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Aliases for OR6K2 Gene

Aliases for OR6K2 Gene

  • Olfactory Receptor Family 6 Subfamily K Member 2 2 3 5
  • Olfactory Receptor OR1-17 3 4
  • Olfactory Receptor, Family 6, Subfamily K, Member 2 2
  • Olfactory Receptor 6K2 3
  • OR1-17 3

External Ids for OR6K2 Gene

Previous GeneCards Identifiers for OR6K2 Gene

  • GC01U990391
  • GC01M155482
  • GC01M156937

Summaries for OR6K2 Gene

Entrez Gene Summary for OR6K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6K2 Gene

OR6K2 (Olfactory Receptor Family 6 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR6K6.

UniProtKB/Swiss-Prot for OR6K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR6K2 Gene

Additional gene information for OR6K2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6K2 Gene

Genomics for OR6K2 Gene

GeneHancer (GH) Regulatory Elements for OR6K2 Gene

Promoters and enhancers for OR6K2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I159067 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.8 -368.0 -367991 3.1 HDAC1 PKNOX1 BMI1 BATF IRF4 TCF12 SCRT2 ATF7 ETV6 FOS OR6K2 AIM2 LOC105371461 RAD1P2
GH01I158808 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 9.5 -109.2 -109249 2.6 CEBPB OR10AA1P MNDA OR6N2 OR6N1 OR6K2 PYHIN1 IFI16
GH01I159054 Enhancer 0.6 ENCODE dbSUPER 9.1 -354.5 -354458 2.2 POLR2A GABPB1 GABPA OR6K2 AIM2 LOC105371461 GC01M159011 IFI16
GH01I159056 Enhancer 0.6 ENCODE dbSUPER 9.1 -355.9 -355914 0.2 CTCF GABPB1 GABPA LOC105371461 OR6K2 GC01M159011
GH01I158654 Enhancer 0.5 Ensembl ENCODE 10.8 +45.7 45713 0.8 REST SPTA1 OR6K2 OR6N1 OR6P1 OR6K6 OR10Z1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR6K2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6K2 gene promoter:

Genomic Locations for OR6K2 Gene

Genomic Locations for OR6K2 Gene
975 bases
Minus strand

Genomic View for OR6K2 Gene

Genes around OR6K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6K2 Gene

Proteins for OR6K2 Gene

  • Protein details for OR6K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6K2
    Protein Accession:
    Secondary Accessions:
    • B9EH33
    • Q6IFR6

    Protein attributes for OR6K2 Gene

    324 amino acids
    Molecular mass:
    36513 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6K2 Gene

Post-translational modifications for OR6K2 Gene

Other Protein References for OR6K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6K2 Gene

Domains & Families for OR6K2 Gene

Gene Families for OR6K2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for OR6K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6K2: view

Function for OR6K2 Gene

Molecular function for OR6K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6K2: view
genes like me logo Genes that share phenotypes with OR6K2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6K2 Gene

Localization for OR6K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6K2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6K2 Gene

Pathways & Interactions for OR6K2 Gene

genes like me logo Genes that share pathways with OR6K2: view

Pathways by source for OR6K2 Gene

Interacting Proteins for OR6K2 Gene

Gene Ontology (GO) - Biological Process for OR6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR6K2: view

No data available for SIGNOR curated interactions for OR6K2 Gene

Drugs & Compounds for OR6K2 Gene

No Compound Related Data Available

Transcripts for OR6K2 Gene

mRNA/cDNA for OR6K2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6K2 Gene

No ASD Table

Relevant External Links for OR6K2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6K2 Gene

Protein differential expression in normal tissues from HIPED for OR6K2 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR6K2 Gene

Protein tissue co-expression partners for OR6K2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6K2 Gene:


SOURCE GeneReport for Unigene cluster for OR6K2 Gene:

genes like me logo Genes that share expression patterns with OR6K2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6K2 Gene

Orthologs for OR6K2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6K2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC744555 33
  • 98.35 (n)
OR6K2 34
  • 96 (a)
(Bos Taurus)
Mammalia OR6K2 33 34
  • 87.47 (n)
(Canis familiaris)
Mammalia OR6K2 34
  • 86 (a)
(Mus musculus)
Mammalia Or6k2 51 Olfr420 33 16 34
  • 84.57 (n)
(Rattus norvegicus)
Mammalia Olr1596 33
  • 83.17 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
-- 34
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
Species where no ortholog for OR6K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6K2 Gene

Gene Tree for OR6K2 (if available)
Gene Tree for OR6K2 (if available)

Paralogs for OR6K2 Gene

Paralogs for OR6K2 Gene

(447) SIMAP similar genes for OR6K2 Gene using alignment to 1 proteins: Pseudogenes for OR6K2 Gene

genes like me logo Genes that share paralogs with OR6K2: view

Variants for OR6K2 Gene

Sequence variations from dbSNP and Humsavar for OR6K2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs193920807 uncertain-significance, Malignant tumor of prostate 158,699,706(-) C/A coding_sequence_variant, missense_variant
rs1004090321 -- 158,701,973(-) A/G upstream_transcript_variant
rs1005113815 -- 158,699,546(-) T/C downstream_transcript_variant
rs1005448640 -- 158,700,955(-) C/T upstream_transcript_variant
rs1007127654 -- 158,702,196(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR6K2 Gene

Variant ID Type Subtype PubMed ID
nsv547987 CNV loss 21841781
dgv445n100 CNV gain 25217958

Variation tolerance for OR6K2 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6K2 Gene

Disorders for OR6K2 Gene

Additional Disease Information for OR6K2

No disorders were found for OR6K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6K2 Gene

Publications for OR6K2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR6K2 Gene

Sources for OR6K2 Gene

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