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Aliases for OR6N2 Gene

Aliases for OR6N2 Gene

  • Olfactory Receptor Family 6 Subfamily N Member 2 2 3 5
  • Olfactory Receptor OR1-23 3 4
  • Olfactory Receptor, Family 6, Subfamily N, Member 2 2
  • Olfactory Receptor 6N2 3
  • OR1-23 3

External Ids for OR6N2 Gene

Previous GeneCards Identifiers for OR6N2 Gene

  • GC01U990385
  • GC01M155559
  • GC01M157014
  • GC01M158746

Summaries for OR6N2 Gene

Entrez Gene Summary for OR6N2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6N2 Gene

OR6N2 (Olfactory Receptor Family 6 Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR6N1.

UniProtKB/Swiss-Prot for OR6N2 Gene

  • Odorant receptor.

Gene Wiki entry for OR6N2 Gene

Additional gene information for OR6N2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6N2 Gene

Genomics for OR6N2 Gene

GeneHancer (GH) Regulatory Elements for OR6N2 Gene

Promoters and enhancers for OR6N2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159004 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -229.9 -229868 12.6 HDGF PKNOX1 ATF1 SMAD1 IRF4 YY1 TCF12 ZNF766 ZNF207 ATF7 IFI16 OR6N2 CADM3-AS1 RAD1P2 ACKR1 AIM2 PYHIN1 GC01M159011
GH01J158829 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 10 -50.6 -50645 3.8 PKNOX1 REST ATF2 IRF4 YY1 POLR2A IKZF1 NBN ATF7 MLLT1 MNDA OR6N2 PYHIN5P
GH01J158800 Enhancer 1 FANTOM5 Ensembl dbSUPER 11.1 -21.1 -21097 4.2 ZNF316 MAFF MAFG REST EMSY MAFK ZNF592 MNDA OR6N1 OR6N2 PYHIN1 IFI16 OR10AA1P OR2AQ1P
GH01J158808 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 11.3 -28.7 -28697 2.6 CEBPB OR10AA1P MNDA OR6N2 OR6N1 OR6K2 PYHIN1 IFI16
GH01J159141 Enhancer 0.8 FANTOM5 Ensembl 10.1 -360.8 -360785 0.8 MXI1 SP1 JUND ATF3 POLR3A ZBTB48 POLR2A FOS PRDM10 ZBTB17 GC01M159143 TRR-TCT4-1 OR6K3 OR6N1 FCER1A CADM3 ACKR1 CADM3-AS1 OR6N2 OR10J5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6N2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6N2 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • AML1a
  • PPAR-alpha
  • YY1
  • HNF-4alpha1
  • Max1
  • c-Myc
  • GR

Genomic Locations for OR6N2 Gene

Genomic Locations for OR6N2 Gene
6,983 bases
Minus strand
954 bases
Minus strand

Genomic View for OR6N2 Gene

Genes around OR6N2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6N2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6N2 Gene

Proteins for OR6N2 Gene

  • Protein details for OR6N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6N2
    Protein Accession:
    Secondary Accessions:
    • Q6IFR2

    Protein attributes for OR6N2 Gene

    317 amino acids
    Molecular mass:
    35692 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6N2 Gene

Post-translational modifications for OR6N2 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6N2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6N2 Gene

Domains & Families for OR6N2 Gene

Gene Families for OR6N2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6N2 Gene

Suggested Antigen Peptide Sequences for OR6N2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6N2: view

Function for OR6N2 Gene

Molecular function for OR6N2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6N2 Gene

Gene Ontology (GO) - Molecular Function for OR6N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6N2: view
genes like me logo Genes that share phenotypes with OR6N2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6N2 Gene

Localization for OR6N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6N2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6N2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6N2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6N2 Gene

Pathways & Interactions for OR6N2 Gene

genes like me logo Genes that share pathways with OR6N2: view

Pathways by source for OR6N2 Gene

Interacting Proteins for OR6N2 Gene

Gene Ontology (GO) - Biological Process for OR6N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR6N2: view

No data available for SIGNOR curated interactions for OR6N2 Gene

Drugs & Compounds for OR6N2 Gene

No Compound Related Data Available

Transcripts for OR6N2 Gene

mRNA/cDNA for OR6N2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR6N2 Gene

Olfactory receptor, family 6, subfamily N, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6N2 Gene

No ASD Table

Relevant External Links for OR6N2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6N2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6N2 Gene

Protein differential expression in normal tissues from HIPED for OR6N2 Gene

This gene is overexpressed in Heart (48.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR6N2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6N2 Gene:


SOURCE GeneReport for Unigene cluster for OR6N2 Gene:

genes like me logo Genes that share expression patterns with OR6N2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6N2 Gene

Orthologs for OR6N2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6N2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC744684 33
  • 99.37 (n)
OR6N2 34
  • 98 (a)
(Canis familiaris)
Mammalia OR6N2 34
  • 88 (a)
LOC488619 33
  • 86.5 (n)
(Bos Taurus)
Mammalia LOC790121 33
  • 87.22 (n)
OR6N2 34
  • 86 (a)
(Mus musculus)
Mammalia Or6n2 51 Olfr430 16 34 33
  • 84.6 (n)
(Rattus norvegicus)
Mammalia Olr1588 33
  • 83.23 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734698 33
  • 56.22 (n)
Species where no ortholog for OR6N2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6N2 Gene

Gene Tree for OR6N2 (if available)
Gene Tree for OR6N2 (if available)
Evolutionary constrained regions (ECRs) for OR6N2: view image

Paralogs for OR6N2 Gene

Paralogs for OR6N2 Gene

(457) SIMAP similar genes for OR6N2 Gene using alignment to 1 proteins:

  • OR6N2_HUMAN Pseudogenes for OR6N2 Gene

genes like me logo Genes that share paralogs with OR6N2: view

Variants for OR6N2 Gene

Sequence variations from dbSNP and Humsavar for OR6N2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000556881 -- 158,779,568(-) A/G upstream_transcript_variant
rs1001182268 -- 158,776,894(-) C/A/T coding_sequence_variant, missense_variant
rs1001447492 -- 158,776,208(-) T/C downstream_transcript_variant
rs1001639693 -- 158,777,213(-) A/C coding_sequence_variant, missense_variant
rs1002592067 -- 158,778,148(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR6N2 Gene

Variant ID Type Subtype PubMed ID
dgv589n54 CNV loss 21841781
nsv1002401 CNV loss 25217958
nsv997861 CNV loss 25217958

Variation tolerance for OR6N2 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6N2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6N2 Gene

Disorders for OR6N2 Gene

Additional Disease Information for OR6N2

No disorders were found for OR6N2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6N2 Gene

Publications for OR6N2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR6N2 Gene

Sources for OR6N2 Gene

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