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Aliases for OR6C68 Gene

Aliases for OR6C68 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 68 2 3 5
  • Olfactory Receptor, Family 6, Subfamily C, Member 68 2

External Ids for OR6C68 Gene

Previous GeneCards Identifiers for OR6C68 Gene

  • GC12U900420
  • GC12P054173
  • GC12P055887

Summaries for OR6C68 Gene

Entrez Gene Summary for OR6C68 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Mar 2014]

GeneCards Summary for OR6C68 Gene

OR6C68 (Olfactory Receptor Family 6 Subfamily C Member 68) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C2.

UniProtKB/Swiss-Prot for OR6C68 Gene

  • Odorant receptor.

Additional gene information for OR6C68 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C68 Gene

Genomics for OR6C68 Gene

GeneHancer (GH) Regulatory Elements for OR6C68 Gene

Promoters and enhancers for OR6C68 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I055467 Enhancer 0.3 FANTOM5 10.6 -24.3 -24272 0.3 ETV6 GC12M055463 OR6C68 OR10A7 MMP19 OR6C2 ENSG00000258763
GH12I055498 Enhancer 0.8 ENCODE 0.4 +7.2 7245 2.5 ELF3 FOXA2 ARID4B RARA ETS1 TCF12 CREM ZNF680 MIER2 PPARG OR6C70 MIP ENSG00000257303 OR6C68 GC12M055509 ENSG00000258763
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR6C68 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6C68 gene promoter:

Genomic Locations for OR6C68 Gene

Genomic Locations for OR6C68 Gene
954 bases
Plus strand

Genomic View for OR6C68 Gene

Genes around OR6C68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C68 Gene

Proteins for OR6C68 Gene

  • Protein details for OR6C68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6C68
    Protein Accession:

    Protein attributes for OR6C68 Gene

    312 amino acids
    Molecular mass:
    35296 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAW96814.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR6C68 Gene

Post-translational modifications for OR6C68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR6C68 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C68 Gene

Domains & Families for OR6C68 Gene

Gene Families for OR6C68 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6C68 Gene

Suggested Antigen Peptide Sequences for OR6C68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C68: view

Function for OR6C68 Gene

Molecular function for OR6C68 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C68: view

Phenotypes for OR6C68 Gene

genes like me logo Genes that share phenotypes with OR6C68: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C68 Gene

Localization for OR6C68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C68 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C68 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C68: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6C68 Gene

Pathways & Interactions for OR6C68 Gene

genes like me logo Genes that share pathways with OR6C68: view

Pathways by source for OR6C68 Gene

Interacting Proteins for OR6C68 Gene

Gene Ontology (GO) - Biological Process for OR6C68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C68: view

No data available for SIGNOR curated interactions for OR6C68 Gene

Drugs & Compounds for OR6C68 Gene

No Compound Related Data Available

Transcripts for OR6C68 Gene

mRNA/cDNA for OR6C68 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR6C68 Gene

Olfactory receptor, family 6, subfamily C, member 68:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C68 Gene

No ASD Table

Relevant External Links for OR6C68 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6C68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6C68 Gene

mRNA differential expression in normal tissues according to GTEx for OR6C68 Gene

This gene is overexpressed in Heart - Atrial Appendage (x28.2), Heart - Left Ventricle (x11.9), and Testis (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of OR6C68 Gene:


SOURCE GeneReport for Unigene cluster for OR6C68 Gene:

genes like me logo Genes that share expression patterns with OR6C68: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C68 Gene

Orthologs for OR6C68 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C68 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC747816 33
  • 98.93 (n)
OR6C68 34
  • 96 (a)
(Mus musculus)
Mammalia Or6c68 51 Olfr780 34
  • 84 (a)
Olfr781 33
  • 74.92 (n)
Olfr799 16
Or6c202 51 Olfr771
  • chr10:129,160,032-129,160,982
Or6c221-ps 51 Olfr783-ps1
  • chr10:129,376,958-129,377,398
(Bos Taurus)
Mammalia -- 34
  • 81 (a)
-- 34
  • 81 (a)
OR6C2 33
  • 75.65 (n)
(Canis familiaris)
Mammalia LOC100856706 33
  • 77.38 (n)
-- 34
  • 76 (a)
(Rattus norvegicus)
Mammalia Olr1049 33
  • 73.94 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 72 (a)
-- 34
  • 70 (a)
-- 34
  • 69 (a)
-- 34
  • 69 (a)
-- 34
  • 68 (a)
-- 34
  • 68 (a)
-- 34
  • 67 (a)
-- 34
  • 66 (a)
-- 34
  • 66 (a)
-- 34
  • 66 (a)
-- 34
  • 65 (a)
Species where no ortholog for OR6C68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C68 Gene

Gene Tree for OR6C68 (if available)
Gene Tree for OR6C68 (if available)

Paralogs for OR6C68 Gene

Paralogs for OR6C68 Gene

(444) SIMAP similar genes for OR6C68 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6C68: view

Variants for OR6C68 Gene

Sequence variations from dbSNP and Humsavar for OR6C68 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001866629 -- 55,491,564(+) G/A upstream_transcript_variant
rs1002086155 -- 55,491,295(+) G/A upstream_transcript_variant
rs1002472349 -- 55,491,843(+) T/A upstream_transcript_variant
rs1003735568 -- 55,490,873(+) T/G upstream_transcript_variant
rs1004101451 -- 55,491,580(+) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR6C68 Gene

Variant ID Type Subtype PubMed ID
esv3629579 CNV loss 21293372
nsv559001 CNV loss 21841781
nsv832422 CNV loss 17160897

Variation tolerance for OR6C68 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.41; 92.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6C68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C68 Gene

Disorders for OR6C68 Gene

Additional Disease Information for OR6C68

No disorders were found for OR6C68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C68 Gene

Publications for OR6C68 Gene

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3 58
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58

Products for OR6C68 Gene

Sources for OR6C68 Gene

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