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Aliases for OR5V1 Gene

Aliases for OR5V1 Gene

  • Olfactory Receptor Family 5 Subfamily V Member 1 2 3 5
  • Olfactory Receptor OR6-26 3 4
  • Hs6M1-21 3 4
  • Olfactory Receptor, Family 5, Subfamily V, Member 1 2
  • Olfactory Receptor 5V1 3
  • 6M1-21 3

External Ids for OR5V1 Gene

Previous GeneCards Identifiers for OR5V1 Gene

  • GC06M029380
  • GC06M029431
  • GC06M029430
  • GC06M029345
  • GC06Mo29253

Summaries for OR5V1 Gene

Entrez Gene Summary for OR5V1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5V1 Gene

OR5V1 (Olfactory Receptor Family 5 Subfamily V Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR5V1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5V1 Gene

Additional gene information for OR5V1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5V1 Gene

Genomics for OR5V1 Gene

GeneHancer (GH) Regulatory Elements for OR5V1 Gene

Promoters and enhancers for OR5V1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J030065 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.6 -609.7 -609738 3 ZFP64 DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC PPP1R11 TRIM39 ZNRD1 HCG4P3 TRIM26 PPP1R10 NRM MDC1 HLA-A RPL7P4
GH06J028586 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.6 +869.9 869902 1.9 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 TRQ-TTG2-1 ZBED9 GPX6 GPX5 ZKSCAN3 ZNF311 ZNF603P ZSCAN12 ZNF90P2 KRT18P1
GH06J029490 Enhancer 0.8 ENCODE 10.8 -33.8 -33772 0.2 HDAC1 TCF12 ZNF766 GATA2 ATF7 CREM NCOA1 ZEB2 MBD2 MTA1 GC06M029498 RPS17P1 OR5V1 LINC01015 LOC105375009
GH06J029477 Enhancer 0.5 FANTOM5 10.9 -21.0 -21031 0.6 MITF VEZF1 E2F5 MAS1L OR12D3 OR5V1 UBD LINC01015 OR2H2 OR14J1 MAS1LP1 LOC105375008
GH06J029509 Enhancer 0.5 FANTOM5 10.7 -52.2 -52242 0.1 IKZF1 EBF1 RUNX3 RELA LINC01015 OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 PIRC24 LOC105375009
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5V1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5V1 gene promoter:
  • STAT5A
  • Brachyury
  • Sox5
  • E47
  • LyF-1
  • Sox9
  • Evi-1
  • PPAR-alpha
  • HNF-4alpha2
  • HNF-4alpha1

Genomic Locations for OR5V1 Gene

Genomic Locations for OR5V1 Gene
chr6:29,353,749-29,457,067
(GRCh38/hg38)
Size:
103,319 bases
Orientation:
Minus strand
chr6:29,323,007-29,399,744
(GRCh37/hg19)
Size:
76,738 bases
Orientation:
Minus strand

Genomic View for OR5V1 Gene

Genes around OR5V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5V1 Gene

Proteins for OR5V1 Gene

  • Protein details for OR5V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGF6-OR5V1_HUMAN
    Recommended name:
    Olfactory receptor 5V1
    Protein Accession:
    Q9UGF6
    Secondary Accessions:
    • A2BDZ0
    • B0S860
    • Q5SQI9
    • Q6NTB5
    • Q8IVL3

    Protein attributes for OR5V1 Gene

    Size:
    321 amino acids
    Molecular mass:
    36057 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5V1 Gene

Post-translational modifications for OR5V1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5V1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5V1 Gene

Domains & Families for OR5V1 Gene

Gene Families for OR5V1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5V1 Gene

Suggested Antigen Peptide Sequences for OR5V1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGF6

UniProtKB/Swiss-Prot:

OR5V1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5V1: view

Function for OR5V1 Gene

Molecular function for OR5V1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5V1 Gene

Gene Ontology (GO) - Molecular Function for OR5V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR5V1: view
genes like me logo Genes that share phenotypes with OR5V1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5V1 Gene

Localization for OR5V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5V1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5V1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR5V1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5V1 Gene

Pathways & Interactions for OR5V1 Gene

genes like me logo Genes that share pathways with OR5V1: view

Pathways by source for OR5V1 Gene

1 KEGG pathway for OR5V1 Gene

Interacting Proteins for OR5V1 Gene

Gene Ontology (GO) - Biological Process for OR5V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5V1: view

No data available for SIGNOR curated interactions for OR5V1 Gene

Drugs & Compounds for OR5V1 Gene

No Compound Related Data Available

Transcripts for OR5V1 Gene

mRNA/cDNA for OR5V1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5V1 Gene

Olfactory receptor, family 5, subfamily V, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5V1 Gene

No ASD Table

Relevant External Links for OR5V1 Gene

GeneLoc Exon Structure for
OR5V1
ECgene alternative splicing isoforms for
OR5V1

Expression for OR5V1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5V1 Gene

mRNA differential expression in normal tissues according to GTEx for OR5V1 Gene

This gene is overexpressed in Testis (x42.4).

NURSA nuclear receptor signaling pathways regulating expression of OR5V1 Gene:

OR5V1

SOURCE GeneReport for Unigene cluster for OR5V1 Gene:

Hs.666316
genes like me logo Genes that share expression patterns with OR5V1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5V1 Gene

Orthologs for OR5V1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5V1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471937 33
  • 98.86 (n)
OR5V1 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR5V1 33
  • 85.76 (n)
-- 34
  • 82 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or5v1 51 Olfr110 34
  • 82 (a)
OneToMany
Or5v1b 51 Olfr111 16 34 33
  • 81.33 (n)
rat
(Rattus norvegicus)
Mammalia Olr1730 33
  • 81.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OR5V1 34
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 56 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491436 33
  • 57.73 (n)
Species where no ortholog for OR5V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5V1 Gene

ENSEMBL:
Gene Tree for OR5V1 (if available)
TreeFam:
Gene Tree for OR5V1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5V1: view image

Paralogs for OR5V1 Gene

(449) SIMAP similar genes for OR5V1 Gene using alignment to 1 proteins:

  • OR5V1_HUMAN
genes like me logo Genes that share paralogs with OR5V1: view

No data available for Paralogs for OR5V1 Gene

Variants for OR5V1 Gene

Sequence variations from dbSNP and Humsavar for OR5V1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs886043176 uncertain-significance, not specified 29,397,421(-) CC/C genic_upstream_transcript_variant, intron_variant
rs1000095897 -- 29,416,734(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000135697 -- 29,402,812(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000202457 -- 29,390,759(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000247447 -- 29,400,098(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5V1 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
esv3608473 CNV gain 21293372
esv3608477 CNV loss 21293372
nsv1015796 CNV gain 25217958
nsv1020683 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv520169 CNV gain 19592680
nsv601223 CNV loss 21841781
nsv830624 CNV loss 17160897

Variation tolerance for OR5V1 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.87; 91.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5V1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5V1 Gene

Disorders for OR5V1 Gene

Additional Disease Information for OR5V1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR5V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5V1 Gene

Publications for OR5V1 Gene

  1. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. (PMID: 19833159) Thompson EE … Ober C (Human immunology 2010) 3 44 58
  2. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K … National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI) (The Journal of infectious diseases 2010) 3 44 58
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  5. Complex transcription and splicing of odorant receptor genes. (PMID: 12637542) Volz A … Ziegler A (The Journal of biological chemistry 2003) 3 4 58

Products for OR5V1 Gene

Sources for OR5V1 Gene

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