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Aliases for OR5T2 Gene

Aliases for OR5T2 Gene

  • Olfactory Receptor Family 5 Subfamily T Member 2 2 3 5
  • Olfactory Receptor OR11-177 3 4
  • Olfactory Receptor, Family 5, Subfamily T, Member 2 2
  • Olfactory Receptor 5T2 3
  • OR11-177 3

External Ids for OR5T2 Gene

Previous GeneCards Identifiers for OR5T2 Gene

  • GC11U990418
  • GC11M055775
  • GC11M055756
  • GC11M055999

Summaries for OR5T2 Gene

Entrez Gene Summary for OR5T2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5T2 Gene

OR5T2 (Olfactory Receptor Family 5 Subfamily T Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5T1.

UniProtKB/Swiss-Prot for OR5T2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5T2 Gene

Additional gene information for OR5T2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5T2 Gene

Genomics for OR5T2 Gene

GeneHancer (GH) Regulatory Elements for OR5T2 Gene

Top Transcription factor binding sites by QIAGEN in the OR5T2 gene promoter:
  • AML1a
  • FOXD3
  • POU3F1
  • CUTL1
  • FOXO4
  • Evi-1
  • NF-kappaB1
  • FOXF2
  • AREB6
  • HNF-3beta

Genomic Locations for OR5T2 Gene

Genomic Locations for OR5T2 Gene
2,974 bases
Minus strand
1,248 bases
Minus strand

Genomic View for OR5T2 Gene

Genes around OR5T2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5T2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5T2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5T2 Gene

Proteins for OR5T2 Gene

  • Protein details for OR5T2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5T2
    Protein Accession:
    Secondary Accessions:
    • B9EGX5
    • Q6IFC8

    Protein attributes for OR5T2 Gene

    359 amino acids
    Molecular mass:
    40696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5T2 Gene

Post-translational modifications for OR5T2 Gene

  • Glycosylation at Asn44
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5T2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5T2 Gene

Domains & Families for OR5T2 Gene

Gene Families for OR5T2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5T2 Gene

Suggested Antigen Peptide Sequences for OR5T2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5T2: view

Function for OR5T2 Gene

Molecular function for OR5T2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA,IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA --
GO:0030594 neurotransmitter receptor activity IBA --
genes like me logo Genes that share ontologies with OR5T2: view
genes like me logo Genes that share phenotypes with OR5T2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5T2 Gene

Localization for OR5T2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5T2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5T2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with OR5T2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5T2 Gene

Pathways & Interactions for OR5T2 Gene

genes like me logo Genes that share pathways with OR5T2: view

Pathways by source for OR5T2 Gene

Interacting Proteins for OR5T2 Gene

Gene Ontology (GO) - Biological Process for OR5T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
GO:0007268 chemical synaptic transmission IBA --
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5T2: view

No data available for SIGNOR curated interactions for OR5T2 Gene

Drugs & Compounds for OR5T2 Gene

No Compound Related Data Available

Transcripts for OR5T2 Gene

mRNA/cDNA for OR5T2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5T2 Gene

Olfactory receptor, family 5, subfamily T, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5T2 Gene

No ASD Table

Relevant External Links for OR5T2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5T2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5T2 Gene

Protein differential expression in normal tissues from HIPED for OR5T2 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR5T2 Gene

Protein tissue co-expression partners for OR5T2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5T2 Gene:


SOURCE GeneReport for Unigene cluster for OR5T2 Gene:

genes like me logo Genes that share expression patterns with OR5T2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5T2 Gene

Orthologs for OR5T2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5T2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466553 33
  • 98.79 (n)
OR5T2 34
  • 97 (a)
(Canis familiaris)
Mammalia LOC610544 33
  • 85.16 (n)
OR5T2 34
  • 80 (a)
(Mus musculus)
Mammalia Or5t7 51 Olfr1086 16 34 33
  • 79.63 (n)
Or5t18 51 Olfr141 34
  • 75 (a)
Or5t15 51 Olfr1095 34
  • 75 (a)
Or5t16 51 Olfr1101 34
  • 74 (a)
Or5n1-ps 51 Olfr1088-ps1
  • chr2:86,704,917-86,705,736
(Rattus norvegicus)
Mammalia Olr510 33
  • 79.55 (n)
(Bos Taurus)
Mammalia -- 34
  • 79 (a)
-- 34
  • 78 (a)
-- 34
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
Species where no ortholog for OR5T2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5T2 Gene

Gene Tree for OR5T2 (if available)
Gene Tree for OR5T2 (if available)
Evolutionary constrained regions (ECRs) for OR5T2: view image

Paralogs for OR5T2 Gene

Paralogs for OR5T2 Gene

(424) SIMAP similar genes for OR5T2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5T2: view

Variants for OR5T2 Gene

Sequence variations from dbSNP and Humsavar for OR5T2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000334622 -- 56,233,449(-) A/G upstream_transcript_variant
rs1000399375 -- 56,234,110(-) T/C upstream_transcript_variant
rs1000784386 -- 56,233,701(-) T/C upstream_transcript_variant
rs1002334145 -- 56,234,035(-) C/T upstream_transcript_variant
rs1007377850 -- 56,234,589(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5T2 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv200e214 CNV gain 21293372
esv3579715 CNV loss 25503493
esv3579722 CNV loss 25503493
esv3579782 CNV gain 25503493
esv3626475 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv521440 CNV loss 19592680
nsv972030 CNV duplication 23825009

Variation tolerance for OR5T2 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.77; 73.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5T2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5T2 Gene

Disorders for OR5T2 Gene

Additional Disease Information for OR5T2

No disorders were found for OR5T2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5T2 Gene

Publications for OR5T2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR5T2 Gene

Sources for OR5T2 Gene

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