Free for academic non-profit institutions. Other users need a Commercial license
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR5M3 (Olfactory Receptor Family 5 Subfamily M Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is ENSG00000284732.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J056474 | Enhancer | 0.2 | ENCODE | 600.7 | -1.6 | -1588 | 0.2 | ENSG00000284732 OR5M3 OR5R1 RTN4RL2 OR5M2P OR5M8 | ||
GH11J056895 | Enhancer | 0.2 | FANTOM5 | 11.8 | -422.5 | -422464 | 0 | OR5M10 OR5M9 OR5AP2 OR5M1 OR5M3 OR5AR1 OR5M8 OR5R1 OR5M11 FADS2B | ||
GH11J056486 | Enhancer | 0.3 | ENCODE | 0.4 | -14.0 | -14029 | 2.3 | SMARCA4 | FAM8A2P OR5M2P OR5M8 ENSG00000284732 OR5M3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | -- |
GO:0005549 | odorant binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IBA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Or5m3b 46 Olfr1033 31 |
|
OneToMany |
|
Or5m3 46 Olfr1032 30 17 31 |
|
OneToMany |
|
||
Dog (Canis familiaris) |
Mammalia | OR5M3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OR5M3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Olr473 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | OR5M3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17150664 | - | p.Gly163Ser | |||
rs605734 | - | p.Leu84Phe |
No disorders were found for OR5M3 Gene.