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Aliases for OR6C65 Gene

Aliases for OR6C65 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 65 2 3 5
  • Olfactory Receptor, Family 6, Subfamily C, Member 65 2

External Ids for OR6C65 Gene

Previous GeneCards Identifiers for OR6C65 Gene

  • GC12U900418
  • GC12P054080
  • GC12P055794

Summaries for OR6C65 Gene

Entrez Gene Summary for OR6C65 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C65 Gene

OR6C65 (Olfactory Receptor Family 6 Subfamily C Member 65) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C76.

UniProtKB/Swiss-Prot for OR6C65 Gene

  • Odorant receptor.

Additional gene information for OR6C65 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C65 Gene

Genomics for OR6C65 Gene

GeneHancer (GH) Regulatory Elements for OR6C65 Gene

Promoters and enhancers for OR6C65 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I055020 Enhancer 0.4 FANTOM5 dbSUPER 7.7 -379.6 -379580 0 NEUROD4 OR6C3 OR6C65 OR9K2 OR6C75 OR6C6 OR6C2 OR10A7 OR6C74 OR6C76
GH12I055881 Enhancer 0.4 FANTOM5 ENCODE 6.6 +480.9 480885 0.3 GC12P055881 OR10P1 OR6C4 MMP19 ORMDL2 SARNP CDK2 PMEL RAB5B OR6C65
GH12I054932 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.4 -465.2 -465156 5.6 ATF1 ZNF766 ZNF143 FOS ATF7 JUNB REST ZNF592 SMARCA4 HMBOX1 TESPA1 NEUROD4 MUCL1 NCKAP1L OR6C65 OR6C3 LOC105369778 GC12P054906
GH12I055629 Enhancer 0.4 FANTOM5 dbSUPER 3.7 +228.9 228852 0 MMP19 OR6C4 OR10P1 OR6C65 ZC3H10 OR6C74 OR9K2 OR6C3 OR6C2 OR6C6
GH12I055825 Enhancer 0.6 FANTOM5 Ensembl 1.7 +424.8 424834 0.5 GLIS1 OR10P1 OR6C4 OR6C65 OR6C3 IKZF4 OR6C2 ENSG00000257390 DNAJC14 ORMDL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR6C65 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6C65 gene promoter:

Genomic Locations for OR6C65 Gene

Genomic Locations for OR6C65 Gene
1,076 bases
Plus strand

Genomic View for OR6C65 Gene

Genes around OR6C65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C65 Gene

Proteins for OR6C65 Gene

  • Protein details for OR6C65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6C65
    Protein Accession:
    Secondary Accessions:
    • B2RNH9

    Protein attributes for OR6C65 Gene

    312 amino acids
    Molecular mass:
    35198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C65 Gene

Post-translational modifications for OR6C65 Gene

  • Glycosylation at Asn3 and Asn93
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C65 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C65 Gene

Domains & Families for OR6C65 Gene

Gene Families for OR6C65 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6C65 Gene

Suggested Antigen Peptide Sequences for OR6C65 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C65: view

Function for OR6C65 Gene

Molecular function for OR6C65 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C65: view

Phenotypes for OR6C65 Gene

GenomeRNAi human phenotypes for OR6C65:
genes like me logo Genes that share phenotypes with OR6C65: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C65 Gene

Localization for OR6C65 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C65 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C65 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C65: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6C65 Gene

Pathways & Interactions for OR6C65 Gene

genes like me logo Genes that share pathways with OR6C65: view

Pathways by source for OR6C65 Gene

Interacting Proteins for OR6C65 Gene

Gene Ontology (GO) - Biological Process for OR6C65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C65: view

No data available for SIGNOR curated interactions for OR6C65 Gene

Drugs & Compounds for OR6C65 Gene

No Compound Related Data Available

Transcripts for OR6C65 Gene

mRNA/cDNA for OR6C65 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C65 Gene

No ASD Table

Relevant External Links for OR6C65 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6C65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6C65 Gene

Protein differential expression in normal tissues from HIPED for OR6C65 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR6C65 Gene

Protein tissue co-expression partners for OR6C65 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6C65 Gene:


SOURCE GeneReport for Unigene cluster for OR6C65 Gene:

genes like me logo Genes that share expression patterns with OR6C65: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C65 Gene

Orthologs for OR6C65 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C65 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Or6c65 51 Olfr808 34
  • 83 (a)
Olfr822 33 16
  • 65.81 (n)
Or6ab1-ps 51 Olfr795-ps1
  • chr10:129,578,744-129,579,458
Or6ac1-ps 51 Olfr797-ps1
  • chr10:129,622,215-129,622,533
Or6o1-ps 51 Olfr793-ps1
  • chr10:129,547,711-129,548,437
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
-- 34
  • 73 (a)
-- 34
  • 73 (a)
-- 34
  • 72 (a)
-- 34
  • 71 (a)
(Bos Taurus)
Mammalia LOC788322 33
  • 68.92 (n)
-- 34
  • 67 (a)
(Canis familiaris)
Mammalia COR6C47 33
  • 68.38 (n)
-- 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
-- 34
  • 64 (a)
-- 34
  • 64 (a)
-- 34
  • 63 (a)
-- 34
  • 63 (a)
-- 34
  • 63 (a)
-- 34
  • 63 (a)
-- 34
  • 61 (a)
-- 34
  • 57 (a)
Species where no ortholog for OR6C65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C65 Gene

Gene Tree for OR6C65 (if available)
Gene Tree for OR6C65 (if available)

Paralogs for OR6C65 Gene

Paralogs for OR6C65 Gene

(453) SIMAP similar genes for OR6C65 Gene using alignment to 1 proteins: Pseudogenes for OR6C65 Gene

genes like me logo Genes that share paralogs with OR6C65: view

Variants for OR6C65 Gene

Sequence variations from dbSNP and Humsavar for OR6C65 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1002022550 -- 55,401,586(+) A/G downstream_transcript_variant
rs1002051583 -- 55,401,895(+) A/G downstream_transcript_variant
rs1002516158 -- 55,399,486(+) C/T upstream_transcript_variant
rs1003452013 -- 55,398,827(+) C/T upstream_transcript_variant
rs1003523447 -- 55,400,592(+) C/T coding_sequence_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for OR6C65 Gene

Variant ID Type Subtype PubMed ID
nsv1045950 CNV gain 25217958
nsv1046651 CNV gain 25217958
nsv559001 CNV loss 21841781

Variation tolerance for OR6C65 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6C65 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C65 Gene

Disorders for OR6C65 Gene

Additional Disease Information for OR6C65

No disorders were found for OR6C65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C65 Gene

Publications for OR6C65 Gene

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3 58
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR6C65 Gene

Sources for OR6C65 Gene

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