Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6K6 Gene

Aliases for OR6K6 Gene

  • Olfactory Receptor Family 6 Subfamily K Member 6 2 3 5
  • Olfactory Receptor OR1-21 3 4
  • Olfactory Receptor 6K6 3 4
  • Olfactory Receptor, Family 6, Subfamily K, Member 6 2
  • OR1-21 3
  • OR6K6 5

External Ids for OR6K6 Gene

Previous GeneCards Identifiers for OR6K6 Gene

  • GC01U990387
  • GC01P155943
  • GC01P155536
  • GC01P156991
  • GC01P158724

Summaries for OR6K6 Gene

Entrez Gene Summary for OR6K6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6K6 Gene

OR6K6 (Olfactory Receptor Family 6 Subfamily K Member 6) is a Protein Coding gene. Diseases associated with OR6K6 include Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex and Intestinal Atresia. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR6K3.

UniProtKB/Swiss-Prot Summary for OR6K6 Gene

Gene Wiki entry for OR6K6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6K6 Gene

Genomics for OR6K6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6K6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J158793 Promoter/Enhancer 0.8 Ensembl dbSUPER 10.3 +39.2 39181 0.2 CTCF REST SMC3 RAD21 ZNF143 OR6N1 SPTA1 OR6K6 OR10X1 OR2AQ1P OR6N2 MNDA HSALNG0007742
GH01J158732 Enhancer 0.7 Ensembl 10.9 -21.9 -21919 1.6 NCOR1 ZNF592 TAL1 STAT5A SMARCA4 FOXM1 RAD51 HDAC2 ZEB2 TCF12 OR6K2 OR6K4P OR6N1 OR6K6 SPTA1 OR6N2 L13713-017 OR6K3
GH01J158729 Enhancer 0.5 Ensembl 10.9 -24.7 -24719 1.6 ZNF316 SMARCE1 PKNOX1 MTA2 MTA1 SMARCA4 EMSY OR6K2 OR6N1 OR6K6 OR6K4P SPTA1 OR6N2 OR6K3 L13713-017
GH01J158674 Enhancer 0.3 Ensembl 9.9 -79.6 -79619 1 NFIC NFIB OR6K2 OR6N1 OR6N2 OR6K6 MN308822 SPTA1 OR10Z1
GH01J158654 Enhancer 0.3 ENCODE 9.8 -99.8 -99781 0.8 REST SPI1 SPTA1 OR6K2 OR6N1 OR6P1 OR6K6 MN308821 MN308822 OR10Z1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6K6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6K6

Top Transcription factor binding sites by QIAGEN in the OR6K6 gene promoter:
  • Cart-1
  • E47
  • GATA-1
  • GATA-2
  • IRF-7A
  • Meis-1
  • Meis-1a
  • Meis-1b
  • S8
  • Tal-1

Genomic Locations for OR6K6 Gene

Latest Assembly
chr1:158,754,720-158,755,891
(GRCh38/hg38)
Size:
1,172 bases
Orientation:
Plus strand

Previous Assembly
chr1:158,724,606-158,725,637
(GRCh37/hg19 by Entrez Gene)
Size:
1,032 bases
Orientation:
Plus strand

chr1:158,724,510-158,725,681
(GRCh37/hg19 by Ensembl)
Size:
1,172 bases
Orientation:
Plus strand

Genomic View for OR6K6 Gene

Genes around OR6K6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6K6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6K6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6K6 Gene

Proteins for OR6K6 Gene

  • Protein details for OR6K6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGW6-OR6K6_HUMAN
    Recommended name:
    Olfactory receptor 6K6
    Protein Accession:
    Q8NGW6
    Secondary Accessions:
    • B9EIM8
    • Q5VUU9
    • Q6IFR4

    Protein attributes for OR6K6 Gene

    Size:
    343 amino acids
    Molecular mass:
    38362 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05876.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR6K6 Gene

Post-translational modifications for OR6K6 Gene

  • Glycosylation at Asn33
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6K6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6K6 Gene

Domains & Families for OR6K6 Gene

Gene Families for OR6K6 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6K6 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6K6 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-21 (OR6K6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGW6

UniProtKB/Swiss-Prot:

OR6K6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6K6: view

Function for OR6K6 Gene

Molecular function for OR6K6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6K6 Gene

Gene Ontology (GO) - Molecular Function for OR6K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR6K6: view
genes like me logo Genes that share phenotypes with OR6K6: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6K6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6K6 Gene

Localization for OR6K6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6K6 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6K6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with OR6K6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6K6 Gene

Pathways & Interactions for OR6K6 Gene

genes like me logo Genes that share pathways with OR6K6: view

Pathways by source for OR6K6 Gene

Interacting Proteins for OR6K6 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000357126 Q8NGW6-OR6K6_HUMAN for OR6K6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR6K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA 21873635
genes like me logo Genes that share ontologies with OR6K6: view

No data available for SIGNOR curated interactions for OR6K6 Gene

Drugs & Compounds for OR6K6 Gene

No Compound Related Data Available

Transcripts for OR6K6 Gene

mRNA/cDNA for OR6K6 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6K6

Alternative Splicing Database (ASD) splice patterns (SP) for OR6K6 Gene

No ASD Table

Relevant External Links for OR6K6 Gene

GeneLoc Exon Structure for
OR6K6

Expression for OR6K6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6K6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6K6

SOURCE GeneReport for Unigene cluster for OR6K6 Gene:

Hs.553591
genes like me logo Genes that share expression patterns with OR6K6: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6K6 Gene

Orthologs for OR6K6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6K6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC469535 29
  • 99.13 (n)
OR6K6 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC508766 29
  • 87.43 (n)
OR6K6 30
  • 84 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or6k6 45 Olfr231 29 16 30
  • 83.71 (n)
OneToOne
Or6h1-ps 45 Olfr428-ps1
  • chr1:174,094,964-174,095,431
Rat
(Rattus norvegicus)
Mammalia Olr1592 29
  • 83.06 (n)
Dog
(Canis familiaris)
Mammalia OR6K6 30
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR6K6 30
  • 78 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 37 (a)
ManyToMany
Species where no ortholog for OR6K6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6K6 Gene

ENSEMBL:
Gene Tree for OR6K6 (if available)
TreeFam:
Gene Tree for OR6K6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6K6: view image
Alliance of Genome Resources:
Additional Orthologs for OR6K6

Paralogs for OR6K6 Gene

(454) SIMAP similar genes for OR6K6 Gene using alignment to 1 proteins:

  • OR6K6_HUMAN
genes like me logo Genes that share paralogs with OR6K6: view

Variants for OR6K6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6K6 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs16840974 -- p.Glu39Asp
rs16840976 -- p.His49Tyr
rs16840980 -- p.Gly80Asp
rs16840991 -- p.Ser134Leu
rs16841001 -- p.Arg159Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6K6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR6K6 Gene

Variant ID Type Subtype PubMed ID
dgv56e214 CNV loss 21293372
dgv589n54 CNV loss 21841781
dgv591n54 CNV loss 21841781
dgv592n54 CNV loss 21841781
esv2562592 CNV insertion 19546169
esv2764266 CNV loss 21179565
nsv1002401 CNV loss 25217958

Variation tolerance for OR6K6 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.48; 97.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6K6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6K6
Leiden Open Variation Database (LOVD)
OR6K6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6K6 Gene

Disorders for OR6K6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR6K6 Gene - From: COP

Disorder Aliases PubMed IDs
bladder exstrophy-epispadias-cloacal exstrophy complex
  • exstrophy-epispadias complex
intestinal atresia
- elite association - COSMIC cancer census association via MalaCards
Search OR6K6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR6K6

genes like me logo Genes that share disorders with OR6K6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR6K6 Gene

Publications for OR6K6 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR6K6 Gene

Sources for OR6K6 Gene