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Aliases for OR6B3 Gene

Aliases for OR6B3 Gene

  • Olfactory Receptor Family 6 Subfamily B Member 3 2 3 5
  • Olfactory Receptor, Family 6, Subfamily B, Member 3 Pseudogene 2 3
  • Olfactory Receptor OR2-2 3 4
  • OR6B3P 3 4
  • Olfactory Receptor, Family 6, Subfamily B, Member 3 2
  • Olfactory Receptor 6B3 3
  • OR6B3Q 3

External Ids for OR6B3 Gene

Previous HGNC Symbols for OR6B3 Gene

  • OR6B3P

Previous GeneCards Identifiers for OR6B3 Gene

  • GC02U900017
  • GC02M241306
  • GC02M240689
  • GC02M240633
  • GC02M240984

Summaries for OR6B3 Gene

Entrez Gene Summary for OR6B3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6B3 Gene

OR6B3 (Olfactory Receptor Family 6 Subfamily B Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR6B2.

UniProtKB/Swiss-Prot for OR6B3 Gene

  • Odorant receptor.

Gene Wiki entry for OR6B3 Gene

Additional gene information for OR6B3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6B3 Gene

Genomics for OR6B3 Gene

GeneHancer (GH) Regulatory Elements for OR6B3 Gene

Promoters and enhancers for OR6B3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J240051 Enhancer 0.4 FANTOM5 650.7 +1.7 1720 0.1 SOX5 SOX13 OR6B3 GC02M240027 PRR21
GH02J240134 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.2 -82.2 -82230 2.5 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF48 ETS1 POLR2B E2F8 ELK1 COPS9 ANKMY1 OR6B3 NDUFA10 PRR21 CAPN10 OR5S1P GC02P240095
GH02J239926 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +126.1 126079 2 GLIS2 CBX5 FOS ATF7 SP3 ATF4 MAFF SMARCA4 KLF1 ZIC2 NDUFA10 OR6B3 PRR21 GC02P239934 GC02P239887
GH02J239111 Enhancer 1 Ensembl ENCODE dbSUPER 4.9 +940.3 940320 3.1 FOXA2 SP5 HLF MAX MAFG FOXA1 ZFP69B MAFF ZNF316 ZNF692 OR6B3 GC02M239110 GC02M239160 HDAC4
GH02J239201 Enhancer 0.6 Ensembl ENCODE dbSUPER 5.1 +852.1 852139 0.9 OR6B3 MGC16025 GC02M239271 HDAC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6B3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6B3 gene promoter:
  • Roaz
  • GATA-2
  • Nkx2-5
  • RORalpha2
  • USF-1
  • USF1
  • ATF6
  • MZF-1
  • SEF-1 (1)
  • CREB

Genomic Locations for OR6B3 Gene

Genomic Locations for OR6B3 Gene
9,076 bases
Minus strand
996 bases
Minus strand

Genomic View for OR6B3 Gene

Genes around OR6B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6B3 Gene

Proteins for OR6B3 Gene

  • Protein details for OR6B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6B3
    Protein Accession:
    Secondary Accessions:
    • Q6IFH3

    Protein attributes for OR6B3 Gene

    331 amino acids
    Molecular mass:
    37232 Da
    Quaternary structure:
    No Data Available
    • Sequence=DAA04687.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR6B3 Gene

Post-translational modifications for OR6B3 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6B3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6B3 Gene

Domains & Families for OR6B3 Gene

Gene Families for OR6B3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6B3 Gene

Suggested Antigen Peptide Sequences for OR6B3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6B3: view

Function for OR6B3 Gene

Molecular function for OR6B3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR6B3: view
genes like me logo Genes that share phenotypes with OR6B3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6B3 Gene

Localization for OR6B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6B3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6B3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6B3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6B3 Gene

Pathways & Interactions for OR6B3 Gene

genes like me logo Genes that share pathways with OR6B3: view

Pathways by source for OR6B3 Gene

Interacting Proteins for OR6B3 Gene

Gene Ontology (GO) - Biological Process for OR6B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6B3: view

No data available for SIGNOR curated interactions for OR6B3 Gene

Drugs & Compounds for OR6B3 Gene

No Compound Related Data Available

Transcripts for OR6B3 Gene

mRNA/cDNA for OR6B3 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR6B3 Gene

Olfactory receptor, family 6, subfamily B, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6B3 Gene

No ASD Table

Relevant External Links for OR6B3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6B3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR6B3 Gene

This gene is overexpressed in Nerve - Tibial (x40.7).

NURSA nuclear receptor signaling pathways regulating expression of OR6B3 Gene:


SOURCE GeneReport for Unigene cluster for OR6B3 Gene:

genes like me logo Genes that share expression patterns with OR6B3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6B3 Gene

Orthologs for OR6B3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6B3 Gene

Organism Taxonomy Gene Similarity Type Details
(Rattus norvegicus)
Mammalia Olr1345 33
  • 87.38 (n)
(Mus musculus)
Mammalia Or6b3 51 Olfr1414 16 34 33
  • 86.86 (n)
Olfr1415 34
  • 84 (a)
Olfr1416 34
  • 84 (a)
Or6b9 51 Olfr6
  • chr7:106,955,987-106,957,015
(Bos Taurus)
Mammalia -- 34
  • 85 (a)
-- 34
  • 82 (a)
(Canis familiaris)
Mammalia -- 34
  • 81 (a)
-- 34
  • 81 (a)
-- 34
  • 80 (a)
-- 34
  • 80 (a)
OR12C12 34
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 62 (a)
Species where no ortholog for OR6B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6B3 Gene

Gene Tree for OR6B3 (if available)
Gene Tree for OR6B3 (if available)
Evolutionary constrained regions (ECRs) for OR6B3: view image

Paralogs for OR6B3 Gene

Paralogs for OR6B3 Gene

(455) SIMAP similar genes for OR6B3 Gene using alignment to 2 proteins:

  • I0EZ58_HUMAN
genes like me logo Genes that share paralogs with OR6B3: view

Variants for OR6B3 Gene

Sequence variations from dbSNP and Humsavar for OR6B3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000151774 -- 240,052,937(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000285555 -- 240,046,481(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000732670 -- 240,045,299(-) C/T coding_sequence_variant, missense_variant
rs1000757271 -- 240,051,361(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000947530 -- 240,044,857(-) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR6B3 Gene

Variant ID Type Subtype PubMed ID
esv3594791 CNV loss 21293372
nsv3236 CNV insertion 18451855
nsv525278 CNV gain 19592680
nsv997288 CNV gain 25217958

Variation tolerance for OR6B3 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6B3 Gene

Disorders for OR6B3 Gene

Additional Disease Information for OR6B3

No disorders were found for OR6B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6B3 Gene

Publications for OR6B3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration. (PMID: 29348145) Fung E … D'Angiolella V (EMBO reports 2018) 3 58
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58
  4. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. (PMID: 21244100) Virok DP … Fülöp L (Journal of proteome research 2011) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR6B3 Gene

Sources for OR6B3 Gene

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