Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone... See more...

Aliases for OR6C68 Gene

Aliases for OR6C68 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 68 2 3 5
  • Olfactory Receptor 6C68 3 4
  • Olfactory Receptor, Family 6, Subfamily C, Member 68 2
  • OR6C68 5

External Ids for OR6C68 Gene

Previous GeneCards Identifiers for OR6C68 Gene

  • GC12U900420
  • GC12P054173
  • GC12P055887

Summaries for OR6C68 Gene

Entrez Gene Summary for OR6C68 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Mar 2014]

GeneCards Summary for OR6C68 Gene

OR6C68 (Olfactory Receptor Family 6 Subfamily C Member 68) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C2.

UniProtKB/Swiss-Prot Summary for OR6C68 Gene

Additional gene information for OR6C68 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6C68 Gene

Genomics for OR6C68 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6C68 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055467 Enhancer 0.6 FANTOM5 Ensembl 10.6 -24.1 -24062 3 CREB1 CEBPG ATF3 SPI1 ETV6 OR6C70 OR6C68 APOF OR10A7 MMP19 piR-55361-124 OR6C2 ENSG00000258763
GH12J055498 Enhancer 1 Ensembl ENCODE 0.4 +7.2 7245 2.5 GATAD2A SOX13 SP1 CEBPA ETS1 TCF7 ZKSCAN8 FOXA2 MAFF USF1 OR6C70 MIP ENSG00000257303 OR6C68 piR-48553-085 OR6C4 ENSG00000258763
GH12J055478 Enhancer 0.2 Ensembl 0.4 -14.3 -14262 0.2 piR-36393-105 piR-31162-096 piR-39488-069 piR-56022-106 piR-43099-113 piR-49732-108 piR-56759-126 piR-54764-122 piR-60597-012 piR-61028-109
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6C68 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6C68

Top Transcription factor binding sites by QIAGEN in the OR6C68 gene promoter:
  • AML1a
  • E47
  • HSF2
  • MRF-2
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • STAT5A
  • Tal-1

Genomic Locations for OR6C68 Gene

Genomic Locations for OR6C68 Gene
chr12:55,492,363-55,493,316
(GRCh38/hg38)
Size:
954 bases
Orientation:
Plus strand
chr12:55,886,147-55,887,100
(GRCh37/hg19)
Size:
954 bases
Orientation:
Plus strand

Genomic View for OR6C68 Gene

Genes around OR6C68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C68 Gene

Proteins for OR6C68 Gene

  • Protein details for OR6C68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDL8-O6C68_HUMAN
    Recommended name:
    Olfactory receptor 6C68
    Protein Accession:
    A6NDL8

    Protein attributes for OR6C68 Gene

    Size:
    312 amino acids
    Molecular mass:
    35296 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW96814.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR6C68 Gene

Post-translational modifications for OR6C68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR6C68 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C68 Gene

Domains & Families for OR6C68 Gene

Gene Families for OR6C68 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6C68 Gene

Suggested Antigen Peptide Sequences for OR6C68 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 6C68 (O6C68_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NDL8

UniProtKB/Swiss-Prot:

O6C68_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C68: view

Function for OR6C68 Gene

Molecular function for OR6C68 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6C68 Gene

Gene Ontology (GO) - Molecular Function for OR6C68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR6C68: view
genes like me logo Genes that share phenotypes with OR6C68: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6C68

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C68 Gene

Localization for OR6C68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C68 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C68 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C68: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6C68 Gene

Pathways & Interactions for OR6C68 Gene

genes like me logo Genes that share pathways with OR6C68: view

Pathways by source for OR6C68 Gene

Interacting Proteins for OR6C68 Gene

Gene Ontology (GO) - Biological Process for OR6C68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C68: view

No data available for SIGNOR curated interactions for OR6C68 Gene

Drugs & Compounds for OR6C68 Gene

No Compound Related Data Available

Transcripts for OR6C68 Gene

mRNA/cDNA for OR6C68 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6C68

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C68 Gene

No ASD Table

Relevant External Links for OR6C68 Gene

GeneLoc Exon Structure for
OR6C68

Expression for OR6C68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6C68 Gene

mRNA differential expression in normal tissues according to GTEx for OR6C68 Gene

This gene is overexpressed in Heart - Atrial Appendage (x28.2), Heart - Left Ventricle (x11.9), and Testis (x5.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6C68

SOURCE GeneReport for Unigene cluster for OR6C68 Gene:

Hs.626886
genes like me logo Genes that share expression patterns with OR6C68: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C68 Gene

Orthologs for OR6C68 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C68 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC747816 30
  • 98.93 (n)
OR6C68 31
  • 96 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or6c68 46 Olfr780 31
  • 84 (a)
OneToOne
Olfr781 30 17
  • 74.92 (n)
Olfr799 17
Or6c202 46 Olfr771
  • chr10:129,160,032-129,160,982
Or6c221-ps 46 Olfr783-ps1
  • chr10:129,376,958-129,377,398
Cow
(Bos Taurus)
Mammalia -- 31
  • 81 (a)
OneToMany
-- 31
  • 81 (a)
OneToMany
OR6C2 30
  • 75.65 (n)
Dog
(Canis familiaris)
Mammalia LOC100856706 30
  • 77.38 (n)
-- 31
  • 76 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr1049 30
  • 73.94 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 72 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
-- 31
  • 65 (a)
ManyToMany
Species where no ortholog for OR6C68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6C68 Gene

ENSEMBL:
Gene Tree for OR6C68 (if available)
TreeFam:
Gene Tree for OR6C68 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6C68: view image

Paralogs for OR6C68 Gene

(444) SIMAP similar genes for OR6C68 Gene using alignment to 1 proteins:

  • O6C68_HUMAN
genes like me logo Genes that share paralogs with OR6C68: view

Variants for OR6C68 Gene

Additional dbSNP identifiers (rs#s) for OR6C68 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR6C68 Gene

Variant ID Type Subtype PubMed ID
esv3629579 CNV loss 21293372
nsv559001 CNV loss 21841781
nsv832422 CNV loss 17160897

Variation tolerance for OR6C68 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.41; 92.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6C68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6C68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6C68 Gene

Disorders for OR6C68 Gene

No disorders were found for OR6C68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C68 Gene

Publications for OR6C68 Gene

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4

Products for OR6C68 Gene

Sources for OR6C68 Gene