Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6K3 Gene

Aliases for OR6K3 Gene

  • Olfactory Receptor Family 6 Subfamily K Member 3 2 3 5
  • Olfactory Receptor OR1-18 3 4
  • Olfactory Receptor 6K3 3 4
  • Olfactory Receptor, Family 6, Subfamily K, Member 3 2
  • Seven Transmembrane Helix Receptor 3
  • OR1-18 3
  • OR6K3 5

External Ids for OR6K3 Gene

Previous GeneCards Identifiers for OR6K3 Gene

  • GC01U990390
  • GC01M155905
  • GC01M155500
  • GC01M156953

Summaries for OR6K3 Gene

Entrez Gene Summary for OR6K3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6K3 Gene

OR6K3 (Olfactory Receptor Family 6 Subfamily K Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR6K6.

UniProtKB/Swiss-Prot Summary for OR6K3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6K3 Gene

Genomics for OR6K3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6K3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159141 Enhancer 0.5 FANTOM5 18.3 -421.4 -421445 0.4 ZBTB48 TCF7L2 SP1 ZBTB17 PRDM10 POLR2A TRR-TCT4-1 OR6K3 OR6N1 FCER1A OR6N2 OR10J5 OR10J1 CADM3 AIM2 PYDC5
GH01J159171 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 3.7 -451.7 -451681 2.8 ZIC2 SIN3A PRDM10 EGR1 SP1 EZH2 ZNF143 POLR2A CADM3 ACKR1 AIM2 CADM3-AS1 ENSG00000212161 OR10J3 OR6N1 OR6K3 FCER1A OR6N2
GH01J158972 Enhancer 0.4 FANTOM5 5.8 -252.3 -252311 0.2 CTCF SMC3 RAD21 FCER1A OR6N1 OR6K3 OR10Z1 DUSP23 OR10R2 OR10X1 OR6N2 PYHIN1 OR6P1
GH01J158689 Enhancer 1.1 FANTOM5 Ensembl dbSUPER 2 +29.9 29919 4.4 NCOR1 NFIC TAL1 NUFIP1 STAT5A THRAP3 SMARCA4 FOXM1 HDAC2 TCF12 SPTA1 OR6K4P OR6N1 OR6K3 OR10K1 OR10Z1 OR6K1P OR6K2
GH01J159024 Enhancer 0.4 FANTOM5 dbSUPER 3.5 -304.4 -304408 0.5 OR6N1 OR6K3 FCER1A OR6N2 OR10Z1 IFI16 OR10X1 OR6P1 MNDA HSALNG0007749
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6K3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6K3

Top Transcription factor binding sites by QIAGEN in the OR6K3 gene promoter:
  • AML1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • IRF-7A
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for OR6K3 Gene

Latest Assembly
chr1:158,716,327-158,720,720
(GRCh38/hg38)
Size:
4,394 bases
Orientation:
Minus strand

Previous Assembly
chr1:158,686,117-158,690,510
(GRCh37/hg19 by Entrez Gene)
Size:
4,394 bases
Orientation:
Minus strand

chr1:158,686,958-158,687,953
(GRCh37/hg19 by Ensembl)
Size:
996 bases
Orientation:
Minus strand

Genomic View for OR6K3 Gene

Genes around OR6K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6K3 Gene

Proteins for OR6K3 Gene

  • Protein details for OR6K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGY3-OR6K3_HUMAN
    Recommended name:
    Olfactory receptor 6K3
    Protein Accession:
    Q8NGY3
    Secondary Accessions:
    • Q5VUV0
    • Q6IFR5

    Protein attributes for OR6K3 Gene

    Size:
    331 amino acids
    Molecular mass:
    37352 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05859.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for OR6K3 Gene

Post-translational modifications for OR6K3 Gene

  • Glycosylation at Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6K3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6K3 Gene

Domains & Families for OR6K3 Gene

Gene Families for OR6K3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6K3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6K3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-18 (OR6K3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGY3

UniProtKB/Swiss-Prot:

OR6K3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6K3: view

Function for OR6K3 Gene

Molecular function for OR6K3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6K3 Gene

Gene Ontology (GO) - Molecular Function for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR6K3: view
genes like me logo Genes that share phenotypes with OR6K3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6K3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6K3 Gene

Localization for OR6K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6K3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6K3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with OR6K3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6K3 Gene

Pathways & Interactions for OR6K3 Gene

genes like me logo Genes that share pathways with OR6K3: view

Pathways by source for OR6K3 Gene

Interacting Proteins for OR6K3 Gene

Gene Ontology (GO) - Biological Process for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA 21873635
genes like me logo Genes that share ontologies with OR6K3: view

No data available for SIGNOR curated interactions for OR6K3 Gene

Drugs & Compounds for OR6K3 Gene

No Compound Related Data Available

Transcripts for OR6K3 Gene

mRNA/cDNA for OR6K3 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6K3

Alternative Splicing Database (ASD) splice patterns (SP) for OR6K3 Gene

No ASD Table

Relevant External Links for OR6K3 Gene

GeneLoc Exon Structure for
OR6K3

Expression for OR6K3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6K3 Gene

mRNA differential expression in normal tissues according to GTEx for OR6K3 Gene

This gene is overexpressed in Lung (x22.6), Whole Blood (x19.0), and Testis (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6K3

SOURCE GeneReport for Unigene cluster for OR6K3 Gene:

Hs.554488
genes like me logo Genes that share expression patterns with OR6K3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6K3 Gene

Orthologs for OR6K3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6K3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC744589 29
  • 98.52 (n)
OR6K3 30
  • 93 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC607515 29
  • 84.74 (n)
OR6K3 30
  • 79 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR6K3 30
  • 79 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Olfr424 30
  • 77 (a)
OneToOne
Or6k3 45 Olfr258
  • chr1:174,142,233-174,143,147
Or6k8-ps 45 Olfr421-ps1
  • chr1:174,151,518-174,152,462
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 73 (a)
OneToMany
-- 30
  • 72 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 34 (a)
ManyToMany
Species where no ortholog for OR6K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6K3 Gene

ENSEMBL:
Gene Tree for OR6K3 (if available)
TreeFam:
Gene Tree for OR6K3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6K3: view image
Alliance of Genome Resources:
Additional Orthologs for OR6K3

Paralogs for OR6K3 Gene

(454) SIMAP similar genes for OR6K3 Gene using alignment to 1 proteins:

  • OR6K3_HUMAN

Pseudogenes.org Pseudogenes for OR6K3 Gene

genes like me logo Genes that share paralogs with OR6K3: view

Variants for OR6K3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6K3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs151330882 -- p.Val216Met
rs16840675 -- p.Arg308Lys
rs28568406 -- p.Pro264Leu
rs857702 -- p.Asp279Asn
rs857703 -- p.Pro244Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6K3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR6K3 Gene

Variant ID Type Subtype PubMed ID
dgv445n100 CNV gain 25217958
dgv589n54 CNV loss 21841781
nsv547987 CNV loss 21841781

Variation tolerance for OR6K3 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.02; 95.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6K3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6K3
Leiden Open Variation Database (LOVD)
OR6K3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6K3 Gene

Disorders for OR6K3 Gene

Additional Disease Information for OR6K3

No disorders were found for OR6K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6K3 Gene

Publications for OR6K3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. (PMID: 32126975) Barnes IHA … Frankish A (BMC genomics 2020) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 4

Products for OR6K3 Gene

Sources for OR6K3 Gene