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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR6B3 (Olfactory Receptor Family 6 Subfamily B Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR6B2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J240051 | Enhancer | 0.4 | FANTOM5 | 600.7 | +1.7 | 1731 | 0.1 | SOX13 SOX5 | OR6B3 OR6B2 | |
GH02J240134 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas | 11.2 | -82.1 | -82079 | 3.2 | POLR2A LARP7 GABPA ZNF143 ZIC2 RBFOX2 IRF2 REST ZNF501 RELA | COPS9 lnc-OTOS-2 ANKMY1 CAPN10 OR6B3 NDUFA10 OR5S1P | |
GH02J239926 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 9.6 | +125.9 | 125913 | 2.4 | CREB1 ATF7 ZNF629 RFX1 ZNF692 JUND ZIC2 PATZ1 ZNF600 EP300 | NDUFA10 OR6B3 HSALNG0023541 MIR4786 LOC401040 | |
GH02J239111 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 4.9 | +940.2 | 940193 | 3.3 | ZNF692 ZNF341 CEBPB CTCF ZNF316 MAFF MAFK MAFG ZFP69B FOXA1 | ENSG00000286307 OR6B3 lnc-NDUFA10-8 TWIST2 HDAC4 | |
GH02J239201 | Enhancer | 0.7 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 5 | +851.3 | 851321 | 3.6 | HDAC4 HDAC4-AS1 OR6B3 MGC16025 lnc-NDUFA10-5 lnc-NDUFA10-4 TWIST2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO:0005549 | odorant binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IBA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Rat (Rattus norvegicus) |
Mammalia | Olr1345 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or6b3 46 Olfr1414 30 17 31 |
|
ManyToMany |
|
Olfr1415 31 |
|
ManyToMany | |||
Olfr1416 31 |
|
ManyToMany | |||
Or6b9 46 Olfr6 |
|
|
|||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
OR12C12 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
767875 | Likely Benign: not provided | 240,045,743(-) | G/A | SYNONYMOUS_VARIANT | |
767876 | Benign: not provided | 240,045,930(-) | G/A | MISSENSE_VARIANT | |
rs12465491 | - | p.Cys234Tyr |
No disorders were found for OR6B3 Gene.