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Aliases for OR6K3 Gene

Aliases for OR6K3 Gene

  • Olfactory Receptor Family 6 Subfamily K Member 3 2 3 5
  • Olfactory Receptor OR1-18 3 4
  • Olfactory Receptor, Family 6, Subfamily K, Member 3 2
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 6K3 3
  • OR1-18 3

External Ids for OR6K3 Gene

Previous GeneCards Identifiers for OR6K3 Gene

  • GC01U990390
  • GC01M155905
  • GC01M155500
  • GC01M156953

Summaries for OR6K3 Gene

Entrez Gene Summary for OR6K3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6K3 Gene

OR6K3 (Olfactory Receptor Family 6 Subfamily K Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR6K6.

UniProtKB/Swiss-Prot for OR6K3 Gene

  • Odorant receptor.

Additional gene information for OR6K3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6K3 Gene

Genomics for OR6K3 Gene

GeneHancer (GH) Regulatory Elements for OR6K3 Gene

Promoters and enhancers for OR6K3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I159141 Enhancer 0.8 FANTOM5 Ensembl 18.3 -421.3 -421269 0.8 MXI1 SP1 JUND ATF3 POLR3A ZBTB48 POLR2A FOS PRDM10 ZBTB17 GC01M159143 TRR-TCT4-1 OR6K3 OR6N1 FCER1A CADM3 ACKR1 CADM3-AS1 OR6N2 OR10J5
GH01I159172 Enhancer 0.9 FANTOM5 Ensembl ENCODE 3.7 -452.4 -452364 1 SP1 ZNF143 SIN3A CTBP2 EBF1 CADM3 ACKR1 CADM3-AS1 AIM2 ENSG00000212161 OR10J3 OR6N1 OR6K3 FCER1A OR6N2
GH01I158972 Enhancer 0.4 FANTOM5 5.8 -252.3 -252311 0.2 CTCF RAD21 FCER1A OR6N1 OR6K3 OR10Z1 DUSP23 OR10R2 OR10X1 OR6N2 PYHIN1 OR6P1
GH01I159024 Enhancer 0.5 FANTOM5 dbSUPER 3.5 -304.4 -304408 0.5 OR6N1 OR6K3 FCER1A OR6N2 OR10Z1 IFI16 OR10X1 OR6P1 MNDA GC01M159011
GH01I158689 Enhancer 0.7 FANTOM5 1.9 +31.4 31437 0.1 TEAD4 TAL1 CC2D1A TCF12 GATA2 NCOR1 CBFA2T2 SMARCE1 MTA2 CBFA2T3 SPTA1 OR6N1 OR6K3 OR10K1 OR10Z1 OR6K1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR6K3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6K3 gene promoter:

Genomic Locations for OR6K3 Gene

Genomic Locations for OR6K3 Gene
4,394 bases
Minus strand

Genomic View for OR6K3 Gene

Genes around OR6K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6K3 Gene

Proteins for OR6K3 Gene

  • Protein details for OR6K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6K3
    Protein Accession:
    Secondary Accessions:
    • Q5VUV0
    • Q6IFR5

    Protein attributes for OR6K3 Gene

    331 amino acids
    Molecular mass:
    37352 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05859.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OR6K3 Gene

Post-translational modifications for OR6K3 Gene

  • Glycosylation at Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6K3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6K3 Gene

Domains & Families for OR6K3 Gene

Gene Families for OR6K3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6K3 Gene

Suggested Antigen Peptide Sequences for OR6K3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6K3: view

Function for OR6K3 Gene

Molecular function for OR6K3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6K3: view
genes like me logo Genes that share phenotypes with OR6K3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6K3 Gene

Localization for OR6K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6K3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6K3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6K3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6K3 Gene

Pathways & Interactions for OR6K3 Gene

genes like me logo Genes that share pathways with OR6K3: view

Pathways by source for OR6K3 Gene

Interacting Proteins for OR6K3 Gene

Gene Ontology (GO) - Biological Process for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR6K3: view

No data available for SIGNOR curated interactions for OR6K3 Gene

Drugs & Compounds for OR6K3 Gene

No Compound Related Data Available

Transcripts for OR6K3 Gene

mRNA/cDNA for OR6K3 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6K3 Gene

No ASD Table

Relevant External Links for OR6K3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6K3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6K3 Gene

mRNA differential expression in normal tissues according to GTEx for OR6K3 Gene

This gene is overexpressed in Lung (x22.6), Whole Blood (x19.0), and Testis (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of OR6K3 Gene:


SOURCE GeneReport for Unigene cluster for OR6K3 Gene:

genes like me logo Genes that share expression patterns with OR6K3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6K3 Gene

Orthologs for OR6K3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6K3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC744589 33
  • 98.52 (n)
OR6K3 34
  • 93 (a)
(Canis familiaris)
Mammalia LOC607515 33
  • 84.74 (n)
OR6K3 34
  • 79 (a)
(Bos Taurus)
Mammalia OR6K3 34
  • 79 (a)
(Mus musculus)
Mammalia Olfr424 34
  • 77 (a)
Or6k3 51 Olfr258
  • chr1:174,142,233-174,143,147
Or6k8-ps 51 Olfr421-ps1
  • chr1:174,151,518-174,152,462
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
-- 34
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
Species where no ortholog for OR6K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6K3 Gene

Gene Tree for OR6K3 (if available)
Gene Tree for OR6K3 (if available)

Paralogs for OR6K3 Gene

Paralogs for OR6K3 Gene

(454) SIMAP similar genes for OR6K3 Gene using alignment to 1 proteins: Pseudogenes for OR6K3 Gene

genes like me logo Genes that share paralogs with OR6K3: view

Variants for OR6K3 Gene

Sequence variations from dbSNP and Humsavar for OR6K3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000098347 -- 158,719,470(-) C/G upstream_transcript_variant
rs1000356155 -- 158,717,626(-) A/C coding_sequence_variant, missense_variant
rs1000932293 -- 158,719,107(-) T/G upstream_transcript_variant
rs1001552567 -- 158,716,846(-) G/A downstream_transcript_variant
rs1002238789 -- 158,716,837(-) G/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR6K3 Gene

Variant ID Type Subtype PubMed ID
dgv445n100 CNV gain 25217958
dgv589n54 CNV loss 21841781
nsv547987 CNV loss 21841781

Variation tolerance for OR6K3 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.02; 95.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6K3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6K3 Gene

Disorders for OR6K3 Gene

Additional Disease Information for OR6K3

No disorders were found for OR6K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6K3 Gene

Publications for OR6K3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 4 58

Products for OR6K3 Gene

Sources for OR6K3 Gene

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