Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6C3 Gene

Aliases for OR6C3 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 3 2 3 5
  • Olfactory Receptor 6C3 3 4
  • OST709 2 3
  • HSA8 3 4
  • Olfactory Receptor, Family 6, Subfamily C, Member 3 2
  • OR6C3 5

External Ids for OR6C3 Gene

Previous GeneCards Identifiers for OR6C3 Gene

  • GC00U990938
  • GC12P054011
  • GC12P055725

Summaries for OR6C3 Gene

Entrez Gene Summary for OR6C3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C3 Gene

OR6C3 (Olfactory Receptor Family 6 Subfamily C Member 3) is a Protein Coding gene. Diseases associated with OR6C3 include Cataract 37 and Cone-Rod Dystrophy 9. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C1.

UniProtKB/Swiss-Prot Summary for OR6C3 Gene

Gene Wiki entry for OR6C3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6C3 Gene

Genomics for OR6C3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6C3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055826 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.4 +499.1 499058 7 SP1 MYC IKZF1 ZNF600 JUND ZNF580 ZMYM3 ATF2 KLF9 POLR2A DNAJC14 TMEM198B ENSG00000257390 HSALNG0091441 piR-35172 lnc-ORMDL2-1 BAZ2A PAN2 ZC3H10 STAT2
GH12J055020 Enhancer 0.3 FANTOM5 dbSUPER 10.1 -309.2 -309193 0 NEUROD4 OR6C3 OR6C65 OR9K2 OR6C75 OR6C6 OR6C2 OR10A7 OR6C74 OR6C76
GH12J054932 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 1.2 -394.8 -394769 5.6 ZNF592 NFIC BCL11A REST MNT MAX ZNF217 CTBP1 RAD21 SMC3 TESPA1 NEUROD4 MUCL1 NCKAP1L OR6C65 OR6C3 piR-54768-003 piR-30444-079 HSALNG0091398 LOC105369778
GH12J054970 Enhancer 0.3 FANTOM5 dbSUPER 2.3 -359.1 -359130 0.2 TESPA1 PDE1B OR6C3 HSALNG0091400 ENSG00000257870 HSALNG0091393-001 MUCL1
GH12J055629 Enhancer 0.3 FANTOM5 dbSUPER 2.2 +299.2 299239 0 MMP19 OR6C4 OR10P1 OR6C65 ZC3H10 OR6C74 OR9K2 OR6C3 OR6C2 OR6C6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6C3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6C3

Top Transcription factor binding sites by QIAGEN in the OR6C3 gene promoter:
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for OR6C3 Gene

Latest Assembly
chr12:55,330,043-55,332,687
(GRCh38/hg38)
Size:
2,645 bases
Orientation:
Plus strand

Previous Assembly
chr12:55,725,485-55,726,420
(GRCh37/hg19 by Entrez Gene)
Size:
936 bases
Orientation:
Plus strand

chr12:55,725,485-55,726,420
(GRCh37/hg19 by Ensembl)
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR6C3 Gene

Genes around OR6C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C3 Gene

Proteins for OR6C3 Gene

  • Protein details for OR6C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZP0-OR6C3_HUMAN
    Recommended name:
    Olfactory receptor 6C3
    Protein Accession:
    Q9NZP0

    Protein attributes for OR6C3 Gene

    Size:
    311 amino acids
    Molecular mass:
    35531 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C3 Gene

Post-translational modifications for OR6C3 Gene

  • Glycosylation at Asn2
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C3 Gene

Domains & Families for OR6C3 Gene

Gene Families for OR6C3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6C3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6C3 Gene

GenScript: Design optimal peptide antigens:
  • HSA8 (OR6C3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NZP0

UniProtKB/Swiss-Prot:

OR6C3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C3: view

Function for OR6C3 Gene

Molecular function for OR6C3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6C3 Gene

Gene Ontology (GO) - Molecular Function for OR6C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 10706615
genes like me logo Genes that share ontologies with OR6C3: view

Phenotypes for OR6C3 Gene

genes like me logo Genes that share phenotypes with OR6C3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6C3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C3 Gene

Localization for OR6C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C3 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for OR6C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10706615
genes like me logo Genes that share ontologies with OR6C3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6C3 Gene

Pathways & Interactions for OR6C3 Gene

genes like me logo Genes that share pathways with OR6C3: view

Pathways by source for OR6C3 Gene

1 BioSystems pathway for OR6C3 Gene
1 KEGG pathway for OR6C3 Gene

Interacting Proteins for OR6C3 Gene

Gene Ontology (GO) - Biological Process for OR6C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 10706615
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C3: view

No data available for SIGNOR curated interactions for OR6C3 Gene

Drugs & Compounds for OR6C3 Gene

No Compound Related Data Available

Transcripts for OR6C3 Gene

mRNA/cDNA for OR6C3 Gene

2 REFSEQ mRNAs :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6C3

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C3 Gene

No ASD Table

Relevant External Links for OR6C3 Gene

GeneLoc Exon Structure for
OR6C3

Expression for OR6C3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6C3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR6C3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6C3

SOURCE GeneReport for Unigene cluster for OR6C3 Gene:

Hs.553653
genes like me logo Genes that share expression patterns with OR6C3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C3 Gene

Orthologs for OR6C3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C3 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia OR04C01 30
  • 94 (a)
OneToOne
LOC102156012 29
  • 80.97 (n)
Cow
(Bos Taurus)
Mammalia -- 30
  • 93 (a)
OneToMany
-- 30
  • 89 (a)
OneToMany
LOC787991 29
  • 80.22 (n)
Mouse
(Mus musculus)
Mammalia Or6c3 45 Olfr788 30
  • 88 (a)
OneToOne
Or6c3b 45 Olfr803 29 16
  • 78.32 (n)
Rat
(Rattus norvegicus)
Mammalia Olr952 29
  • 76.77 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
-- 30
  • 63 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 61 (a)
ManyToMany
-- 30
  • 57 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 65 (a)
ManyToMany
Species where no ortholog for OR6C3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6C3 Gene

ENSEMBL:
Gene Tree for OR6C3 (if available)
TreeFam:
Gene Tree for OR6C3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6C3: view image
Alliance of Genome Resources:
Additional Orthologs for OR6C3

Paralogs for OR6C3 Gene

(456) SIMAP similar genes for OR6C3 Gene using alignment to 1 proteins:

  • OR6C3_HUMAN

Pseudogenes.org Pseudogenes for OR6C3 Gene

genes like me logo Genes that share paralogs with OR6C3: view

Variants for OR6C3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6C3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs115313932 Benign: not provided 55,331,916(+) C/A
NM_054104.1(OR6C3):c.216C>A (p.Thr72=)
SYNONYMOUS
rs80148330 Benign: not provided 55,332,355(+) A/T
NM_054104.1(OR6C3):c.655A>T (p.Ile219Phe)
MISSENSE
rs11832940 -- p.Ala234Ser
rs11835321 -- p.Met133Thr
rs4318060 -- p.Ser69Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6C3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR6C3 Gene

Variant ID Type Subtype PubMed ID
esv3629572 CNV gain 21293372
nsv438211 CNV loss 16468122
nsv509469 CNV insertion 20534489
nsv559001 CNV loss 21841781
nsv718 CNV insertion 18451855
nsv826381 CNV loss 20364138

Variation tolerance for OR6C3 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.73; 83.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6C3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6C3
Leiden Open Variation Database (LOVD)
OR6C3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C3 Gene

Disorders for OR6C3 Gene

MalaCards: The human disease database

(10) MalaCards diseases for OR6C3 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search OR6C3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR6C3

genes like me logo Genes that share disorders with OR6C3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR6C3 Gene

Publications for OR6C3 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
  2. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PMID: 10706615) Rouquier S … Giorgi D (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4
  3. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR6C3 Gene

Sources for OR6C3 Gene