OR6B1 Gene (Protein Coding)

Olfactory Receptor Family 6 Subfamily B Member 1

GC07P144752
GIFtS:
29
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6B1 Gene

Aliases for OR6B1 Gene

  • Olfactory Receptor Family 6 Subfamily B Member 1 2 3 5
  • Olfactory Receptor OR7-9 3 4
  • Olfactory Receptor 6B1 3 4
  • Olfactory Receptor 7-3 3 4
  • OR7-3 3 4
  • Olfactory Receptor, Family 6, Subfamily B, Member 1 2
  • OR7-9 3

External Ids for OR6B1 Gene

Previous GeneCards Identifiers for OR6B1 Gene

  • GC07U990166
  • GC07P143090
  • GC07P143138
  • GC07P143332
  • GC07P143701
  • GC07P144003
  • GC07P144247
  • GC07P144381
  • GC07P144510
  • GC07P144004
  • GC07P144104

Summaries for OR6B1 Gene

Entrez Gene Summary for OR6B1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6B1 Gene

OR6B1 (Olfactory Receptor Family 6 Subfamily B Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6A2.

UniProtKB/Swiss-Prot Summary for OR6B1 Gene

Gene Wiki entry for OR6B1 Gene

Additional gene information for OR6B1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6B1 Gene

Genomics for OR6B1 Gene

GeneHancer (GH) Regulatory Elements for OR6B1 Gene

Promoters and enhancers for OR6B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J143972 Enhancer 0.8 Ensembl ENCODE 12.5 -26.2 -26204 2.3 ZNF217 TCF12 ZNF830 CTBP1 FOSL2 CEBPB RBBP5 JUND ELF1 GATA3 OR6B1 OR2A5 CAPZA1P5 lnc-OR2F1-1 OR2F1
GH07J144127 Enhancer 0.8 ENCODE 10.7 +127.6 127583 0.2 ZNF217 CTCF USF1 ZNF10 CLOCK REST USF2 NR3C1 MYC TOE1 OR6B1 OR2A14 RF00017-6714 OR2A13P
GH07J144030 Enhancer 0.3 Ensembl 12.7 +30.4 30381 0.6 SPI1 ARHGEF35 OR6B1 OR2A25 OR2A41P OR2F1 HSALNG0061982 lnc-OR6B1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6B1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6B1

Top Transcription factor binding sites by QIAGEN in the OR6B1 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • FOXF2
  • FOXO3
  • FOXO3a
  • FOXO3b
  • ISGF-3
  • YY1

Genomic Locations for OR6B1 Gene

Genomic Locations for OR6B1 Gene
chr7:144,000,320-144,008,793
(GRCh38/hg38)
Size:
8,474 bases
Orientation:
Plus strand
chr7:143,701,022-143,702,068
(GRCh37/hg19)
Size:
1,047 bases
Orientation:
Plus strand

Genomic View for OR6B1 Gene

Genes around OR6B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6B1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR6B1 Gene

Proteins for OR6B1 Gene

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  • Protein details for OR6B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95007-OR6B1_HUMAN
    Recommended name:
    Olfactory receptor 6B1
    Protein Accession:
    O95007
    Secondary Accessions:
    • A4D2G2
    • B9EH47
    • Q6IFP6
    • Q96R38

    Protein attributes for OR6B1 Gene

    Size:
    311 amino acids
    Molecular mass:
    35299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6B1 Gene

Post-translational modifications for OR6B1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6B1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6B1 Gene

Domains & Families for OR6B1 Gene

Gene Families for OR6B1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6B1 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR6B1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR7-9 (OR6B1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95007

UniProtKB/Swiss-Prot:

OR6B1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6B1: view

Function for OR6B1 Gene

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Molecular function for OR6B1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 6,subfamily B,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR6B1 Gene

Gene Ontology (GO) - Molecular Function for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR6B1: view

Animal Model Products

CRISPR Products

miRNA for OR6B1 Gene

miRTarBase miRNAs that target OR6B1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR6B1 Gene

Localization for OR6B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6B1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6B1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6B1 Gene

Pathways & Interactions for OR6B1 Gene

genes like me logo Genes that share pathways with OR6B1: view

Pathways by source for OR6B1 Gene

1 BioSystems pathway for OR6B1 Gene
1 KEGG pathway for OR6B1 Gene

Interacting Proteins for OR6B1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000386151 O95007-OR6B1_HUMAN for OR6B1 Gene via STRING IID

GPS-Prot Interaction Network for OR6B1
;

Gene Ontology (GO) - Biological Process for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6B1: view

No data available for SIGNOR curated interactions for OR6B1 Gene

Drugs & Compounds for OR6B1 Gene

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No Compound Related Data Available

Transcripts for OR6B1 Gene

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mRNA/cDNA for OR6B1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6B1 Gene

No ASD Table

Relevant External Links for OR6B1 Gene

GeneLoc Exon Structure for
OR6B1

Expression for OR6B1 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6B1 Gene

mRNA expression in normal human tissues for OR6B1 Gene
mRNA expression by BioGPS for OR6B1 GenemRNA expression by GTEx for OR6B1 Gene

mRNA differential expression in normal tissues according to GTEx for OR6B1 Gene

This gene is overexpressed in Testis (x44.6) and Brain - Amygdala (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6B1

SOURCE GeneReport for Unigene cluster for OR6B1 Gene:

Hs.632031
genes like me logo Genes that share expression patterns with OR6B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6B1 Gene

Orthologs for OR6B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6B1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia OR6B1 31 30
  • 88.53 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia OR6B1 31 30
  • 87.85 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Olr811 30
  • 86.39 (n)
mouse
(Mus musculus)
 Mammalia Or6b1 47 Olfr449 17 31 30
  • 86.28 (n)
Or6z1 47 Olfr1348
  • chr7:6,501,289-6,502,224
oppossum
(Monodelphis domestica)
 Mammalia OR6B1 31
  • 85 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves COR7A 31 30
  • 64.78 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia OR6B1 31
  • 64 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100486033 30
  • 62.13 (n)
Species where no ortholog for OR6B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6B1 Gene

ENSEMBL:
Gene Tree for OR6B1 (if available)
TreeFam:
Gene Tree for OR6B1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6B1: view image

Paralogs for OR6B1 Gene

Paralogs for OR6B1 Gene

(449) SIMAP similar genes for OR6B1 Gene using alignment to 1 proteins:

  • OR6B1_HUMAN
genes like me logo Genes that share paralogs with OR6B1: view

Variants for OR6B1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6B1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs7787378 - p.Arg143Cys

Additional dbSNP identifiers (rs#s) for OR6B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR6B1 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1682998 OTHER inversion 17803354
esv2422489 CNV duplication 17116639
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv3891223 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv1023400 CNV gain 25217958
nsv428188 CNV gain+loss 18775914
nsv522225 CNV gain 19592680
nsv5987 CNV deletion 18451855
nsv608682 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv831173 CNV gain 17160897

Variation tolerance for OR6B1 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.06; 84.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6B1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6B1 Gene

Disorders for OR6B1 Gene

Additional Disease Information for OR6B1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR6B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6B1 Gene

Publications for OR6B1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 54
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

ExternalLinks

View latest publications for OR6B1 gene in Mastermind

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