Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6C1 Gene

Aliases for OR6C1 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 1 2 3 5
  • OST267 2 3 4
  • Olfactory Receptor 6C1 3 4
  • Olfactory Receptor, Family 6, Subfamily C, Member 1 2
  • OR6C1 5

External Ids for OR6C1 Gene

Previous GeneCards Identifiers for OR6C1 Gene

  • GC00U990606
  • GC12P054001
  • GC12P054002
  • GC12P055715

Summaries for OR6C1 Gene

Entrez Gene Summary for OR6C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C1 Gene

OR6C1 (Olfactory Receptor Family 6 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C3.

UniProtKB/Swiss-Prot Summary for OR6C1 Gene

Gene Wiki entry for OR6C1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6C1 Gene

Genomics for OR6C1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6C1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055354 Enhancer 0.2 Ensembl 10.8 +40.9 40858 1.6 lnc-OR6C6-1 OR6C2 OR6C1 RAB5B OR6C75 piR-55361-123 OR6C3
GH12J055629 Enhancer 0.3 FANTOM5 dbSUPER 1.3 +314.9 314939 0 MMP19 OR6C4 OR10P1 OR6C65 ZC3H10 OR6C74 OR9K2 OR6C3 OR6C2 OR6C6
GH12J055320 Enhancer 0.2 ENCODE 0.4 +6.2 6168 0.6 OR6C1 OR6C3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6C1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6C1

Top Transcription factor binding sites by QIAGEN in the OR6C1 gene promoter:
  • FAC1
  • GATA-1
  • GR
  • GR-alpha
  • Ik-1
  • ITF-2
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha2
  • Tal-1beta

Genomic Locations for OR6C1 Gene

Latest Assembly
chr12:55,314,343-55,322,364
(GRCh38/hg38)
Size:
8,022 bases
Orientation:
Plus strand

Previous Assembly
chr12:55,714,384-55,715,322
(GRCh37/hg19 by Entrez Gene)
Size:
939 bases
Orientation:
Plus strand

chr12:55,714,346-55,715,408
(GRCh37/hg19 by Ensembl)
Size:
1,063 bases
Orientation:
Plus strand

Genomic View for OR6C1 Gene

Genes around OR6C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C1 Gene

Proteins for OR6C1 Gene

  • Protein details for OR6C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD1-OR6C1_HUMAN
    Recommended name:
    Olfactory receptor 6C1
    Protein Accession:
    Q96RD1
    Secondary Accessions:
    • B2RNM0

    Protein attributes for OR6C1 Gene

    Size:
    312 amino acids
    Molecular mass:
    35660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C1 Gene

Post-translational modifications for OR6C1 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C1 Gene

Domains & Families for OR6C1 Gene

Gene Families for OR6C1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6C1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6C1 Gene

GenScript: Design optimal peptide antigens:
  • OST267 (OR6C1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96RD1

UniProtKB/Swiss-Prot:

OR6C1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C1: view

Function for OR6C1 Gene

Molecular function for OR6C1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6C1 Gene

Gene Ontology (GO) - Molecular Function for OR6C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with OR6C1: view

Phenotypes for OR6C1 Gene

genes like me logo Genes that share phenotypes with OR6C1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6C1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C1 Gene

Localization for OR6C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6C1 Gene

Pathways & Interactions for OR6C1 Gene

genes like me logo Genes that share pathways with OR6C1: view

Pathways by source for OR6C1 Gene

Interacting Proteins for OR6C1 Gene

Gene Ontology (GO) - Biological Process for OR6C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C1: view

No data available for SIGNOR curated interactions for OR6C1 Gene

Drugs & Compounds for OR6C1 Gene

No Compound Related Data Available

Transcripts for OR6C1 Gene

mRNA/cDNA for OR6C1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6C1

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C1 Gene

No ASD Table

Relevant External Links for OR6C1 Gene

GeneLoc Exon Structure for
OR6C1

Expression for OR6C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6C1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6C1

SOURCE GeneReport for Unigene cluster for OR6C1 Gene:

Hs.553763
genes like me logo Genes that share expression patterns with OR6C1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C1 Gene

Orthologs for OR6C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC746860 29
  • 98.82 (n)
OR6C1 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR6C1 29
  • 88.74 (n)
-- 30
  • 86 (a)
OneToMany
-- 30
  • 80 (a)
OneToMany
-- 30
  • 80 (a)
OneToMany
-- 30
  • 78 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC100683479 29
  • 85.85 (n)
-- 30
  • 82 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or6c1b 45 Olfr786 30
  • 84 (a)
OneToMany
Or6c1 45 Olfr802 29 16 30
  • 83.82 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr964 29
  • 82.63 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 65 (a)
ManyToMany
-- 30
  • 63 (a)
ManyToMany
-- 30
  • 63 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 61 (a)
ManyToMany
-- 30
  • 56 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia OR6C1 30
  • 64 (a)
OneToOne
Species where no ortholog for OR6C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6C1 Gene

ENSEMBL:
Gene Tree for OR6C1 (if available)
TreeFam:
Gene Tree for OR6C1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6C1: view image
Alliance of Genome Resources:
Additional Orthologs for OR6C1

Paralogs for OR6C1 Gene

(455) SIMAP similar genes for OR6C1 Gene using alignment to 1 proteins:

  • OR6C1_HUMAN

Pseudogenes.org Pseudogenes for OR6C1 Gene

genes like me logo Genes that share paralogs with OR6C1: view

Variants for OR6C1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6C1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs75222609 Benign: not provided 55,321,532(+) C/A
NM_001005182.1(OR6C1):c.933C>A (p.Ser311Arg)
MISSENSE
rs7132347 -- p.His165Asp
rs7132431 -- p.Cys130Tyr
rs7132600 -- p.Thr222Ile
rs7132916 -- p.Val246Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6C1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR6C1 Gene

Variant ID Type Subtype PubMed ID
esv2761740 CNV loss 21179565
esv3629571 CNV loss 21293372
nsv1050720 CNV loss 25217958
nsv438211 CNV loss 16468122
nsv559001 CNV loss 21841781
nsv559002 CNV loss 21841781
nsv718 CNV insertion 18451855
nsv82 CNV insertion 15895083
nsv826381 CNV loss 20364138

Variation tolerance for OR6C1 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.32; 94.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6C1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6C1
Leiden Open Variation Database (LOVD)
OR6C1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C1 Gene

Disorders for OR6C1 Gene

Additional Disease Information for OR6C1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR6C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C1 Gene

Publications for OR6C1 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 40
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3

Products for OR6C1 Gene

Sources for OR6C1 Gene