Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR6A2 Gene

Aliases for OR6A2 Gene

  • Olfactory Receptor Family 6 Subfamily A Member 2 2 3 5
  • OR11-55 2 3 4
  • Olfactory Receptor OR11-83 3 4
  • Olfactory Receptor 11-55 3 4
  • Olfactory Receptor 6A2 3 4
  • HP2 Olfactory Receptor 3 4
  • Olfactory Receptor 6A1 3 4
  • OR6A2P 3 4
  • OR6A1 3 4
  • Olfactory Receptor, Family 6, Subfamily A, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 6, Subfamily A, Member 2 2
  • Olfactory Receptor, Family 6, Subfamily A, Member 1 3
  • Seven Transmembrane Helix Receptor 3
  • HI7 Olfactory Receptor 3
  • OR6A2 5
  • I7 3

External Ids for OR6A2 Gene

Previous HGNC Symbols for OR6A2 Gene

  • OR6A2P
  • OR6A1

Previous GeneCards Identifiers for OR6A2 Gene

  • GC11M006781
  • GC11M006772

Summaries for OR6A2 Gene

Entrez Gene Summary for OR6A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6A2 Gene

OR6A2 (Olfactory Receptor Family 6 Subfamily A Member 2) is a Protein Coding gene. Diseases associated with OR6A2 include Gestational Choriocarcinoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6Y1.

UniProtKB/Swiss-Prot Summary for OR6A2 Gene

Gene Wiki entry for OR6A2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR6A2 Gene

Genomics for OR6A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR6A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006801 Enhancer 0.2 Ensembl 250.7 -1.7 -1712 0.4 OR6A2 OR2AG2 OR10A5 ENSG00000254712 lnc-OR6A2-1
GH11J006742 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.2 +54.6 54557 6.7 ZNF207 MYC NCOR1 IKZF1 ZNF592 POLR2A SIN3A TRIM22 TAL1 ZNF316 GVINP1 MRPL17 lnc-OR2AG2-1 ILK OR2AG2 CAVIN3 RRP8 ENSG00000254641 TAF10 OR10A4
GH11J006645 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.8 +152.7 152688 2.9 NFIC BCL11A TRIM22 HES1 BHLHE40 ZNF341 IRF4 EBF1 SPI1 MYC ILK DCHS1 OR6A2 ENSG00000255410 TPP1
GH11J006468 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.6 +330.3 330318 1.5 ZNF10 NFIC POLR2A MBD2 KLF9 SP2 ELF1 ZFP91 ZBTB48 SUPT5H OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11J006678 Enhancer 0.2 FANTOM5 1.6 +121.1 121137 0.3 HSALNG0082466-001 HSALNG0082466-002 OR10A2 OR10A4 OR2AG2 OR52W1 OR2AG1 OR6A2 MRPL17 lnc-ILK-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR6A2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR6A2

Top Transcription factor binding sites by QIAGEN in the OR6A2 gene promoter:
  • E47
  • FAC1
  • HNF-1
  • HNF-1A
  • HNF-4alpha1
  • LCR-F1
  • Nkx2-5
  • Pbx1a
  • PPAR-alpha
  • Tal-1beta

Genomic Locations for OR6A2 Gene

Latest Assembly
chr11:6,791,736-6,799,689
(GRCh38/hg38)
Size:
7,954 bases
Orientation:
Minus strand

Previous Assembly
chr11:6,812,967-6,820,920
(GRCh37/hg19 by Entrez Gene)
Size:
7,954 bases
Orientation:
Minus strand

chr11:6,815,756-6,817,128
(GRCh37/hg19 by Ensembl)
Size:
1,373 bases
Orientation:
Minus strand

Genomic View for OR6A2 Gene

Genes around OR6A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6A2 Gene

Proteins for OR6A2 Gene

  • Protein details for OR6A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95222-OR6A2_HUMAN
    Recommended name:
    Olfactory receptor 6A2
    Protein Accession:
    O95222
    Secondary Accessions:
    • Q3MJC7
    • Q6IF35
    • Q9H206

    Protein attributes for OR6A2 Gene

    Size:
    327 amino acids
    Molecular mass:
    36154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6A2 Gene

Post-translational modifications for OR6A2 Gene

  • Glycosylation at Asn5 and Asn191

Other Protein References for OR6A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6A2 Gene

Domains & Families for OR6A2 Gene

Gene Families for OR6A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6A2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR6A2 Gene

GenScript: Design optimal peptide antigens:
  • hP2 olfactory receptor (OR6A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95222

UniProtKB/Swiss-Prot:

OR6A2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6A2: view

Function for OR6A2 Gene

Molecular function for OR6A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6A2 Gene

Gene Ontology (GO) - Molecular Function for OR6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 14983052
genes like me logo Genes that share ontologies with OR6A2: view
genes like me logo Genes that share phenotypes with OR6A2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6A2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR6A2 Gene

Localization for OR6A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6A2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6A2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for OR6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 14983052
genes like me logo Genes that share ontologies with OR6A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6A2 Gene

Pathways & Interactions for OR6A2 Gene

genes like me logo Genes that share pathways with OR6A2: view

Pathways by source for OR6A2 Gene

1 KEGG pathway for OR6A2 Gene

Interacting Proteins for OR6A2 Gene

Gene Ontology (GO) - Biological Process for OR6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9787077
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 14983052
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6A2: view

No data available for SIGNOR curated interactions for OR6A2 Gene

Drugs & Compounds for OR6A2 Gene

No Compound Related Data Available

Transcripts for OR6A2 Gene

mRNA/cDNA for OR6A2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR6A2

Alternative Splicing Database (ASD) splice patterns (SP) for OR6A2 Gene

No ASD Table

Relevant External Links for OR6A2 Gene

GeneLoc Exon Structure for
OR6A2

Expression for OR6A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6A2 Gene

mRNA differential expression in normal tissues according to GTEx for OR6A2 Gene

This gene is overexpressed in Testis (x8.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR6A2

SOURCE GeneReport for Unigene cluster for OR6A2 Gene:

Hs.652252

Evidence on tissue expression from TISSUES for OR6A2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with OR6A2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6A2 Gene

Orthologs for OR6A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466418 29
  • 99.18 (n)
OR6A2 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR6A2 30
  • 91 (a)
OneToOne
LOC485348 29
  • 88.34 (n)
Cow
(Bos Taurus)
Mammalia OR6A2 29 30
  • 88.3 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or6a2 45 Olfr2 29 16 30
  • 87.32 (n)
OneToOne
Or6b13 45 Olfr524
  • chr7:140,201,815-140,202,876
Or6z3 45 Olfr1336
  • chr7:6,460,511-6,461,452
Or6z5 45 Olfr1346
  • chr7:6,474,112-6,475,050
Or6z6 45 Olfr1347
  • chr7:6,487,916-6,488,872
Or6z7 45 Olfr5
  • chr7:6,480,219-6,481,154
Rat
(Rattus norvegicus)
Mammalia LOC100911376 29
  • 86.91 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR6A2 30
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OR6A2 30
  • 58 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 58 (a)
ManyToMany
Species where no ortholog for OR6A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR6A2 Gene

ENSEMBL:
Gene Tree for OR6A2 (if available)
TreeFam:
Gene Tree for OR6A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR6A2: view image
Alliance of Genome Resources:
Additional Orthologs for OR6A2

Paralogs for OR6A2 Gene

(441) SIMAP similar genes for OR6A2 Gene using alignment to 1 proteins:

  • OR6A2_HUMAN

Pseudogenes.org Pseudogenes for OR6A2 Gene

genes like me logo Genes that share paralogs with OR6A2: view

Variants for OR6A2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR6A2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs71946386 Benign: not provided 6,795,057(-) CAG/C
NC_000011.10:g.6795058_6795059AG[2]
FRAMESHIFT
rs7122644 -- p.Ala22Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR6A2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR6A2 Gene

Variant ID Type Subtype PubMed ID
dgv1056n100 CNV loss 25217958
dgv1626n54 CNV loss 21841781
esv3579329 CNV loss 25503493
nsv1035138 CNV gain 25217958
nsv1046129 CNV loss 25217958
nsv467701 CNV loss 19166990
nsv832060 CNV gain 17160897

Variation tolerance for OR6A2 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR6A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6A2
Leiden Open Variation Database (LOVD)
OR6A2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6A2 Gene

Disorders for OR6A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR6A2 Gene - From: COP

Disorder Aliases PubMed IDs
gestational choriocarcinoma
  • gestational chorionepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search OR6A2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR6A2

genes like me logo Genes that share disorders with OR6A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR6A2 Gene

Publications for OR6A2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PMID: 11416212) Lane RP … Trask BJ (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4
  4. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner JA … Evans GA (Genomics 1998) 3 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR6A2 Gene

Sources for OR6A2 Gene