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Aliases for OR6B1 Gene

Aliases for OR6B1 Gene

  • Olfactory Receptor Family 6 Subfamily B Member 1 2 3 5
  • Olfactory Receptor OR7-9 3 4
  • Olfactory Receptor 7-3 3 4
  • OR7-3 3 4
  • Olfactory Receptor, Family 6, Subfamily B, Member 1 2
  • Olfactory Receptor 6B1 3
  • OR7-9 3

External Ids for OR6B1 Gene

Previous GeneCards Identifiers for OR6B1 Gene

  • GC07U990166
  • GC07P143090
  • GC07P143138
  • GC07P143332
  • GC07P143701
  • GC07P144003

Summaries for OR6B1 Gene

Entrez Gene Summary for OR6B1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6B1 Gene

OR6B1 (Olfactory Receptor Family 6 Subfamily B Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6A2.

UniProtKB/Swiss-Prot for OR6B1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6B1 Gene

Additional gene information for OR6B1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6B1 Gene

Genomics for OR6B1 Gene

GeneHancer (GH) Regulatory Elements for OR6B1 Gene

Promoters and enhancers for OR6B1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J144127 Enhancer 0.8 ENCODE 10.7 +127.6 127583 0.2 CLOCK RB1 SIN3A RAD21 ARID2 SCRT2 ZNF143 RCOR1 SMARCA5 ZNF654 OR6B1 OR2A14 OR2A13P
GH07J143972 Enhancer 0.6 ENCODE 12.5 -26.2 -26204 2.3 ELF3 CEBPB ELF1 SP1 ZNF217 CTBP1 GATA3 JUND FOSL2 TCF7L2 OR6B1 OR2A5 LOC100422324 OR2F2 OR2F1
GH07J144018 Enhancer 0.9 Ensembl ENCODE 0.4 +19.8 19789 3.4 MEIS2 SOX13 JUN CEBPG BMI1 FOSL1 CTBP1 GATA3 POLR2A EGR1 ARHGEF35 OR2A5 OR2F1 LOC154761 OR6B1
GH07J143989 Enhancer 0.7 ENCODE 0.4 -10.9 -10897 0.2 MEIS2 PKNOX1 ATF1 TEAD4 TAL1 CHAMP1 TCF12 CTBP1 GATA2 NUFIP1 OR2F1 OR2A5 SLC16A1P1 OR6B1
GH07J144031 Enhancer 0.5 ENCODE 0.3 +31.4 31423 1.3 NFIC NFIB ZSCAN4 NR2F2 ARHGEF35 OR2A25 OR2A41P OR2A5 OR6B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6B1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR6B1 gene promoter:
  • FOXF2
  • CHOP-10
  • C/EBPalpha
  • ISGF-3
  • YY1
  • FOXO3b
  • FOXO3a
  • FOXO3

Genomic Locations for OR6B1 Gene

Genomic Locations for OR6B1 Gene
8,474 bases
Plus strand
1,047 bases
Plus strand

Genomic View for OR6B1 Gene

Genes around OR6B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6B1 Gene

Proteins for OR6B1 Gene

  • Protein details for OR6B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6B1
    Protein Accession:
    Secondary Accessions:
    • A4D2G2
    • B9EH47
    • Q6IFP6
    • Q96R38

    Protein attributes for OR6B1 Gene

    311 amino acids
    Molecular mass:
    35299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6B1 Gene

Post-translational modifications for OR6B1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6B1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6B1 Gene

Domains & Families for OR6B1 Gene

Gene Families for OR6B1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6B1 Gene

Suggested Antigen Peptide Sequences for OR6B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6B1: view

Function for OR6B1 Gene

Molecular function for OR6B1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 6,subfamily B,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR6B1 Gene

Gene Ontology (GO) - Molecular Function for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR6B1: view

Animal Model Products

miRNA for OR6B1 Gene

miRTarBase miRNAs that target OR6B1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR6B1 Gene

Localization for OR6B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6B1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6B1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6B1 Gene

Pathways & Interactions for OR6B1 Gene

genes like me logo Genes that share pathways with OR6B1: view

Pathways by source for OR6B1 Gene

1 KEGG pathway for OR6B1 Gene

Interacting Proteins for OR6B1 Gene

Gene Ontology (GO) - Biological Process for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6B1: view

No data available for SIGNOR curated interactions for OR6B1 Gene

Drugs & Compounds for OR6B1 Gene

No Compound Related Data Available

Transcripts for OR6B1 Gene

mRNA/cDNA for OR6B1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR6B1 Gene

Olfactory receptor, family 6, subfamily B, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6B1 Gene

No ASD Table

Relevant External Links for OR6B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6B1 Gene

mRNA differential expression in normal tissues according to GTEx for OR6B1 Gene

This gene is overexpressed in Testis (x44.6) and Brain - Amygdala (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of OR6B1 Gene:


SOURCE GeneReport for Unigene cluster for OR6B1 Gene:

genes like me logo Genes that share expression patterns with OR6B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6B1 Gene

Orthologs for OR6B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia OR6B1 34 33
  • 88.53 (n)
(Bos Taurus)
Mammalia OR6B1 34 33
  • 87.85 (n)
(Rattus norvegicus)
Mammalia Olr811 33
  • 86.39 (n)
(Mus musculus)
Mammalia Or6b1 51 Olfr449 16 34 33
  • 86.28 (n)
Or6z1 51 Olfr1348
  • chr7:6,501,289-6,502,224
(Monodelphis domestica)
Mammalia OR6B1 34
  • 85 (a)
(Gallus gallus)
Aves COR7A 34 33
  • 64.78 (n)
(Anolis carolinensis)
Reptilia OR6B1 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486033 33
  • 62.13 (n)
Species where no ortholog for OR6B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6B1 Gene

Gene Tree for OR6B1 (if available)
Gene Tree for OR6B1 (if available)
Evolutionary constrained regions (ECRs) for OR6B1: view image

Paralogs for OR6B1 Gene

Paralogs for OR6B1 Gene

(449) SIMAP similar genes for OR6B1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6B1: view

Variants for OR6B1 Gene

Sequence variations from dbSNP and Humsavar for OR6B1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000460420 -- 144,002,371(+) A/G upstream_transcript_variant
rs1001745374 -- 144,003,336(+) A/G upstream_transcript_variant
rs1001821295 -- 144,004,355(+) A/G coding_sequence_variant, missense_variant
rs1002070142 -- 144,003,143(+) C/A upstream_transcript_variant
rs1003760104 -- 144,005,362(+) G/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR6B1 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1682998 OTHER inversion 17803354
esv2422489 CNV duplication 17116639
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv3891223 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv1023400 CNV gain 25217958
nsv428188 CNV gain+loss 18775914
nsv522225 CNV gain 19592680
nsv5987 CNV deletion 18451855
nsv608682 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv831173 CNV gain 17160897

Variation tolerance for OR6B1 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.06; 84.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6B1 Gene

Disorders for OR6B1 Gene

Additional Disease Information for OR6B1

No disorders were found for OR6B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6B1 Gene

Publications for OR6B1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 4 58

Products for OR6B1 Gene

Sources for OR6B1 Gene

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