OR5M3 Gene (Protein Coding)

Olfactory Receptor Family 5 Subfamily M Member 3

GC11M056469
GIFtS:
31
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5M3 Gene

Aliases for OR5M3 Gene

  • Olfactory Receptor Family 5 Subfamily M Member 3 2 3 5
  • Olfactory Receptor OR11-191 3 4
  • Olfactory Receptor 5M3 3 4
  • Olfactory Receptor, Family 5, Subfamily M, Member 3 2
  • OR11-191 3
  • OR5M3 5

External Ids for OR5M3 Gene

Previous GeneCards Identifiers for OR5M3 Gene

  • GC11U990361
  • GC11M056014
  • GC11M055993
  • GC11M056237

Summaries for OR5M3 Gene

Entrez Gene Summary for OR5M3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5M3 Gene

OR5M3 (Olfactory Receptor Family 5 Subfamily M Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is ENSG00000284732.

UniProtKB/Swiss-Prot Summary for OR5M3 Gene

Gene Wiki entry for OR5M3 Gene

Additional gene information for OR5M3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5M3 Gene

Genomics for OR5M3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR5M3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J056474 Enhancer 0.2 ENCODE 250.7 -1.6 -1588 0.2 ENSG00000284732 OR5M3 RTN4RL2 OR5M2P OR5M8
GH11J056895 Enhancer 0.2 FANTOM5 11.8 -422.5 -422464 0 OR5M10 OR5M9 OR5AP2 OR5M1 OR5M3 OR5AR1 OR5M8 OR8U3 OR5M11 FADS2B
GH11J056486 Enhancer 0.2 ENCODE 0.4 -14.0 -14029 2.3 FAM8A2P OR5M2P OR5M8 ENSG00000284732 OR5M3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5M3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5M3

Top Transcription factor binding sites by QIAGEN in the OR5M3 gene promoter:
  • AML1a
  • Bach1
  • CREB
  • deltaCREB
  • FOXO1
  • FOXO1a
  • Pbx1a
  • POU2F1
  • POU2F1a

Genomic Locations for OR5M3 Gene

Latest Assembly
chr11:56,469,274-56,473,352
(GRCh38/hg38)
Size:
4,079 bases
Orientation:
Minus strand

Previous Assembly
chr11:56,236,750-56,240,828
(GRCh37/hg19 by Entrez Gene)
Size:
4,079 bases
Orientation:
Minus strand

chr11:56,236,964-56,238,014
(GRCh37/hg19 by Ensembl)
Size:
1,051 bases
Orientation:
Minus strand

Genomic View for OR5M3 Gene

Genes around OR5M3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5M3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5M3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR5M3 Gene

Proteins for OR5M3 Gene

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  • Protein details for OR5M3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGP4-OR5M3_HUMAN
    Recommended name:
    Olfactory receptor 5M3
    Protein Accession:
    Q8NGP4
    Secondary Accessions:
    • B2RNM7
    • Q6IEW4
    • Q96RC0

    Protein attributes for OR5M3 Gene

    Size:
    307 amino acids
    Molecular mass:
    35156 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5M3 Gene

Protein Expression for OR5M3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OR5M3 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5M3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5M3 Gene

Domains & Families for OR5M3 Gene

Gene Families for OR5M3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5M3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR5M3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-191 (OR5M3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGP4

UniProtKB/Swiss-Prot:

OR5M3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5M3: view

Function for OR5M3 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for OR5M3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5M3 Gene

Gene Ontology (GO) - Molecular Function for OR5M3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5M3: view
genes like me logo Genes that share phenotypes with OR5M3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5M3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5M3 Gene

Localization for OR5M3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5M3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5M3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5M3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5M3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5M3 Gene

Pathways & Interactions for OR5M3 Gene

genes like me logo Genes that share pathways with OR5M3: view

Pathways by source for OR5M3 Gene

1 KEGG pathway for OR5M3 Gene

Interacting Proteins for OR5M3 Gene

Selected Interacting proteins: Q8NGP4-OR5M3_HUMAN for OR5M3 Gene via IID

GPS-Prot Interaction Network for OR5M3

Gene Ontology (GO) - Biological Process for OR5M3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5M3: view

No data available for SIGNOR curated interactions for OR5M3 Gene

Drugs & Compounds for OR5M3 Gene

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No Compound Related Data Available

Transcripts for OR5M3 Gene

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mRNA/cDNA for OR5M3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5M3

Alternative Splicing Database (ASD) splice patterns (SP) for OR5M3 Gene

No ASD Table

Relevant External Links for OR5M3 Gene

GeneLoc Exon Structure for
OR5M3

Expression for OR5M3 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5M3 Gene

mRNA expression in normal human tissues for OR5M3 Gene
mRNA expression by GTEx for OR5M3 Gene

Protein differential expression in normal tissues from HIPED for OR5M3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR5M3 Gene



Protein tissue co-expression partners for OR5M3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5M3

SOURCE GeneReport for Unigene cluster for OR5M3 Gene:

Hs.553631
genes like me logo Genes that share expression patterns with OR5M3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5M3 Gene

Orthologs for OR5M3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5M3 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
 Mammalia Or5m3b 45 Olfr1033 30
  • 89 (a)
 OneToMany
Or5m3 45 Olfr1032 29 16 30
  • 85.62 (n)
 OneToMany
Dog
(Canis familiaris)
 Mammalia OR5M3 29 30
  • 87.73 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia OR5M3 29 30
  • 87.58 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Olr473 29
  • 85.73 (n)
Oppossum
(Monodelphis domestica)
 Mammalia OR5M3 30
  • 82 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 58 (a)
 OneToMany
Species where no ortholog for OR5M3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5M3 Gene

ENSEMBL:
Gene Tree for OR5M3 (if available)
TreeFam:
Gene Tree for OR5M3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5M3: view image
Alliance of Genome Resources:
Additional Orthologs for OR5M3

Paralogs for OR5M3 Gene

Paralogs for OR5M3 Gene

(448) SIMAP similar genes for OR5M3 Gene using alignment to 1 proteins:

  • OR5M3_HUMAN

Pseudogenes.org Pseudogenes for OR5M3 Gene

genes like me logo Genes that share paralogs with OR5M3: view

Variants for OR5M3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5M3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs17150664 -- p.Gly163Ser
rs605734 -- p.Leu84Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5M3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5M3 Gene

Variant ID Type Subtype PubMed ID
dgv220n67 CNV gain 20364138
esv3579724 CNV loss 25503493
nsv825910 CNV gain 20364138
nsv825911 CNV gain 20364138

Variation tolerance for OR5M3 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5M3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5M3
Leiden Open Variation Database (LOVD)
OR5M3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5M3 Gene

Disorders for OR5M3 Gene

Additional Disease Information for OR5M3

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR5M3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5M3 Gene

Publications for OR5M3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair. (PMID: 31900314) Chen Z … Chen J (Molecular & cellular proteomics : MCP 2020) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

ExternalLinks

View latest publications for OR5M3 gene in Mastermind

Products for OR5M3 Gene

Sources for OR5M3 Gene