Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5T2 Gene

Aliases for OR5T2 Gene

  • Olfactory Receptor Family 5 Subfamily T Member 2 2 3 5
  • Olfactory Receptor OR11-177 3 4
  • Olfactory Receptor 5T2 3 4
  • Olfactory Receptor, Family 5, Subfamily T, Member 2 2
  • OR11-177 3
  • OR5T2 5

External Ids for OR5T2 Gene

Previous GeneCards Identifiers for OR5T2 Gene

  • GC11U990418
  • GC11M055775
  • GC11M055756
  • GC11M055999
  • GC11M056232
  • GC11M056434
  • GC11M057045
  • GC11M056363
  • GC11M059775
  • GC11M056430
  • GC11M061212
  • GC11M063677

Summaries for OR5T2 Gene

Entrez Gene Summary for OR5T2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5T2 Gene

OR5T2 (Olfactory Receptor Family 5 Subfamily T Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5T1.

UniProtKB/Swiss-Prot Summary for OR5T2 Gene

Gene Wiki entry for OR5T2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5T2 Gene

Genomics for OR5T2 Gene

GeneHancer (GH) Regulatory Elements Pubs


Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5T2

Top Transcription factor binding sites by QIAGEN in the OR5T2 gene promoter:
  • AML1a
  • AREB6
  • CUTL1
  • Evi-1
  • FOXD3
  • FOXF2
  • FOXO4
  • HNF-3beta
  • NF-kappaB1
  • POU3F1

Genomic Locations for OR5T2 Gene

Latest Assembly
chr11:56,231,282-56,234,255
(GRCh38/hg38)
Size:
2,974 bases
Orientation:
Minus strand

Previous Assembly
chr11:55,998,758-56,001,731
(GRCh37/hg19 by Entrez Gene)
Size:
2,974 bases
Orientation:
Minus strand

chr11:55,999,490-56,000,737
(GRCh37/hg19 by Ensembl)
Size:
1,248 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr11(ALT_REF_LOCI_1):42,031-45,004 (-)

Genomic View for OR5T2 Gene

Genes around OR5T2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5T2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5T2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5T2 Gene

Proteins for OR5T2 Gene

  • Protein details for OR5T2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGG2-OR5T2_HUMAN
    Recommended name:
    Olfactory receptor 5T2
    Protein Accession:
    Q8NGG2
    Secondary Accessions:
    • B9EGX5
    • Q6IFC8

    Protein attributes for OR5T2 Gene

    Size:
    359 amino acids
    Molecular mass:
    40696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5T2 Gene

Post-translational modifications for OR5T2 Gene

  • Glycosylation at Asn44
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5T2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5T2 Gene

Domains & Families for OR5T2 Gene

Gene Families for OR5T2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5T2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR5T2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-177 (OR5T2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGG2

UniProtKB/Swiss-Prot:

OR5T2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5T2: view

Function for OR5T2 Gene

Molecular function for OR5T2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5T2 Gene

Gene Ontology (GO) - Molecular Function for OR5T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR5T2: view
genes like me logo Genes that share phenotypes with OR5T2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5T2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5T2 Gene

Localization for OR5T2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5T2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5T2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with OR5T2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5T2 Gene

Pathways & Interactions for OR5T2 Gene

genes like me logo Genes that share pathways with OR5T2: view

Pathways by source for OR5T2 Gene

Interacting Proteins for OR5T2 Gene

Gene Ontology (GO) - Biological Process for OR5T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5T2: view

No data available for SIGNOR curated interactions for OR5T2 Gene

Drugs & Compounds for OR5T2 Gene

No Compound Related Data Available

Transcripts for OR5T2 Gene

mRNA/cDNA for OR5T2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5T2

Alternative Splicing Database (ASD) splice patterns (SP) for OR5T2 Gene

No ASD Table

Relevant External Links for OR5T2 Gene

GeneLoc Exon Structure for
OR5T2

Expression for OR5T2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5T2 Gene

Protein differential expression in normal tissues from HIPED for OR5T2 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR5T2 Gene



Protein tissue co-expression partners for OR5T2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5T2

SOURCE GeneReport for Unigene cluster for OR5T2 Gene:

Hs.553627
genes like me logo Genes that share expression patterns with OR5T2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5T2 Gene

Orthologs for OR5T2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5T2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466553 29
  • 98.79 (n)
OR5T2 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC610544 29
  • 85.16 (n)
OR5T2 30
  • 80 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or5t7 45 Olfr1086 29 16 30
  • 79.63 (n)
OneToMany
Or5t18 45 Olfr141 30
  • 75 (a)
OneToMany
Or5t15 45 Olfr1095 30
  • 75 (a)
OneToMany
Or5t16 45 Olfr1101 30
  • 74 (a)
OneToMany
Or5n1-ps 45 Olfr1088-ps1
  • chr2:86,704,917-86,705,736
Rat
(Rattus norvegicus)
Mammalia Olr510 29
  • 79.55 (n)
Cow
(Bos Taurus)
Mammalia -- 30
  • 79 (a)
OneToMany
-- 30
  • 78 (a)
OneToMany
-- 30
  • 74 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 68 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 64 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 51 (a)
OneToMany
Species where no ortholog for OR5T2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5T2 Gene

ENSEMBL:
Gene Tree for OR5T2 (if available)
TreeFam:
Gene Tree for OR5T2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5T2: view image
Alliance of Genome Resources:
Additional Orthologs for OR5T2

Paralogs for OR5T2 Gene

(424) SIMAP similar genes for OR5T2 Gene using alignment to 1 proteins:

  • OR5T2_HUMAN
genes like me logo Genes that share paralogs with OR5T2: view

Variants for OR5T2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5T2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10791893 -- p.Val87Leu
rs11227599 -- p.Thr64Ile
rs12221615 -- p.Leu238Val
rs3919907 -- p.Ser21Tyr
rs7121880 -- p.His309Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5T2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5T2 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv200e214 CNV gain 21293372
esv3579715 CNV loss 25503493
esv3579722 CNV loss 25503493
esv3579782 CNV gain 25503493
esv3626475 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv521440 CNV loss 19592680
nsv972030 CNV duplication 23825009

Variation tolerance for OR5T2 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.77; 73.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5T2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5T2
Leiden Open Variation Database (LOVD)
OR5T2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5T2 Gene

Disorders for OR5T2 Gene

Additional Disease Information for OR5T2

No disorders were found for OR5T2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5T2 Gene

Publications for OR5T2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR5T2 Gene

Sources for OR5T2 Gene