Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6K2 Gene

Aliases for OR6K2 Gene

  • Olfactory Receptor Family 6 Subfamily K Member 2 2 3 5
  • Olfactory Receptor OR1-17 3 4
  • Olfactory Receptor 6K2 3 4
  • Olfactory Receptor, Family 6, Subfamily K, Member 2 2
  • OR1-17 3

External Ids for OR6K2 Gene

Previous GeneCards Identifiers for OR6K2 Gene

  • GC01U990391
  • GC01M155482
  • GC01M156937

Summaries for OR6K2 Gene

Entrez Gene Summary for OR6K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6K2 Gene

OR6K2 (Olfactory Receptor Family 6 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR6K3.

UniProtKB/Swiss-Prot Summary for OR6K2 Gene

Gene Wiki entry for OR6K2 Gene

Additional gene information for OR6K2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6K2 Gene

Genomics for OR6K2 Gene

GeneHancer (GH) Regulatory Elements for OR6K2 Gene

Promoters and enhancers for OR6K2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159067 Enhancer 1 ENCODE dbSUPER 9.8 -368.0 -367991 3.1 SP1 FOS EP300 JUND MEF2C RCOR1 CTBP1 TRIM22 POLR2A BCL11A OR6K2 AIM2 lnc-AIM2-2 RAD1P2 lnc-OR10J3-2
GH01J158732 Enhancer 0.7 Ensembl 11.3 -32.1 -32149 1.6 TOE1 CTBP1 NCOR1 ZNF592 TAL1 STAT5A HDAC2 FOXM1 TCF12 MITF OR6K2 OR6K4P OR6N1 OR6K6 SPTA1 OR6N2 L13713-017
GH01J159054 Enhancer 0.8 Ensembl ENCODE dbSUPER 9.2 -357.2 -357249 9 CTCF GABPA FOS SPI1 POLR2A GABPB1 LOC105371461 lnc-AIM2-2 OR6K2 AIM2 PIGM IFI16
GH01J158729 Enhancer 0.5 Ensembl 11.4 -29.3 -29349 1.6 ZNF316 IRF1 PBX2 GATA2 SMARCE1 PKNOX1 MTA2 MTA1 SMARCA4 EMSY OR6K2 OR6N1 OR6K6 OR6K4P SPTA1 OR6N2 L13713-017
GH01J158806 Promoter/Enhancer 0.6 Ensembl dbSUPER 10.1 -104.0 -104049 0.2 REST OR6N2 OR6K2 OR10AA1P OR2AQ1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6K2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6K2

Top Transcription factor binding sites by QIAGEN in the OR6K2 gene promoter:
  • AML1a
  • AP-1
  • Brachyury
  • FOXJ2
  • FOXJ2 (long isoform)
  • Ik-3
  • Olf-1
  • PPAR-gamma1
  • PPAR-gamma2
  • XBP-1

Genomic Locations for OR6K2 Gene

Genomic Locations for OR6K2 Gene
chr1:158,699,678-158,700,652
(GRCh38/hg38)
Size:
975 bases
Orientation:
Minus strand
chr1:158,669,369-158,670,486
(GRCh37/hg19)
Size:
1,118 bases
Orientation:
Minus strand

Genomic View for OR6K2 Gene

Genes around OR6K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6K2 Gene

Proteins for OR6K2 Gene

  • Protein details for OR6K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGY2-OR6K2_HUMAN
    Recommended name:
    Olfactory receptor 6K2
    Protein Accession:
    Q8NGY2
    Secondary Accessions:
    • B9EH33
    • Q6IFR6

    Protein attributes for OR6K2 Gene

    Size:
    324 amino acids
    Molecular mass:
    36513 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6K2 Gene

Post-translational modifications for OR6K2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6K2 Gene

Domains & Families for OR6K2 Gene

Gene Families for OR6K2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6K2 Gene

Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR6K2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-17 (OR6K2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGY2

UniProtKB/Swiss-Prot:

OR6K2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6K2: view

Function for OR6K2 Gene

Molecular function for OR6K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6K2 Gene

Gene Ontology (GO) - Molecular Function for OR6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6K2: view
genes like me logo Genes that share phenotypes with OR6K2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6K2 Gene

Localization for OR6K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6K2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6K2 Gene

Pathways & Interactions for OR6K2 Gene

genes like me logo Genes that share pathways with OR6K2: view

Pathways by source for OR6K2 Gene

Interacting Proteins for OR6K2 Gene

;

Gene Ontology (GO) - Biological Process for OR6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6K2: view

No data available for SIGNOR curated interactions for OR6K2 Gene

Drugs & Compounds for OR6K2 Gene

No Compound Related Data Available

Transcripts for OR6K2 Gene

mRNA/cDNA for OR6K2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6K2 Gene

No ASD Table

Relevant External Links for OR6K2 Gene

GeneLoc Exon Structure for
OR6K2

Expression for OR6K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6K2 Gene

Protein differential expression in normal tissues from HIPED for OR6K2 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR6K2 Gene



Protein tissue co-expression partners for OR6K2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6K2

SOURCE GeneReport for Unigene cluster for OR6K2 Gene:

Hs.554489
genes like me logo Genes that share expression patterns with OR6K2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6K2 Gene

Orthologs for OR6K2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6K2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC744555 30
  • 98.35 (n)
OR6K2 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR6K2 31 30
  • 87.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OR6K2 31
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or6k2 47 Olfr420 17 31 30
  • 84.57 (n)
rat
(Rattus norvegicus)
Mammalia Olr1596 30
  • 83.17 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 79 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 37 (a)
ManyToMany
Species where no ortholog for OR6K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6K2 Gene

ENSEMBL:
Gene Tree for OR6K2 (if available)
TreeFam:
Gene Tree for OR6K2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6K2: view image

Paralogs for OR6K2 Gene

(447) SIMAP similar genes for OR6K2 Gene using alignment to 1 proteins:

  • OR6K2_HUMAN

Pseudogenes.org Pseudogenes for OR6K2 Gene

genes like me logo Genes that share paralogs with OR6K2: view

Variants for OR6K2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6K2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1553241101 Not Provided: not provided 158,699,983(-) C/CT FRAMESHIFT_VARIANT
rs193920807 Uncertain Significance: Malignant tumor of prostate 158,699,706(-) C/A MISSENSE_VARIANT
rs413029 - p.Arg6Gln
rs423141 - p.Leu156Val
rs6686179 - p.Ile159Phe

Additional dbSNP identifiers (rs#s) for OR6K2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR6K2 Gene

Variant ID Type Subtype PubMed ID
dgv445n100 CNV gain 25217958
nsv547987 CNV loss 21841781

Variation tolerance for OR6K2 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6K2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6K2 Gene

Disorders for OR6K2 Gene

Additional Disease Information for OR6K2

No disorders were found for OR6K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6K2 Gene

Publications for OR6K2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for OR6K2 Gene

Sources for OR6K2 Gene