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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR6M1 (Olfactory Receptor Family 6 Subfamily M Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6J1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J123740 | Promoter/Enhancer | 2.2 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas | 8.3 | +64.6 | 64591 | 4.4 | PRDM10 TFE3 ZNF512 LEF1 POLR2A ZNF7 BACH1 JUND GABPA MTA2 | ZNF202 lnc-GRAMD1B-6 lnc-ZNF202-1 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P | |
GH11J123774 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 11 | +30.5 | 30536 | 5.3 | ZNF316 MAFF USF1 MAFK ETS1 JUN PRDM10 ZNF143 ZNF558 TAF1 | ZNF202 OR6X1 OR6M1 TMEM225 OR8D4 RNU1-21P RF00003-018 HSALNG0087854 | |
GH11J123841 | Enhancer | 0.4 | Ensembl | 11 | -35.3 | -35314 | 1.4 | ATF4 ATF3 JUN | OR6M2P ZNF202 OR6M1 TMEM225 | |
GH11J123852 | Enhancer | 0.3 | Ensembl | 10.5 | -46.7 | -46714 | 1.4 | NANOG | TMEM225 OR6M1 OR8D4 lnc-TMEM225-1 OR6M2P | |
GH11J123861 | Enhancer | 0.3 | Ensembl | 10.2 | -55.4 | -55414 | 0.4 | POLR2A | OR6M3P lnc-TMEM225-1 TMEM225 OR8D4 OR6M1 OR6T1 OR6M2P |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC466812 30 |
|
||
OR6M1 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | OR6M1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | OR6M1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OR6M1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Olfr212 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs4936845 | - | p.Thr276Lys |
No disorders were found for OR6M1 Gene.