Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5P2 Gene

Aliases for OR5P2 Gene

  • Olfactory Receptor Family 5 Subfamily P Member 2 2 3 5
  • Olfactory Receptor-Like Protein JCG3 3 4
  • Olfactory Receptor 5P2 3 4
  • JCG3 2 3
  • Olfactory Receptor, Family 5, Subfamily P, Member 2 2
  • Olfactory Receptor OR11-93 3
  • OR5P2 5
  • JCG4 3

External Ids for OR5P2 Gene

Previous GeneCards Identifiers for OR5P2 Gene

  • GC11U990303
  • GC11M007782
  • GC11M007774
  • GC11M007817
  • GC11M007799
  • GC11M007798

Summaries for OR5P2 Gene

Entrez Gene Summary for OR5P2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5P2 Gene

OR5P2 (Olfactory Receptor Family 5 Subfamily P Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5P3.

UniProtKB/Swiss-Prot Summary for OR5P2 Gene

Gene Wiki entry for OR5P2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5P2 Gene

Genomics for OR5P2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR5P2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J007805 Enhancer 0.2 Ensembl 0.4 -8.8 -8828 0.8 LOC283299 piR-36575-018 OR5P2 OR5P3 ENSG00000271758
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5P2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5P2

Top Transcription factor binding sites by QIAGEN in the OR5P2 gene promoter:
  • En-1
  • GR
  • GR-alpha
  • GR-beta
  • Max1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Nkx5-1
  • USF2

Genomic Locations for OR5P2 Gene

Latest Assembly
chr11:7,795,905-7,796,973
(GRCh38/hg38)
Size:
1,069 bases
Orientation:
Minus strand

Previous Assembly
chr11:7,817,521-7,818,489
(GRCh37/hg19 by Entrez Gene)
Size:
969 bases
Orientation:
Minus strand

chr11:7,817,452-7,818,520
(GRCh37/hg19 by Ensembl)
Size:
1,069 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr11(ALT_REF_LOCI_1):16,842-17,810 (-)
  • chr11(PATCHES):16,842-17,810 (-)

Genomic View for OR5P2 Gene

Genes around OR5P2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5P2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5P2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5P2 Gene

Proteins for OR5P2 Gene

  • Protein details for OR5P2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ92-OR5P2_HUMAN
    Recommended name:
    Olfactory receptor 5P2
    Protein Accession:
    Q8WZ92
    Secondary Accessions:
    • Q3MIS8

    Protein attributes for OR5P2 Gene

    Size:
    322 amino acids
    Molecular mass:
    35786 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5P2 Gene

Post-translational modifications for OR5P2 Gene

  • Glycosylation at Asn8 and Asn259

Other Protein References for OR5P2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5P2 Gene

Domains & Families for OR5P2 Gene

Gene Families for OR5P2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5P2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR5P2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor-like protein JCG3 (OR5P2_HUMAN)
  • Olfactory receptor-like protein JCG4 (Q8WZ86_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WZ92

UniProtKB/Swiss-Prot:

OR5P2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5P2: view

Function for OR5P2 Gene

Molecular function for OR5P2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.

Phenotypes From GWAS Catalog for OR5P2 Gene

Gene Ontology (GO) - Molecular Function for OR5P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5P2: view
genes like me logo Genes that share phenotypes with OR5P2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5P2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5P2 Gene

Localization for OR5P2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5P2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5P2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5P2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5P2 Gene

Pathways & Interactions for OR5P2 Gene

genes like me logo Genes that share pathways with OR5P2: view

Pathways by source for OR5P2 Gene

Interacting Proteins for OR5P2 Gene

Gene Ontology (GO) - Biological Process for OR5P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5P2: view

No data available for SIGNOR curated interactions for OR5P2 Gene

Drugs & Compounds for OR5P2 Gene

No Compound Related Data Available

Transcripts for OR5P2 Gene

mRNA/cDNA for OR5P2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5P2

Alternative Splicing Database (ASD) splice patterns (SP) for OR5P2 Gene

No ASD Table

Relevant External Links for OR5P2 Gene

GeneLoc Exon Structure for
OR5P2

Expression for OR5P2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5P2 Gene

mRNA differential expression in normal tissues according to GTEx for OR5P2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x13.2), Skin - Sun Exposed (Lower leg) (x12.1), and Bladder (x10.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5P2

SOURCE GeneReport for Unigene cluster for OR5P2 Gene:

Hs.351824

mRNA Expression by UniProt/SwissProt for OR5P2 Gene:

Q8WZ92-OR5P2_HUMAN
Tissue specificity: Expressed in the tongue.
genes like me logo Genes that share expression patterns with OR5P2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5P2 Gene

Orthologs for OR5P2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5P2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466430 29
  • 99.07 (n)
OR5P2 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC516263 29
  • 84.52 (n)
-- 30
  • 79 (a)
OneToMany
-- 30
  • 73 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC100683576 29
  • 84.37 (n)
OR5P2 30
  • 76 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or5p76 45 Olfr502 29 16 30
  • 81.87 (n)
OneToMany
Or5p6 45 Olfr478 30
  • 77 (a)
OneToMany
Or5p68 45 Olfr493 30
  • 75 (a)
OneToMany
Or5p78 45 Olfr506 30
  • 75 (a)
OneToMany
Or5p50 45 Olfr469 30
  • 74 (a)
OneToMany
Or5p69 45 Olfr494 30
  • 74 (a)
OneToMany
Or5p60 45 Olfr484 30
  • 73 (a)
OneToMany
Or5p66 45 Olfr490 30
  • 73 (a)
OneToMany
Or5p79 45 Olfr507 30
  • 73 (a)
OneToMany
Or5p81 45 Olfr510 30
  • 72 (a)
OneToMany
Or5p59 45 Olfr483 30
  • 72 (a)
OneToMany
Or5p51 45 Olfr470 30
  • 72 (a)
OneToMany
Or5p72 45 Olfr497 30
  • 72 (a)
OneToMany
Or5p58 45 Olfr482 30
  • 71 (a)
OneToMany
Or5p64 45 Olfr488 30
  • 69 (a)
OneToMany
Or5p62 45 Olfr486 30
  • 67 (a)
OneToMany
Or5p70 45 Olfr495 30
  • 67 (a)
OneToMany
Or5p63 45 Olfr487 30
  • 67 (a)
OneToMany
Or5p73 45 Olfr498 30
  • 66 (a)
OneToMany
Or5p61 45 Olfr485
  • chr7:108,158,921-108,159,871
Or5p65-ps 45 Olfr489-ps1
  • chr7:108,276,748-108,277,685
Or5p67 45 Olfr492
  • chr7:108,322,733-108,323,674
Or5p71-ps 45 Olfr496-ps1
  • chr7:108,417,104-108,418,004
Or5p74-ps 45 Olfr500-ps1
  • chr7:108,485,906-108,486,857
Or5p75-ps 45 Olfr501-ps1
  • chr7:108,508,058-108,509,000
Or5p77-ps 45 Olfr505-ps1
  • chr7:108,574,560-108,575,385
Rat
(Rattus norvegicus)
Mammalia Olr279 29
  • 81.43 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 59 (a)
OneToMany
-- 30
  • 58 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 57 (a)
OneToMany
-- 30
  • 56 (a)
OneToMany
-- 30
  • 55 (a)
OneToMany
-- 30
  • 55 (a)
OneToMany
-- 30
  • 55 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 53 (a)
OneToMany
-- 30
  • 53 (a)
OneToMany
-- 30
  • 53 (a)
OneToMany
-- 30
  • 52 (a)
OneToMany
-- 30
  • 52 (a)
OneToMany
Species where no ortholog for OR5P2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5P2 Gene

ENSEMBL:
Gene Tree for OR5P2 (if available)
TreeFam:
Gene Tree for OR5P2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5P2: view image
Alliance of Genome Resources:
Additional Orthologs for OR5P2

Paralogs for OR5P2 Gene

(441) SIMAP similar genes for OR5P2 Gene using alignment to 1 proteins:

  • OR5P2_HUMAN
genes like me logo Genes that share paralogs with OR5P2: view

Variants for OR5P2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5P2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1482804 -- p.Gly7Arg
rs7949771 -- p.Asn318Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5P2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5P2 Gene

Variant ID Type Subtype PubMed ID
dgv1632n54 CNV loss 21841781
dgv1633n54 CNV loss 21841781
dgv1634n54 CNV loss 21841781
dgv1635n54 CNV loss 21841781
dgv1636n54 CNV loss 21841781
dgv1637n54 CNV loss 21841781
dgv1638n54 CNV loss 21841781
dgv18e203 CNV loss 21179565
dgv190e199 CNV deletion 23128226
dgv199n67 CNV loss 20364138
dgv320e212 CNV loss 25503493
dgv321e212 CNV loss 25503493
esv22126 CNV loss 19812545
esv2422018 CNV deletion 20811451
esv3547283 CNV deletion 23714750
esv3625301 CNV loss 21293372
esv3625302 CNV gain 21293372
esv3891927 CNV loss 25118596
nsv1035675 CNV loss 25217958
nsv1047533 CNV loss 25217958
nsv1159830 OTHER complex 26073780
nsv436124 CNV deletion 17901297
nsv442601 CNV loss 18776908
nsv498751 CNV loss 21111241
nsv499766 OTHER inversion 21111241
nsv509387 CNV insertion 20534489
nsv510998 OTHER complex 20534489
nsv514633 CNV loss 21397061
nsv553408 CNV loss 21841781
nsv553409 CNV loss 21841781
nsv553411 CNV loss 21841781
nsv7215 OTHER inversion 18451855
nsv7660 CNV deletion 18451855

Variation tolerance for OR5P2 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.81; 95.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5P2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5P2
Leiden Open Variation Database (LOVD)
OR5P2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5P2 Gene

Disorders for OR5P2 Gene

Additional Disease Information for OR5P2

No disorders were found for OR5P2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5P2 Gene

Publications for OR5P2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin JC … Haertlé T (Chemical senses 2001) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR5P2 Gene

Sources for OR5P2 Gene