Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6C4 Gene

Aliases for OR6C4 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 4 2 3 5
  • Olfactory Receptor OR12-10 3 4
  • Olfactory Receptor 6C4 3 4
  • Olfactory Receptor, Family 6, Subfamily C, Member 4 2
  • OR12-10 3
  • OR6C4 5

External Ids for OR6C4 Gene

Previous GeneCards Identifiers for OR6C4 Gene

  • GC00U903092
  • GC12P054232
  • GC12U900485
  • GC12P055946

Summaries for OR6C4 Gene

Entrez Gene Summary for OR6C4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C4 Gene

OR6C4 (Olfactory Receptor Family 6 Subfamily C Member 4) is a Protein Coding gene. Diseases associated with OR6C4 include Chronic Wasting Disease. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2AP1.

UniProtKB/Swiss-Prot Summary for OR6C4 Gene

Gene Wiki entry for OR6C4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6C4 Gene

Genomics for OR6C4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6C4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055880 Enhancer 0.8 FANTOM5 Ensembl ENCODE 12.9 +331.7 331699 1 NR2F1 ATF4 ATF2 ZNF518A MTA2 HSALNG0091449 lnc-DGKA-2 OR10P1 OR6C4 MMP19 ORMDL2 SARNP CDK2 PMEL RAB5B
GH12J056040 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.2 +492.4 492397 3.3 BCLAF1 SP1 ZNF654 ZNF207 MYC NCOR1 IKZF1 ZNF600 SIX5 ZNF580 RPS26 ENSG00000257449 HSALNG0091480 LOC105369780 NONHSAG011344.2 piR-36475-004 BAZ2A ZC3H10 STAT2 PAN2
GH12J055736 Promoter/Enhancer 1.9 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 1.7 +188.3 188296 3.3 BCLAF1 SP1 ZNF207 ZNF654 IKZF1 ZNF600 ZNF580 ZNF10 POLR2A NFIC BAZ2A DNAJC14 ZC3H10 RN7SL809P TMEM198B RNU6-343P CDK2 PAN2 STAT2 MMP19
GH12J055629 Enhancer 0.3 FANTOM5 dbSUPER 4.3 +79.7 79680 0 MMP19 OR6C4 OR10P1 OR6C65 ZC3H10 OR6C74 OR9K2 OR6C3 OR6C2 OR6C6
GH12J055825 Enhancer 0.2 FANTOM5 2.6 +275.7 275749 0.4 HSALNG0091440 lnc-SARNP-1 OR10P1 OR6C4 OR6C65 OR6C3 IKZF4 OR6C2 ENSG00000257390 DNAJC14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6C4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6C4

Top Transcription factor binding sites by QIAGEN in the OR6C4 gene promoter:
  • Cart-1
  • Chx10
  • GCNF
  • GCNF-1
  • GCNF-2
  • POU2F1
  • POU2F1a
  • TBP

Genomic Locations for OR6C4 Gene

Latest Assembly
chr12:55,549,602-55,555,832
(GRCh38/hg38)
Size:
6,231 bases
Orientation:
Plus strand

Previous Assembly
chr12:55,943,386-55,949,616
(GRCh37/hg19 by Entrez Gene)
Size:
6,231 bases
Orientation:
Plus strand

chr12:55,944,983-55,946,028
(GRCh37/hg19 by Ensembl)
Size:
1,046 bases
Orientation:
Plus strand

Genomic View for OR6C4 Gene

Genes around OR6C4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C4 Gene

Proteins for OR6C4 Gene

  • Protein details for OR6C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE1-OR6C4_HUMAN
    Recommended name:
    Olfactory receptor 6C4
    Protein Accession:
    Q8NGE1
    Secondary Accessions:
    • A8MZG7
    • B2RNN2
    • Q6IFK1

    Protein attributes for OR6C4 Gene

    Size:
    309 amino acids
    Molecular mass:
    35010 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C4 Gene

Post-translational modifications for OR6C4 Gene

  • Glycosylation at Asn3

Other Protein References for OR6C4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C4 Gene

Domains & Families for OR6C4 Gene

Gene Families for OR6C4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6C4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6C4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR12-10 (OR6C4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGE1

UniProtKB/Swiss-Prot:

OR6C4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C4: view

Function for OR6C4 Gene

Molecular function for OR6C4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6C4 Gene

Gene Ontology (GO) - Molecular Function for OR6C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR6C4: view
genes like me logo Genes that share phenotypes with OR6C4: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6C4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C4 Gene

Localization for OR6C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6C4 Gene

Pathways & Interactions for OR6C4 Gene

genes like me logo Genes that share pathways with OR6C4: view

Pathways by source for OR6C4 Gene

Interacting Proteins for OR6C4 Gene

Gene Ontology (GO) - Biological Process for OR6C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C4: view

No data available for SIGNOR curated interactions for OR6C4 Gene

Drugs & Compounds for OR6C4 Gene

No Compound Related Data Available

Transcripts for OR6C4 Gene

mRNA/cDNA for OR6C4 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6C4

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C4 Gene

No ASD Table

Relevant External Links for OR6C4 Gene

GeneLoc Exon Structure for
OR6C4

Expression for OR6C4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6C4 Gene

Protein differential expression in normal tissues from HIPED for OR6C4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR6C4 Gene



Protein tissue co-expression partners for OR6C4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6C4

SOURCE GeneReport for Unigene cluster for OR6C4 Gene:

Hs.495021
genes like me logo Genes that share expression patterns with OR6C4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C4 Gene

Orthologs for OR6C4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC467024 29
  • 99.35 (n)
OR6C4 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 91 (a)
OneToMany
-- 30
  • 91 (a)
OneToMany
LOC510046 29
  • 89.36 (n)
Dog
(Canis familiaris)
Mammalia OR6C4 30
  • 91 (a)
OneToOne
LOC100683286 29
  • 88.31 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 75 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 69 (a)
ManyToMany
-- 30
  • 69 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr820 30
  • 67 (a)
ManyToMany
Or6c200-ps 45 Olfr764-ps1
  • chr10:129,033,863-129,034,789
Or6c63-ps 45 Olfr766-ps1
  • chr10:129,063,031-129,063,957
Or6g1-ps 45 Olfr210-ps1
  • chr6:73,420,317-73,421,218
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 65 (a)
ManyToMany
Species where no ortholog for OR6C4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6C4 Gene

ENSEMBL:
Gene Tree for OR6C4 (if available)
TreeFam:
Gene Tree for OR6C4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6C4: view image
Alliance of Genome Resources:
Additional Orthologs for OR6C4

Paralogs for OR6C4 Gene

(454) SIMAP similar genes for OR6C4 Gene using alignment to 1 proteins:

  • OR6C4_HUMAN
genes like me logo Genes that share paralogs with OR6C4: view

Variants for OR6C4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6C4 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs11835716 -- p.Met83Thr
rs7313899 -- p.Ile37Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6C4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR6C4 Gene

Variant ID Type Subtype PubMed ID
nsv559001 CNV loss 21841781
nsv832422 CNV loss 17160897

Variation tolerance for OR6C4 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.55; 82.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6C4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6C4
Leiden Open Variation Database (LOVD)
OR6C4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C4 Gene

Disorders for OR6C4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR6C4 Gene - From: COP

Disorder Aliases PubMed IDs
chronic wasting disease
  • wasting disease, chronic
- elite association - COSMIC cancer census association via MalaCards
Search OR6C4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR6C4

genes like me logo Genes that share disorders with OR6C4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR6C4 Gene

Publications for OR6C4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR6C4 Gene

Sources for OR6C4 Gene