Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6N1 Gene

Aliases for OR6N1 Gene

  • Olfactory Receptor Family 6 Subfamily N Member 1 2 3 5
  • Olfactory Receptor 6N1 3 4
  • Olfactory Receptor, Family 6, Subfamily N, Member 1 2
  • Olfactory Receptor OR1-22 3
  • OR1-22 3
  • OR6N1 5

External Ids for OR6N1 Gene

Previous GeneCards Identifiers for OR6N1 Gene

  • GC01U990386
  • GC01M155632
  • GC01M155548
  • GC01M157002
  • GC01M158735

Summaries for OR6N1 Gene

Entrez Gene Summary for OR6N1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6N1 Gene

OR6N1 (Olfactory Receptor Family 6 Subfamily N Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6N2.

UniProtKB/Swiss-Prot Summary for OR6N1 Gene

Gene Wiki entry for OR6N1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6N1 Gene

Genomics for OR6N1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6N1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J158808 Promoter/Enhancer 0.9 FANTOM5 Ensembl dbSUPER 10.4 +31.4 31353 1.3 SPI1 CEBPB OR10AA1P MNDA OR6N2 OR6N1 PYHIN1 IFI16 piR-32023-021 HSALNG0007742
GH01J158800 Promoter/Enhancer 0.8 FANTOM5 Ensembl dbSUPER 11.2 +40.2 40154 0.4 SPI1 MNDA OR6N1 PYHIN1 IFI16 OR2AQ1P OR10AA1P OR6N2 HSALNG0007742
GH01J158793 Promoter/Enhancer 0.8 Ensembl dbSUPER 11.4 +47.1 47078 0.2 CTCF REST SMC3 RAD21 ZNF143 OR6N1 SPTA1 OR6K6 OR10X1 OR2AQ1P OR6N2 MNDA HSALNG0007742
GH01J158805 Promoter/Enhancer 0.8 Ensembl dbSUPER 10.4 +36.8 36778 0.4 REST MAFF ZNF316 MAFK MAFG EMSY OR6N2 OR6N1 OR10AA1P OR2AQ1P MNDA HSALNG0007742
GH01J158803 Promoter/Enhancer 0.8 Ensembl dbSUPER 10.6 +37.6 37578 0.8 MAFF ZNF316 MAFK MAFG EMSY OR6N2 OR6N1 OR10AA1P OR2AQ1P MNDA HSALNG0007742
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6N1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6N1

Top Transcription factor binding sites by QIAGEN in the OR6N1 gene promoter:
  • AML1a
  • COMP1
  • NF-kappaB
  • NF-kappaB1
  • POU3F2
  • PPAR-alpha
  • RelA
  • RORalpha1
  • STAT3

Genomic Locations for OR6N1 Gene

Latest Assembly
chr1:158,747,814-158,840,979
(GRCh38/hg38)
Size:
93,166 bases
Orientation:
Minus strand

Previous Assembly
chr1:158,734,026-158,741,985
(GRCh37/hg19 by Entrez Gene)
Size:
7,960 bases
Orientation:
Minus strand

chr1:158,735,466-158,736,492
(GRCh37/hg19 by Ensembl)
Size:
1,027 bases
Orientation:
Minus strand

Genomic View for OR6N1 Gene

Genes around OR6N1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6N1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6N1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6N1 Gene

Proteins for OR6N1 Gene

  • Protein details for OR6N1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGY5-OR6N1_HUMAN
    Recommended name:
    Olfactory receptor 6N1
    Protein Accession:
    Q8NGY5
    Secondary Accessions:
    • B2RUT4
    • Q5VUU8
    • Q96R35

    Protein attributes for OR6N1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34869 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6N1 Gene

Post-translational modifications for OR6N1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6N1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6N1 Gene

Domains & Families for OR6N1 Gene

Gene Families for OR6N1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6N1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6N1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 6, subfamily N, member 1 (B2RUT4_HUMAN)
  • Olfactory receptor 6N1 (OR6N1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGY5

UniProtKB/Swiss-Prot:

OR6N1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6N1: view

Function for OR6N1 Gene

Molecular function for OR6N1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6N1 Gene

Gene Ontology (GO) - Molecular Function for OR6N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6N1: view
genes like me logo Genes that share phenotypes with OR6N1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6N1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6N1 Gene

Localization for OR6N1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6N1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6N1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6N1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6N1 Gene

Pathways & Interactions for OR6N1 Gene

genes like me logo Genes that share pathways with OR6N1: view

Pathways by source for OR6N1 Gene

Interacting Proteins for OR6N1 Gene

Gene Ontology (GO) - Biological Process for OR6N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6N1: view

No data available for SIGNOR curated interactions for OR6N1 Gene

Drugs & Compounds for OR6N1 Gene

No Compound Related Data Available

Transcripts for OR6N1 Gene

mRNA/cDNA for OR6N1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6N1

Alternative Splicing Database (ASD) splice patterns (SP) for OR6N1 Gene

No ASD Table

Relevant External Links for OR6N1 Gene

GeneLoc Exon Structure for
OR6N1

Expression for OR6N1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6N1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6N1

SOURCE GeneReport for Unigene cluster for OR6N1 Gene:

Hs.553592
genes like me logo Genes that share expression patterns with OR6N1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6N1 Gene

Orthologs for OR6N1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6N1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC469536 29
  • 99.25 (n)
OR6N1 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR16E08 30
  • 87 (a)
OneToOne
OR6N1 29
  • 84.52 (n)
Cow
(Bos Taurus)
Mammalia OR6N1 29 30
  • 86.71 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or6n1 45 Olfr429 29 16 30
  • 85.32 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR6N1 30
  • 85 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1589 29
  • 84.94 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 38 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496592 29
  • 56.17 (n)
Species where no ortholog for OR6N1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6N1 Gene

ENSEMBL:
Gene Tree for OR6N1 (if available)
TreeFam:
Gene Tree for OR6N1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6N1: view image
Alliance of Genome Resources:
Additional Orthologs for OR6N1

Paralogs for OR6N1 Gene

(459) SIMAP similar genes for OR6N1 Gene using alignment to 2 proteins:

  • OR6N1_HUMAN
  • B2RUT4_HUMAN
genes like me logo Genes that share paralogs with OR6N1: view

Variants for OR6N1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6N1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1864346 -- p.Ala10Thr
rs857824 -- p.Arg293His
rs857825 -- p.Gln261Arg
rs857826 -- p.Phe245Leu
rs857827 -- p.Ile194Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6N1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR6N1 Gene

Variant ID Type Subtype PubMed ID
dgv589n54 CNV loss 21841781
nsv1002401 CNV loss 25217958
nsv824975 CNV loss 20364138
nsv997861 CNV loss 25217958

Variation tolerance for OR6N1 Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6N1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6N1
Leiden Open Variation Database (LOVD)
OR6N1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6N1 Gene

Disorders for OR6N1 Gene

Additional Disease Information for OR6N1

No disorders were found for OR6N1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6N1 Gene

Publications for OR6N1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Human olfactory receptor responses to odorants. (PMID: 25977809) Mainland JD … Matsunami H (Scientific data 2015) 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3

Products for OR6N1 Gene

Sources for OR6N1 Gene