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Aliases for OR5L2 Gene

Aliases for OR5L2 Gene

  • Olfactory Receptor Family 5 Subfamily L Member 2 2 3 5
  • Olfactory Receptor OR11-153 3 4
  • HTPCRX16 3 4
  • Olfactory Receptor, Family 5, Subfamily L, Member 1 3
  • Olfactory Receptor, Family 5, Subfamily L, Member 2 2
  • Olfactory Receptor 5L2 3
  • HSHTPCRX16 3
  • OR11-153 3

External Ids for OR5L2 Gene

Previous GeneCards Identifiers for OR5L2 Gene

  • GC11P057988
  • GC11U900022
  • GC11P055845
  • GC11P055371
  • GC11P055351
  • GC11P055594

Summaries for OR5L2 Gene

Entrez Gene Summary for OR5L2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5L2 Gene

OR5L2 (Olfactory Receptor Family 5 Subfamily L Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5L1.

UniProtKB/Swiss-Prot for OR5L2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5L2 Gene

Additional gene information for OR5L2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5L2 Gene

Genomics for OR5L2 Gene

GeneHancer (GH) Regulatory Elements for OR5L2 Gene

Promoters and enhancers for OR5L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J055430 Enhancer 0.2 FANTOM5 14.7 -396.9 -396888 0 GC11P055433 GC11P055434 OR4A10P OR5D14 OR5D18 OR4C15 OR5L2 OR4C16 OR5D16 OR4C6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5L2 gene promoter:
  • Chx10
  • Nkx3-1
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • STAT3
  • Lmo2

Genomic Locations for OR5L2 Gene

Genomic Locations for OR5L2 Gene
936 bases
Plus strand
936 bases
Plus strand

Genomic View for OR5L2 Gene

Genes around OR5L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5L2 Gene

Proteins for OR5L2 Gene

  • Protein details for OR5L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5L2
    Protein Accession:
    Secondary Accessions:
    • Q6IF66
    • Q96RB2

    Protein attributes for OR5L2 Gene

    311 amino acids
    Molecular mass:
    34682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5L2 Gene

Post-translational modifications for OR5L2 Gene

  • Glycosylation at Asn195 and isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5L2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5L2 Gene

Domains & Families for OR5L2 Gene

Gene Families for OR5L2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5L2 Gene

Suggested Antigen Peptide Sequences for OR5L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5L2: view

Function for OR5L2 Gene

Molecular function for OR5L2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5L2: view
genes like me logo Genes that share phenotypes with OR5L2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5L2 Gene

Localization for OR5L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5L2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5L2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5L2 Gene

Pathways & Interactions for OR5L2 Gene

genes like me logo Genes that share pathways with OR5L2: view

Pathways by source for OR5L2 Gene

Interacting Proteins for OR5L2 Gene

Gene Ontology (GO) - Biological Process for OR5L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5L2: view

No data available for SIGNOR curated interactions for OR5L2 Gene

Drugs & Compounds for OR5L2 Gene

No Compound Related Data Available

Transcripts for OR5L2 Gene

mRNA/cDNA for OR5L2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5L2 Gene

Olfactory receptor, family 5, subfamily L, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5L2 Gene

No ASD Table

Relevant External Links for OR5L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5L2 Gene:


SOURCE GeneReport for Unigene cluster for OR5L2 Gene:

genes like me logo Genes that share expression patterns with OR5L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5L2 Gene

Orthologs for OR5L2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466540 33
  • 98.93 (n)
OR5L2 34
  • 98 (a)
(Canis familiaris)
Mammalia -- 34
  • 82 (a)
(Bos Taurus)
Mammalia OR5L2 33
  • 78.24 (n)
-- 34
  • 77 (a)
-- 34
  • 67 (a)
-- 34
  • 67 (a)
(Mus musculus)
Mammalia Olfr1157 34
  • 78 (a)
Olfr1156 16 33
  • 76.96 (n)
(Rattus norvegicus)
Mammalia Olr601 33
  • 76.95 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
Species where no ortholog for OR5L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5L2 Gene

Gene Tree for OR5L2 (if available)
Gene Tree for OR5L2 (if available)
Evolutionary constrained regions (ECRs) for OR5L2: view image

Paralogs for OR5L2 Gene

Paralogs for OR5L2 Gene

(446) SIMAP similar genes for OR5L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5L2: view

Variants for OR5L2 Gene

Sequence variations from dbSNP and Humsavar for OR5L2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000012435 -- 55,826,221(+) A/G upstream_transcript_variant
rs1000085459 -- 55,826,032(+) A/G upstream_transcript_variant
rs1000726862 -- 55,827,189(+) T/C upstream_transcript_variant
rs1000778154 -- 55,827,367(+) A/G coding_sequence_variant, missense_variant
rs1003376437 -- 55,828,394(+) ATTATTA/ATTA downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5L2 Gene

Variant ID Type Subtype PubMed ID
dgv1193n100 CNV loss 25217958
dgv1204n100 CNV loss 25217958
dgv1205n100 CNV gain 25217958
dgv12n64 CNV loss 17921354
dgv150n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1941n54 CNV loss 21841781
dgv212e199 CNV deletion 23128226
dgv50e55 CNV loss 17911159
dgv51e55 CNV loss 17911159
esv22842 CNV gain+loss 19812545
esv2744537 CNV deletion 23290073
esv2751030 CNV gain 17911159
esv2759828 CNV gain+loss 17122850
esv2760216 CNV loss 21179565
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626453 CNV loss 21293372
esv3626454 CNV gain 21293372
esv3626456 CNV loss 21293372
nsv1044174 CNV loss 25217958
nsv39282 CNV deletion 16902084
nsv428256 CNV loss 18775914
nsv437717 CNV loss 16327808
nsv469885 CNV loss 16826518
nsv469958 CNV loss 18288195
nsv517440 CNV gain+loss 19592680
nsv554801 CNV loss 21841781
nsv821668 CNV loss 15273396
nsv832158 CNV gain 17160897
nsv972027 CNV duplication 23825009

Variation tolerance for OR5L2 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5L2 Gene

Disorders for OR5L2 Gene

Additional Disease Information for OR5L2

No disorders were found for OR5L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5L2 Gene

Publications for OR5L2 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR5L2 Gene

Sources for OR5L2 Gene

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