Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6J1 Gene

Aliases for OR6J1 Gene

  • Olfactory Receptor Family 6 Subfamily J Member 1 2 3 5
  • Olfactory Receptor 6J1 3 3 4
  • Olfactory Receptor 6J2 3 4
  • OR6J2 3 4
  • Olfactory Receptor, Family 6, Subfamily J, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 6 Subfamily J Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 6, Subfamily J, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 6, Subfamily J, Member 1 2
  • Olfactory Receptor, Family 6, Subfamily J, Member 2 3
  • Seven Transmembrane Helix Receptor 3
  • OR6J1P 3
  • OR6J1 5

External Ids for OR6J1 Gene

Previous HGNC Symbols for OR6J1 Gene

  • OR6J2
  • OR6J1P

Previous GeneCards Identifiers for OR6J1 Gene

  • GC14M021094
  • GC14M022172
  • GC14M023102

Summaries for OR6J1 Gene

Entrez Gene Summary for OR6J1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR6J1 Gene

OR6J1 (Olfactory Receptor Family 6 Subfamily J Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6M1.

UniProtKB/Swiss-Prot Summary for OR6J1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6J1 Gene

Genomics for OR6J1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6J1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J022645 Enhancer 0.3 Ensembl 250.7 -1.1 -1149 0.2 IKZF1 OR6J1 ABHD4 MMP14 lnc-ABHD4-3 OXA1L
GH14J022472 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.9 +122.3 122291 99 BCLAF1 SP1 ZNF207 MYC ZNF654 NCOR1 ZNF600 IKZF1 SSRP1 JUND LOC112267867 TRAJ21 TRAJ22 TRAJ23 LINC02332 ACIN1 RBM23 C14orf93 NGDN ABHD4
GH14J022587 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +54.7 54652 4.6 ZNF207 MYC IKZF1 SSRP1 ZNF592 ZMYM3 KLF9 CEBPA POLR2A CHD4 DAD1 lnc-OR6J1-2 ACIN1 RBM23 AP1G2-AS1 MMP14 NGDN ABHD4 C14orf93 PABPN1
GH14J022612 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.4 +30.4 30420 3.1 ZNF600 JUND ATF3 CEBPB ZNF639 IRF3 CTCF MAX EP300 CTBP1 HSALNG0099962 piR-48209-188 OR6J1 ABHD4
GH14J022386 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.8 +254.3 254306 6.7 BCLAF1 ZNF654 ZIC2 ZBTB10 CTCF REST ZNF592 TRIM22 ZNF341 ZNF217 MMP14 MRPL52 SLC7A7 OR6J1 TRAV38-2DV8 Z46652 Z46638 TRDV2 TRAV41 LOC105370401
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6J1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6J1

Genomic Locations for OR6J1 Gene

Latest Assembly
chr14:22,630,929-22,644,352
(GRCh38/hg38)
Size:
13,424 bases
Orientation:
Minus strand

Previous Assembly
chr14:23,099,834-23,113,561
(GRCh37/hg19 by Entrez Gene)
Size:
13,728 bases
Orientation:
Minus strand

chr14:23,102,673-23,103,716
(GRCh37/hg19 by Ensembl)
Size:
1,044 bases
Orientation:
Minus strand

Genomic View for OR6J1 Gene

Genes around OR6J1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6J1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6J1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6J1 Gene

Proteins for OR6J1 Gene

  • Protein details for OR6J1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC5-OR6J1_HUMAN
    Recommended name:
    Olfactory receptor 6J1
    Protein Accession:
    Q8NGC5

    Protein attributes for OR6J1 Gene

    Size:
    347 amino acids
    Molecular mass:
    38693 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6J1 Gene

Post-translational modifications for OR6J1 Gene

  • Glycosylation at Asn3

Other Protein References for OR6J1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6J1 Gene

Domains & Families for OR6J1 Gene

Gene Families for OR6J1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6J1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6J1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 6J2 (OR6J1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGC5

UniProtKB/Swiss-Prot:

OR6J1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6J1: view

Function for OR6J1 Gene

Molecular function for OR6J1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6J1 Gene

Gene Ontology (GO) - Molecular Function for OR6J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR6J1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6J1 Gene

Localization for OR6J1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6J1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6J1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6J1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6J1 Gene

Pathways & Interactions for OR6J1 Gene

genes like me logo Genes that share pathways with OR6J1: view

Pathways by source for OR6J1 Gene

Interacting Proteins for OR6J1 Gene

Gene Ontology (GO) - Biological Process for OR6J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6J1: view

No data available for SIGNOR curated interactions for OR6J1 Gene

Drugs & Compounds for OR6J1 Gene

No Compound Related Data Available

Transcripts for OR6J1 Gene

mRNA/cDNA for OR6J1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR6J1 Gene

No ASD Table

Relevant External Links for OR6J1 Gene

GeneLoc Exon Structure for
OR6J1

Expression for OR6J1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6J1 Gene

Protein differential expression in normal tissues from HIPED for OR6J1 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR6J1 Gene



Protein tissue co-expression partners for OR6J1 Gene

genes like me logo Genes that share expression patterns with OR6J1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6J1 Gene

Orthologs for OR6J1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6J1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR6J1 30
  • 98 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 85 (a)
OneToMany
-- 30
  • 76 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia OR6J1 30
  • 79 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 57 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr214 30
  • 43 (a)
ManyToMany
Species where no ortholog for OR6J1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6J1 Gene

ENSEMBL:
Gene Tree for OR6J1 (if available)
TreeFam:
Gene Tree for OR6J1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6J1: view image
Alliance of Genome Resources:
Additional Orthologs for OR6J1

Paralogs for OR6J1 Gene

(440) SIMAP similar genes for OR6J1 Gene using alignment to 1 proteins:

  • OR6J1_HUMAN

Pseudogenes.org Pseudogenes for OR6J1 Gene

genes like me logo Genes that share paralogs with OR6J1: view

Variants for OR6J1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6J1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR6J1 Gene

Gene Damage Index Score: 15.76; 97.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6J1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6J1
Leiden Open Variation Database (LOVD)
OR6J1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for OR6J1 Gene

Disorders for OR6J1 Gene

Additional Disease Information for OR6J1

No disorders were found for OR6J1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6J1 Gene

Publications for OR6J1 Gene

  1. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR6J1 Gene

Sources for OR6J1 Gene