Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6B3 Gene

Aliases for OR6B3 Gene

  • Olfactory Receptor Family 6 Subfamily B Member 3 2 3 5
  • Olfactory Receptor, Family 6, Subfamily B, Member 3 Pseudogene 2 3
  • Olfactory Receptor OR2-2 3 4
  • Olfactory Receptor 6B3 3 4
  • OR6B3P 3 4
  • OR6B3Q 2 3
  • Olfactory Receptor, Family 6, Subfamily B, Member 3 2
  • OR6B3 5

External Ids for OR6B3 Gene

Previous HGNC Symbols for OR6B3 Gene

  • OR6B3P

Previous GeneCards Identifiers for OR6B3 Gene

  • GC02U900017
  • GC02M241306
  • GC02M240689
  • GC02M240633
  • GC02M240984

Summaries for OR6B3 Gene

Entrez Gene Summary for OR6B3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6B3 Gene

OR6B3 (Olfactory Receptor Family 6 Subfamily B Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR6B2.

UniProtKB/Swiss-Prot Summary for OR6B3 Gene

Gene Wiki entry for OR6B3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6B3 Gene

Genomics for OR6B3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6B3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J240051 Enhancer 0.5 FANTOM5 Ensembl 250.7 +1.8 1796 0.6 SOX5 SOX13 OR6B3 HSALNG0023548 OR6B2
GH02J240134 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 11.2 -82.3 -82280 3.2 EZH2 BCLAF1 ZNF207 MYC POLR2A ZIC2 SMAD5 TARDBP ELK1 ETS1 COPS9 lnc-OTOS-2 ANKMY1 CAPN10 OR6B3 NDUFA10 OR5S1P
GH02J239926 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 9.6 +125.9 125889 2 NCOR1 ZNF600 ATF2 ZIC2 CEBPB BHLHE40 TBP MAX ZNF217 TAF9B NDUFA10 OR6B3 HSALNG0023542 HSALNG0023541 LOC401040
GH02J240098 Enhancer 0.5 Ensembl 11.3 -42.7 -42702 0.4 RFX1 EGR2 EZH2 TARDBP ZFHX2 HSALNG0023551 OR6B3 piR-60794-010 COPS9
GH02J239111 Enhancer 0.9 Ensembl ENCODE dbSUPER 4.9 +940.1 940092 3.1 ZNF341 MAFF ZNF316 MAFK MAX FOXA1 MAFG GLIS1 ZFP69B HLF ENSG00000286307 OR6B3 lnc-NDUFA10-8 TWIST2 HDAC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6B3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6B3

Top Transcription factor binding sites by QIAGEN in the OR6B3 gene promoter:
  • ATF6
  • CREB
  • GATA-2
  • MZF-1
  • Nkx2-5
  • Roaz
  • RORalpha2
  • SEF-1 (1)
  • USF-1
  • USF1

Genomic Locations for OR6B3 Gene

Latest Assembly
chr2:240,044,571-240,053,521
(GRCh38/hg38)
Size:
8,951 bases
Orientation:
Minus strand

Previous Assembly
chr2:240,983,988-240,992,938
(GRCh37/hg19 by Entrez Gene)
Size:
8,951 bases
Orientation:
Minus strand

chr2:240,984,494-240,985,489
(GRCh37/hg19 by Ensembl)
Size:
996 bases
Orientation:
Minus strand

Genomic View for OR6B3 Gene

Genes around OR6B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6B3 Gene

Proteins for OR6B3 Gene

  • Protein details for OR6B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGW1-OR6B3_HUMAN
    Recommended name:
    Olfactory receptor 6B3
    Protein Accession:
    Q8NGW1
    Secondary Accessions:
    • Q6IFH3

    Protein attributes for OR6B3 Gene

    Size:
    331 amino acids
    Molecular mass:
    37232 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04687.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR6B3 Gene

Post-translational modifications for OR6B3 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6B3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6B3 Gene

Domains & Families for OR6B3 Gene

Gene Families for OR6B3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6B3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6B3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR2-2 (OR6B3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGW1

UniProtKB/Swiss-Prot:

OR6B3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6B3: view

Function for OR6B3 Gene

Molecular function for OR6B3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6B3 Gene

Gene Ontology (GO) - Molecular Function for OR6B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR6B3: view
genes like me logo Genes that share phenotypes with OR6B3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6B3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6B3 Gene

Localization for OR6B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6B3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6B3 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OR6B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6B3: view

Pathways & Interactions for OR6B3 Gene

genes like me logo Genes that share pathways with OR6B3: view

Pathways by source for OR6B3 Gene

Interacting Proteins for OR6B3 Gene

Gene Ontology (GO) - Biological Process for OR6B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6B3: view

No data available for SIGNOR curated interactions for OR6B3 Gene

Drugs & Compounds for OR6B3 Gene

No Compound Related Data Available

Transcripts for OR6B3 Gene

mRNA/cDNA for OR6B3 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6B3

Alternative Splicing Database (ASD) splice patterns (SP) for OR6B3 Gene

No ASD Table

Relevant External Links for OR6B3 Gene

GeneLoc Exon Structure for
OR6B3

Expression for OR6B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6B3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR6B3 Gene

This gene is overexpressed in Nerve - Tibial (x40.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6B3

SOURCE GeneReport for Unigene cluster for OR6B3 Gene:

Hs.626616
genes like me logo Genes that share expression patterns with OR6B3: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6B3 Gene

Orthologs for OR6B3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6B3 Gene

Organism Taxonomy Gene Similarity Type Details
Rat
(Rattus norvegicus)
Mammalia Olr1345 29
  • 87.38 (n)
Mouse
(Mus musculus)
Mammalia Or6b3 45 Olfr1414 29 16 30
  • 86.86 (n)
ManyToMany
Olfr1415 30
  • 84 (a)
ManyToMany
Olfr1416 30
  • 84 (a)
ManyToMany
Or6b9 45 Olfr6
  • chr7:106,955,987-106,957,015
Cow
(Bos Taurus)
Mammalia -- 30
  • 85 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 81 (a)
ManyToMany
-- 30
  • 81 (a)
ManyToMany
-- 30
  • 80 (a)
ManyToMany
-- 30
  • 80 (a)
ManyToMany
OR12C12 30
  • 79 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 75 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 62 (a)
OneToMany
Species where no ortholog for OR6B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6B3 Gene

ENSEMBL:
Gene Tree for OR6B3 (if available)
TreeFam:
Gene Tree for OR6B3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6B3: view image
Alliance of Genome Resources:
Additional Orthologs for OR6B3

Paralogs for OR6B3 Gene

(455) SIMAP similar genes for OR6B3 Gene using alignment to 2 proteins:

  • OR6B3_HUMAN
  • I0EZ58_HUMAN
genes like me logo Genes that share paralogs with OR6B3: view

Variants for OR6B3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6B3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs13030992 Benign: not provided 240,045,930(-) G/A
NM_173351.1(OR6B3):c.143C>T (p.Thr48Ile)
MISSENSE
rs57303374 Likely Benign: not provided 240,045,743(-) G/A
NM_173351.1(OR6B3):c.330C>T (p.Thr110=)
SYNONYMOUS
rs12465491 -- p.Cys234Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6B3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR6B3 Gene

Variant ID Type Subtype PubMed ID
esv3594791 CNV loss 21293372
nsv3236 CNV insertion 18451855
nsv525278 CNV gain 19592680
nsv997288 CNV gain 25217958

Variation tolerance for OR6B3 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6B3
Leiden Open Variation Database (LOVD)
OR6B3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6B3 Gene

Disorders for OR6B3 Gene

Additional Disease Information for OR6B3

No disorders were found for OR6B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6B3 Gene

Publications for OR6B3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration. (PMID: 29348145) Fung E … D'Angiolella V (EMBO reports 2018) 3
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3
  4. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. (PMID: 21244100) Virok DP … Fülöp L (Journal of proteome research 2011) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR6B3 Gene

Sources for OR6B3 Gene