Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR6C70 Gene

Aliases for OR6C70 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 70 2 3 5
  • Olfactory Receptor, Family 6, Subfamily C, Member 70 2

External Ids for OR6C70 Gene

Previous GeneCards Identifiers for OR6C70 Gene

  • GC12M054151
  • GC12U900479
  • GC12M055862

Summaries for OR6C70 Gene

Entrez Gene Summary for OR6C70 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C70 Gene

OR6C70 (Olfactory Receptor Family 6 Subfamily C Member 70) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C6.

UniProtKB/Swiss-Prot for OR6C70 Gene

  • Odorant receptor.

Additional gene information for OR6C70 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C70 Gene

Genomics for OR6C70 Gene

GeneHancer (GH) Regulatory Elements for OR6C70 Gene

Promoters and enhancers for OR6C70 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I055656 Enhancer 1.1 Ensembl ENCODE dbSUPER 550.8 +1.4 1384 4.1 CTCF ATF1 FOXA2 EBF1 CEBPG RAD21 TEAD3 FOSL1 ZNF664 CTBP1 ENSG00000258921 OR6C70 RNF41 PSMB3P1 GC12P055653
GH12I055498 Enhancer 0.8 ENCODE 10.4 +160.2 160236 2.5 ELF3 FOXA2 ARID4B RARA ETS1 TCF12 CREM ZNF680 MIER2 PPARG OR6C70 MIP ENSG00000257303 OR6C68 GC12M055509 ENSG00000258763
GH12I055645 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.4 +13.3 13272 1.9 HDGF ARNT ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF416 ZNF207 ZNF143 OR10AE3P SMARCC2 ANKRD52 PHC1P1 DNAJC14 IKZF4 PAN2 TMEM198B IL23A ENSG00000257740
GH12I055641 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +17.2 17243 1.6 CTCF BCOR POLR2A ZMYM3 GABPA SPI1 MMP19 ZC3H10 BLOC1S1 OR10AE3P OR10P1 ENSG00000258921 OR6C70
GH12I055649 Enhancer 0.7 FANTOM5 ENCODE 0.4 +8.8 8805 3.2 CTCF ZNF585B PHC1P1 SMARCC2 IKZF4 ANKRD52 ENSG00000257740 BLOC1S1 ITGA7 MMP19 ORMDL2 OR10P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR6C70 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6C70 gene promoter:

Genomic Locations for OR6C70 Gene

Genomic Locations for OR6C70 Gene
190,645 bases
Minus strand

Genomic View for OR6C70 Gene

Genes around OR6C70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C70 Gene

Proteins for OR6C70 Gene

  • Protein details for OR6C70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6C70
    Protein Accession:

    Protein attributes for OR6C70 Gene

    312 amino acids
    Molecular mass:
    35468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C70 Gene

Post-translational modifications for OR6C70 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C70 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C70 Gene

Domains & Families for OR6C70 Gene

Gene Families for OR6C70 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6C70 Gene

Suggested Antigen Peptide Sequences for OR6C70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C70: view

Function for OR6C70 Gene

Molecular function for OR6C70 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6C70 Gene

Gene Ontology (GO) - Molecular Function for OR6C70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C70: view
genes like me logo Genes that share phenotypes with OR6C70: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C70 Gene

Localization for OR6C70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C70 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C70 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C70: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6C70 Gene

Pathways & Interactions for OR6C70 Gene

genes like me logo Genes that share pathways with OR6C70: view

Pathways by source for OR6C70 Gene

Interacting Proteins for OR6C70 Gene

Gene Ontology (GO) - Biological Process for OR6C70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C70: view

No data available for SIGNOR curated interactions for OR6C70 Gene

Drugs & Compounds for OR6C70 Gene

No Compound Related Data Available

Transcripts for OR6C70 Gene

mRNA/cDNA for OR6C70 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C70 Gene

No ASD Table

Relevant External Links for OR6C70 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6C70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6C70 Gene

Protein differential expression in normal tissues from HIPED for OR6C70 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR6C70 Gene

Protein tissue co-expression partners for OR6C70 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6C70 Gene:


SOURCE GeneReport for Unigene cluster for OR6C70 Gene:

genes like me logo Genes that share expression patterns with OR6C70: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C70 Gene

Orthologs for OR6C70 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C70 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Or6c70 51 Olfr814 34
  • 80 (a)
Or6c217 51 Olfr815 34
  • 78 (a)
Olfr810 33 16
  • 67.63 (n)
(Canis familiaris)
Mammalia -- 34
  • 70 (a)
COR6C13 33
  • 66.77 (n)
(Pan troglodytes)
Mammalia -- 34
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
(Bos Taurus)
Mammalia LOC788357 33
  • 66.99 (n)
-- 34
  • 62 (a)
(Rattus norvegicus)
Mammalia Olr1002 33
  • 66.77 (n)
Species where no ortholog for OR6C70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C70 Gene

Gene Tree for OR6C70 (if available)
Gene Tree for OR6C70 (if available)

Paralogs for OR6C70 Gene

Paralogs for OR6C70 Gene

(452) SIMAP similar genes for OR6C70 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6C70: view

Variants for OR6C70 Gene

Sequence variations from dbSNP and Humsavar for OR6C70 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001447099 -- 55,469,679(-) T/G coding_sequence_variant, missense_variant
rs1001763705 -- 55,472,129(-) A/C upstream_transcript_variant
rs1002226401 -- 55,471,190(-) G/A upstream_transcript_variant
rs1003151227 -- 55,471,528(-) G/A upstream_transcript_variant
rs1003448161 -- 55,472,076(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR6C70 Gene

Variant ID Type Subtype PubMed ID
esv3629576 CNV loss 21293372
nsv1054105 CNV loss 25217958
nsv437144 CNV loss 16327808
nsv559001 CNV loss 21841781
nsv832422 CNV loss 17160897

Variation tolerance for OR6C70 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6C70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C70 Gene

Disorders for OR6C70 Gene

Additional Disease Information for OR6C70

No disorders were found for OR6C70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C70 Gene

Publications for OR6C70 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3 58
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58

Products for OR6C70 Gene

Sources for OR6C70 Gene

Loading form....