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Aliases for OR6B2 Gene

Aliases for OR6B2 Gene

  • Olfactory Receptor Family 6 Subfamily B Member 2 2 3 5
  • Olfactory Receptor, Family 6, Subfamily B, Member 2 Pseudogene 2 3
  • Olfactory Receptor OR2-1 3 4
  • OR6B2P 3 4
  • Olfactory Receptor, Family 6, Subfamily B, Member 2 2
  • Olfactory Receptor 6B2 3
  • OR2-1 3

External Ids for OR6B2 Gene

Previous HGNC Symbols for OR6B2 Gene

  • OR6B2P

Previous GeneCards Identifiers for OR6B2 Gene

  • GC02U900763
  • GC02M240690
  • GC02M240617
  • GC02M240968

Summaries for OR6B2 Gene

Entrez Gene Summary for OR6B2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6B2 Gene

OR6B2 (Olfactory Receptor Family 6 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR6B3.

UniProtKB/Swiss-Prot for OR6B2 Gene

  • Odorant receptor.

Gene Wiki entry for OR6B2 Gene

Additional gene information for OR6B2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6B2 Gene

Genomics for OR6B2 Gene

GeneHancer (GH) Regulatory Elements for OR6B2 Gene

Promoters and enhancers for OR6B2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J240070 Enhancer 0.7 ENCODE 10.9 -36.2 -36211 0.1 NCOA3 CLOCK ESRRA NFIB NEUROD1 SIN3A NFXL1 CEBPG ZKSCAN1 RFX5 PRR21 OR6B2 NDUFA10 OR9S24P GC02M240027
GH02J239979 Enhancer 0.6 ENCODE dbSUPER 11.1 +54.5 54459 0.1 CTCF ZNF143 RAD21 NDUFA10 OR6B2 PRR21 PIR48148 GC02P239972 GC02P239934
GH02J239978 Enhancer 0.5 FANTOM5 dbSUPER 11.1 +55.2 55242 0.3 NDUFA10 OR6B2 PRR21 PIR48148 GC02P239972 GC02P239934
GH02J239988 Enhancer 0.5 dbSUPER 11 +43.3 43316 5 CTCF ZNF654 TRIM22 ZNF143 SMC3 RAD21 MIXL1 NDUFA10 OR6B2 PRR21 LOC401040 LOC101928111 HDAC4 PIR48148 PIR31958 GC02P239934
GH02J239957 Enhancer 0.5 dbSUPER 10.7 +72.8 72774 7.1 ZNF366 ZNF207 ZBTB33 YBX1 SUPT5H NDUFA10 OR6B2 PRR21 GC02P239972 MIR4786 GC02P239934
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6B2 gene promoter:
  • AP-2alphaA
  • AP-2alpha isoform 4
  • AP-2alpha isoform 3
  • AP-2alpha isoform 2
  • AP-2alpha
  • GATA-2
  • HOXA5
  • Roaz
  • RORalpha2

Genomic Locations for OR6B2 Gene

Genomic Locations for OR6B2 Gene
4,894 bases
Minus strand
1,066 bases
Minus strand

Genomic View for OR6B2 Gene

Genes around OR6B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6B2 Gene

Proteins for OR6B2 Gene

  • Protein details for OR6B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6B2
    Protein Accession:
    Secondary Accessions:
    • B2RPR3
    • Q8NGW0

    Protein attributes for OR6B2 Gene

    312 amino acids
    Molecular mass:
    35029 Da
    Quaternary structure:
    No Data Available
    • Sequence=DAA04686.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR6B2 Gene

Post-translational modifications for OR6B2 Gene

No Post-translational modifications

Other Protein References for OR6B2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6B2 Gene

Domains & Families for OR6B2 Gene

Gene Families for OR6B2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6B2 Gene

Suggested Antigen Peptide Sequences for OR6B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6B2: view

Function for OR6B2 Gene

Molecular function for OR6B2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6B2 Gene

Gene Ontology (GO) - Molecular Function for OR6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR6B2: view
genes like me logo Genes that share phenotypes with OR6B2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6B2 Gene

Localization for OR6B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6B2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6B2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6B2 Gene

Pathways & Interactions for OR6B2 Gene

genes like me logo Genes that share pathways with OR6B2: view

Pathways by source for OR6B2 Gene

Interacting Proteins for OR6B2 Gene

Gene Ontology (GO) - Biological Process for OR6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6B2: view

No data available for SIGNOR curated interactions for OR6B2 Gene

Drugs & Compounds for OR6B2 Gene

No Compound Related Data Available

Transcripts for OR6B2 Gene

mRNA/cDNA for OR6B2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR6B2 Gene

Olfactory receptor, family 6, subfamily B, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6B2 Gene

No ASD Table

Relevant External Links for OR6B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6B2 Gene

mRNA differential expression in normal tissues according to GTEx for OR6B2 Gene

This gene is overexpressed in Nerve - Tibial (x43.0) and Testis (x5.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR6B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6B2 Gene:


SOURCE GeneReport for Unigene cluster for OR6B2 Gene:

genes like me logo Genes that share expression patterns with OR6B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6B2 Gene

Orthologs for OR6B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC470698 33
  • 98.72 (n)
(Bos Taurus)
Mammalia LOC618817 33
  • 89.11 (n)
-- 34
  • 86 (a)
-- 34
  • 83 (a)
(Canis familiaris)
Mammalia LOC100856687 33
  • 87.49 (n)
-- 34
  • 83 (a)
-- 34
  • 82 (a)
-- 34
  • 82 (a)
-- 34
  • 82 (a)
OR12C12 34
  • 80 (a)
(Mus musculus)
Mammalia Olfr1414 34
  • 87 (a)
Or6b2 51 Olfr1416 16 34 33
  • 86.32 (n)
Or6b2b 51 Olfr1415 34
  • 86 (a)
Or6b6 51 Olfr711
  • chr7:106,971,401-106,972,342
Or6i1-ps 51 Olfr712-ps1
  • chr7:106,989,099-106,989,666
(Rattus norvegicus)
Mammalia Olr1343 33
  • 86.08 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 61 (a)
Species where no ortholog for OR6B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6B2 Gene

Gene Tree for OR6B2 (if available)
Gene Tree for OR6B2 (if available)
Evolutionary constrained regions (ECRs) for OR6B2: view image

Paralogs for OR6B2 Gene

Paralogs for OR6B2 Gene

(455) SIMAP similar genes for OR6B2 Gene using alignment to 2 proteins:

  • I0EZ57_HUMAN
genes like me logo Genes that share paralogs with OR6B2: view

Variants for OR6B2 Gene

Sequence variations from dbSNP and Humsavar for OR6B2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1002000858 -- 240,031,408(-) G/A upstream_transcript_variant
rs1002572492 -- 240,031,241(-) G/A upstream_transcript_variant
rs1002709830 -- 240,031,597(-) T/C upstream_transcript_variant
rs1003307445 -- 240,030,665(-) T/A upstream_transcript_variant
rs1003419350 -- 240,029,331(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR6B2 Gene

Variant ID Type Subtype PubMed ID
esv3594790 CNV loss 21293372
nsv525278 CNV gain 19592680
nsv834584 CNV gain 17160897
nsv997288 CNV gain 25217958

Variation tolerance for OR6B2 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.96; 94.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6B2 Gene

Disorders for OR6B2 Gene

Additional Disease Information for OR6B2

No disorders were found for OR6B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6B2 Gene

Publications for OR6B2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Identification of regions associated with variation in sensitivity to food-related odors in the human genome. (PMID: 23910658) McRae JF … Newcomb RD (Current biology : CB 2013) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR6B2 Gene

Sources for OR6B2 Gene

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