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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR6B1 (Olfactory Receptor Family 6 Subfamily B Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | OR6B1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OR6B1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Olr811 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or6b1 46 Olfr449 30 17 31 |
|
OneToOne |
|
Or6z1 46 Olfr1348 |
|
|
|||
Oppossum (Monodelphis domestica) |
Mammalia | OR6B1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | COR7A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | OR6B1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486033 30 |
|
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs7787378 | - | p.Arg143Cys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv11664n54 | CNV | gain | 21841781 |
dgv6725n100 | CNV | gain | 25217958 |
dgv842n27 | CNV | gain | 19166990 |
esv1682998 | OTHER | inversion | 17803354 |
esv2422489 | CNV | duplication | 17116639 |
esv2752147 | CNV | gain | 17911159 |
esv2759570 | CNV | gain+loss | 17122850 |
esv3891223 | CNV | loss | 25118596 |
nsv1016831 | CNV | gain | 25217958 |
nsv1023400 | CNV | gain | 25217958 |
nsv428188 | CNV | gain+loss | 18775914 |
nsv522225 | CNV | gain | 19592680 |
nsv5987 | CNV | deletion | 18451855 |
nsv608682 | CNV | gain | 21841781 |
nsv8227 | CNV | gain+loss | 18304495 |
nsv831173 | CNV | gain | 17160897 |
No disorders were found for OR6B1 Gene.