OR6M1 Gene (Protein Coding)

Olfactory Receptor Family 6 Subfamily M Member 1

GC11M123805
GIFtS:
29
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6M1 Gene

Aliases for OR6M1 Gene

  • Olfactory Receptor Family 6 Subfamily M Member 1 2 3 5
  • Olfactory Receptor OR11-271 3 4
  • Olfactory Receptor 6M1 3 4
  • Olfactory Receptor, Family 6, Subfamily M, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 6, Subfamily M, Member 1 2
  • OR11-271 3
  • OR6M1 5

External Ids for OR6M1 Gene

Previous GeneCards Identifiers for OR6M1 Gene

  • GC11U990377
  • GC11M123214
  • GC11M123181
  • GC11M123676

Summaries for OR6M1 Gene

Entrez Gene Summary for OR6M1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6M1 Gene

OR6M1 (Olfactory Receptor Family 6 Subfamily M Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6J1.

UniProtKB/Swiss-Prot Summary for OR6M1 Gene

Gene Wiki entry for OR6M1 Gene

Additional gene information for OR6M1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6M1 Gene

Genomics for OR6M1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR6M1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J123740 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 8.3 +64.6 64591 4.4 BCLAF1 ZNF207 ZNF600 MYC NCOR1 POLR2A NFIC YY1 MXD4 REST ZNF202 lnc-ZNF202-1 lnc-GRAMD1B-6 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P
GH11J123774 Enhancer 0.9 Ensembl ENCODE dbSUPER 11 +30.5 30536 5.3 ETS1 MAFF ZNF316 MAFK PRDM10 TAF1 SP1 POU5F1 NANOG ZNF143 ZNF202 OR6X1 OR6M1 TMEM225 OR8D4 HSALNG0087853 HSALNG0087854
GH11J123841 Enhancer 0.3 Ensembl 11 -35.3 -35314 1.4 ATF4 ATF3 OR6M2P ZNF202 OR6M1 TMEM225
GH11J123852 Enhancer 0.3 Ensembl 10.5 -46.8 -46814 1.2 NANOG TMEM225 OR6M1 OR8D4 lnc-TMEM225-1 OR6M2P
GH11J123861 Enhancer 0.3 Ensembl 10.2 -55.4 -55414 0.4 POLR2A OR6M3P lnc-TMEM225-1 TMEM225 OR8D4 OR6M1 OR6T1 OR6M2P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6M1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6M1

Top Transcription factor binding sites by QIAGEN in the OR6M1 gene promoter:
  • Evi-1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR6M1 Gene

Latest Assembly
chr11:123,805,335-123,806,387
(GRCh38/hg38)
Size:
1,053 bases
Orientation:
Minus strand

Previous Assembly
chr11:123,676,116-123,677,057
(GRCh37/hg19 by Entrez Gene)
Size:
942 bases
Orientation:
Minus strand

chr11:123,676,043-123,677,095
(GRCh37/hg19 by Ensembl)
Size:
1,053 bases
Orientation:
Minus strand

Genomic View for OR6M1 Gene

Genes around OR6M1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6M1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6M1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR6M1 Gene

Proteins for OR6M1 Gene

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  • Protein details for OR6M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGM8-OR6M1_HUMAN
    Recommended name:
    Olfactory receptor 6M1
    Protein Accession:
    Q8NGM8
    Secondary Accessions:
    • B2RNK0
    • Q6IEW9
    • Q96R37

    Protein attributes for OR6M1 Gene

    Size:
    313 amino acids
    Molecular mass:
    35328 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6M1 Gene

Post-translational modifications for OR6M1 Gene

  • Glycosylation at Asn3 and Asn262

Other Protein References for OR6M1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6M1 Gene

Domains & Families for OR6M1 Gene

Gene Families for OR6M1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6M1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6M1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-271 (OR6M1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGM8

UniProtKB/Swiss-Prot:

OR6M1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6M1: view

Function for OR6M1 Gene

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  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for OR6M1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6M1 Gene

Gene Ontology (GO) - Molecular Function for OR6M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR6M1: view

Phenotypes for OR6M1 Gene

GenomeRNAi human phenotypes for OR6M1:
genes like me logo Genes that share phenotypes with OR6M1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6M1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6M1 Gene

Localization for OR6M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6M1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6M1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6M1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6M1 Gene

Pathways & Interactions for OR6M1 Gene

genes like me logo Genes that share pathways with OR6M1: view

Pathways by source for OR6M1 Gene

1 KEGG pathway for OR6M1 Gene

Interacting Proteins for OR6M1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000311038 Q8NGM8-OR6M1_HUMAN for OR6M1 Gene via STRING IID

GPS-Prot Interaction Network for OR6M1

Gene Ontology (GO) - Biological Process for OR6M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6M1: view

No data available for SIGNOR curated interactions for OR6M1 Gene

Drugs & Compounds for OR6M1 Gene

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No Compound Related Data Available

Transcripts for OR6M1 Gene

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mRNA/cDNA for OR6M1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6M1

Alternative Splicing Database (ASD) splice patterns (SP) for OR6M1 Gene

No ASD Table

Relevant External Links for OR6M1 Gene

GeneLoc Exon Structure for
OR6M1

Expression for OR6M1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6M1 Gene

mRNA expression in normal human tissues for OR6M1 Gene
mRNA expression by BioGPS for OR6M1 GenemRNA expression by GTEx for OR6M1 Gene

mRNA differential expression in normal tissues according to GTEx for OR6M1 Gene

This gene is overexpressed in Pancreas (x31.5), Testis (x14.3), and Colon - Transverse (x5.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6M1

SOURCE GeneReport for Unigene cluster for OR6M1 Gene:

Hs.557924
genes like me logo Genes that share expression patterns with OR6M1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6M1 Gene

Orthologs for OR6M1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6M1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC466812 29
  • 99.15 (n)
OR6M1 30
  • 99 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia OR6M1 29 30
  • 87.75 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia OR6M1 30
  • 77 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia OR6M1 30
  • 71 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Olfr212 30
  • 42 (a)
 ManyToMany
Species where no ortholog for OR6M1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6M1 Gene

ENSEMBL:
Gene Tree for OR6M1 (if available)
TreeFam:
Gene Tree for OR6M1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6M1: view image
Alliance of Genome Resources:
Additional Orthologs for OR6M1

Paralogs for OR6M1 Gene

Paralogs for OR6M1 Gene

(453) SIMAP similar genes for OR6M1 Gene using alignment to 1 proteins:

  • OR6M1_HUMAN

Pseudogenes.org Pseudogenes for OR6M1 Gene

genes like me logo Genes that share paralogs with OR6M1: view

Variants for OR6M1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6M1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs4936845 -- p.Thr276Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6M1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR6M1 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.29; 92.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6M1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6M1
Leiden Open Variation Database (LOVD)
OR6M1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR6M1 Gene

Disorders for OR6M1 Gene

Additional Disease Information for OR6M1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR6M1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6M1 Gene

Publications for OR6M1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. (PMID: 30232004) Abraham CG … Espinosa JM (Cell reports 2018) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

ExternalLinks

View latest publications for OR6M1 gene in Mastermind

Products for OR6M1 Gene

Sources for OR6M1 Gene