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Aliases for OR6C74 Gene

Aliases for OR6C74 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 74 2 3 5
  • Olfactory Receptor, Family 6, Subfamily C, Member 74 2

External Ids for OR6C74 Gene

Previous GeneCards Identifiers for OR6C74 Gene

  • GC12P053928
  • GC12U900474
  • GC12P055640

Summaries for OR6C74 Gene

Entrez Gene Summary for OR6C74 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C74 Gene

OR6C74 (Olfactory Receptor Family 6 Subfamily C Member 74) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C76.

UniProtKB/Swiss-Prot for OR6C74 Gene

  • Odorant receptor.

Additional gene information for OR6C74 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C74 Gene

Genomics for OR6C74 Gene

GeneHancer (GH) Regulatory Elements for OR6C74 Gene

Promoters and enhancers for OR6C74 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I055020 Enhancer 0.4 FANTOM5 dbSUPER 4.7 -218.9 -218912 0 NEUROD4 OR6C3 OR6C65 OR9K2 OR6C75 OR6C6 OR6C2 OR10A7 OR6C74 OR6C76
GH12I055629 Enhancer 0.4 FANTOM5 dbSUPER 2.5 +389.5 389520 0 MMP19 OR6C4 OR10P1 OR6C65 ZC3H10 OR6C74 OR9K2 OR6C3 OR6C2 OR6C6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR6C74 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6C74 gene promoter:

Genomic Locations for OR6C74 Gene

Genomic Locations for OR6C74 Gene
chr12:55,239,762-55,248,302
(GRCh38/hg38)
Size:
8,541 bases
Orientation:
Plus strand
chr12:55,640,982-55,642,086
(GRCh37/hg19)

Genomic View for OR6C74 Gene

Genes around OR6C74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C74 Gene

Proteins for OR6C74 Gene

  • Protein details for OR6C74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCV1-O6C74_HUMAN
    Recommended name:
    Olfactory receptor 6C74
    Protein Accession:
    A6NCV1

    Protein attributes for OR6C74 Gene

    Size:
    312 amino acids
    Molecular mass:
    35253 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C74 Gene

Post-translational modifications for OR6C74 Gene

  • Glycosylation at isoforms=3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C74 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C74 Gene

Domains & Families for OR6C74 Gene

Gene Families for OR6C74 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6C74 Gene

Suggested Antigen Peptide Sequences for OR6C74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NCV1

UniProtKB/Swiss-Prot:

O6C74_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C74: view

Function for OR6C74 Gene

Molecular function for OR6C74 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C74: view

Phenotypes for OR6C74 Gene

genes like me logo Genes that share phenotypes with OR6C74: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C74 Gene

Localization for OR6C74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C74 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C74 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C74: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6C74 Gene

Pathways & Interactions for OR6C74 Gene

genes like me logo Genes that share pathways with OR6C74: view

Pathways by source for OR6C74 Gene

Interacting Proteins for OR6C74 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342836%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000312262%0d%0a9606.ENSP00000317578%0d%0a
Selected Interacting proteins: A6NCV1-O6C74_HUMAN ENSP00000342836 for OR6C74 Gene via IID STRING

Gene Ontology (GO) - Biological Process for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C74: view

No data available for SIGNOR curated interactions for OR6C74 Gene

Drugs & Compounds for OR6C74 Gene

No Compound Related Data Available

Transcripts for OR6C74 Gene

mRNA/cDNA for OR6C74 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C74 Gene

No ASD Table

Relevant External Links for OR6C74 Gene

GeneLoc Exon Structure for
OR6C74
ECgene alternative splicing isoforms for
OR6C74

Expression for OR6C74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6C74 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6C74 Gene:

OR6C74

SOURCE GeneReport for Unigene cluster for OR6C74 Gene:

Hs.554556
genes like me logo Genes that share expression patterns with OR6C74: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C74 Gene

Orthologs for OR6C74 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC467021 33
  • 99.25 (n)
OR6C74 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC788372 33
  • 89 (n)
-- 34
  • 88 (a)
OneToMany
-- 34
  • 87 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR6C74 33 34
  • 88.03 (n)
mouse
(Mus musculus)
Mammalia Or6c74 51 Olfr821 33 16 34
  • 86.02 (n)
rat
(Rattus norvegicus)
Mammalia Olr1064 33
  • 85.9 (n)
oppossum
(Monodelphis domestica)
Mammalia OR6C74 34
  • 85 (a)
OneToOne
Species where no ortholog for OR6C74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C74 Gene

ENSEMBL:
Gene Tree for OR6C74 (if available)
TreeFam:
Gene Tree for OR6C74 (if available)

Paralogs for OR6C74 Gene

Paralogs for OR6C74 Gene

(452) SIMAP similar genes for OR6C74 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR6C74: view

Variants for OR6C74 Gene

Sequence variations from dbSNP and Humsavar for OR6C74 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000240326 -- 55,243,320(+) A/G upstream_transcript_variant
rs1000839163 -- 55,244,755(+) T/A genic_upstream_transcript_variant, intron_variant
rs1001358247 -- 55,245,020(+) G/C genic_upstream_transcript_variant, intron_variant
rs1001623900 -- 55,244,170(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1002012119 -- 55,244,435(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OR6C74 Gene

Variant ID Type Subtype PubMed ID
nsv559001 CNV loss 21841781

Variation tolerance for OR6C74 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.02; 98.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6C74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6C74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C74 Gene

Disorders for OR6C74 Gene

Additional Disease Information for OR6C74

No disorders were found for OR6C74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C74 Gene

Publications for OR6C74 Gene

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3 58
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR6C74 Gene

Sources for OR6C74 Gene

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