Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6F1 Gene

Aliases for OR6F1 Gene

  • Olfactory Receptor Family 6 Subfamily F Member 1 2 3 5
  • Olfactory Receptor OR1-38 3 4
  • Olfactory Receptor 6F1 3 4
  • OST731 2 3
  • Olfactory Receptor, Family 6, Subfamily F, Member 1 2
  • Olfactory Receptor OR1-34 Pseudogene 3
  • OR1-34 3
  • OR1-38 3
  • OR6F1 5

External Ids for OR6F1 Gene

Previous GeneCards Identifiers for OR6F1 Gene

  • GC01U990393
  • GC01M244773
  • GC01M244201
  • GC01M245941
  • GC01M247876
  • GC01M247712
  • GC01M247714

Summaries for OR6F1 Gene

Entrez Gene Summary for OR6F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6F1 Gene

OR6F1 (Olfactory Receptor Family 6 Subfamily F Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6M1.

UniProtKB/Swiss-Prot Summary for OR6F1 Gene

Gene Wiki entry for OR6F1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6F1 Gene

Genomics for OR6F1 Gene

GeneHancer (GH) Regulatory Elements Pubs


Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6F1

Top Transcription factor binding sites by QIAGEN in the OR6F1 gene promoter:
  • AML1a
  • AP-1
  • c-Fos
  • c-Jun
  • NF-AT
  • NF-AT1
  • p53
  • RFX1
  • YY1

Genomic Locations for OR6F1 Gene

Latest Assembly
chr1:247,711,436-247,716,646
(GRCh38/hg38)
Size:
5,211 bases
Orientation:
Minus strand

Previous Assembly
chr1:247,874,738-247,879,948
(GRCh37/hg19 by Entrez Gene)
Size:
5,211 bases
Orientation:
Minus strand

chr1:247,875,045-247,876,105
(GRCh37/hg19 by Ensembl)
Size:
1,061 bases
Orientation:
Minus strand

Genomic View for OR6F1 Gene

Genes around OR6F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6F1 Gene

Proteins for OR6F1 Gene

  • Protein details for OR6F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGZ6-OR6F1_HUMAN
    Recommended name:
    Olfactory receptor 6F1
    Protein Accession:
    Q8NGZ6
    Secondary Accessions:
    • B2RNV6
    • Q6IF02
    • Q96R39

    Protein attributes for OR6F1 Gene

    Size:
    308 amino acids
    Molecular mass:
    33961 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6F1 Gene

Post-translational modifications for OR6F1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6F1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6F1 Gene

Domains & Families for OR6F1 Gene

Gene Families for OR6F1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6F1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6F1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-38 (OR6F1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGZ6

UniProtKB/Swiss-Prot:

OR6F1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6F1: view

Function for OR6F1 Gene

Molecular function for OR6F1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6F1 Gene

Gene Ontology (GO) - Molecular Function for OR6F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR6F1: view

Phenotypes for OR6F1 Gene

GenomeRNAi human phenotypes for OR6F1:
genes like me logo Genes that share phenotypes with OR6F1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6F1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6F1 Gene

Localization for OR6F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6F1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6F1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6F1 Gene

Pathways & Interactions for OR6F1 Gene

genes like me logo Genes that share pathways with OR6F1: view

Pathways by source for OR6F1 Gene

Interacting Proteins for OR6F1 Gene

Gene Ontology (GO) - Biological Process for OR6F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6F1: view

No data available for SIGNOR curated interactions for OR6F1 Gene

Drugs & Compounds for OR6F1 Gene

No Compound Related Data Available

Transcripts for OR6F1 Gene

mRNA/cDNA for OR6F1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6F1

Alternative Splicing Database (ASD) splice patterns (SP) for OR6F1 Gene

No ASD Table

Relevant External Links for OR6F1 Gene

GeneLoc Exon Structure for
OR6F1

Expression for OR6F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6F1 Gene

mRNA differential expression in normal tissues according to GTEx for OR6F1 Gene

This gene is overexpressed in Testis (x44.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6F1

SOURCE GeneReport for Unigene cluster for OR6F1 Gene:

Hs.591529

Evidence on tissue expression from TISSUES for OR6F1 Gene

  • Spleen(2.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with OR6F1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6F1 Gene

Orthologs for OR6F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6F1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC469750 29
  • 98.92 (n)
OR6F1 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR6F1 30
  • 90 (a)
OneToOne
LOC482210 29
  • 86.26 (n)
Cow
(Bos Taurus)
Mammalia OR6F1 29 30
  • 86.36 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr13 29
  • 81.26 (n)
Mouse
(Mus musculus)
Mammalia Or6f1 45 Olfr308 29 16 30
  • 79.65 (n)
OneToOne
Or6aa1 45 Olfr303
  • chr7:86,394,540-86,395,496
Or6f2 45 Olfr523
  • chr7:140,176,104-140,177,054
Oppossum
(Monodelphis domestica)
Mammalia OR6F1 30
  • 68 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OR6F1 30
  • 62 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii or101-1 30
  • 35 (a)
OneToMany
Species where no ortholog for OR6F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OR6F1 Gene

ENSEMBL:
Gene Tree for OR6F1 (if available)
TreeFam:
Gene Tree for OR6F1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6F1: view image
Alliance of Genome Resources:
Additional Orthologs for OR6F1

Paralogs for OR6F1 Gene

(456) SIMAP similar genes for OR6F1 Gene using alignment to 1 proteins:

  • OR6F1_HUMAN
genes like me logo Genes that share paralogs with OR6F1: view

Variants for OR6F1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6F1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2282316 -- p.Phe215Leu
rs60303431 -- p.Leu13Pro
rs6665599 -- p.Pro159Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6F1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR6F1 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3589522 CNV gain 21293372
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv5310 CNV deletion 18451855
nsv549597 CNV gain 21841781
nsv549598 CNV loss 21841781

Variation tolerance for OR6F1 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6F1
Leiden Open Variation Database (LOVD)
OR6F1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6F1 Gene

Disorders for OR6F1 Gene

Additional Disease Information for OR6F1

No disorders were found for OR6F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6F1 Gene

Publications for OR6F1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PMID: 12908129) Gilad Y … Pääbo S (American journal of human genetics 2003) 3

Products for OR6F1 Gene

Sources for OR6F1 Gene