • Q6IFR9

    Protein attributes for OR6P1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35831 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6P1 Gene

Post-translational modifications for OR6P1 Gene

  • Glycosylation at Asn3 and Asn186

Other Protein References for OR6P1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6P1 Gene

Domains & Families for OR6P1 Gene

Gene Families for OR6P1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6P1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR6P1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-12 (OR6P1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGX9

UniProtKB/Swiss-Prot:

OR6P1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6P1: view

Function for OR6P1 Gene

Molecular function for OR6P1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6P1 Gene

Gene Ontology (GO) - Molecular Function for OR6P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR6P1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6P1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6P1 Gene

Localization for OR6P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6P1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6P1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6P1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6P1 Gene

Pathways & Interactions for OR6P1 Gene

genes like me logo Genes that share pathways with OR6P1: view

Pathways by source for OR6P1 Gene

Interacting Proteins for OR6P1 Gene

Gene Ontology (GO) - Biological Process for OR6P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6P1: view

No data available for SIGNOR curated interactions for OR6P1 Gene

Drugs & Compounds for OR6P1 Gene

No Compound Related Data Available

Transcripts for OR6P1 Gene

mRNA/cDNA for OR6P1 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6P1

Alternative Splicing Database (ASD) splice patterns (SP) for OR6P1 Gene

No ASD Table

Relevant External Links for OR6P1 Gene

GeneLoc Exon Structure for
OR6P1

Expression for OR6P1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6P1 Gene

Protein differential expression in normal tissues from HIPED for OR6P1 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR6P1 Gene



Protein tissue co-expression partners for OR6P1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6P1

SOURCE GeneReport for Unigene cluster for OR6P1 Gene:

Hs.723122
genes like me logo Genes that share expression patterns with OR6P1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6P1 Gene

Orthologs for OR6P1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6P1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC469530 30
  • 99.26 (n)
OR6P1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR6P1 30 31
  • 87.91 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or6p1 46 Olfr414 30 17 31
  • 86.01 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OR6P1 30 31
  • 86.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1601 30
  • 84.75 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 82 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 53 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488993 30
  • 59.34 (n)
Species where no ortholog for OR6P1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6P1 Gene

ENSEMBL:
Gene Tree for OR6P1 (if available)
TreeFam:
Gene Tree for OR6P1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6P1: view image

Paralogs for OR6P1 Gene

(452) SIMAP similar genes for OR6P1 Gene using alignment to 1 proteins:

  • OR6P1_HUMAN
genes like me logo Genes that share paralogs with OR6P1: view

Variants for OR6P1 Gene

Additional dbSNP identifiers (rs#s) for OR6P1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR6P1 Gene

Variant ID Type Subtype PubMed ID
dgv444n100 CNV gain 25217958
nsv547986 CNV loss 21841781

Variation tolerance for OR6P1 Gene

Gene Damage Index Score: 5.91; 74.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6P1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6P1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6P1 Gene

Disorders for OR6P1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR6P1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
benign epilepsy with centrotemporal spikes
  • centrotemporal epilepsy
- elite association - COSMIC cancer census association via MalaCards
Search OR6P1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with OR6P1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR6P1 Gene

Publications for OR6P1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3

Products for OR6P1 Gene

Sources for OR6P1 Gene